KEGG   Homo sapiens (human): 3034
Entry
3034              CDS       T01001                                 

Gene name
HAL, HIS, HSTD
Definition
(RefSeq) histidine ammonia-lyase
  KO
K01745  histidine ammonia-lyase [EC:4.3.1.3]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00340  Histidine metabolism
hsa01100  Metabolic pathways
Module
hsa_M00045  Histidine degradation, histidine => N-formiminoglutamate => glutamate
Disease
H00171  Histidinemia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00340 Histidine metabolism
    3034 (HAL)
Enzymes [BR:hsa01000]
 4. Lyases
  4.3  Carbon-nitrogen lyases
   4.3.1  Ammonia-lyases
    4.3.1.3  histidine ammonia-lyase
     3034 (HAL)
SSDB
Motif
Pfam: Lyase_aromatic Par3_HAL_N_term NFACT-C
Other DBs
NCBI-GeneID: 3034
NCBI-ProteinID: NP_002099
OMIM: 609457
HGNC: 4806
Ensembl: ENSG00000084110
Vega: OTTHUMG00000170354
Pharos: P42357(Tbio)
UniProt: P42357
Position
12q23.1
AA seq 657 aa
MPRYTVHVRGEWLAVPCQDAQLTVGWLGREAVRRYIKNKPDNGGFTSVDDAHFLVRRCKG
LGLLDNEDRLEVALENNEFVEVVIEGDAMSPDFIPSQPEGVYLYSKYREPEKYIELDGDR
LTTEDLVNLGKGRYKIKLTPTAEKRVQKSREVIDSIIKEKTVVYGITTGFGKFARTVIPI
NKLQELQVNLVRSHSSGVGKPLSPERCRMLLALRINVLAKGYSGISLETLKQVIEMFNAS
CLPYVPEKGTVGASGDLAPLSHLALGLVGEGKMWSPKSGWADAKYVLEAHGLKPVILKPK
EGLALINGTQMITSLGCEAVERASAIARQADIVAALTLEVLKGTTKAFDTDIHALRPHRG
QIEVAFRFRSLLDSDHHPSEIAESHRFCDRVQDAYTLRCCPQVHGVVNDTIAFVKNIITT
ELNSATDNPMVFANRGETVSGGNFHGEYPAKALDYLAIGIHELAAISERRIERLCNPSLS
ELPAFLVAEGGLNSGFMIAHCTAAALVSENKALCHPSSVDSLSTSAATEDHVSMGGWAAR
KALRVIEHVEQVLAIELLAACQGIEFLRPLKTTTPLEKVYDLVRSVVRPWIKDRFMAPDI
EAAHRLLLEQKVWEVAAPYIEKYRMEHIPESRPLSPTAFSLQFLHKKSTKIPESEDL
NT seq 1974 nt   +upstreamnt  +downstreamnt
atgcccagatacacggtgcacgtacgtggggaatggctggcagtgccctgccaggacgcg
cagctcactgtgggctggctgggccgggaggccgtgaggcgctatatcaagaataagccc
gacaatggtggcttcacctccgtggatgacgcgcacttccttgtgcgccggtgcaagggc
ctgggcctgctggacaacgaggaccggctcgaggtggccctagagaacaacgagttcgtg
gaagtggttatagagggtgatgccatgtctcctgacttcattccatctcaaccagaagga
gtttatctatacagcaagtaccgggagcctgaaaagtacatcgagttagatggagaccgt
ctgaccacggaggatctggtcaacttgggaaagggacgctacaaaataaagctcacccca
acagctgagaagagggtgcagaaatccagggaggtcatagatagcatcataaaagagaaa
acagttgtttacggtattactacaggttttgggaaatttgccagaactgtaattcctatc
aataagctacaggagcttcaggtcaacttagtacgctcacattcttcaggtgttgggaaa
ccactaagtcctgagaggtgtcggatgctcttggctttaaggatcaatgtcttagccaaa
ggatacagtggcatttccctggagaccctcaaacaagtcatagaaatgtttaatgcctcc
tgcctgccctatgtcccagagaaaggaaccgttggtgccagtggagaccttgccccactc
tctcatcttgctcttgggctagttggagaagggaagatgtggtctccgaagagtggctgg
gctgatgctaaatacgtgctagaagcccatggattgaaaccagttattttaaaaccaaaa
gagggcctggcactcatcaatgggacgcagatgatcacatccctgggctgtgaagctgta
gagcgagccagtgctattgcacggcaggctgacattgtggcagccctgacccttgaggtg
ctgaagggcaccaccaaagcctttgacactgacattcatgctcttcgacctcaccgtggg
caaattgaagttgcttttcggtttcggtcactcttggactcagatcaccacccatcagaa
atagcagagagtcacaggttctgtgatcgcgtccaggatgcatacaccttgcgctgctgt
ccacaggtccatggtgtggtgaatgatacaatagcatttgtgaagaacatcattaccaca
gaactgaacagcgcaacagataatcctatggtctttgccaataggggagagacagtttct
ggaggaaacttccatggtgaatacccagccaaagccctagactacttggccattggcatc
catgaacttgctgcaatcagtgagagaagaatcgagcggctctgcaatccctccctcagt
gagctgcctgccttcctggtggctgaaggtggtctgaactctgggttcatgatagctcac
tgcacggcagcagcccttgtttctgagaacaaggctctgtgccatccctcgtctgttgac
tccctctccaccagcgcagccacggaggaccacgtctccatgggaggatgggcagcaagg
aaagccctcagggtcatcgagcatgtggagcaagtgctggccatcgagctccttgcagcc
tgccagggcatagagtttctacgtcccctgaaaacaaccactccgctggagaaggtctat
gacctggtgcgctctgttgtaaggccctggataaaagatcgcttcatggccccggacatc
gaggcagcccacaggctgctcctggagcagaaggtttgggaagtagctgctccatacatt
gaaaaatacagaatggagcatattccagaatcaagacctctttctccaacagccttttca
ctgcaatttctgcacaagaaatccaccaaaatcccggagtctgaggacctttaa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (3)   
   KEGG PATHWAY (2)   
   KEGG MODULE (1)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (15)   
   KEGG ORTHOLOGY (1)   
   RefGene (7)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (7)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (25)   
   RefSeq(nuc) (5)   
   GenBank (10)   
   EMBL (10)   
Protein domain (3)   
   Pfam (3)   
All databases (64)   

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