KEGG   Homo sapiens (human): 3061
Entry
3061              CDS       T01001                                 

Gene name
HCRTR1, OX1R
Definition
(RefSeq) hypocretin receptor 1
  KO
K04238  hypocretin (orexin) receptor 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
Drug target
Almorexant: D09964
Daridorexant (DG03119): D11886 D11887
Filorexant: D10345
Lemborexant: D11022<JP/US>
Suvorexant: D10082<JP/US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    3061 (HCRTR1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    3061 (HCRTR1)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Peptide
   Orexin
    3061 (HCRTR1)
SSDB
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srw 7tm_4 Orexin_rec2
Other DBs
NCBI-GeneID: 3061
NCBI-ProteinID: NP_001516
OMIM: 602392
HGNC: 4848
Ensembl: ENSG00000121764
Vega: OTTHUMG00000003876
Pharos: O43613(Tclin)
UniProt: O43613
Position
1p35.2
AA seq 425 aa
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQA
AVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFR
KLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSV
TTVLP
NT seq 1278 nt   +upstreamnt  +downstreamnt
atggagccctcagccaccccaggggcccagatgggggtcccccctggcagcagagagccg
tcccctgtgcctccagactatgaagatgagtttctccgctatctgtggcgcgattatctg
tacccaaaacagtatgagtgggtcctcatcgcagcctatgtggctgtgttcgtcgtggcc
ctggtgggcaacacgctggtctgcctggccgtgtggcggaaccaccacatgaggacagtc
accaactacttcattgtcaacctgtccctggctgacgttctggtgactgctatctgcctg
ccggccagcctgctggtggacatcactgagtcctggctgttcggccatgccctctgcaag
gtcatcccctatctacaggctgtgtccgtgtcagtggcagtgctaactctcagcttcatc
gccctggaccgctggtatgccatctgccacccactattgttcaagagcacagcccggcgg
gcccgtggctccatcctgggcatctgggctgtgtcgctggccatcatggtgccccaggct
gcagtcatggaatgcagcagtgtgctgcctgagctagccaaccgcacacggctcttctca
gtctgtgatgaacgctgggcagatgacctctatcccaagatctaccacagttgcttcttt
attgtcacctacctggccccactgggcctcatggccatggcctatttccagatattccgc
aagctctggggccgccagatccccggcaccacctcagcactggtgcggaactggaagcgc
ccctcagaccagctgggggacctggagcagggcctgagtggagagccccagccccgggcc
cgcgccttcctggctgaagtgaagcagatgcgtgcacggaggaagacagccaagatgctg
atggtggtgctgctggtcttcgccctctgctacctgcccatcagcgtcctcaatgtcctt
aagagggtgttcgggatgttccgccaagccagtgaccgcgaagctgtctacgcctgcttc
accttctcccactggctggtgtacgccaacagcgctgccaaccccatcatctacaacttc
ctcagtggcaaattccgggagcagtttaaggctgccttctcctgctgcctgcctggcctg
ggtccctgcggctctctgaaggcccctagtccccgctcctctgccagccacaagtccttg
tccttgcagagccgatgctccatctccaaaatctctgagcatgtggtgctcaccagcgtc
accacagtgctgccctga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
   OMIM (1)   
Drug (6)   
   KEGG DRUG (6)   
Genome (1)   
   KEGG GENOME (1)   
Gene (8)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (8)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (6)   
DNA sequence (18)   
   RefSeq(nuc) (6)   
   GenBank (6)   
   EMBL (6)   
Protein domain (5)   
   Pfam (5)   
All databases (50)   

Download RDF
KEGG   Homo sapiens (human): 3062
Entry
3062              CDS       T01001                                 

Gene name
HCRTR2, OX2R
Definition
(RefSeq) hypocretin receptor 2
  KO
K04239  hypocretin (orexin) receptor 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
Drug target
Almorexant: D09964
Daridorexant (DG03119): D11886 D11887
Filorexant: D10345
Lemborexant: D11022<JP/US>
Seltorexant: D11269
Suvorexant: D10082<JP/US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    3062 (HCRTR2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    3062 (HCRTR2)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Peptide
   Orexin
    3062 (HCRTR2)
SSDB
Motif
Pfam: 7tm_1 Orexin_rec2 7TM_GPCR_Srsx 7tm_4 SNARE
Other DBs
NCBI-GeneID: 3062
NCBI-ProteinID: NP_001517
OMIM: 602393
HGNC: 4849
Ensembl: ENSG00000137252
Vega: OTTHUMG00000016150
Pharos: O43614(Tclin)
UniProt: O43614 S4X0W3
Position
6p12.1
AA seq 444 aa
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARR
KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKL
SEQVVLTSISTLPAANGAGPLQNW
NT seq 1335 nt   +upstreamnt  +downstreamnt
atgtccggcaccaaattggaggactcccccccttgtcgcaactggtcatctgcttcggag
ctgaatgaaactcaagagccctttttaaaccccaccgactatgacgacgaggaattcctg
cggtacctgtggagggaatacctgcacccgaaagaatatgagtgggtcctgatcgccggg
tacatcatcgtgttcgtcgtggctctcattgggaacgtcctggtttgtgtggcagtgtgg
aagaaccaccacatgaggacggtaaccaactacttcatagtcaatctttctctggctgat
gtgctcgtgaccatcacctgccttccagccacactggtcgtggatatcactgagacctgg
ttttttggacagtccctttgcaaagtgattccttatctacagaccgtgtcggtgtctgtg
tctgtcctcacactgagctgtatcgccttggatcggtggtatgcaatctgtcaccctttg
atgtttaagagcacagcaaagcgggcccgtaacagcattgtcatcatctggattgtctcc
tgcattataatgattcctcaggccatcgtcatggagtgcagcaccgtgttcccaggctta
gccaataaaaccaccctctttacggtgtgtgatgagcgctggggtggtgaaatttatccc
aagatgtaccacatctgtttctttctggtgacatacatggcaccactgtgtctcatggtg
ttggcttatctgcaaatatttcgcaaactctggtgtcgacagatccctggaacatcatct
gtagttcagagaaaatggaagcccctgcagcctgtttcacagcctcgagggccaggacag
ccaacgaagtcccggatgagcgctgtggcggctgaaataaagcagatccgagccagaagg
aaaacagcccggatgttgatgattgtgcttttggtatttgcaatttgctatctaccaatt
agcatcctcaatgtgctaaagagagtatttgggatgtttgcccatactgaagacagagag
actgtgtatgcctggtttaccttttcacactggcttgtatatgccaatagtgctgcgaat
ccaattatttataattttctcagtggaaaatttcgagaggaatttaaagctgcgttttct
tgctgttgccttggagttcaccatcgccaggaggatcggctcaccaggggacgaactagc
acagagagccggaagtccttgaccactcaaatcagcaactttgataacatatcaaaactt
tctgagcaagttgtgctcactagcataagcacactcccagcagccaatggagcaggacca
cttcaaaactggtag

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
   OMIM (1)   
Drug (7)   
   KEGG DRUG (7)   
Genome (1)   
   KEGG GENOME (1)   
Gene (15)   
   KEGG ORTHOLOGY (1)   
   RefGene (7)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (6)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (23)   
   RefSeq(nuc) (3)   
   GenBank (10)   
   EMBL (10)   
Protein domain (5)   
   Pfam (5)   
All databases (61)   

Download RDF
DBGET integrated database retrieval system