KEGG   Homo sapiens (human): 3111
Entry
3111              CDS       T01001                                 

Gene name
HLA-DOA, HLA-DNA, HLA-DZA, HLADZ
Definition
(RefSeq) major histocompatibility complex, class II, DO alpha
  KO
K06752  MHC class II antigen
Organism
hsa  Homo sapiens (human)
Pathway
hsa04145  Phagosome
hsa04514  Cell adhesion molecules (CAMs)
hsa04612  Antigen processing and presentation
hsa04640  Hematopoietic cell lineage
hsa04658  Th1 and Th2 cell differentiation
hsa04659  Th17 cell differentiation
hsa04672  Intestinal immune network for IgA production
hsa04940  Type I diabetes mellitus
hsa05140  Leishmaniasis
hsa05145  Toxoplasmosis
hsa05150  Staphylococcus aureus infection
hsa05152  Tuberculosis
hsa05164  Influenza A
hsa05166  Human T-cell leukemia virus 1 infection
hsa05168  Herpes simplex virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05310  Asthma
hsa05320  Autoimmune thyroid disease
hsa05321  Inflammatory bowel disease (IBD)
hsa05322  Systemic lupus erythematosus
hsa05323  Rheumatoid arthritis
hsa05330  Allograft rejection
hsa05332  Graft-versus-host disease
hsa05416  Viral myocarditis
Network
nt06129  MHC presentation (viruses)
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06168  Herpes simplex virus 1 (HSV-1)
  Element
N00508  HTLV-1 Tax to NFY-mediated transcription
N00590  Antigen processing and presentation by MHC class II molecules
N00591  HSV gB to antigen processing and presentation by MHC class II molecules
Drug target
Glatiramer acetate: D04318
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecules (CAMs)
    3111 (HLA-DOA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    3111 (HLA-DOA)
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    3111 (HLA-DOA)
   04612 Antigen processing and presentation
    3111 (HLA-DOA)
   04658 Th1 and Th2 cell differentiation
    3111 (HLA-DOA)
   04659 Th17 cell differentiation
    3111 (HLA-DOA)
   04672 Intestinal immune network for IgA production
    3111 (HLA-DOA)
 09160 Human Diseases
  09163 Immune disease
   05310 Asthma
    3111 (HLA-DOA)
   05322 Systemic lupus erythematosus
    3111 (HLA-DOA)
   05323 Rheumatoid arthritis
    3111 (HLA-DOA)
   05320 Autoimmune thyroid disease
    3111 (HLA-DOA)
   05321 Inflammatory bowel disease (IBD)
    3111 (HLA-DOA)
   05330 Allograft rejection
    3111 (HLA-DOA)
   05332 Graft-versus-host disease
    3111 (HLA-DOA)
  09166 Cardiovascular disease
   05416 Viral myocarditis
    3111 (HLA-DOA)
  09167 Endocrine and metabolic disease
   04940 Type I diabetes mellitus
    3111 (HLA-DOA)
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    3111 (HLA-DOA)
   05152 Tuberculosis
    3111 (HLA-DOA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    3111 (HLA-DOA)
   05164 Influenza A
    3111 (HLA-DOA)
   05168 Herpes simplex virus 1 infection
    3111 (HLA-DOA)
   05169 Epstein-Barr virus infection
    3111 (HLA-DOA)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    3111 (HLA-DOA)
   05140 Leishmaniasis
    3111 (HLA-DOA)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    3111 (HLA-DOA)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   3111 (HLA-DOA)
  Exosomal proteins of epithelial cells
   3111 (HLA-DOA)
  Exosomal proteins of breast milk
   3111 (HLA-DOA)
SSDB
Motif
Pfam: MHC_II_alpha C1-set Ig_3 C2-set_2 Marek_A
Other DBs
NCBI-GeneID: 3111
NCBI-ProteinID: NP_002110
OMIM: 142930
HGNC: 4936
Ensembl: ENSG00000204252
Vega: OTTHUMG00000031211
Pharos: P06340(Tbio)
UniProt: P06340 X5CF87 A0A1V0E3Q8 A0A1V0E3S6 A0A1V0E3R8 A0A1V0E3Q1 A0A1V0E3N6 A0A1V0E3P3 A0A1V0E3Q3 A0A1V0E3S4 A0A1V0E3P8 A0A1V0E3Q4 A0A1V0E3R4 A0A1V0E3N7 A0A1V0E3R0 A0A1V0E3R3 A0A1V0E3N1 A0A1V0E3N3 A0A1V0E3P0 A0A1V0E3R6 A0A1V0E3Q7 A0A1V0E3Q5 A0A1V0E3P1 A0A1V0E3M7 A0A1V0E3P9 A0A1V0E3P6 A0A1V0E3Q2 A0A1V0E3T1 A0A1V0E3S0 A0A1V0E3S7 A0A1V0E3Q6
Structure
PDB: 
4I0P

Position
6p21.32
AA seq 250 aa
MALRAGLVLGFHTLMTLLSPQEAGATKADHMGSYGPAFYQSYGASGQFTHEFDEEQLFSV
DLKKSEAVWRLPEFGDFARFDPQGGLAGIAAIKAHLDILVERSNRSRAINVPPRVTVLPK
SRVELGQPNILICIVDNIFPPVINITWLRNGQTVTEGVAQTSFYSQPDHLFRKFHYLPFV
PSAEDVYDCQVEHWGLDAPLLRHWELQVPIPPPDAMETLVCALGLAIGLVGFLVGTVLII
MGTYVSSVPR
NT seq 753 nt   +upstreamnt  +downstreamnt
atggccctcagagcagggctggtcctggggttccacaccctgatgaccctcctgagcccg
caggaggcaggggccaccaaggctgaccacatgggctcctacggacccgccttctaccag
tcttacggcgcctcgggccagttcacccatgaatttgatgaggaacagctgttctctgtg
gacctgaagaaaagcgaggccgtgtggcgtctgcctgagtttggtgactttgcccgcttt
gacccgcagggcgggctggccggcatcgccgcaatcaaagcccatctggacatcctggtg
gagcgctccaaccgcagcagagccatcaacgtgcctccacgggtgaccgtgctccccaag
tctcgggtggagctgggccagcccaacatcctcatctgcatcgtggacaacatcttcccc
cctgtgatcaatatcacctggctgcgcaacggccaaactgtcactgagggagtggcccag
accagcttctattcccagcctgaccatttgttccgcaagttccactacctgcccttcgtg
ccctcagccgaggacgtctatgactgccaggtggagcactggggcctggatgcgccactc
ctcaggcattgggagctccaggtgcctattccaccaccagatgccatggagaccctggtc
tgtgccctgggcctggccatcggcctggtgggcttcctcgtgggcaccgtcctcatcatc
atgggcacatatgtgtccagtgtccccaggtaa

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (24)   
   KEGG PATHWAY (24)   
Network (3)   
   KEGG NETWORK (3)   
Disease (1)   
   OMIM (1)   
Drug (1)   
   KEGG DRUG (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (12)   
   KEGG ORTHOLOGY (1)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (33)   
   UniProt (31)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (31)   
   RefSeq(nuc) (1)   
   GenBank (15)   
   EMBL (15)   
Protein domain (5)   
   Pfam (5)   
All databases (113)   

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