KEGG T01001: 2941

Homo sapiens (human): 2941

Entry

2941              CDS       T01001

Symbol

GSTA4, GSTA4-4, GTA4

Name

(RefSeq) glutathione S-transferase alpha 4

K00799

glutathione S-transferase [EC:2.5.1.18]

Organism

hsa Homo sapiens (human)

Pathway

hsa00480

Glutathione metabolism

hsa00980

Metabolism of xenobiotics by cytochrome P450

hsa00982

Drug metabolism - cytochrome P450

hsa00983

Drug metabolism - other enzymes

hsa01100

Metabolic pathways

hsa01524

Platinum drug resistance

hsa05200

Pathways in cancer

hsa05204

Chemical carcinogenesis - DNA adducts

hsa05207

Chemical carcinogenesis - receptor activation

hsa05208

Chemical carcinogenesis - reactive oxygen species

hsa05225

Hepatocellular carcinoma

hsa05418

Fluid shear stress and atherosclerosis

Network

nt06226  KEAP1-NRF2 signaling (cancer)
nt06227  Nuclear receptor signaling (cancer)
nt06250  DNA adduct formation (cancer)
nt06263  Hepatocellular carcinoma
nt06463  Parkinson disease

Element

N00243

KEAP1-NRF2 signaling pathway

N00244

Mutation-inactivated KEAP1 to KEAP1-NRF2 signaling pathway

N00245

Mutation-activated NRF2 to KEAP1-NRF2 signaling pathway

N01365

TCDD to Ahr signaling pathway

N01386

DCE to DNA adducts

Brite

KEGG Orthology (KO) [BR:hsa00001]
09100 Metabolism
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    2941 (GSTA4)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    2941 (GSTA4)
   00982 Drug metabolism - cytochrome P450
    2941 (GSTA4)
   00983 Drug metabolism - other enzymes
    2941 (GSTA4)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    2941 (GSTA4)
   05204 Chemical carcinogenesis - DNA adducts
    2941 (GSTA4)
   05207 Chemical carcinogenesis - receptor activation
    2941 (GSTA4)
   05208 Chemical carcinogenesis - reactive oxygen species
    2941 (GSTA4)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    2941 (GSTA4)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    2941 (GSTA4)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    2941 (GSTA4)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    2941 (GSTA4)
Enzymes [BR:hsa01000]
2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.18  glutathione transferase
     2941 (GSTA4)
Transporters [BR:hsa02000]
Other transporters
  Pores ion channels [TC:1]
   2941 (GSTA4)

SSDB

Motif

Pfam:

GST_C_3 GST_N GST_C GST_C_2 GST_N_2 GST_N_3

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

Position

6:complement(52977953..52995284)

AA seq 222 aa
MAARPKLHYPNGRGRMESVRWVLAAAGVEFDEEFLETKEQLYKLQDGNHLLFQQVPMVEI
DGMKLVQTRSILHYIADKHNLFGKNLKERTLIDMYVEGTLDLLELLIMHPFLKPDDQQKE
VVNMAQKAIIRYFPVFEKILRGHGQSFLVGNQLSLADVILLQTILALEEKIPNILSAFPF
LQEYTVKLSNIPTIKRFLEPGSKKKPPPDEIYVRTVYNIFRP

NT seq 669 nt +upstreamnt +downstreamnt
atggcagcaaggcccaagctccactatcccaacggaagaggccggatggagtccgtgaga
tgggttttagctgccgccggagtcgagtttgatgaagaatttctggaaacaaaagaacag
ttgtacaagttgcaggatggtaaccacctgctgttccaacaagtgcccatggttgaaatt
gacgggatgaagttggtacagacccgaagcattctccactacatagcagacaagcacaat
ctctttggcaagaacctcaaggagagaaccctgattgacatgtacgtggaggggacactg
gatctgctggaactgcttatcatgcatcctttcttaaaaccagatgatcagcaaaaggaa
gtggttaacatggcccagaaggctataattagatactttcctgtgtttgaaaagatttta
aggggtcacggacaaagctttcttgttggtaatcagctgagccttgcagatgtgatttta
ctccaaaccattttagctctagaagagaaaattcctaatatcctgtctgcatttcctttc
ctccaggaatacacagtgaaactaagtaatatccctacaattaagagattccttgaacct
ggcagcaagaagaagcctccccctgatgaaatttatgtgagaaccgtctacaacatcttt
aggccataa

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