KEGG   Homo sapiens (human): 3274
Entry
3274              CDS       T01001                                 
Symbol
HRH2, H2R, HH2R
Name
(RefSeq) histamine receptor H2
  KO
K04150  histamine receptor H2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04082  Neuroactive ligand signaling
hsa04971  Gastric acid secretion
Drug target
Betazole: D01187
Cimetidine (DG00017): D00295<JP/US> D03503<US>
Dalcotidine: D01698
Donetidine: D03889
Etintidine hydrochloride: D04098
Famotidine: D00318<JP/US>
Histamine: D08040
Histamine phosphate: D04445<US>
Icotidine: D04494
Impromidine hydrochloride: D04517
Lafutidine: D01131<JP>
Lavoltidine succinate: D04680
Lupitidine hydrochloride: D04794
Methantheline (DG00036): D00721
Metiamide: D05004
Niperotidine: D07072
Nizatidine: D00440<JP/US>
Osutidine: D01193
Oxmetidine (DG01225): D05306 D05307
Pibutidine hydrochloride: D01861
Ranitidine (DG00018): D00422 D00673<US>
Ranitidine bismuth citrate: D05699
Roxatidine (DG00019): D01467<JP> D08494 D08495
Sufotidine: D05939
Tiotidine: D06157
Zaltidine hydrochloride: D06355
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    3274 (HRH2)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    3274 (HRH2)
   04082 Neuroactive ligand signaling
    3274 (HRH2)
 09150 Organismal Systems
  09154 Digestive system
   04971 Gastric acid secretion
    3274 (HRH2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    3274 (HRH2)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Biogenic amine
   Histamine
    3274 (HRH2)
SSDB
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7tm_4
Other DBs
NCBI-GeneID: 3274
NCBI-ProteinID: NP_001124527
OMIM: 142703
HGNC: 5183
Ensembl: ENSG00000113749
UniProt: P25021
Structure
Position
5:175658071..175710756
AA seq 397 aa
MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSL
AITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV
MDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNE
VYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVM
GAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQ
QLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDRP
WLCLPECWSVELTHSFIHLFIHSFANIHPIPTTCQEL
NT seq 1194 nt   +upstreamnt  +downstreamnt
atggcacccaatggcacagcctcttccttttgcctggactctaccgcatgcaagatcacc
atcaccgtggtccttgcggtcctcatcctcatcaccgttgctggcaatgtggtcgtctgt
ctggccgtgggcttgaaccgccggctccgcaacctgaccaattgtttcatcgtgtccttg
gctatcactgacctgctcctcggcctcctggtgctgcccttctctgccatctaccagctg
tcctgcaagtggagctttggcaaggtcttctgcaatatctacaccagcctggatgtgatg
ctctgcacagcctccattcttaacctcttcatgatcagcctcgaccggtactgcgctgtc
atggacccactgcggtaccctgtgctggtcaccccagttcgggtcgccatctctctggtc
ttaatttgggtcatctccattaccctgtcctttctgtctatccacctggggtggaacagc
aggaacgagaccagcaagggcaatcataccacctctaagtgcaaagtccaggtcaatgaa
gtgtacgggctggtggatgggctggtcaccttctacctcccgctactgatcatgtgcatc
acctactaccgcatcttcaaggtcgcccgggatcaggccaagaggatcaatcacattagc
tcctggaaggcagccaccatcagggagcacaaagccacagtgacactggccgccgtcatg
ggggccttcatcatctgctggtttccctacttcaccgcgtttgtgtaccgtgggctgaga
ggggatgatgccatcaatgaggtgttagaagccatcgttctgtggctgggctatgccaac
tcagccctgaaccccatcctgtatgctgcgctgaacagagacttccgcaccgggtaccaa
cagctcttctgctgcaggctggccaaccgcaactcccacaaaacttctctgaggtccaac
gcctctcagctgtccaggacccaaagccgagaacccaggcaacaggaagagaaacccctg
aagctccaggtgtggagtgggacagaagtcacggccccccagggagccacagacagacca
tggctttgccttccagaatgctggtctgtggaactgacccattcattcattcatttgttc
attcattcatttgcaaacattcatccaattcccaccacatgccaggaattatga

  All links  
Disease (1)   
   OMIM (1)   
Gene (18)   
   RefGene (11)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (10)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (8)   
DNA sequence (21)   
   RefSeq(nuc) (11)   
   GenBank (5)   
   EMBL (5)   
3D Structure (5)   
   PDB (5)   
Protein domain (3)   
   Pfam (3)   
All databases (58)   

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