KEGG   Homo sapiens (human): 30849
Entry
30849             CDS       T01001                                 
Symbol
PIK3R4, VPS15, p150
Name
(RefSeq) phosphoinositide-3-kinase regulatory subunit 4
  KO
K08333  phosphoinositide-3-kinase, regulatory subunit 4 [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04136  Autophagy - other
hsa04140  Autophagy - animal
hsa04371  Apelin signaling pathway
hsa05010  Alzheimer disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05131  Shigellosis
Network
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06181  Salmonella
nt06461  Huntington disease
nt06462  Spinocerebellar ataxia
nt06466  Pathways of neurodegeneration
nt06532  Autophagy
  Element
N00155  Autophagy-vesicle nucleation/elongation/maturation, mTORC1-PI3KC3-C1
N00962  Mutation-inactivated ATXN3 to autophagy-vesicle nucleation
N00993  Mutation-caused aberrant Htt to autophagy-vesicle nucleation
N01302  Early endosomal fusion
N01715  Autophagy-vesicle nucleation/elongation/maturation, PI3P synthesis by PI3KC3-C1
N01718  Autophagy-vesicle nucleation/elongation/maturation, PACER-RUBCN-PI3KC3-C2
N01719  Autophagy-vesicle nucleation/elongation/maturation, E3 ubiquitin-ligase Malin
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    30849 (PIK3R4)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    30849 (PIK3R4)
   04136 Autophagy - other
    30849 (PIK3R4)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05131 Shigellosis
    30849 (PIK3R4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    30849 (PIK3R4)
   05014 Amyotrophic lateral sclerosis
    30849 (PIK3R4)
   05016 Huntington disease
    30849 (PIK3R4)
   05017 Spinocerebellar ataxia
    30849 (PIK3R4)
   05022 Pathways of neurodegeneration - multiple diseases
    30849 (PIK3R4)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    30849 (PIK3R4)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    30849 (PIK3R4)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     30849 (PIK3R4)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: Other
  VPS15 family
   30849 (PIK3R4)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    30849 (PIK3R4)
 Autophagy
  Autophagosome formation proteins
   PI3K complex
    30849 (PIK3R4)
SSDB
Motif
Pfam: VPS15-like_hel Pkinase WD40 WD40_Prp19 WD40_CDC20-Fz WD40_WDHD1_1st Beta-prop_EML_2 WDR55 Beta-prop_RIG_2nd HEAT Beta-prop_TEP1_C Beta-prop_HPS5 Beta-prop_TEP1_2nd Beta-prop_Vps41 PK_Tyr_Ser-Thr EIF3I Beta-prop_IFT140_1st Beta-prop_EIPR1 NBCH_WD40 WD40_MABP1-WDR62_2nd Beta-prop_CAF1B_HIR1 WDR90_beta-prop_4th Beta-prop_WDR19_1st Beta-prop_WDR11_1st TCAD9 APH
Other DBs
NCBI-GeneID: 30849
NCBI-ProteinID: NP_055417
OMIM: 602610
HGNC: 8982
Ensembl: ENSG00000196455
UniProt: Q99570
Structure
Position
3:complement(130678934..130746829)
AA seq 1358 aa
MGNQLAGIAPSQILSVESYFSDIHDFEYDKSLGSTRFFKVARAKHREGLVVVKVFAIQDP
TLPLTSYKQELEELKIRLNSAQNCLPFQKASEKASEKAAMLFRQYVRDNLYDRISTRPFL
NNIEKRWIAFQILTAVDQAHKSGVRHGDIKTENVMVTSWNWVLLTDFASFKPTYLPEDNP
ADFNYFFDTSRRRTCYIAPERFVDGGMFATELEYMRDPSTPLVDLNSNQRTRGELKRAMD
IFSAGCVIAELFTEGVPLFDLSQLLAYRNGHFFPEQVLNKIEDHSIRELVTQMIHREPDK
RLEAEDYLKQQRGNAFPEIFYTFLQPYMAQFAKETFLSADERILVIRKDLGNIIHNLCGH
DLPEKAEGEPKENGLVILVSVITSCLQTLKYCDSKLAALELILHLAPRLSVEILLDRITP
YLLHFSNDSVPRVRAEALRTLTKVLALVKEVPRNDINIYPEYILPGIAHLAQDDATIVRL
AYAENIALLAETALRFLELVQLKNLNMENDPNNEEIDEVTHPNGNYDTELQALHEMVQQK
VVTLLSDPENIVKQTLMENGITRLCVFFGRQKANDVLLSHMITFLNDKNDWHLRGAFFDS
IVGVAAYVGWQSSSILKPLLQQGLSDAEEFVIVKALYALTCMCQLGLLQKPHVYEFASDI
APFLCHPNLWIRYGAVGFITVVARQISTADVYCKLMPYLDPYITQPIIQIERKLVLLSVL
KEPVSRSIFDYALRSKDITSLFRHLHMRQKKRNGSLPDCPPPEDPAIAQLLKKLLSQGMT
EEEEDKLLALKDFMMKSNKAKANIVDQSHLHDSSQKGVIDLAALGITGRQVDLVKTKQEP
DDKRARKHVKQDSNVNEEWKSMFGSLDPPNMPQALPKGSDQEVIQTGKPPRSESSAGICV
PLSTSSQVPEVTTVQNKKPVIPVLSSTILPSTYQIRITTCKTELQQLIQQKREQCNAERI
AKQMMENAEWESKPPPPGWRPKGLLVAHLHEHKSAVNRIRVSDEHSLFATCSNDGTVKIW
NSQKMEGKTTTTRSILTYSRIGGRVKTLTFCQGSHYLAIASDNGAVQLLGIEASKLPKSP
KIHPLQSRILDQKEDGCVVDMHHFNSGAQSVLAYATVNGSLVGWDLRSSSNAWTLKHDLK
SGLITSFAVDIHQCWLCIGTSSGTMACWDMRFQLPISSHCHPSRARIRRLSMHPLYQSWV
IAAVQGNNEVSMWDMETGDRRFTLWASSAPPLSELQPSPHSVHGIYCSPADGNPILLTAG
SDMKIRFWDLAYPERSYVVAGSTSSPSVSYYRKIIEGTEVVQEIQNKQKVGPSDDTPRRG
PESLPVGHHDIITDVATFQTTQGFIVTASRDGIVKVWK
NT seq 4077 nt   +upstreamnt  +downstreamnt
atgggaaatcagcttgctggcattgctccctcccagatcctttctgtagagagttatttt
tcagatattcatgactttgaatatgataaaagcctggggagtactcggttttttaaagtt
gctcgagccaagcaccgagaaggcctggtcgttgtgaaggtttttgcaattcaggatccc
acattgcctttaaccagctataaacaagagctggaggaactgaaaatcaggcttaattct
gcacagaattgtctacctttccagaaagcatcagaaaaagcatctgagaaagcagctatg
ctctttaggcagtatgtgcgagacaatctctatgatcgcatcagtacccgtccattcttg
aataacattgagaagcgctggattgctttccagatcctgacagctgtggaccaagcacac
aaatctggagttcgtcatggggacatcaagactgagaatgtgatggtcaccagttggaat
tgggttcttctaactgattttgccagttttaagcccacttatcttccagaagacaacccg
gcagatttcaattatttctttgacacatcacggaggagaacttgctatattgctcctgaa
cgttttgttgatggtgggatgtttgccactgagttagaatatatgagagatccttcaact
ccgcttgtagacttaaatagcaatcagagaacaagaggagagttgaagagagcaatggac
atcttttcagcaggttgtgtgatagctgagctttttacagaaggtgtaccattatttgat
ctctctcaacttttggcttatagaaatggacattttttccctgaacaagtgctaaataaa
attgaagatcacagtatcagagaattggtaactcagatgattcaccgtgagccagataaa
cgtttagaggcagaagattacttaaaacagcagcgtggcaatgcctttcctgaaatattt
tacacttttcttcagccctacatggcccagtttgccaaggaaacgtttctttctgcagat
gagcgtattctggttatacggaaggatttgggcaacattattcacaatctctgtggacat
gatctgccagaaaaagccgaaggagagcctaaggaaaatgggctggttatcttggtatct
gttataacatcctgcctacagacccttaaatactgtgattccaaactagctgctttggaa
ctgattcttcatttggctccaagattaagtgttgaaatccttttggatcgtattactcca
tatcttttgcatttcagcaatgactctgttcctagggtgagggctgaagccttgaggacg
ttgaccaaagttcttgctctcgtcaaagaggttcctcgtaatgatatcaatatttatccg
gaatacattctgccaggcatagcccacttagcccaagatgatgctactatcgttagacta
gcctatgctgaaaacatagctctgctggcagaaacagctctgagattcctggaattagta
cagttaaaaaatcttaatatggaaaatgaccccaataatgaagaaatagatgaggttaca
catccaaatggaaattatgacacagagctccaagccttacatgaaatggtccagcagaaa
gttgttactttgctaagtgaccctgaaaatattgtaaaacaaaccttgatggaaaatgga
ataacacggctgtgtgtattctttggacgtcagaaagccaacgatgttttgttgtcccac
atgattactttcctaaatgataagaatgattggcatctacgtggagcattttttgatagt
atagttggtgttgctgcctatgttggctggcaaagctcctcaattctcaagcctctgctg
caacaaggtcttagtgatgctgaggaatttgtcattgtgaaagctctttatgcccttact
tgtatgtgccagttaggactgctacaaaaaccccatgtttacgaatttgccagtgatatt
gcccccttcctgtgtcatcccaatttatggatacgttatggtgccgtgggatttatcaca
gtggtagctcgtcaaataagtacagctgatgtctactgtaaactgatgccttatcttgac
ccatatattacccaaccaataatacagattgaaagaaaacttgttctgctcagtgtttta
aaggaaccagtaagtcgttctatatttgattatgctttgaggtctaaagatattactagc
ttgttcagacatcttcacatgcgtcagaagaaacgaaatggttctcttcccgactgccct
ccgccagaggatcctgccatagcacagcttctgaagaagttgctctcacagggaatgaca
gaggaagaggaagacaaacttctggcactgaaagacttcatgatgaaatctaataaagca
aaggccaatatagtggaccagagccatcttcatgatagtagtcagaaaggtgtaattgac
ttggcagctttaggcataactgggagacaagttgatcttgttaaaaccaaacaagaacca
gatgacaaacgggccagaaaacatgtaaaacaagactcaaatgtaaatgaagaatggaaa
agcatgtttgggtcactggacccaccaaacatgccacaggccctacctaaagggagtgat
caggaggtgattcagactgggaaacctcctcgttccgagtcctctgctggcatttgtgtc
cctttgtcaacttcttcacaggttccagaagtgacaactgtccaaaataaaaaaccagta
ataccggttttaagtagtacaatcttaccatccacctatcagattcgaattacaacttgt
aaaactgaacttcagcaactcatccagcaaaagcgggagcagtgcaatgctgagagaata
gctaagcagatgatggaaaatgctgaatgggagagtaaaccaccaccacctggatggcgt
cctaaagggctgttagttgcccatcttcatgagcataaatctgctgtgaatcgaattaga
gtctctgatgaacactcactttttgcaacatgttcaaatgatggcacagtgaaaatctgg
aacagtcaaaagatggaggggaagaccaccactaccagatctattcttacatacagccga
attggaggacgagtcaagacgctcacattctgccaaggctcccactatttagccatagca
tctgataatggtgctgtccagcttcttggaattgaggcttctaagctgcccaagtctcct
aaaatccatcctctacaaagcagaattctagatcagaaggaggacggttgtgttgtggat
atgcatcacttcaactctggagcacagtctgttcttgcctatgccactgtgaatggctct
ctggttggctgggaccttaggtcttcaagcaatgcgtggactttaaagcatgatttaaag
tcgggcctcatcacttcctttgctgtggacatccaccaatgctggctctgcattggtaca
agcagtggtaccatggcttgttgggacatgaggttccagttgccaatttcaagtcactgt
catccttccagggctcgaatcagacgcctctcaatgcaccctctgtatcagtcctgggtg
attgcagctgttcagggcaacaacgaagtgtccatgtgggacatggagactggtgacaga
agatttactctctgggccagcagtgcaccaccactttctgaattacagccttctcctcat
agcgtccatggtatctactgtagtcctgcagatggaaatcctatcctactaacagctggc
tcagatatgaaaataaggttttgggacttggcttacccagaaaggtcctatgttgttgca
ggaagtactagttccccatctgtgtcctactacaggaaaataattgaaggcactgaagtt
gtccaggaaattcagaataagcagaaagtaggaccaagtgatgacacccctcgaaggggc
ccagagtccctgcccgtgggacatcatgacatcatcactgatgtcgccacattccagacc
acacagggcttcatcgtaactgcttctagagatgggattgtgaaggtgtggaaataa

  All links  
Disease (1)   
   OMIM (1)   
Gene (22)   
   RefGene (13)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (21)   
   RefSeq(nuc) (1)   
   GenBank (10)   
   EMBL (10)   
3D Structure (6)   
   PDB (6)   
Protein domain (26)   
   Pfam (26)   
All databases (79)   

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