KEGG   Homo sapiens (human): 3081
Entry
3081              CDS       T01001                                 
Symbol
HGD, AKU, HGO
Name
(RefSeq) homogentisate 1,2-dioxygenase
  KO
K00451  homogentisate 1,2-dioxygenase [EC:1.13.11.5]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00350  Tyrosine metabolism
hsa01100  Metabolic pathways
Module
hsa_M00044  Tyrosine degradation, tyrosine => homogentisate
Network
nt06016  Phenylalanine and tyrosine metabolism
  Element
N00708  Tyrosine degradation
Disease
H00163  Alkaptonuria
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00350 Tyrosine metabolism
    3081 (HGD)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.11  With incorporation of two atoms of oxygen
    1.13.11.5  homogentisate 1,2-dioxygenase
     3081 (HGD)
SSDB
Motif
Pfam: HgmA_N HgmA_C
Other DBs
NCBI-GeneID: 3081
NCBI-ProteinID: NP_000178
OMIM: 607474
HGNC: 4892
Ensembl: ENSG00000113924
UniProt: Q93099
Structure
Position
3:complement(120628172..120682239)
AA seq 445 aa
MAELKYISGFGNECSSEDPRCPGSLPEGQNNPQVCPYNLYAEQLSGSAFTCPRSTNKRSW
LYRILPSVSHKPFESIDEGQVTHNWDEVDPDPNQLRWKPFEIPKASQKKVDFVSGLHTLC
GAGDIKSNNGLAIHIFLCNTSMENRCFYNSDGDFLIVPQKGNLLIYTEFGKMLVQPNEIC
VIQRGMRFSIDVFEETRGYILEVYGVHFELPDLGPIGANGLANPRDFLIPIAWYEDRQVP
GGYTVINKYQGKLFAAKQDVSPFNVVAWHGNYTPYKYNLKNFMVINSVAFDHADPSIFTV
LTAKSVRPGVAIADFVIFPPRWGVADKTFRPPYYHRNCMSEFMGLIRGHYEAKQGGFLPG
GGSLHSTMTPHGPDADCFEKASKVKLAPERIADGTMAFMFESSLSLAVTKWGLKASRCLD
ENYHKCWEPLKSHFTPNSRNPAEPN
NT seq 1338 nt   +upstreamnt  +downstreamnt
atggctgagttaaagtacatttctggatttgggaatgagtgttcttcagaggatcctcgc
tgcccaggttccctgccagaaggacagaataatcctcaggtctgcccctacaatctctat
gctgagcagctctcaggatcggctttcacttgtccacggagcaccaataagagaagctgg
ctgtataggattctaccttcagtttctcacaagccctttgaatccattgacgaaggccaa
gtcactcacaactgggatgaagttgatcctgatcctaaccagcttagatggaaaccattt
gagattccaaaagcatctcagaagaaagtagactttgtgagtggcctgcataccttgtgt
ggagctggagacataaagtctaacaatgggcttgctatccacattttcctctgcaatacc
tccatggagaacagatgcttttacaattcagatggggacttcttgattgttccgcagaaa
gggaaccttctcatttacaccgagtttggcaagatgcttgtacagcccaatgagatctgc
gtcattcagagaggaatgcggttcagcatagatgtctttgaggagaccaggggctacatc
ttggaggtctatggtgtccactttgagttacctgaccttggaccaattggggccaatggc
ttggccaatcctcgtgatttcttgatacccattgcctggtatgaggatcgccaagtacca
ggtggttacacggtcattaataaataccagggcaagctgtttgctgccaaacaggatgtc
tccccgttcaatgttgtggcctggcacgggaattatacaccctacaagtacaacctgaag
aatttcatggttatcaactcagtggcctttgaccatgcagacccatccattttcacagta
ttgactgctaagtctgtccgccctggagtggccattgctgattttgtcatcttcccacct
cgatggggggttgctgataagaccttcaggcctccttattaccataggaactgcatgagt
gagttcatgggactcatccgaggtcactatgaggcaaagcaaggtgggttcctgccaggg
ggagggagtctacacagcacaatgaccccccatggacctgatgctgactgctttgagaag
gccagcaaggtcaagctggcacctgagaggattgccgatggcaccatggcatttatgttt
gaatcatctttaagtctggcggtcacaaagtggggactcaaggcctccaggtgtttggat
gagaactaccacaagtgctgggagccactcaagagccacttcactcccaactccaggaac
ccagcagaacctaattga

  All links  
Disease (2)   
   OMIM (2)   
Gene (9)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (17)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (15)   
DNA sequence (37)   
   RefSeq(nuc) (15)   
   GenBank (11)   
   EMBL (11)   
3D Structure (2)   
   PDB (2)   
Protein domain (2)   
   Pfam (2)   
All databases (69)   

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