KEGG   Homo sapiens (human): 29761
Entry
29761             CDS       T01001                                 
Symbol
USP25, EIG19, USP21
Name
(RefSeq) ubiquitin specific peptidase 25
  KO
K11849  ubiquitin carboxyl-terminal hydrolase 25 [EC:3.4.19.12]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04657  IL-17 signaling pathway
Disease
H00808  Idiopathic generalized epilepsies
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04657 IL-17 signaling pathway
    29761 (USP25)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    29761 (USP25)
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    29761 (USP25)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.19  Omega peptidases
    3.4.19.12  ubiquitinyl hydrolase 1
     29761 (USP25)
Peptidases and inhibitors [BR:hsa01002]
 Cysteine peptidases
  Family C19: ubiquitin-specific protease family
   29761 (USP25)
Ubiquitin system [BR:hsa04121]
 Deubiquitinating enzyme (DUB)
  Ubiquitin-specific proteases (UBPs)
   UBP/USP
    29761 (USP25)
SSDB
Motif
Pfam: UCH USP_UIM_N UBA_8 UIM UIM_2 UBA_4
Other DBs
NCBI-GeneID: 29761
NCBI-ProteinID: NP_037528
OMIM: 604736
HGNC: 12624
Ensembl: ENSG00000155313
UniProt: Q9UHP3
Structure
Position
21:15729982..15880064
AA seq 1055 aa
MTVEQNVLQQSAAQKHQQTFLNQLREITGINDTQILQQALKDSNGNLELAVAFLTAKNAK
TPQQEETTYYQTALPGNDRYISVGSQADTNVIDLTGDDKDDLQRAIALSLAESNRAFRET
GITDEEQAISRVLEASIAENKACLKRTPTEVWRDSRNPYDRKRQDKAPVGLKNVGNTCWF
SAVIQSLFNLLEFRRLVLNYKPPSNAQDLPRNQKEHRNLPFMRELRYLFALLVGTKRKYV
DPSRAVEILKDAFKSNDSQQQDVSEFTHKLLDWLEDAFQMKAEEETDEEKPKNPMVELFY
GRFLAVGVLEGKKFENTEMFGQYPLQVNGFKDLHECLEAAMIEGEIESLHSENSGKSGQE
HWFTELPPVLTFELSRFEFNQALGRPEKIHNKLEFPQVLYLDRYMHRNREITRIKREEIK
RLKDYLTVLQQRLERYLSYGSGPKRFPLVDVLQYALEFASSKPVCTSPVDDIDASSPPSG
SIPSQTLPSTTEQQGALSSELPSTSPSSVAAISSRSVIHKPFTQSRIPPDLPMHPAPRHI
TEEELSVLESCLHRWRTEIENDTRDLQESISRIHRTIELMYSDKSMIQVPYRLHAVLVHE
GQANAGHYWAYIFDHRESRWMKYNDIAVTKSSWEELVRDSFGGYRNASAYCLMYINDKAQ
FLIQEEFNKETGQPLVGIETLPPDLRDFVEEDNQRFEKELEEWDAQLAQKALQEKLLASQ
KLRESETSVTTAQAAGDPEYLEQPSRSDFSKHLKEETIQIITKASHEHEDKSPETVLQSA
IKLEYARLVKLAQEDTPPETDYRLHHVVVYFIQNQAPKKIIEKTLLEQFGDRNLSFDERC
HNIMKVAQAKLEMIKPEEVNLEEYEEWHQDYRKFRETTMYLIIGLENFQRESYIDSLLFL
ICAYQNNKELLSKGLYRGHDEELISHYRRECLLKLNEQAAELFESGEDREVNNGLIIMNE
FIVPFLPLLLVDEMEEKDILAVEDMRNRWCSYLGQEMEPHLQEKLTDFLPKLLDCSMEIK
SFHEPPKLPSYSTHELCERFARIMLSLSRTPADGR
NT seq 3168 nt   +upstreamnt  +downstreamnt
atgaccgtggagcagaacgtgctgcagcagagcgcggcgcagaagcaccagcagacgttt
ttgaatcaactgagagaaattacggggattaatgacacccagatactacagcaagccttg
aaggatagtaatggaaacttggaattagcagtggctttccttactgcgaagaatgctaag
acccctcagcaggaggagacaacttactaccaaacagcacttcctggcaatgatagatac
atcagtgtgggaagccaagcagatacaaatgtgattgatctcactggagatgataaagat
gatcttcagagagcaattgccttgagtttggccgaatcaaacagggcattcagggagact
ggaataactgatgaggaacaagccattagcagagttcttgaagccagcatagcagagaat
aaagcatgtttgaagaggacacctacagaagtttggagggattctcgaaacccttatgat
agaaaaagacaggacaaagctcccgttgggctaaagaatgttggcaatacttgttggttt
agtgctgttattcagtcattatttaatcttttggaatttagaagattagttctgaattac
aagcctccatcaaatgctcaagatttaccccgaaaccaaaaggaacatcggaatttgcct
tttatgcgtgagctgaggtatctatttgcacttcttgttggtaccaaaaggaagtatgtt
gatccatcaagagcagttgaaattcttaaggatgctttcaaatcaaatgactcacagcag
caagatgtgagtgagtttacacacaaattattagattggttagaagatgccttccaaatg
aaagctgaagaggagacggatgaagagaagccaaagaaccccatggtagagttgttctat
ggcagattcctggctgtgggagtacttgaaggtaaaaaatttgaaaacactgaaatgttt
ggtcagtacccacttcaggtcaatgggttcaaagatctgcatgagtgcctagaagctgca
atgattgaaggagaaattgagtctttacattcagagaattcaggaaaatcaggccaagag
cattggtttactgaattaccacctgtgttaacatttgaattgtcaagatttgaatttaat
caggcattgggaagaccagaaaaaattcacaacaaattagaatttccccaagttttatat
ttggacagatacatgcacagaaacagagaaataacaagaattaagagggaagagatcaag
agactgaaagattacctcacggtattacaacaaaggctagaaagatatttaagctatggt
tccggtcccaaacgattccccttggtagatgttcttcagtatgcattggaatttgcctca
agtaaacctgtttgcacttctcctgttgacgatattgacgctagttccccacctagtggt
tccataccatcacagacattaccaagcacaacagaacaacagggagccctatcttcagaa
ctgccaagcacatcaccttcatcagttgctgccatttcatcgagatcagtaatacacaaa
ccatttactcagtcccggatacctccagatttgcccatgcatccggcaccaaggcacata
acggaggaagaactttctgtgctggaaagttgtttacatcgctggaggacagaaatagaa
aatgacaccagagatttgcaggaaagcatatccagaatccatcgaacaattgaattaatg
tactctgacaaatctatgatacaagttccttatcgattacatgccgttttagttcacgaa
ggccaagctaatgctgggcactactgggcatatatttttgatcatcgtgaaagcagatgg
atgaagtacaatgatattgctgtgacaaaatcatcatgggaagagctagtgagggactct
tttggtggttatagaaatgccagtgcatactgtttaatgtacataaatgataaggcacag
ttcctaatacaagaggagtttaataaagaaactgggcagccccttgttggtatagaaaca
ttaccaccggatttgagagattttgttgaggaagacaaccaacgatttgaaaaagaacta
gaagaatgggatgcacaacttgcccagaaagctttgcaggaaaagcttttagcgtctcag
aaattgagagagtcagagacttctgtgacaacagcacaagcagcaggagacccagaatat
ctagagcagccatcaagaagtgatttctcaaagcacttgaaagaagaaactattcaaata
attaccaaggcatcacatgagcatgaagataaaagtcctgaaacagttttgcagtcggca
attaagttggaatatgcaaggttggttaagttggcccaagaagacaccccaccagaaacc
gattatcgtttacatcatgtagtggtctactttatccagaaccaggcaccaaagaaaatt
attgagaaaacattactagaacaatttggagatagaaatttgagttttgatgaaaggtgt
cacaacataatgaaagttgctcaagccaaactggaaatgataaaacctgaagaagtaaac
ttggaggaatatgaggagtggcatcaggattataggaaattcagggaaacaactatgtat
ctcataattgggctagaaaattttcaaagagaaagttatatagattccttgctgttcctc
atctgtgcttatcagaataacaaagaactcttgtctaaaggcttatacagaggacatgat
gaagaattgatatcacattatagaagagaatgtttgctaaaattaaatgagcaagccgca
gaactcttcgaatctggagaggatcgagaagtaaacaatggtttgattatcatgaatgag
tttattgtcccatttttgccattattactggtggatgaaatggaagaaaaggatatacta
gctgtagaagatatgagaaatcgatggtgttcctaccttggtcaagaaatggaaccacac
ctccaagaaaagctgacagattttttgccaaaactgcttgattgttctatggagattaaa
agtttccatgagccaccgaagttaccttcatattccacgcatgaactctgtgagcgattt
gcccgaatcatgttgtccctcagtcgaactcctgctgatggaagataa

  All links  
Disease (2)   
   OMIM (2)   
Gene (15)   
   RefGene (9)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (32)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (30)   
DNA sequence (56)   
   RefSeq(nuc) (30)   
   GenBank (13)   
   EMBL (13)   
3D Structure (7)   
   PDB (7)   
Protein domain (6)   
   Pfam (6)   
All databases (118)   

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