KEGG T01001: 3269

Homo sapiens (human): 3269

Entry

3269              CDS       T01001

Symbol

HRH1, H1-R, H1R, HH1R, hisH1

Name

(RefSeq) histamine receptor H1

K04149

histamine receptor H1

Organism

hsa Homo sapiens (human)

Pathway

hsa04020

Calcium signaling pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04082

Neuroactive ligand signaling

hsa04750

Inflammatory mediator regulation of TRP channels

Network

nt06528 Calcium signaling

Element

N01640

GPCR-PLCB-ITPR signaling pathway

Drug target

Acrivastine:

D02760

Alcaftadine:

D06552<US>

Alimemazine (DG01101):

D02245<JP> D07125

Antazoline (DG01037):

D02950 D07458 D07459

Astemizole:

D00234

Azatadine (DG01112):

D00662 D07482

Azelastine (DG01036):

D00659<JP/US> D07483

Bamipine (DG00388):

D07197 D07492 D07493

Barmastine:

D03056

Bepotastine (DG01327):

D01654<JP/US> D09705

Betahistine (DG01004):

D01592<JP> D03102 D07522

Bilastine:

D09570<JP>

Bisulepin:

D07532

Bisulepin hydrochloride:

D07533

Broizine:

D09838

Bromazine:

D03166

Brompheniramine (DG01097):

D00663 D07543

Buclizine (DG01104):

D02089 D07547

Carbinoxamine (DG01095):

D01336<US> D07617 D09808

Cetirizine (DG01107):

D00664<JP/US> D07662

Chloropyramine (DG00384):

D07195 D07679

Chlorphenamine (DG01099):

D00665<JP> D03475 D07398

Chlorphenoxamine (DG00391):

D07198 D07684

Chlorpromazine (DG00867):

D00270 D00789<JP/US> D03274 D04034<JP> D09819

Cidoxepin hydrochloride:

D03491

Cinnarizine (DG01005):

D01295 D07734

Clemastine (DG00387):

D00666<JP/US> D03535

Closiramine aceturate:

D03568

Cycliramine maleate:

D03620

Cyclizine (DG01105):

D02090 D03621 D03622

Cyproheptadine (DG01109):

D02234<JP/US> D07765

Deptropine (DG01114):

D07404 D07790

Desloratadine:

D03693<JP/US>

Dexbrompheniramine:

D03704

Dexchlorpheniramine (DG01098):

D00668<JP/US> D07803

Difeterol (DG02077):

D01701 D09747 D09748

Dimenhydrinate:

D00520<JP/US>

Dimetindene (DG00386):

D01343 D07853

Dimetotiazine (DG00843):

D01902<JP> D07854

Dioxopromethazine hydrochloride:

D07860

Diphenhydramine (DG00390):

D00300<JP> D00669<JP/US> D02419 D03285 D03360 D03854

Diphenylimidazole:

D02067

Diphenylpyraline (DG01094):

D01172 D01627 D07862

Dorastine hydrochloride:

D03893

Doxepin (DG00937):

D00814<US> D07875

Doxylamine (DG01096):

D02327 D07878

Ebastine:

D01478<JP>

Efletirizine dihydrochloride:

D03963

Embramine:

D07889

Emedastine (DG01144):

D02249<JP> D07890

Epinastine (DG01116):

D01713<JP/US> D07900

Esmirtazapine maleate:

D04055

Fexofenadine (DG01117):

D00671<JP> D07958

Histamine:

D08040

Histamine phosphate:

D04445<US>

Histapyrrodine:

D07400

Homochlorcyclizine (DG01328):

D01460 D08041

Hydroxyzine (DG00912):

D00672<JP/US> D01096<JP/US> D08054

Icotidine:

D04494

Isothipendyl (DG00389):

D01143 D08091

Ketotifen (DG01115):

D01332<JP> D08105

Levocabastine (DG01035):

D01717<JP> D08117

Levocetirizine (DG01108):

D07402 D08118<JP/US>

Loratadine:

D00364<JP/US>

Mebhydrolin (DG01113):

D01786 D08161

Meclozine (DG01106):

D01317<US> D08163

Mepyramine (DG00382):

D05660 D08183

Mequitazine:

D01324<JP>

Methdilazine (DG01103):

D04979 D04980

Mianserin (DG00951):

D01358<JP> D08216

Mizolastine:

D01117

Noberastine:

D05196

Olanzapine (DG00898):

D00454<JP/US> D06623<US>

Olopatadine (DG01039):

D01192<JP/US> D08293

Opipramol (DG00930):

D01477 D08297

Orphenadrine (DG01252):

D08305

Orphenadrine (chloride):

D02599

Orphenadrine (citrate):

D00774<US>

Oxomemazine:

D07401

Phenindamine (DG01110):

D02148 D08353

Pheniramine (DG01100):

D01174 D08355

Phenyltoloxamine citrate:

D08967

Pimethixene:

D07406

Promethazine (DG00385):

D00480<JP/US> D00494 D01242 D03290<JP> D08432 D08768<JP>

Pyroxamine maleate:

D05664

Pyrrobutamine:

D07403

Quifenadine:

D10230

Rocastine hydrochloride:

D05742

Rotoxamine:

D05769

Rupatadine (DG01118):

D07407 D08497<JP>

Sequifenadine:

D10510

Tazifylline hydrochloride:

Tecastemizole:

Temelastine:

Terfenadine:

Tesmilifene hydrochloride:

D06084

Thenalidine:

D07194

Thonzylamine (DG00381):

D01801 D08587

Tolpropamine:

D07196

Tripelennamine (DG00383):

D02091 D06246 D08645

Triprolidine (DG01111):

D01782 D08648

Zolamine hydrochloride:

D06376

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    3269 (HRH1)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    3269 (HRH1)
   04082 Neuroactive ligand signaling
    3269 (HRH1)
09150 Organismal Systems
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    3269 (HRH1)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    3269 (HRH1)
G protein-coupled receptors [BR:hsa04030]
Rhodopsin family
  Biogenic amine
   Histamine
    3269 (HRH1)

SSDB

Motif

Pfam:

7tm_1 7TM_GPCR_Srsx 7tm_4

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

Position

3:11137238..11263557

AA seq 487 aa
MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
RILHIRS

NT seq 1464 nt +upstreamnt +downstreamnt
atgagcctccccaattcctcctgcctcttagaagacaagatgtgtgagggcaacaagacc
actatggccagcccccagctgatgcccctggtggtggtcctgagcactatctgcttggtc
acagtagggctcaacctgctggtgctgtatgccgtacggagtgagcggaagctccacact
gtggggaacctgtacatcgtcagcctctcggtggcggacttgatcgtgggtgccgtcgtc
atgcctatgaacatcctctacctgctcatgtccaagtggtcactgggccgtcctctctgc
ctcttttggctttccatggactatgtggccagcacagcgtccattttcagtgtcttcatc
ctgtgcattgatcgctaccgctctgtccagcagcccctcaggtaccttaagtatcgtacc
aagacccgagcctcggccaccattctgggggcctggtttctctcttttctgtgggttatt
cccattctaggctggaatcacttcatgcagcagacctcggtgcgccgagaggacaagtgt
gagacagacttctatgatgtcacctggttcaaggtcatgactgccatcatcaacttctac
ctgcccaccttgctcatgctctggttctatgccaagatctacaaggccgtacgacaacac
tgccagcaccgggagctcatcaataggtccctcccttccttctcagaaattaagctgagg
ccagagaaccccaagggggatgccaagaaaccagggaaggagtctccctgggaggttctg
aaaaggaagccaaaagatgctggtggtggatctgtcttgaagtcaccatcccaaaccccc
aaggagatgaaatccccagttgtcttcagccaagaggatgatagagaagtagacaaactc
tactgctttccacttgatattgtgcacatgcaggctgcggcagaggggagtagcagggac
tatgtagccgtcaaccggagccatggccagctcaagacagatgagcagggcctgaacaca
catggggccagcgagatatcagaggatcagatgttaggtgatagccaatccttctctcga
acggactcagataccaccacagagacagcaccaggcaaaggcaaattgaggagtgggtct
aacacaggcctggattacatcaagtttacttggaagaggctccgctcgcattcaagacag
tatgtatctgggttgcacatgaaccgcgaaaggaaggccgccaaacagttgggttttatc
atggcagccttcatcctctgctggatcccttatttcatcttcttcatggtcattgccttc
tgcaagaactgttgcaatgaacatttgcacatgttcaccatctggctgggctacatcaac
tccacactgaaccccctcatctaccccttgtgcaatgagaacttcaagaagacattcaag
agaattctgcatattcgctcctaa

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