KEGG   Homo sapiens (human): 3269
Entry
3269              CDS       T01001                                 

Gene name
HRH1, H1-R, H1R, HH1R, hisH1
Definition
(RefSeq) histamine receptor H1
  KO
K04149  histamine receptor H1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04750  Inflammatory mediator regulation of TRP channels
Drug target
Acrivastine: D02760
Alcaftadine: D06552<US>
Alimemazine (DG01101): D02245<JP> D07125
Antazoline (DG01037): D02950 D07458 D07459
Astemizole: D00234
Azatadine (DG01112): D00662 D07482
Azelastine (DG01036): D00659<JP/US> D07483
Bamipine (DG00388): D07197 D07492 D07493
Barmastine: D03056
Bepotastine (DG01327): D01654<JP/US> D09705
Betahistine (DG01004): D01592<JP> D03102 D07522
Bilastine: D09570<JP>
Bisulepin: D07532
Bisulepin hydrochloride: D07533
Broizine: D09838
Bromazine: D03166
Brompheniramine (DG01097): D00663 D07543
Buclizine (DG01104): D02089 D07547
Carbinoxamine (DG01095): D01336<US> D07617 D09808
Cetirizine (DG01107): D00664<JP/US> D07662
Chloropyramine (DG00384): D07195 D07679
Chlorphenamine (DG01099): D00665<JP> D03475 D07398
Chlorphenoxamine (DG00391): D07198 D07684
Chlorpromazine (DG00867): D00270 D00789<JP/US> D03274 D04034<JP> D09819
Cidoxepin hydrochloride: D03491
Cinnarizine (DG01005): D01295 D07734
Clemastine (DG00387): D00666<JP/US> D03535
Closiramine aceturate: D03568
Cycliramine maleate: D03620
Cyclizine (DG01105): D02090 D03621 D03622
Cyproheptadine (DG01109): D02234<JP/US> D07765
Deptropine (DG01114): D07404 D07790
Desloratadine: D03693<JP/US>
Dexbrompheniramine: D03704
Dexchlorpheniramine (DG01098): D00668<JP/US> D07803
Difeterol (DG02077): D01701 D09747 D09748
Dimenhydrinate: D00520<JP/US>
Dimetindene (DG00386): D01343 D07853
Dimetotiazine (DG00843): D01902<JP> D07854
Dioxopromethazine hydrochloride: D07860
Diphenhydramine (DG00390): D00300<JP> D00669<JP/US> D02419 D03285 D03360<JP> D03854
Diphenylimidazole: D02067
Diphenylpyraline (DG01094): D01172 D01627 D07862
Dorastine hydrochloride: D03893
Doxepin (DG00937): D00814<US> D07875
Doxylamine (DG01096): D02327 D07878
Ebastine: D01478<JP>
Efletirizine dihydrochloride: D03963
Embramine: D07889
Emedastine (DG01144): D02249<JP/US> D07890
Epinastine (DG01116): D01713<JP/US> D07900
Esmirtazapine maleate: D04055
Fexofenadine (DG01117): D00671<JP/US> D07958
Histamine: D08040
Histamine phosphate: D04445<US>
Histapyrrodine: D07400
Homochlorcyclizine (DG01328): D01460<JP> D08041
Hydroxyzine (DG00912): D00672<JP/US> D01096<JP/US> D08054
Icotidine: D04494
Isothipendyl (DG00389): D01143 D08091
Ketotifen (DG01115): D01332<JP> D08105
Levocabastine (DG01035): D01717<JP> D08117
Levocetirizine (DG01108): D07402 D08118<JP/US>
Loratadine: D00364<JP>
Mebhydrolin (DG01113): D01786 D08161
Meclozine (DG01106): D01317<US> D08163
Mepyramine (DG00382): D05660 D08183
Mequitazine: D01324<JP>
Methdilazine (DG01103): D04979 D04980
Mizolastine: D01117
Noberastine: D05196
Olanzapine (DG00898): D00454<JP/US> D06623<US>
Olopatadine (DG01039): D01192<JP/US> D08293
Opipramol (DG00930): D01477 D08297
Orphenadrine (DG01252): D08305
Orphenadrine (chloride): D02599
Orphenadrine (citrate): D00774<US>
Oxomemazine: D07401
Phenindamine (DG01110): D02148 D08353
Pheniramine (DG01100): D01174 D08355
Phenyltoloxamine citrate: D08967
Pimethixene: D07406
Promethazine (DG00385): D00480<JP/US> D00494 D01242 D03290<JP> D08432 D08768<JP>
Pyroxamine maleate: D05664
Pyrrobutamine: D07403
Quifenadine: D10230
Rocastine hydrochloride: D05742
Rotoxamine: D05769
Rupatadine (DG01118): D07407 D08497<JP>
Sequifenadine: D10510
Tazifylline hydrochloride: D06012
Tecastemizole: D06021
Temelastine: D06063
Terfenadine: D00521
Tesmilifene hydrochloride: D06084
Thenalidine: D07194
Thonzylamine (DG00381): D01801 D08587
Tolpropamine: D07196
Tripelennamine (DG00383): D02091 D06246 D08645
Triprolidine (DG01111): D01782 D08648
Zolamine hydrochloride: D06376
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    3269 (HRH1)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    3269 (HRH1)
 09150 Organismal Systems
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    3269 (HRH1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    3269 (HRH1)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Biogenic amine
   Histamine
    3269 (HRH1)
SSDB
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7tm_4 DUF1601
Other DBs
NCBI-GeneID: 3269
NCBI-ProteinID: NP_000852
OMIM: 600167
HGNC: 5182
Ensembl: ENSG00000196639
Vega: OTTHUMG00000129719
Pharos: P35367(Tclin)
UniProt: P35367
Position
3p25.3
AA seq 487 aa
MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
RILHIRS
NT seq 1464 nt   +upstreamnt  +downstreamnt
atgagcctccccaattcctcctgcctcttagaagacaagatgtgtgagggcaacaagacc
actatggccagcccccagctgatgcccctggtggtggtcctgagcactatctgcttggtc
acagtagggctcaacctgctggtgctgtatgccgtacggagtgagcggaagctccacact
gtggggaacctgtacatcgtcagcctctcggtggcggacttgatcgtgggtgccgtcgtc
atgcctatgaacatcctctacctgctcatgtccaagtggtcactgggccgtcctctctgc
ctcttttggctttccatggactatgtggccagcacagcgtccattttcagtgtcttcatc
ctgtgcattgatcgctaccgctctgtccagcagcccctcaggtaccttaagtatcgtacc
aagacccgagcctcggccaccattctgggggcctggtttctctcttttctgtgggttatt
cccattctaggctggaatcacttcatgcagcagacctcggtgcgccgagaggacaagtgt
gagacagacttctatgatgtcacctggttcaaggtcatgactgccatcatcaacttctac
ctgcccaccttgctcatgctctggttctatgccaagatctacaaggccgtacgacaacac
tgccagcaccgggagctcatcaataggtccctcccttccttctcagaaattaagctgagg
ccagagaaccccaagggggatgccaagaaaccagggaaggagtctccctgggaggttctg
aaaaggaagccaaaagatgctggtggtggatctgtcttgaagtcaccatcccaaaccccc
aaggagatgaaatccccagttgtcttcagccaagaggatgatagagaagtagacaaactc
tactgctttccacttgatattgtgcacatgcaggctgcggcagaggggagtagcagggac
tatgtagccgtcaaccggagccatggccagctcaagacagatgagcagggcctgaacaca
catggggccagcgagatatcagaggatcagatgttaggtgatagccaatccttctctcga
acggactcagataccaccacagagacagcaccaggcaaaggcaaattgaggagtgggtct
aacacaggcctggattacatcaagtttacttggaagaggctccgctcgcattcaagacag
tatgtatctgggttgcacatgaaccgcgaaaggaaggccgccaaacagttgggttttatc
atggcagccttcatcctctgctggatcccttatttcatcttcttcatggtcattgccttc
tgcaagaactgttgcaatgaacatttgcacatgttcaccatctggctgggctacatcaac
tccacactgaaccccctcatctaccccttgtgcaatgagaacttcaagaagacattcaag
agaattctgcatattcgctcctaa

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (3)   
   KEGG PATHWAY (3)   
Disease (1)   
   OMIM (1)   
Drug (173)   
   KEGG DRUG (173)   
Genome (1)   
   KEGG GENOME (1)   
Gene (24)   
   KEGG ORTHOLOGY (1)   
   RefGene (13)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (6)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (30)   
   RefSeq(nuc) (4)   
   GenBank (13)   
   EMBL (13)   
Protein domain (4)   
   Pfam (4)   
All databases (244)   

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