KEGG   Homo sapiens (human): 3306Help
Entry
3306              CDS       T01001                                 

Gene name
HSPA2, HSP70-2, HSP70-3
Definition
(RefSeq) heat shock protein family A (Hsp70) member 2
  KO
K03283  heat shock 70kDa protein 1/2/6/8
Organism
hsa  Homo sapiens (human)
Pathway
hsa03040  Spliceosome
hsa04010  MAPK signaling pathway
hsa04141  Protein processing in endoplasmic reticulum
hsa04144  Endocytosis
hsa04213  Longevity regulating pathway - multiple species
hsa04612  Antigen processing and presentation
hsa04915  Estrogen signaling pathway
hsa05134  Legionellosis
hsa05145  Toxoplasmosis
hsa05162  Measles
hsa05164  Influenza A
hsa05169  Epstein-Barr virus infection
Module
hsa_M00353  Spliceosome, Prp19/CDC5L complex
hsa_M00355  Spliceosome, 35S U5-snRNP
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09121 Transcription
   03040 Spliceosome
    3306 (HSPA2)
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    3306 (HSPA2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    3306 (HSPA2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    3306 (HSPA2)
 09150 Organismal Systems
  09151 Immune system
   04612 Antigen processing and presentation
    3306 (HSPA2)
  09152 Endocrine system
   04915 Estrogen signaling pathway
    3306 (HSPA2)
  09149 Aging
   04213 Longevity regulating pathway - multiple species
    3306 (HSPA2)
 09160 Human Diseases
  09167 Infectious diseases
   05134 Legionellosis
    3306 (HSPA2)
   05162 Measles
    3306 (HSPA2)
   05164 Influenza A
    3306 (HSPA2)
   05169 Epstein-Barr virus infection
    3306 (HSPA2)
   05145 Toxoplasmosis
    3306 (HSPA2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatase and associated proteins [BR:hsa01009]
    3306 (HSPA2)
  09182 Protein families: genetic information processing
   03041 Spliceosome [BR:hsa03041]
    3306 (HSPA2)
   03009 Ribosome biogenesis [BR:hsa03009]
    3306 (HSPA2)
   03110 Chaperones and folding catalysts [BR:hsa03110]
    3306 (HSPA2)
   04131 Membrane trafficking [BR:hsa04131]
    3306 (HSPA2)
   03051 Proteasome [BR:hsa03051]
    3306 (HSPA2)
   03029 Mitochondrial biogenesis [BR:hsa03029]
    3306 (HSPA2)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    3306 (HSPA2)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein Ser/ Thr phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-5
    PP5-interacting proteins
     3306 (HSPA2)
Spliceosome [BR:hsa03041]
 Complex B
  Other components
   Prp19 complex
    3306 (HSPA2)
 Complex C
   Prp19-CDC5 complex
    3306 (HSPA2)
Ribosome biogenesis [BR:hsa03009]
 Eukaryotic Type
  Pre-60S particles
   Export and cytoplasmic maturation factors
    3306 (HSPA2)
Chaperones and folding catalysts [BR:hsa03110]
 Heat shock proteins
  HSP70 / DNAK
   3306 (HSPA2)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Other core components
    3306 (HSPA2)
 Autophagy
  Chaperone mediated autophagy (CMA)
   Chaperones
    3306 (HSPA2)
Proteasome [BR:hsa03051]
 Eukaryotic proteasome
  Assembling factors
   Other assembling factors
    3306 (HSPA2)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial protein import machinery
  Endoplasmic reticulum membrane and cytosol
   Other ER-memrane and cytosol factors
    3306 (HSPA2)
Exosome [BR:hsa04147]
 Exosomal proteins
  Proteins found in most exosomes
   3306 (HSPA2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: HSP70 MreB_Mbl FGGY_C BcrAD_BadFG DUF1464 DDR CRIC_ras_sig Zincin_2
Motif
Other DBs
NCBI-GeneID: 3306
NCBI-ProteinID: NP_068814
OMIM: 140560
HGNC: 5235
Ensembl: ENSG00000126803
Vega: OTTHUMG00000141311
Pharos: P54652(Tbio)
UniProt: P54652 A0A024R6B5
Structure
PDB: 

Position
14q23.3
AA seq 639 aa AA seqDB search
MSARGPAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQV
AMNPTNTIFDAKRLIGRKFEDATVQSDMKHWPFRVVSEGGKPKVQVEYKGETKTFFPEEI
SSMVLTKMKEIAEAYLGGKVHSAVITVPAYFNDSQRQATKDAGTITGLNVLRIINEPTAA
AIAYGLDKKGCAGGEKNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRM
VSHLAEEFKRKHKKDIGPNKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEGVDFYTSI
TRARFEELNADLFRGTLEPVEKALRDAKLDKGQIQEIVLVGGSTRIPKIQKLLQDFFNGK
ELNKSINPDEAVAYGAAVQAAILIGDKSENVQDLLLLDVTPLSLGIETAGGVMTPLIKRN
TTIPTKQTQTFTTYSDNQSSVLVQVYEGERAMTKDNNLLGKFDLTGIPPAPRGVPQIEVT
FDIDANGILNVTAADKSTGKENKITITNDKGRLSKDDIDRMVQEAERYKSEDEANRDRVA
AKNALESYTYNIKQTVEDEKLRGKISEQDKNKILDKCQEVINWLDRNQMAEKDEYEHKQK
ELERVCNPIISKLYQGGPGGGSGGGGSGASGGPTIEEVD
NT seq 1920 nt NT seq  +upstreamnt  +downstreamnt
atgtctgcccgtggcccggctatcggcatcgacctgggcaccacctattcgtgcgtcggg
gtcttccaacatggcaaggtggagatcatcgccaacgaccagggcaatcgcaccaccccc
agctacgtggccttcacggacaccgagcgcctcatcggcgacgccgccaagaaccaggtg
gccatgaaccccaccaacaccatcttcgacgccaagaggctgattggacggaaattcgag
gatgccacagtgcagtcggatatgaaacactggccgttccgggtggtgagcgagggaggc
aagcccaaagtgcaagtagagtacaagggggagaccaagaccttcttcccagaggagata
tcctccatggtcctcacgaagatgaaggagatcgcggaagcctacctggggggcaaggtg
cacagcgcggtcataacggtcccggcctatttcaacgactcgcagcgccaggccaccaag
gacgcaggcaccatcacggggctcaatgtgctgcgcatcatcaacgagcccacggcggcg
gccatcgcctacggcctggacaagaagggctgcgcgggcggcgagaagaacgtgctcatc
tttgacctgggcggtggcactttcgacgtgtccatcctgaccatcgaggatggcatcttc
gaggtgaagtccacggccggcgacacccacctgggcggtgaggacttcgacaaccgcatg
gtgagccacctggcggaggagttcaagcgcaagcacaagaaggacattgggcccaacaag
cgcgccgtgaggcggctgcgcaccgcttgcgagcgcgccaagcgcaccctgagctcgtcc
acgcaggcgagcatcgagatcgactcgctctacgagggcgtggacttctatacgtccatc
acgcgcgcccgcttcgaggagctcaatgccgacctctttcgcgggaccctggagccggtg
gagaaggcgctgcgcgacgccaagctggacaagggccagatccaggagatcgtgctggtg
ggcggctccactcgtatccccaagatccagaagctgctgcaggatttcttcaacggcaag
gagctgaacaagagcatcaaccccgacgaggcggtggcctatggcgccgcggtgcaggcg
gccatcctcatcggcgacaaatcagagaatgtgcaggacctgctgctactcgacgtgacc
ccgttgtcgctgggcatcgagacagctggcggtgtcatgaccccactcatcaagaggaac
accacgatccccaccaagcagacgcagaccttcaccacctactcggacaaccagagcagc
gtactggtgcaggtatacgagggcgaacgggccatgaccaaggacaataacctgctgggc
aagttcgacctgaccgggattccccctgcgcctcgcggggtcccccaaatcgaggttacc
ttcgacattgacgccaatggcatccttaacgttaccgccgccgacaagagcaccggtaag
gaaaacaaaatcaccatcaccaatgacaaaggtcgtctgagcaaggacgacattgaccgg
atggtgcaggaggcggagcggtacaaatcggaagatgaggcgaatcgcgaccgagtcgcg
gccaaaaacgccctggagtcctatacctacaacatcaagcagacggtggaagacgagaaa
ctgaggggcaagattagcgagcaggacaaaaacaagatcctcgacaagtgtcaggaggtg
atcaactggctcgaccgaaaccagatggcagagaaagatgagtatgaacacaagcagaaa
gagctcgaaagagtttgcaaccccatcatcagcaaactttaccaaggtggtcctggcggc
ggcagcggcggcggcggttcaggagcctccgggggacccaccatcgaagaagtggactaa

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