KEGG   Homo sapiens (human): 3081
Entry
3081              CDS       T01001                                 

Symbol
HGD, AKU, HGO
Name
(RefSeq) homogentisate 1,2-dioxygenase
  KO
K00451  homogentisate 1,2-dioxygenase [EC:1.13.11.5]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00350  Tyrosine metabolism
hsa01100  Metabolic pathways
Module
hsa_M00044  Tyrosine degradation, tyrosine => homogentisate
Network
nt06016  Phenylalanine and tyrosine metabolism
  Element
N00708  Tyrosine degradation
N00709  FAH deficiency in tyrosine degradation
N00712  HGD deficiency in tyrosine degradation
Disease
H00163  Alkaptonuria
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00350 Tyrosine metabolism
    3081 (HGD)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.11  With incorporation of two atoms of oxygen
    1.13.11.5  homogentisate 1,2-dioxygenase
     3081 (HGD)
SSDB
Motif
Pfam: HgmA
Other DBs
NCBI-GeneID: 3081
NCBI-ProteinID: NP_000178
OMIM: 607474
HGNC: 4892
Ensembl: ENSG00000113924
Vega: OTTHUMG00000159441
Pharos: Q93099(Tbio)
UniProt: Q93099
Structure
PDB: 
1EYB 1EY2

Position
3q13.33
AA seq 445 aa
MAELKYISGFGNECSSEDPRCPGSLPEGQNNPQVCPYNLYAEQLSGSAFTCPRSTNKRSW
LYRILPSVSHKPFESIDEGQVTHNWDEVDPDPNQLRWKPFEIPKASQKKVDFVSGLHTLC
GAGDIKSNNGLAIHIFLCNTSMENRCFYNSDGDFLIVPQKGNLLIYTEFGKMLVQPNEIC
VIQRGMRFSIDVFEETRGYILEVYGVHFELPDLGPIGANGLANPRDFLIPIAWYEDRQVP
GGYTVINKYQGKLFAAKQDVSPFNVVAWHGNYTPYKYNLKNFMVINSVAFDHADPSIFTV
LTAKSVRPGVAIADFVIFPPRWGVADKTFRPPYYHRNCMSEFMGLIRGHYEAKQGGFLPG
GGSLHSTMTPHGPDADCFEKASKVKLAPERIADGTMAFMFESSLSLAVTKWGLKASRCLD
ENYHKCWEPLKSHFTPNSRNPAEPN
NT seq 1338 nt   +upstreamnt  +downstreamnt
atggctgagttaaagtacatttctggatttgggaatgagtgttcttcagaggatcctcgc
tgcccaggttccctgccagaaggacagaataatcctcaggtctgcccctacaatctctat
gctgagcagctctcaggatcggctttcacttgtccacggagcaccaataagagaagctgg
ctgtataggattctaccttcagtttctcacaagccctttgaatccattgacgaaggccaa
gtcactcacaactgggatgaagttgatcctgatcctaaccagcttagatggaaaccattt
gagattccaaaagcatctcagaagaaagtagactttgtgagtggcctgcataccttgtgt
ggagctggagacataaagtctaacaatgggcttgctatccacattttcctctgcaatacc
tccatggagaacagatgcttttacaattcagatggggacttcttgattgttccgcagaaa
gggaaccttctcatttacaccgagtttggcaagatgcttgtacagcccaatgagatctgc
gtcattcagagaggaatgcggttcagcatagatgtctttgaggagaccaggggctacatc
ttggaggtctatggtgtccactttgagttacctgaccttggaccaattggggccaatggc
ttggccaatcctcgtgatttcttgatacccattgcctggtatgaggatcgccaagtacca
ggtggttacacggtcattaataaataccagggcaagctgtttgctgccaaacaggatgtc
tccccgttcaatgttgtggcctggcacgggaattatacaccctacaagtacaacctgaag
aatttcatggttatcaactcagtggcctttgaccatgcagacccatccattttcacagta
ttgactgctaagtctgtccgccctggagtggccattgctgattttgtcatcttcccacct
cgatggggggttgctgataagaccttcaggcctccttattaccataggaactgcatgagt
gagttcatgggactcatccgaggtcactatgaggcaaagcaaggtgggttcctgccaggg
ggagggagtctacacagcacaatgaccccccatggacctgatgctgactgctttgagaag
gccagcaaggtcaagctggcacctgagaggattgccgatggcaccatggcatttatgttt
gaatcatctttaagtctggcggtcacaaagtggggactcaaggcctccaggtgtttggat
gagaactaccacaagtgctgggagccactcaagagccacttcactcccaactccaggaac
ccagcagaacctaattga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (3)   
   KEGG PATHWAY (2)   
   KEGG MODULE (1)   
Network (3)   
   KEGG NETWORK (3)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (12)   
   KEGG ORTHOLOGY (1)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (8)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (6)   
DNA sequence (28)   
   RefSeq(nuc) (6)   
   GenBank (11)   
   EMBL (11)   
Protein domain (1)   
   Pfam (1)   
All databases (66)   

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