KEGG   Homo sapiens (human): 2977Help
Entry
2977              CDS       T01001                                 

Gene name
GUCY1A2, GC-SA2, GUC1A2
Definition
(RefSeq) guanylate cyclase 1 soluble subunit alpha 2
  KO
K12318  guanylate cyclase soluble subunit alpha [EC:4.6.1.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00230  Purine metabolism
hsa01100  Metabolic pathways
hsa04022  cGMP-PKG signaling pathway
hsa04270  Vascular smooth muscle contraction
hsa04540  Gap junction
hsa04611  Platelet activation
hsa04713  Circadian entrainment
hsa04730  Long-term depression
hsa04921  Oxytocin signaling pathway
hsa04924  Renin secretion
hsa04970  Salivary secretion
Drug target
Amyl nitrite: D00517
Cinaciguat: D07577
Molsidomine: D01320
Nicorandil: D01810
Olinciguat: D11475
Praliciguat: D11274
Riociguat: D09572
Vericiguat: D11051
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    2977 (GUCY1A2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04022 cGMP-PKG signaling pathway
    2977 (GUCY1A2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    2977 (GUCY1A2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    2977 (GUCY1A2)
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    2977 (GUCY1A2)
   04924 Renin secretion
    2977 (GUCY1A2)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    2977 (GUCY1A2)
  09154 Digestive system
   04970 Salivary secretion
    2977 (GUCY1A2)
  09156 Nervous system
   04730 Long-term depression
    2977 (GUCY1A2)
  09159 Environmental adaptation
   04713 Circadian entrainment
    2977 (GUCY1A2)
Enzymes [BR:hsa01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.2  guanylate cyclase
     2977 (GUCY1A2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Guanylate_cyc HNOBA HNOB Rx_N
Motif
Other DBs
NCBI-GeneID: 2977
NCBI-ProteinID: NP_000846
OMIM: 601244
HGNC: 4684
Ensembl: ENSG00000152402
Vega: OTTHUMG00000166296
Pharos: P33402(Tclin)
UniProt: P33402
Position
11q22.3
AA seq 732 aa AA seqDB search
MSRRKISSESFSSLGSDYLETSPEEEGECPLSRLCWNGSRSPPGPLEPSPAAAAAAAAPA
PTPAASAAAAAATAGARRVQRRRRVNLDSLGESISRLTAPSPQTIQQTLKRTLQYYEHQV
IGYRDAEKNFHNISNRCSYADHSNKEEIEDVSGILQCTANILGLKFEEIQKRFGEEFFNI
CFHENERVLRAVGGTLQDFFNGFDALLEHIRTSFGKQATLESPSFLCKELPEGTLMLHYF
HPHHIVGFAMLGMIKAAGKKIYRLDVEVEQVANEKLCSDVSNPGNCSCLTFLIKECENTN
IMKNLPQGTSQVPADLRISINTFCRAFPFHLMFDPSMSVLQLGEGLRKQLRCDTHKVLKF
EDCFEIVSPKVNATFERVLLRLSTPFVIRTKPEASGSENKDKVMEVKGQMIHVPESNSIL
FLGSPCVDKLDELMGRGLHLSDIPIHDATRDVILVGEQAKAQDGLKKRMDKLKATLERTH
QALEEEKKKTVDLLYSIFPGDVAQQLWQGQQVQARKFDDVTMLFSDIVGFTAICAQCTPM
QVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGLHRKSLCHAKPIALMALKMMELS
EEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSP
TTYQLLKREESFTFIPRSREELPDNFPKEIPGICYFLEVRTGPKPPKPSLSSSRIKKVSY
NIGTMFLRETSL
NT seq 2199 nt NT seq  +upstreamnt  +downstreamnt
atgtctcgaaggaagatttcgtccgagtccttcagctccctgggctccgactacctggag
accagcccggaggaggagggggagtgccccctgtctaggctctgctggaatggcagccgg
agcccgcccgggccgctggagcccagcccggccgcagctgccgctgccgccgccccggcc
ccgaccccggctgcttctgccgccgccgccgctgccactgccggggccaggagggtgcag
cgccggaggcgggtcaacctggactcgctgggcgagagcatcagccgcctgacggcgccc
tcgcctcagacgatacagcagactctcaagaggacactgcagtattatgaacatcaagtt
attggttacagggatgcagaaaagaatttccacaatatctctaacagatgctcctatgca
gaccactccaacaaagaagaaattgaagatgtctcaggaattcttcagtgtactgctaat
atactcggtttgaagtttgaggaaattcaaaaaagatttggtgaagagttctttaatata
tgctttcatgagaatgagagagtccttcgagctgtaggtggcactttgcaggactttttt
aacggctttgatgctttgttggaacacattagaacttcttttggaaaacaggccactctg
gagtcaccatctttcctatgcaaagagctccctgaaggtactctcatgctccactacttc
caccctcaccatattgtggggtttgcaatgctggggatgattaaggctgcaggaaagaag
atctatcggctggatgtggaagtggaacaggttgcaaatgagaagctatgctctgatgtt
tcaaacccaggcaattgtagctgtcttactttccttatcaaagaatgtgaaaatactaat
atcatgaagaaccttccacagggaacctcccaagttcctgcggacctcagaattagcatc
aacaccttctgtagagccttccctttccacttgatgtttgatcccagcatgtcagtcctt
cagttgggggaaggtctaaggaagcagcttcgatgtgacactcacaaagtgctcaagttt
gaggactgcttcgagattgtatctccaaaggttaatgccacctttgaaagggtcctgctg
cgactgtctaccccgtttgtgattagaaccaagcctgaggcttctggctctgaaaataaa
gacaaggtgatggaagtcaaaggacaaatgatccatgttccagaatcaaattccatttta
tttttgggctctccatgtgtggacaagttggatgaactcatgggccgagggctacatctc
tcagacatccctatccatgatgccacccgagatgtcattttggttggtgagcaggcaaag
gcccaagatgggttgaagaaaaggatggataaattaaaggcaactttagaaagaactcac
caggccctggaagaagagaaaaagaagacagtggatcttctatattctattttccctggt
gatgtagcccagcaattatggcaagggcagcaagtacaggccagaaagtttgatgatgtc
accatgctcttttcagacattgttggcttcacagccatatgtgcccagtgtactcccatg
caagtaatcagcatgctgaatgaactgtacaccagatttgaccaccagtgtggatttttg
gatatttataaggtggaaacaataggtgatgcctactgtgttgcagcagggctccacaga
aaaagcctctgccatgctaaacccattgctctgatggccttgaagatgatggaactttca
gaagaggtgctgacacctgatggaagaccgattcagatgaggataggaattcactcaggc
tccgtgctggctggagttgttggggtgcgaatgccacgttattgcctgtttggaaataat
gtcacactggcaagcaaattcgagtcgggaagtcaccctcggcgcatcaatgtcagccca
accacttaccaattattaaaacgagaagaaagtttcacattcattccgcggtctcgtgaa
gagcttccagacaactttccaaaggaaattcctgggatctgctatttcctggaggtaagg
actggtccaaagccaccaaagccttctctttcttcgtcgagaataaaaaaggtttcctac
aacatcggcaccatgttcctccgggagacaagcctctga

KEGG   Homo sapiens (human): 2982Help
Entry
2982              CDS       T01001                                 

Gene name
GUCY1A1, GC-SA3, GUC1A3, GUCA3, GUCSA3, GUCY1A3, MYMY6
Definition
(RefSeq) guanylate cyclase 1 soluble subunit alpha 1
  KO
K12318  guanylate cyclase soluble subunit alpha [EC:4.6.1.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00230  Purine metabolism
hsa01100  Metabolic pathways
hsa04022  cGMP-PKG signaling pathway
hsa04270  Vascular smooth muscle contraction
hsa04540  Gap junction
hsa04611  Platelet activation
hsa04713  Circadian entrainment
hsa04730  Long-term depression
hsa04921  Oxytocin signaling pathway
hsa04924  Renin secretion
hsa04970  Salivary secretion
Disease
H01396  Moyamoya disease
Drug target
Amyl nitrite: D00517
Cinaciguat: D07577
Nicorandil: D01810
Olinciguat: D11475
Praliciguat: D11274
Riociguat: D09572
Vericiguat: D11051
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    2982 (GUCY1A1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04022 cGMP-PKG signaling pathway
    2982 (GUCY1A1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    2982 (GUCY1A1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    2982 (GUCY1A1)
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    2982 (GUCY1A1)
   04924 Renin secretion
    2982 (GUCY1A1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    2982 (GUCY1A1)
  09154 Digestive system
   04970 Salivary secretion
    2982 (GUCY1A1)
  09156 Nervous system
   04730 Long-term depression
    2982 (GUCY1A1)
  09159 Environmental adaptation
   04713 Circadian entrainment
    2982 (GUCY1A1)
Enzymes [BR:hsa01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.2  guanylate cyclase
     2982 (GUCY1A1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Guanylate_cyc HNOBA HNOB
Motif
Other DBs
NCBI-GeneID: 2982
NCBI-ProteinID: NP_000847
OMIM: 139396
HGNC: 4685
Ensembl: ENSG00000164116
Vega: OTTHUMG00000161700
Pharos: Q02108(Tclin)
UniProt: Q02108
Structure
PDB: 

Position
4q32.1
AA seq 690 aa AA seqDB search
MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLP
QRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAE
QAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAG
KRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCF
HNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQ
FGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKS
SRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQAR
AQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNV
TMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHK
ESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNN
VTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAY
QQGTNSKPCFQKKDVEDGNANFLGKASGID
NT seq 2073 nt NT seq  +upstreamnt  +downstreamnt
atgttctgcacgaagctcaaggatctcaagatcacaggagagtgtcctttctccttactg
gcaccaggtcaagttcctaacgagtcttcagaggaggcagcaggaagctcagagagctgc
aaagcaaccgtgcccatctgtcaagacattcctgagaagaacatacaagaaagtcttcct
caaagaaaaaccagtcggagccgagtctatcttcacactttggcagagagtatttgcaaa
ctgattttcccagagtttgaacggctgaatgttgcacttcagagaacattggcaaagcac
aaaataaaagaaagcaggaaatctttggaaagagaagactttgaaaaaacaattgcagag
caagcagttgcagcaggagttccagtggaggttatcaaagaatctcttggtgaagaggtt
tttaaaatatgttacgaggaagatgaaaacatccttggggtggttggaggcacccttaaa
gattttttaaacagcttcagtacccttctgaaacagagcagccattgccaagaagcagga
aaaaggggcaggcttgaggacgcctccattctatgcctggataaggaggatgattttcta
catgtttactacttcttccctaagagaaccacctccctgattcttcccggcatcataaag
gcagctgctcacgtattatatgaaacggaagtggaagtgtcgttaatgcctccctgcttc
cataatgattgcagcgagtttgtgaatcagccctacttgttgtactccgttcacatgaaa
agcaccaagccatccctgtcccccagcaaaccccagtcctcgctggtgattcccacatcg
ctattctgcaagacatttccattccatttcatgtttgacaaagatatgacaattctgcaa
tttggcaatggcatcagaaggctgatgaacaggagagactttcaaggaaagcctaatttt
gaagaatactttgaaattctgactccaaaaatcaaccagacgtttagcgggatcatgact
atgttgaatatgcagtttgttgtacgagtgaggagatgggacaactctgtgaaaaaatct
tcaagggttatggacctcaaaggccaaatgatctacattgttgaatccagtgcaatcttg
tttttggggtcaccctgtgtggacagattagaagattttacaggacgagggctctacctc
tcagacatcccaattcacaatgcactgagggatgtggtcttaataggggaacaagcccga
gctcaagatggcctgaagaagaggctggggaagctgaaggctacccttgagcaagcccac
caagccctggaggaggagaagaaaaagacagtagaccttctgtgctccatatttccctgt
gaggttgctcagcagctgtggcaagggcaagttgtgcaagccaagaagttcagtaatgtc
accatgctcttctcagacatcgttgggttcactgccatctgctcccagtgctcaccgctg
caggtcatcaccatgctcaatgcactgtacactcgcttcgaccagcagtgtggagagctg
gatgtctacaaggtggagaccattggcgatgcctattgtgtagctgggggattacacaaa
gagagtgatactcatgctgttcagatagcgctgatggccctgaagatgatggagctctct
gatgaagttatgtctccccatggagaacctatcaagatgcgaattggactgcactctgga
tcagtttttgctggcgtcgttggagttaaaatgccccgttactgtctttttggaaacaat
gtcactctggctaacaaatttgagtcctgcagtgtaccacgaaaaatcaatgtcagccca
acaacttacagattactcaaagactgtcctggtttcgtgtttacccctcgatcaagggag
gaacttccaccaaacttccctagtgaaatccccggaatctgccattttctggatgcttac
caacaaggaacaaactcaaaaccatgcttccaaaagaaagatgtggaagatggcaatgcc
aattttttaggcaaagcatcaggaatagattag

KEGG   Homo sapiens (human): 2983Help
Entry
2983              CDS       T01001                                 

Gene name
GUCY1B1, GC-S-beta-1, GC-SB3, GUC1B3, GUCB3, GUCSB3, GUCY1B3
Definition
(RefSeq) guanylate cyclase 1 soluble subunit beta 1
  KO
K12319  guanylate cyclase soluble subunit beta [EC:4.6.1.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00230  Purine metabolism
hsa01100  Metabolic pathways
hsa04022  cGMP-PKG signaling pathway
hsa04270  Vascular smooth muscle contraction
hsa04540  Gap junction
hsa04611  Platelet activation
hsa04713  Circadian entrainment
hsa04730  Long-term depression
hsa04921  Oxytocin signaling pathway
hsa04924  Renin secretion
hsa04970  Salivary secretion
Drug target
Amyl nitrite: D00517
Cinaciguat: D07577
Nicorandil: D01810
Olinciguat: D11475
Praliciguat: D11274
Riociguat: D09572
Vericiguat: D11051
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    2983 (GUCY1B1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04022 cGMP-PKG signaling pathway
    2983 (GUCY1B1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    2983 (GUCY1B1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    2983 (GUCY1B1)
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    2983 (GUCY1B1)
   04924 Renin secretion
    2983 (GUCY1B1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    2983 (GUCY1B1)
  09154 Digestive system
   04970 Salivary secretion
    2983 (GUCY1B1)
  09156 Nervous system
   04730 Long-term depression
    2983 (GUCY1B1)
  09159 Environmental adaptation
   04713 Circadian entrainment
    2983 (GUCY1B1)
Enzymes [BR:hsa01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.2  guanylate cyclase
     2983 (GUCY1B1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Guanylate_cyc HNOBA HNOB 4_1_CTD
Motif
Other DBs
NCBI-GeneID: 2983
NCBI-ProteinID: NP_000848
OMIM: 139397
HGNC: 4687
Ensembl: ENSG00000061918
Vega: OTTHUMG00000161698
Pharos: Q02153(Tclin)
UniProt: Q02153
Structure
PDB: 

Position
4q32.1
AA seq 619 aa AA seqDB search
MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYDDSKTYDLVAAASKVLN
LNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSF
RCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDHTQFL
IEEKESKEEDFYEDLDRFEENGTQESRISPYTFCKAFPFHIIFDRDLVVTQCGNAIYRVL
PQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTGTE
ISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFR
EEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYDNV
TILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYM
TVSGLPEPCIHHARSICHLALDMMEIAGQVQVDGESVQITIGIHTGEVVTGVIGQRMPRY
CLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKEPMQ
VWFLSRKNTGTEETKQDDD
NT seq 1860 nt NT seq  +upstreamnt  +downstreamnt
atgtacggatttgtgaatcacgccctggagttgctggtgatccgcaattacggccccgag
gtgtgggaagacatcaaaaaagaggcacagttagatgaagaaggacagtttcttgtcaga
ataatatatgatgactccaaaacttatgatttggttgctgctgcaagcaaagtcctcaat
ctcaatgctggagaaatcctccaaatgtttgggaagatgtttttcgtcttttgccaagaa
tctggttatgatacaatcttgcgtgtcctgggctctaatgtcagagaatttctacagaac
cttgatgctctgcacgaccaccttgctaccatctacccaggaatgcgtgcaccttccttt
aggtgcactgatgcagaaaagggcaaaggactcattttgcactactactcagagagagaa
ggacttcaggatattgtcattggaatcatcaaaacagtggcacaacaaatccatggcact
gaaatagacatgaaggttattcagcaaagaaatgaagaatgtgatcatactcaattttta
attgaagaaaaagagtcaaaagaagaggatttttatgaagatcttgacagatttgaagaa
aatggtacccaggaatcacgcatcagcccatatacattctgcaaagcttttccttttcat
ataatatttgaccgggacctagtggtcactcagtgtggcaatgctatatacagagttctc
ccccagctccagcctgggaattgcagccttctgtctgtcttctcgctggttcgtcctcat
attgatattagtttccatgggatcctttctcacatcaatactgtttttgtattgagaagc
aaggaaggattgttggatgtggagaaattagaatgtgaggatgaactgactgggactgag
atcagctgcttacgtctcaagggtcaaatgatctacttacctgaagcagatagcatactt
tttctatgttcaccaagtgtcatgaacctggacgatttgacaaggagagggctgtatcta
agtgacatccctctgcatgatgccacgcgcgatcttgttcttttgggagaacaatttaga
gaggaatacaaactcacccaagaactggaaatcctcactgacaggctacagctcacgtta
agagccctggaagatgaaaagaaaaagacagacacattgctgtattctgtccttcctccg
tctgttgccaatgagctgcggcacaagcgtccagtgcctgccaaaagatatgacaatgtg
accatcctctttagtggcattgtgggcttcaatgctttctgtagcaagcatgcatctgga
gaaggagccatgaagatcgtcaacctcctcaacgacctctacaccagatttgacacactg
actgattcccggaaaaacccatttgtttataaggtggagactgttggtgacaagtatatg
acagtgagtggtttaccagagccatgcattcaccatgcacgatccatctgccacctggcc
ttggacatgatggaaattgctggccaggttcaagtagatggtgaatctgttcagataaca
atagggatacacactggagaggtagttacaggtgtcataggacagcggatgcctcgatac
tgtctttttgggaatactgtcaacctcacaagccgaacagaaaccacaggagaaaaggga
aaaataaatgtgtctgaatatacatacagatgtcttatgtctccagaaaattcagatcca
caattccacttggagcacagaggcccagtgtccatgaagggcaaaaaagaaccaatgcaa
gtttggtttctatccagaaaaaatacaggaacagaggaaacaaagcaggatgatgactga

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