KEGG   Homo sapiens (human): 3162
Entry
3162              CDS       T01001                                 
Symbol
HMOX1, HMOX1D, HO-1, HSP32, bK286B10
Name
(RefSeq) heme oxygenase 1
  KO
K00510  heme oxygenase 1 [EC:1.14.14.18]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00860  Porphyrin metabolism
hsa01100  Metabolic pathways
hsa04066  HIF-1 signaling pathway
hsa04216  Ferroptosis
hsa04978  Mineral absorption
hsa05200  Pathways in cancer
hsa05206  MicroRNAs in cancer
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05225  Hepatocellular carcinoma
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06226  KEAP1-NRF2 signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06463  Parkinson disease
  Element
N00243  KEAP1-NRF2 signaling pathway
N00244  Mutation-inactivated KEAP1 to KEAP1-NRF2 signaling pathway
N00245  Mutation-activated NRF2 to KEAP1-NRF2 signaling pathway
N01413  Metals to KEAP1-NRF2 signalig pathway
Disease
H01714  Chronic obstructive pulmonary disease (COPD)
H02929  Heme oxygenase-1 deficiency
Drug target
Stannsoporfin: D05922
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00860 Porphyrin metabolism
    3162 (HMOX1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    3162 (HMOX1)
 09140 Cellular Processes
  09143 Cell growth and death
   04216 Ferroptosis
    3162 (HMOX1)
 09150 Organismal Systems
  09154 Digestive system
   04978 Mineral absorption
    3162 (HMOX1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    3162 (HMOX1)
   05206 MicroRNAs in cancer
    3162 (HMOX1)
   05208 Chemical carcinogenesis - reactive oxygen species
    3162 (HMOX1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    3162 (HMOX1)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    3162 (HMOX1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.18  heme oxygenase (biliverdin-producing)
     3162 (HMOX1)
SSDB
Motif
Pfam: Heme_oxygenase REC1
Other DBs
NCBI-GeneID: 3162
NCBI-ProteinID: NP_002124
OMIM: 141250
HGNC: 5013
Ensembl: ENSG00000100292
UniProt: P09601 Q6FH11
Structure
Position
22:35381096..35394207
AA seq 288 aa
MERPQPDSMPQDLSEALKEATKEVHTQAENAEFMRNFQKGQVTRDGFKLVMASLYHIYVA
LEEEIERNKESPVFAPVYFPEELHRKAALEQDLAFWYGPRWQEVIPYTPAMQRYVKRLHE
VGRTEPELLVAHAYTRYLGDLSGGQVLKKIAQKALDLPSSGEGLAFFTFPNIASATKFKQ
LYRSRMNSLEMTPAVRQRVIEEAKTAFLLNIQLFEELQELLTHDTKDQSPSRAPGLRQRA
SNKVQDSAPVETPRGKPPLNTRSQAPLLRWVLTLSFLVATVAVGLYAM
NT seq 867 nt   +upstreamnt  +downstreamnt
atggagcgtccgcaacccgacagcatgccccaggatttgtcagaggccctgaaggaggcc
accaaggaggtgcacacccaggcagagaatgctgagttcatgaggaactttcagaagggc
caggtgacccgagacggcttcaagctggtgatggcctccctgtaccacatctatgtggcc
ctggaggaggagattgagcgcaacaaggagagcccagtcttcgcccctgtctacttccca
gaagagctgcaccgcaaggctgccctggagcaggacctggccttctggtacgggccccgc
tggcaggaggtcatcccctacacaccagccatgcagcgctatgtgaagcggctccacgag
gtggggcgcacagagcccgagctgctggtggcccacgcctacacccgctacctgggtgac
ctgtctgggggccaggtgctcaaaaagattgcccagaaagccctggacctgcccagctct
ggcgagggcctggccttcttcaccttccccaacattgccagtgccaccaagttcaagcag
ctctaccgctcccgcatgaactccctggagatgactcccgcagtcaggcagagggtgata
gaagaggccaagactgcgttcctgctcaacatccagctctttgaggagttgcaggagctg
ctgacccatgacaccaaggaccagagcccctcacgggcaccagggcttcgccagcgggcc
agcaacaaagtgcaagattctgcccccgtggagactcccagagggaagcccccactcaac
acccgctcccaggctccgcttctccgatgggtccttacactcagctttctggtggcgaca
gttgctgtagggctttatgccatgtga

  All links  
Disease (3)   
   OMIM (3)   
Gene (21)   
   RefGene (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (15)   
   OC (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (31)   
   RefSeq(nuc) (1)   
   GenBank (15)   
   EMBL (15)   
3D Structure (26)   
   PDB (26)   
Protein domain (2)   
   Pfam (2)   
All databases (87)   

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KEGG   Homo sapiens (human): 3163
Entry
3163              CDS       T01001                                 
Symbol
HMOX2, HO-2
Name
(RefSeq) heme oxygenase 2
  KO
K21418  heme oxygenase 2 [EC:1.14.14.18]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00860  Porphyrin metabolism
hsa01100  Metabolic pathways
hsa04978  Mineral absorption
Drug target
Stannsoporfin: D05922
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00860 Porphyrin metabolism
    3163 (HMOX2)
 09150 Organismal Systems
  09154 Digestive system
   04978 Mineral absorption
    3163 (HMOX2)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.18  heme oxygenase (biliverdin-producing)
     3163 (HMOX2)
SSDB
Motif
Pfam: Heme_oxygenase SsgA
Other DBs
NCBI-GeneID: 3163
NCBI-ProteinID: NP_001120676
OMIM: 141251
HGNC: 5014
Ensembl: ENSG00000103415
UniProt: P30519
Structure
Position
16:4474736..4510347
AA seq 316 aa
MSAEVETSEGVDESEKKNSGALEKENQMRMADLSELLKEGTKEAHDRAENTQFVKDFLKG
NIKKELFKLATTALYFTYSALEEEMERNKDHPAFAPLYFPMELHRKEALTKDMEYFFGEN
WEEQVQCPKAAQKYVERIHYIGQNEPELLVAHAYTRYMGDLSGGQVLKKVAQRALKLPST
GEGTQFYLFENVDNAQQFKQLYRARMNALDLNMKTKERIVEEANKAFEYNMQIFNELDQA
GSTLARETLEDGFPVHDGKGDMRKCPFYAAEQDKGALEGSSCPFRTAMAVLRKPSLQFIL
AAGVALAAGLLAWYYM
NT seq 951 nt   +upstreamnt  +downstreamnt
atgtcagcggaagtggaaacctcagagggggtagacgagtcagaaaaaaagaactctggg
gccctagaaaaggagaaccaaatgagaatggctgacctctcggagctcctgaaggaaggg
accaaggaagcacacgaccgggcagaaaacacccagtttgtcaaggacttcttgaaaggc
aacattaagaaggagctgtttaagctggccaccacggcactttacttcacatactcagcc
ctcgaggaggaaatggagcgcaacaaggaccatccagcctttgcccctttgtacttcccc
atggagctgcaccggaaggaggcgctgaccaaggacatggagtatttctttggtgaaaac
tgggaggagcaggtgcagtgccccaaggctgcccagaagtacgtggagcggatccactac
atagggcagaacgagccggagctactggtggcccatgcatacacccgctacatgggggat
ctctcggggggccaggtgctgaagaaggtggcccagcgagcactgaaactccccagcaca
ggggaagggacccagttctacctgtttgagaatgtggacaatgcccagcagttcaagcag
ctctaccgggccaggatgaacgccctggacctgaacatgaagaccaaagagaggatcgtg
gaggaggccaacaaggcttttgagtataacatgcagatattcaatgaactggaccaggcc
ggctccacactggccagagagaccttggaggatgggttccctgtacacgatgggaaagga
gacatgcgtaaatgccctttctacgctgctgaacaagacaaaggtgccctggagggcagc
agctgtcccttccgaacagctatggctgtgctgaggaagcccagcctccagttcatcctg
gccgctggtgtggccctagctgctggactcttggcctggtactacatgtga

  All links  
Disease (1)   
   OMIM (1)   
Gene (13)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (6)   
   OC (1)   
Protein sequence (17)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (15)   
DNA sequence (53)   
   RefSeq(nuc) (15)   
   GenBank (19)   
   EMBL (19)   
3D Structure (7)   
   PDB (7)   
Protein domain (2)   
   Pfam (2)   
All databases (93)   

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