KEGG   Homo sapiens (human): 3312Help
Entry
3312              CDS       T01001                                 

Gene name
HSPA8, HEL-33, HEL-S-72p, HSC54, HSC70, HSC71, HSP71, HSP73, HSPA10, LAP-1, LAP1, NIP71
Definition
(RefSeq) heat shock protein family A (Hsp70) member 8
  KO
K03283  heat shock 70kDa protein 1/2/6/8
Organism
hsa  Homo sapiens (human)
Pathway
hsa03040  Spliceosome
hsa04010  MAPK signaling pathway
hsa04141  Protein processing in endoplasmic reticulum
hsa04144  Endocytosis
hsa04213  Longevity regulating pathway - multiple species
hsa04612  Antigen processing and presentation
hsa04915  Estrogen signaling pathway
hsa05134  Legionellosis
hsa05145  Toxoplasmosis
hsa05162  Measles
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09121 Transcription
   03040 Spliceosome
    3312 (HSPA8)
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    3312 (HSPA8)
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    3312 (HSPA8)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    3312 (HSPA8)
 09150 Organismal Systems
  09151 Immune system
   04612 Antigen processing and presentation
    3312 (HSPA8)
  09152 Endocrine system
   04915 Estrogen signaling pathway
    3312 (HSPA8)
  09149 Aging
   04213 Longevity regulating pathway - multiple species
    3312 (HSPA8)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05134 Legionellosis
    3312 (HSPA8)
  09172 Infectious disease: viral
   05162 Measles
    3312 (HSPA8)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    3312 (HSPA8)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    3312 (HSPA8)
  09182 Protein families: genetic information processing
   03041 Spliceosome [BR:hsa03041]
    3312 (HSPA8)
   03009 Ribosome biogenesis [BR:hsa03009]
    3312 (HSPA8)
   03110 Chaperones and folding catalysts [BR:hsa03110]
    3312 (HSPA8)
   04131 Membrane trafficking [BR:hsa04131]
    3312 (HSPA8)
   03051 Proteasome [BR:hsa03051]
    3312 (HSPA8)
   03029 Mitochondrial biogenesis [BR:hsa03029]
    3312 (HSPA8)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    3312 (HSPA8)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-5
    PP5-interacting proteins
     3312 (HSPA8)
Spliceosome [BR:hsa03041]
 Complex B
  Other components
   Prp19 complex
    3312 (HSPA8)
 Complex C
   Prp19-CDC5 complex
    3312 (HSPA8)
Ribosome biogenesis [BR:hsa03009]
 Eukaryotic type
  Pre-60S particles
   Export and cytoplasmic maturation factors
    3312 (HSPA8)
Chaperones and folding catalysts [BR:hsa03110]
 Heat shock proteins
  HSP70 / DNAK
   3312 (HSPA8)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Other core components
    3312 (HSPA8)
 Autophagy
  Chaperone mediated autophagy (CMA)
   Chaperones
    3312 (HSPA8)
Proteasome [BR:hsa03051]
 Eukaryotic proteasome
  Assembling factors
   Other assembling factors
    3312 (HSPA8)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial protein import machinery
  Endoplasmic reticulum membrane and cytosol
   Other ER-memrane and cytosol factors
    3312 (HSPA8)
Exosome [BR:hsa04147]
 Exosomal proteins
  Proteins found in most exosomes
   3312 (HSPA8)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: HSP70 MreB_Mbl FGGY_C DDR HORMA MetOD2
Motif
Other DBs
NCBI-GeneID: 3312
NCBI-ProteinID: NP_006588
OMIM: 600816
HGNC: 5241
Ensembl: ENSG00000109971
Vega: OTTHUMG00000166030
Pharos: P11142(Tchem)
UniProt: P11142 V9HW22 Q53HF2
Structure
PDB: 

Position
11q24.1
AA seq 646 aa AA seqDB search
MSKGPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVA
MNPTNTVFDAKRLIGRRFDDAVVQSDMKHWPFMVVNDAGRPKVQVEYKGETKSFYPEEVS
SMVLTKMKEIAEAYLGKTVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAA
IAYGLDKKVGAERNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNH
FIAEFKRKHKKDISENKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRA
RFEELNADLFRGTLDPVEKALRDAKLDKSQIHDIVLVGGSTRIPKIQKLLQDFFNGKELN
KSINPDEAVAYGAAVQAAILSGDKSENVQDLLLLDVTPLSLGIETAGGVMTVLIKRNTTI
PTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLGKFELTGIPPAPRGVPQIEVTFDI
DANGILNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQEAEKYKAEDEKQRDKVSSKN
SLESYAFNMKATVEDEKLQGKINDEDKQKILDKCNEIINWLDKNQTAEKEEFEHQQKELE
KVCNPIITKLYQSAGGMPGGMPGGFPGGGAPPSGGASSGPTIEEVD
NT seq 1941 nt NT seq  +upstreamnt  +downstreamnt
atgtccaagggacctgcagttggtattgatcttggcaccacctactcttgtgtgggtgtt
ttccagcacggaaaagtcgagataattgccaatgatcagggaaaccgaaccactccaagc
tatgtcgcctttacggacactgaacggttgatcggtgatgccgcaaagaatcaagttgca
atgaaccccaccaacacagtttttgatgccaaacgtctgattggacgcagatttgatgat
gctgttgtccagtctgatatgaaacattggccctttatggtggtgaatgatgctggcagg
cccaaggtccaagtagaatacaagggagagaccaaaagcttctatccagaggaggtgtct
tctatggttctgacaaagatgaaggaaattgcagaagcctaccttgggaagactgttacc
aatgctgtggtcacagtgccagcttactttaatgactctcagcgtcaggctaccaaagat
gctggaactattgctggtctcaatgtacttagaattattaatgagccaactgctgctgct
attgcttacggcttagacaaaaaggttggagcagaaagaaacgtgctcatctttgacctg
ggaggtggcacttttgatgtgtcaatcctcactattgaggatggaatctttgaggtcaag
tctacagctggagacacccacttgggtggagaagattttgacaaccgaatggtcaaccat
tttattgctgagtttaagcgcaagcataagaaggacatcagtgagaacaagagagctgta
agacgcctccgtactgcttgtgaacgtgctaagcgtaccctctcttccagcacccaggcc
agtattgagatcgattctctctatgaaggaatcgacttctatacctccattacccgtgcc
cgatttgaagaactgaatgctgacctgttccgtggcaccctggacccagtagagaaagcc
cttcgagatgccaaactagacaagtcacagattcatgatattgtcctggttggtggttct
actcgtatccccaagattcagaagcttctccaagacttcttcaatggaaaagaactgaat
aagagcatcaaccctgatgaagctgttgcttatggtgcagctgtccaggcagccatcttg
tctggagacaagtctgagaatgttcaagatttgctgctcttggatgtcactcctctttcc
cttggtattgaaactgctggtggagtcatgactgtcctcatcaagcgtaataccaccatt
cctaccaagcagacacagaccttcactacctattctgacaaccagcctggtgtgcttatt
caggtttatgaaggcgagcgtgccatgacaaaggataacaacctgcttggcaagtttgaa
ctcacaggcatacctcctgcaccccgaggtgttcctcagattgaagtcacttttgacatt
gatgccaatggtatactcaatgtctctgctgtggacaagagtacgggaaaagagaacaag
attactatcactaatgacaagggccgtttgagcaaggaagacattgaacgtatggtccag
gaagctgagaagtacaaagctgaagatgagaagcagagggacaaggtgtcatccaagaat
tcacttgagtcctatgccttcaacatgaaagcaactgttgaagatgagaaacttcaaggc
aagattaacgatgaggacaaacagaagattctggacaagtgtaatgaaattatcaactgg
cttgataagaatcagactgctgagaaggaagaatttgaacatcaacagaaagagctggag
aaagtttgcaaccccatcatcaccaagctgtaccagagtgcaggaggcatgccaggagga
atgcctgggggatttcctggtggtggagctcctccctctggtggtgcttcctcagggccc
accattgaagaggttgattaa

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