KEGG   Homo sapiens (human): 3127
Entry
3127              CDS       T01001                                 

Gene name
HLA-DRB5, HLA-DRB5*
Definition
(RefSeq) major histocompatibility complex, class II, DR beta 5
  KO
K06752  MHC class II antigen
Organism
hsa  Homo sapiens (human)
Pathway
hsa04145  Phagosome
hsa04514  Cell adhesion molecules
hsa04612  Antigen processing and presentation
hsa04640  Hematopoietic cell lineage
hsa04658  Th1 and Th2 cell differentiation
hsa04659  Th17 cell differentiation
hsa04672  Intestinal immune network for IgA production
hsa04940  Type I diabetes mellitus
hsa05140  Leishmaniasis
hsa05145  Toxoplasmosis
hsa05150  Staphylococcus aureus infection
hsa05152  Tuberculosis
hsa05164  Influenza A
hsa05166  Human T-cell leukemia virus 1 infection
hsa05168  Herpes simplex virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05310  Asthma
hsa05320  Autoimmune thyroid disease
hsa05321  Inflammatory bowel disease
hsa05322  Systemic lupus erythematosus
hsa05323  Rheumatoid arthritis
hsa05330  Allograft rejection
hsa05332  Graft-versus-host disease
hsa05416  Viral myocarditis
Network
nt06129  MHC presentation (viruses)
nt06140  Transcription (viruses)
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06168  Herpes simplex virus 1 (HSV-1)
  Element
N00508  HTLV-1 Tax to NFY-mediated transcription
N00590  Antigen processing and presentation by MHC class II molecules
Disease
H02424  Primary central nervous system lymphoma
Drug target
Apolizumab: D02967
Glatiramer acetate: D04318<JP/US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecules
    3127 (HLA-DRB5)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    3127 (HLA-DRB5)
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    3127 (HLA-DRB5)
   04612 Antigen processing and presentation
    3127 (HLA-DRB5)
   04658 Th1 and Th2 cell differentiation
    3127 (HLA-DRB5)
   04659 Th17 cell differentiation
    3127 (HLA-DRB5)
   04672 Intestinal immune network for IgA production
    3127 (HLA-DRB5)
 09160 Human Diseases
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    3127 (HLA-DRB5)
   05164 Influenza A
    3127 (HLA-DRB5)
   05168 Herpes simplex virus 1 infection
    3127 (HLA-DRB5)
   05169 Epstein-Barr virus infection
    3127 (HLA-DRB5)
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    3127 (HLA-DRB5)
   05152 Tuberculosis
    3127 (HLA-DRB5)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    3127 (HLA-DRB5)
   05140 Leishmaniasis
    3127 (HLA-DRB5)
  09163 Immune disease
   05310 Asthma
    3127 (HLA-DRB5)
   05322 Systemic lupus erythematosus
    3127 (HLA-DRB5)
   05323 Rheumatoid arthritis
    3127 (HLA-DRB5)
   05320 Autoimmune thyroid disease
    3127 (HLA-DRB5)
   05321 Inflammatory bowel disease
    3127 (HLA-DRB5)
   05330 Allograft rejection
    3127 (HLA-DRB5)
   05332 Graft-versus-host disease
    3127 (HLA-DRB5)
  09166 Cardiovascular disease
   05416 Viral myocarditis
    3127 (HLA-DRB5)
  09167 Endocrine and metabolic disease
   04940 Type I diabetes mellitus
    3127 (HLA-DRB5)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    3127 (HLA-DRB5)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   3127 (HLA-DRB5)
  Exosomal proteins of epithelial cells
   3127 (HLA-DRB5)
  Exosomal proteins of breast milk
   3127 (HLA-DRB5)
SSDB
Motif
Pfam: MHC_II_beta C1-set Ig_3 Ig_2 ig
Other DBs
NCBI-GeneID: 3127
NCBI-ProteinID: NP_002116
OMIM: 604776
HGNC: 4953
Ensembl: ENSG00000198502
Vega: OTTHUMG00000031027
Pharos: Q30154(Tbio)
UniProt: Q30154 A0A2Z4LKS3
Structure
PDB: 
1FV1 1ZGL 1HQR 1H15

Position
6p21.32
AA seq 266 aa
MVCLKLPGGSYMAKLTVTLMVLSSPLALAGDTRPRFLQQDKYECHFFNGTERVRFLHRDI
YNQEEDLRFDSDVGEYRAVTELGRPDAEYWNSQKDFLEDRRAAVDTYCRHNYGVGESFTV
QRRVEPKVTVYPARTQTLQHHNLLVCSVNGFYPGSIEVRWFRNSQEEKAGVVSTGLIQNG
DWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRAQSESAQSKMLSGVGGFVLGLL
FLGAGLFIYFKNQKGHSGLHPTGLVS
NT seq 801 nt   +upstreamnt  +downstreamnt
atggtgtgtctgaagctccctggaggttcctacatggcaaagctgacagtgacactgatg
gtgctgagctccccactggctttggctggggacacccgaccacgtttcttgcagcaggat
aagtatgagtgtcatttcttcaacgggacggagcgggtgcggttcctgcacagagacatc
tataaccaagaggaggacttgcgcttcgacagcgacgtgggggagtaccgggcggtgacg
gagctggggcggcctgacgctgagtactggaacagccagaaggacttcctggaagacagg
cgcgccgcggtggacacctactgcagacacaactacggggttggtgagagcttcacagtg
cagcggcgagttgagcctaaggtgactgtgtatcctgcaaggacccagaccctgcagcac
cacaacctcctggtctgctctgtgaatggtttctatccaggcagcattgaagtcaggtgg
ttccggaacagccaggaagagaaggctggggtggtgtccacaggcctgattcagaatgga
gactggaccttccagaccctggtgatgctggaaacagttcctcgaagtggagaggtttac
acctgccaagtggagcacccaagcgtgacgagccctctcacagtggaatggagagcacag
tctgaatctgcacagagcaagatgctgagtggagtcgggggctttgtgctgggcctgctc
ttccttggggccgggctattcatctacttcaagaatcagaaagggcactctggacttcac
ccaacaggactcgtgagctga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (24)   
   KEGG PATHWAY (24)   
Network (2)   
   KEGG NETWORK (2)   
Disease (2)   
   KEGG DISEASE (1)   
   OMIM (1)   
Drug (2)   
   KEGG DRUG (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (10)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (5)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (106)   
   RefSeq(nuc) (2)   
   GenBank (52)   
   EMBL (52)   
Protein domain (5)   
   Pfam (5)   
All databases (159)   

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