KEGG   Homo sapiens (human): 3248
Entry
3248              CDS       T01001                                 
Symbol
HPGD, 15-PGDH, PGDH, PGDH1, PHOAR1, SDR36C1
Name
(RefSeq) 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1
  KO
K00069  15-hydroxyprostaglandin dehydrogenase (NAD) [EC:1.1.1.141]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00590  Arachidonic acid metabolism
hsa05202  Transcriptional misregulation in cancer
Network
nt06240  Transcription (cancer)
  Element
N00120  MLL-ENL fusion to transcriptional activation
Disease
H00457  Primary hypertrophic osteoarthropathy
H01246  Isolated congenital nail clubbing
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    3248 (HPGD)
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    3248 (HPGD)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    3248 (HPGD)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.141  15-hydroxyprostaglandin dehydrogenase (NAD+)
     3248 (HPGD)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   3248 (HPGD)
SSDB
Motif
Pfam: adh_short adh_short_C2 KR Epimerase GDP_Man_Dehyd SDR Lectin_leg-like 3Beta_HSD
Other DBs
NCBI-GeneID: 3248
NCBI-ProteinID: NP_000851
OMIM: 601688
HGNC: 5154
Ensembl: ENSP00000296522.6
UniProt: P15428
Structure
Position
4:complement(174490175..174522893)
AA seq 266 aa
MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLF
IQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLD
YMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNA
ICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNG
AIMKITTSKGIHFQDYDTTPFQAKTQ
NT seq 801 nt   +upstreamnt  +downstreamnt
atgcacgtgaacggcaaagtggcgctggtgaccggcgcggctcagggcataggcagagcc
tttgcagaggcgctgctgcttaagggcgccaaggtagcgctggtggattggaatcttgaa
gcaggtgtacagtgtaaagctgccctggatgagcagtttgaacctcagaagactctgttc
atccagtgcgatgtggctgaccagcaacaactgagagacacttttagaaaagttgtagac
cactttggaagactggacattttggtcaataatgctggagtgaataatgagaaaaactgg
gaaaaaactctgcaaattaatttggtttctgttatcagtggaacctatcttggtttggat
tacatgagtaagcaaaatggaggtgaaggcggcatcattatcaatatgtcatctttagca
ggactcatgcccgttgcacagcagccggtttattgtgcttcaaagcatggcatagttgga
ttcacacgctcagcagcgttggctgctaatcttatgaacagtggtgtgagactgaatgcc
atttgtccaggctttgttaacacagccatccttgaatcaattgaaaaagaagaaaacatg
ggacaatatatagaatataaggatcatatcaaggatatgattaaatactatggaattttg
gacccaccattgattgccaatggattgataacactcattgaagatgatgctttaaatggt
gctattatgaagatcacaacttctaagggaattcattttcaagactatgatacaactcca
tttcaagcaaaaacccaatga

  All links  
Disease (3)   
   OMIM (3)   
Gene (10)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (9)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (7)   
DNA sequence (39)   
   RefSeq(nuc) (9)   
   GenBank (15)   
   EMBL (15)   
3D Structure (6)   
   PDB (6)   
Protein domain (8)   
   Pfam (8)   
All databases (75)   

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