KEGG   Homo sapiens (human): 3292
Entry
3292              CDS       T01001                                 
Symbol
HSD17B1, 17-beta-HSD, 20-alpha-HSD, E2DH, EDH17B2, EDHB17, HSD17, SDR28C1
Name
(RefSeq) 17-beta-hydroxysteroid dehydrogenase type 1 isoform 1
  KO
K00044  17beta-estradiol 17-dehydrogenase [EC:1.1.1.62]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00140  Steroid hormone biosynthesis
hsa01100  Metabolic pathways
hsa04913  Ovarian steroidogenesis
Drug target
Linustedastat: D13078
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    3292 (HSD17B1)
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    3292 (HSD17B1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.62  17beta-estradiol 17-dehydrogenase
     3292 (HSD17B1)
SSDB
Motif
Pfam: adh_short adh_short_C2 KR Epimerase GDP_Man_Dehyd DUF1776 Plexin_cytopl
Other DBs
NCBI-GeneID: 3292
NCBI-ProteinID: NP_000404
OMIM: 109684
HGNC: 5210
Ensembl: ENSP00000466799.1
UniProt: P14061
Structure
Position
17:42552923..42555214
AA seq 328 aa
MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSL
ETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTV
RMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVH
LSLIECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHSKQVFREAAQNPEEVAEV
FLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVFGDVPAKAEAGAEAGG
GAGPGAEDEAGRGAVGDPELGDPPAAPQ
NT seq 987 nt   +upstreamnt  +downstreamnt
atggcccgcaccgtggtgctcatcaccggctgttcctcgggcatcggcctgcacttggcc
gtacgtctggcttcagatccatcccagagcttcaaagtgtatgccacgttgagggacctg
aaaacacagggccggctgtgggaggcggcccgggccctggcatgccctccgggatccctg
gagacgttgcagctggacgtaagggactcaaaatccgtggccgctgcccgggaacgcgtg
actgagggccgcgtggacgtgctggtgtgtaacgcaggcctgggcctgctggggccgctg
gaggcgctgggggaggacgccgtggcctctgtgctggacgtgaatgtagtagggactgtg
cggatgctgcaggccttcctgccagacatgaagaggcgcggttcgggacgcgtgttggtg
accgggagcgtgggaggattgatggggctgcctttcaatgacgtttattgcgccagcaag
ttcgcgctcgaaggcttatgcgagagtctggcggttctgctgctgccctttggggtccac
ttgagcctgatcgagtgcggcccagtgcacaccgccttcatggagaaggtgttgggcagc
ccagaggaggtgctggaccgcacggacatccacaccttccaccgcttctaccaatacctc
gcccacagcaagcaagtctttcgcgaggcggcgcagaaccctgaggaggtggcggaggtc
ttcctcaccgctttgcgcgccccgaagccgaccctgcgctacttcaccaccgagcgcttc
ctgcccctgctgcggatgcgcctggacgaccccagcggctccaactacgtcaccgccatg
caccgggaagtgttcggcgacgttccggcaaaggccgaggctggggccgaggctgggggc
ggggccgggcctggggcagaggacgaggccgggcgcggtgcggtgggggaccctgagctc
ggcgatcctccggccgccccgcagtaa

  All links  
Disease (1)   
   OMIM (1)   
Gene (21)   
   RefGene (5)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (11)   
   OC (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (43)   
   RefSeq(nuc) (3)   
   GenBank (20)   
   EMBL (20)   
3D Structure (28)   
   PDB (28)   
Protein domain (7)   
   Pfam (7)   
All databases (104)   

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