KEGG   Homo sapiens (human): 3061
Entry
3061              CDS       T01001                                 
Symbol
HCRTR1, ORXR1, OX1R, OXR1
Name
(RefSeq) hypocretin receptor 1
  KO
K04238  hypocretin (orexin) receptor 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04081  Hormone signaling
Network
nt06325  Hormone/cytokine signaling
  Element
N01794  HCRT-HCRTR signaling pathway
Drug target
Almorexant: D09964
Daridorexant (DG03119): D11886 D11887<JP/US>
Filorexant: D10345
Lemborexant: D11022<JP/US>
Suvorexant: D10082<JP/US>
Vornorexant hydrate: D12611
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    3061 (HCRTR1)
   04081 Hormone signaling
    3061 (HCRTR1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    3061 (HCRTR1)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Peptide
   Orexin
    3061 (HCRTR1)
SSDB
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srw 7tm_4 Orexin_rec2 SteA-like_C Form_Nir_trans
Other DBs
NCBI-GeneID: 3061
NCBI-ProteinID: NP_001516
OMIM: 602392
HGNC: 4848
Ensembl: ENSG00000121764
UniProt: O43613
Structure
Position
1:31617689..31634492
AA seq 425 aa
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQA
AVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFR
KLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSV
TTVLP
NT seq 1278 nt   +upstreamnt  +downstreamnt
atggagccctcagccaccccaggggcccagatgggggtcccccctggcagcagagagccg
tcccctgtgcctccagactatgaagatgagtttctccgctatctgtggcgcgattatctg
tacccaaaacagtatgagtgggtcctcatcgcagcctatgtggctgtgttcgtcgtggcc
ctggtgggcaacacgctggtctgcctggccgtgtggcggaaccaccacatgaggacagtc
accaactacttcattgtcaacctgtccctggctgacgttctggtgactgctatctgcctg
ccggccagcctgctggtggacatcactgagtcctggctgttcggccatgccctctgcaag
gtcatcccctatctacaggctgtgtccgtgtcagtggcagtgctaactctcagcttcatc
gccctggaccgctggtatgccatctgccacccactattgttcaagagcacagcccggcgg
gcccgtggctccatcctgggcatctgggctgtgtcgctggccatcatggtgccccaggct
gcagtcatggaatgcagcagtgtgctgcctgagctagccaaccgcacacggctcttctca
gtctgtgatgaacgctgggcagatgacctctatcccaagatctaccacagttgcttcttt
attgtcacctacctggccccactgggcctcatggccatggcctatttccagatattccgc
aagctctggggccgccagatccccggcaccacctcagcactggtgcggaactggaagcgc
ccctcagaccagctgggggacctggagcagggcctgagtggagagccccagccccgggcc
cgcgccttcctggctgaagtgaagcagatgcgtgcacggaggaagacagccaagatgctg
atggtggtgctgctggtcttcgccctctgctacctgcccatcagcgtcctcaatgtcctt
aagagggtgttcgggatgttccgccaagccagtgaccgcgaagctgtctacgcctgcttc
accttctcccactggctggtgtacgccaacagcgctgccaaccccatcatctacaacttc
ctcagtggcaaattccgggagcagtttaaggctgccttctcctgctgcctgcctggcctg
ggtccctgcggctctctgaaggcccctagtccccgctcctctgccagccacaagtccttg
tccttgcagagccgatgctccatctccaaaatctctgagcatgtggtgctcaccagcgtc
accacagtgctgccctga

  All links  
Disease (1)   
   OMIM (1)   
Gene (5)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (8)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (6)   
DNA sequence (18)   
   RefSeq(nuc) (6)   
   GenBank (6)   
   EMBL (6)   
3D Structure (14)   
   PDB (14)   
Protein domain (7)   
   Pfam (7)   
All databases (53)   

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KEGG   Homo sapiens (human): 3062
Entry
3062              CDS       T01001                                 
Symbol
HCRTR2, ORXR2, OX2R, OXR2
Name
(RefSeq) hypocretin receptor 2
  KO
K04239  hypocretin (orexin) receptor 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04081  Hormone signaling
Network
nt06325  Hormone/cytokine signaling
  Element
N01794  HCRT-HCRTR signaling pathway
Drug target
Almorexant: D09964
Daridorexant (DG03119): D11886 D11887<JP/US>
Filorexant: D10345
Lemborexant: D11022<JP/US>
Seltorexant: D11269
Suvorexant: D10082<JP/US>
Vornorexant hydrate: D12611
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    3062 (HCRTR2)
   04081 Hormone signaling
    3062 (HCRTR2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    3062 (HCRTR2)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Peptide
   Orexin
    3062 (HCRTR2)
SSDB
Motif
Pfam: 7tm_1 Orexin_rec2 7TM_GPCR_Srsx 7tm_4 SNARE
Other DBs
NCBI-GeneID: 3062
NCBI-ProteinID: NP_001517
OMIM: 602393
HGNC: 4849
Ensembl: ENSG00000137252
UniProt: O43614 S4X0W3
Structure
Position
6:55106469..55284713
AA seq 444 aa
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARR
KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKL
SEQVVLTSISTLPAANGAGPLQNW
NT seq 1335 nt   +upstreamnt  +downstreamnt
atgtccggcaccaaattggaggactcccccccttgtcgcaactggtcatctgcttcggag
ctgaatgaaactcaagagccctttttaaaccccaccgactatgacgacgaggaattcctg
cggtacctgtggagggaatacctgcacccgaaagaatatgagtgggtcctgatcgccggg
tacatcatcgtgttcgtcgtggctctcattgggaacgtcctggtttgtgtggcagtgtgg
aagaaccaccacatgaggacggtaaccaactacttcatagtcaatctttctctggctgat
gtgctcgtgaccatcacctgccttccagccacactggtcgtggatatcactgagacctgg
ttttttggacagtccctttgcaaagtgattccttatctacagaccgtgtcggtgtctgtg
tctgtcctcacactgagctgtatcgccttggatcggtggtatgcaatctgtcaccctttg
atgtttaagagcacagcaaagcgggcccgtaacagcattgtcatcatctggattgtctcc
tgcattataatgattcctcaggccatcgtcatggagtgcagcaccgtgttcccaggctta
gccaataaaaccaccctctttacggtgtgtgatgagcgctggggtggtgaaatttatccc
aagatgtaccacatctgtttctttctggtgacatacatggcaccactgtgtctcatggtg
ttggcttatctgcaaatatttcgcaaactctggtgtcgacagatccctggaacatcatct
gtagttcagagaaaatggaagcccctgcagcctgtttcacagcctcgagggccaggacag
ccaacgaagtcccggatgagcgctgtggcggctgaaataaagcagatccgagccagaagg
aaaacagcccggatgttgatgattgtgcttttggtatttgcaatttgctatctaccaatt
agcatcctcaatgtgctaaagagagtatttgggatgtttgcccatactgaagacagagag
actgtgtatgcctggtttaccttttcacactggcttgtatatgccaatagtgctgcgaat
ccaattatttataattttctcagtggaaaatttcgagaggaatttaaagctgcgttttct
tgctgttgccttggagttcaccatcgccaggaggatcggctcaccaggggacgaactagc
acagagagccggaagtccttgaccactcaaatcagcaactttgataacatatcaaaactt
tctgagcaagttgtgctcactagcataagcacactcccagcagccaatggagcaggacca
cttcaaaactggtag

  All links  
Disease (1)   
   OMIM (1)   
Gene (12)   
   RefGene (7)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (7)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (24)   
   RefSeq(nuc) (4)   
   GenBank (10)   
   EMBL (10)   
3D Structure (11)   
   PDB (11)   
Protein domain (5)   
   Pfam (5)   
All databases (60)   

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