KEGG   Homo sapiens (human): 29927
Entry
29927             CDS       T01001                                 
Symbol
SEC61A1, ADTKD5, CVID15, HNFJ4, HSEC61, SEC61, SEC61A
Name
(RefSeq) SEC61 translocon subunit alpha 1
  KO
K10956  protein transport protein SEC61 subunit alpha
Organism
hsa  Homo sapiens (human)
Pathway
hsa03060  Protein export
hsa04141  Protein processing in endoplasmic reticulum
hsa04145  Phagosome
hsa05110  Vibrio cholerae infection
Disease
H00088  Common variable immunodeficiency
H00100  Neutropenic disorders
H00541  Autosomal dominant tubulointerstitial kidney disease
H02011  Familial juvenile hyperuricemic nephropathy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03060 Protein export
    29927 (SEC61A1)
   04141 Protein processing in endoplasmic reticulum
    29927 (SEC61A1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    29927 (SEC61A1)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05110 Vibrio cholerae infection
    29927 (SEC61A1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    29927 (SEC61A1)
  09183 Protein families: signaling and cellular processes
   02044 Secretion system [BR:hsa02044]
    29927 (SEC61A1)
Membrane trafficking [BR:hsa04131]
 Endoplasmic reticulum (ER) - Golgi transport
  Others
   SEC61 complex
    29927 (SEC61A1)
Secretion system [BR:hsa02044]
 Sec (secretion) system
  Eukaryotic Sec-SRP protein
   29927 (SEC61A1)
SSDB
Motif
Pfam: SecY Plug_translocon DUF2975
Other DBs
NCBI-GeneID: 29927
NCBI-ProteinID: NP_037468
OMIM: 609213
HGNC: 18276
Ensembl: ENSG00000058262
UniProt: P61619 B3KME8 B3KNF6
Structure
Position
3:128051641..128071683
AA seq 476 aa
MAIKFLEVIKPFCVILPEIQKPERKIQFKEKVLWTAITLFIFLVCCQIPLFGIMSSDSAD
PFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFG
MIITIGQSIVYVMTGMYGDPSEMGAGICLLITIQLFVAGLIVLLLDELLQKGYGLGSGIS
LFIATNICETIVWKAFSPTTVNTGRGMEFEGAIIALFHLLATRTDKVRALREAFYRQNLP
NLMNLIATIFVFAVVIYFQGFRVDLPIKSARYRGQYNTYPIKLFYTSNIPIILQSALVSN
LYVISQMLSARFSGNLLVSLLGTWSDTSSGGPARAYPVGGLCYYLSPPESFGSVLEDPVH
AVVYIVFMLGSCAFFSKTWIEVSGSSAKDVAKQLKEQQMVMRGHRETSMVHELNRYIPTA
AAFGGLCIGALSVLADFLGAIGSGTGILLAVTIIYQYFEIFVKEQSEVGSMGALLF
NT seq 1431 nt   +upstreamnt  +downstreamnt
atggcaatcaaatttctggaagtcatcaagcccttctgtgtcatcctgccggaaattcag
aagccagagaggaagattcagtttaaggagaaagtgctgtggaccgctatcaccctcttt
atcttcttagtgtgctgccagattcccctgtttgggatcatgtcttcagattcagctgac
cctttctattggatgagagtgattctagcctctaacagaggcacattgatggagctaggg
atctctcctattgtcacgtctggccttataatgcaactcttggctggcgccaagataatt
gaagttggtgacaccccaaaagaccgagctctcttcaacggagcccaaaagttatttggc
atgatcattactatcggccagtctatcgtgtatgtgatgaccgggatgtatggggaccct
tctgaaatgggtgctggaatttgcctgctaatcaccattcagctctttgttgctggctta
attgtcctacttttggatgaactcctgcaaaaaggatatggccttggctctggtatttct
ctcttcattgcaactaacatctgtgaaaccatcgtatggaaggcattcagccccactact
gtcaacactggccgaggaatggaatttgaaggtgctatcatcgcacttttccatctgctg
gccacacgcacagacaaggtccgagcccttcgggaggcgttctaccgccagaatcttccc
aacctcatgaatctcatcgccaccatctttgtctttgcagtggtcatctatttccagggc
ttccgagtggacctgccaatcaagtcggcccgctaccgtggccagtacaacacctatccc
atcaagctcttctatacgtccaacatccccatcatcctgcagtctgccctggtgtccaac
ctttatgtcatctcccaaatgctctcagctcgcttcagtggcaacttgctggtcagcctg
ctgggcacctggtcggacacgtcttctgggggcccagcacgtgcttatccagttggtggc
ctttgctattacctgtcccctccagaatcttttggctccgtgttagaagacccggtccat
gcagttgtatacatagtgttcatgctgggctcctgtgcattcttctccaaaacgtggatt
gaggtctcaggttcctctgccaaagatgttgcaaagcagctgaaggagcagcagatggtg
atgagaggccaccgagagacctccatggtccatgaactcaaccggtacatccccacagcc
gcggcctttggtgggctgtgcatcggggccctctcggtcctggctgacttcctaggcgcc
attgggtctggaaccgggatcctgctcgcagtcacaatcatctaccagtactttgagatc
ttcgttaaggagcaaagcgaggttggcagcatgggggccctgctcttctga

  All links  
Disease (4)   
   OMIM (4)   
Gene (57)   
   RefGene (46)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (6)   
   OC (1)   
Protein sequence (7)   
   UniProt (3)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (39)   
   RefSeq(nuc) (3)   
   GenBank (18)   
   EMBL (18)   
3D Structure (12)   
   PDB (12)   
Protein domain (3)   
   Pfam (3)   
All databases (122)   

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