KEGG   Homo sapiens (human): 2938
Entry
2938              CDS       T01001                                 
Symbol
GSTA1, GST-epsilon, GST2, GSTA1-1, GTH1
Name
(RefSeq) glutathione S-transferase alpha 1
  KO
K00799  glutathione S-transferase [EC:2.5.1.18]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00480  Glutathione metabolism
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa00983  Drug metabolism - other enzymes
hsa01100  Metabolic pathways
hsa01524  Platinum drug resistance
hsa05200  Pathways in cancer
hsa05204  Chemical carcinogenesis - DNA adducts
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05225  Hepatocellular carcinoma
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06226  KEAP1-NRF2 signaling (cancer)
nt06227  Nuclear receptor signaling (cancer)
nt06250  DNA adduct formation (cancer)
nt06263  Hepatocellular carcinoma
nt06463  Parkinson disease
  Element
N00243  KEAP1-NRF2 signaling pathway
N00244  Mutation-inactivated KEAP1 to KEAP1-NRF2 signaling pathway
N00245  Mutation-activated NRF2 to KEAP1-NRF2 signaling pathway
N01365  TCDD to Ahr signaling pathway
N01386  DCE to DNA adducts
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    2938 (GSTA1)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    2938 (GSTA1)
   00982 Drug metabolism - cytochrome P450
    2938 (GSTA1)
   00983 Drug metabolism - other enzymes
    2938 (GSTA1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    2938 (GSTA1)
   05204 Chemical carcinogenesis - DNA adducts
    2938 (GSTA1)
   05207 Chemical carcinogenesis - receptor activation
    2938 (GSTA1)
   05208 Chemical carcinogenesis - reactive oxygen species
    2938 (GSTA1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    2938 (GSTA1)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    2938 (GSTA1)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    2938 (GSTA1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    2938 (GSTA1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.18  glutathione transferase
     2938 (GSTA1)
Transporters [BR:hsa02000]
 Other transporters
  Pores ion channels [TC:1]
   2938 (GSTA1)
SSDB
Motif
Pfam: GST_C GST_C_3 GST_N GST_N_3 GST_N_2
Other DBs
NCBI-GeneID: 2938
NCBI-ProteinID: NP_665683
OMIM: 138359
HGNC: 4626
Ensembl: ENSG00000243955
UniProt: P08263 A0A140VJK4
Structure
Position
6:complement(52791371..52803816)
AA seq 222 aa
MAEKPKLHYFNARGRMESTRWLLAAAGVEFEEKFIKSAEDLDKLRNDGYLMFQQVPMVEI
DGMKLVQTRAILNYIASKYNLYGKDIKERALIDMYIEGIADLGEMILLLPVCPPEEKDAK
LALIKEKIKNRYFPAFEKVLKSHGQDYLVGNKLSRADIHLVELLYYVEELDSSLISSFPL
LKALKTRISNLPTVKKFLQPGSPRKPPMDEKSLEEARKIFRF
NT seq 669 nt   +upstreamnt  +downstreamnt
atggcagagaagcccaagctccactacttcaatgcacggggcagaatggagtccacccgg
tggctcctggctgcagctggagtagagtttgaagagaaatttataaaatctgcagaagat
ttggacaagttaagaaatgatggatatttgatgttccagcaagtgccaatggttgagatt
gatgggatgaagctggtgcagaccagagccattctcaactacattgccagcaaatacaac
ctctatgggaaagacataaaggagagagccctgattgatatgtatatagaaggtatagca
gatttgggtgaaatgatcctccttctgcccgtatgtccacctgaggaaaaagatgccaag
cttgccttgatcaaagagaaaataaaaaatcgctacttccctgcctttgaaaaagtctta
aagagccatggacaagactaccttgttggcaacaagctgagccgggctgacattcatctg
gtggaacttctctactacgtcgaggagcttgactccagtcttatctccagcttccctctg
ctgaaggccctgaaaaccagaatcagcaacctgcccacagtgaagaagtttctacagcct
ggcagcccaaggaagcctcccatggatgagaaatctttagaagaagcaaggaagattttc
aggttttaa

  All links  
Disease (1)   
   OMIM (1)   
Gene (31)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (9)   
   OC (1)   
   PROTHERM (17)   
Protein sequence (7)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (40)   
   RefSeq(nuc) (4)   
   GenBank (18)   
   EMBL (18)   
3D Structure (39)   
   PDB (39)   
Protein domain (5)   
   Pfam (5)   
All databases (123)   

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