KEGG   Homo sapiens (human): 29920
Entry
29920             CDS       T01001                                 
Symbol
PYCR2, HLD10, P5CR2
Name
(RefSeq) pyrroline-5-carboxylate reductase 2
  KO
K00286  pyrroline-5-carboxylate reductase [EC:1.5.1.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00330  Arginine and proline metabolism
hsa01100  Metabolic pathways
hsa01230  Biosynthesis of amino acids
Module
hsa_M00015  Proline biosynthesis, glutamate => proline
hsa_M00972  Proline metabolism
Network
nt06033  Glycine, serine and arginine metabolism
  Element
N01618  Proline biosynthesis, Orn to Pro
Disease
H00679  Hypomyelinating leukodystrophy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00330 Arginine and proline metabolism
    29920 (PYCR2)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.2  pyrroline-5-carboxylate reductase
     29920 (PYCR2)
SSDB
Motif
Pfam: P5CR_dimer F420_oxidored Rossmann-like NAD_Gly3P_dh_N 2-Hacid_dh_C ApbA
Other DBs
NCBI-GeneID: 29920
NCBI-ProteinID: NP_037460
OMIM: 616406
HGNC: 30262
Ensembl: ENSG00000143811
UniProt: Q96C36 A0A0S2Z5U6
Structure
Position
1:complement(225919878..225924250)
AA seq 320 aa
MSVGFIGAGQLAYALARGFTAAGILSAHKIIASSPEMNLPTVSALRKMGVNLTRSNKETV
KHSDVLFLAVKPHIIPFILDEIGADVQARHIVVSCAAGVTISSVEKKLMAFQPAPKVIRC
MTNTPVVVQEGATVYATGTHALVEDGQLLEQLMSSVGFCTEVEEDLIDAVTGLSGSGPAY
AFMALDALADGGVKMGLPRRLAIQLGAQALLGAAKMLLDSEQHPCQLKDNVCSPGGATIH
ALHFLESGGFRSLLINAVEASCIRTRELQSMADQEKISPAALKKTLLDRVKLESPTVSTL
TPSSPGKLLTRSLALGGKKD
NT seq 963 nt   +upstreamnt  +downstreamnt
atgagcgtgggcttcatcggggccggccagctggcctatgctctggcgcggggcttcacg
gccgcaggcatcctgtcggctcacaagataatagccagctccccagaaatgaacctgccc
acggtgtccgcgctcaggaagatgggtgtgaacctgacacgcagcaacaaggagacggtg
aagcacagcgacgtcctgtttctggctgtgaagccacatatcatccccttcatcctggat
gagattggggccgacgtgcaagccagacacatcgtggtctcctgtgcggctggtgtcacc
atcagctctgtggagaagaagctgatggcattccagccagcccccaaagtgattcgctgc
atgaccaacacacctgtggtagtgcaggaaggcgctacagtgtacgccacgggcacccat
gccctggtggaggatgggcagctcctggagcagctcatgagcagcgtgggcttctgcact
gaggtggaagaggacctcatcgatgccgtcacggggctcagtggcagcgggcctgcctat
gcattcatggctctggacgcattggctgatggtggggtgaagatgggtttgccacggcgc
ctggcaatccaactcggggcccaggctttgctgggagctgccaagatgctgctggactcg
gagcagcatccatgccagcttaaggacaatgtctgctcccctgggggagccaccatccac
gccctgcactttctagagagtgggggcttccgctctctgctcatcaatgcagttgaggcc
tcctgtatccgaacacgagagctacagtccatggccgaccaagaaaagatctccccagct
gcccttaagaagaccctcttagacagagtgaagctggaatcccccacagtctccacactg
accccctccagcccagggaagctcctcacaagaagcctggccctgggaggcaagaaggac
taa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (5)   
   KEGG PATHWAY (3)   
   KEGG MODULE (2)   
Network (2)   
   KEGG NETWORK (2)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical substance (9)   
   KEGG COMPOUND (9)   
Chemical reaction (5)   
   KEGG ENZYME (1)   
   KEGG REACTION (4)   
Genome (1)   
   KEGG GENOME (1)   
Gene (12)   
   KEGG ORTHOLOGY (1)   
   RefGene (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (5)   
   OC (1)   
Protein sequence (5)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (28)   
   RefSeq(nuc) (2)   
   GenBank (13)   
   EMBL (13)   
3D Structure (1)   
   PDB (1)   
Protein domain (6)   
   Pfam (6)   
All databases (79)   

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