KEGG   Homo sapiens (human): 3320
Entry
3320              CDS       T01001                                 
Symbol
HSP90AA1, EL52, HEL-S-65p, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp103, Hsp89, Hsp90, LAP-2, LAP2
Name
(RefSeq) heat shock protein 90 alpha family class A member 1
  KO
K04079  molecular chaperone HtpG
Organism
hsa  Homo sapiens (human)
Pathway
hsa04141  Protein processing in endoplasmic reticulum
hsa04151  PI3K-Akt signaling pathway
hsa04217  Necroptosis
hsa04612  Antigen processing and presentation
hsa04621  NOD-like receptor signaling pathway
hsa04657  IL-17 signaling pathway
hsa04659  Th17 cell differentiation
hsa04914  Progesterone-mediated oocyte maturation
hsa04915  Estrogen signaling pathway
hsa05132  Salmonella infection
hsa05200  Pathways in cancer
hsa05207  Chemical carcinogenesis - receptor activation
hsa05215  Prostate cancer
hsa05417  Lipid and atherosclerosis
hsa05418  Fluid shear stress and atherosclerosis
Drug target
Alvespimycin hydrochloride: D06554
Ganetespib: D10126
Luminespib (DG01842): D10646 D10647
Onalespib (DG03099): D10719 D11766
Pimitespib: D11920<JP>
Retaspimycin (DG01880): D09375 D09376
Tanespimycin: D06650
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    3320 (HSP90AA1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    3320 (HSP90AA1)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    3320 (HSP90AA1)
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    3320 (HSP90AA1)
   04612 Antigen processing and presentation
    3320 (HSP90AA1)
   04659 Th17 cell differentiation
    3320 (HSP90AA1)
   04657 IL-17 signaling pathway
    3320 (HSP90AA1)
  09152 Endocrine system
   04915 Estrogen signaling pathway
    3320 (HSP90AA1)
   04914 Progesterone-mediated oocyte maturation
    3320 (HSP90AA1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    3320 (HSP90AA1)
   05207 Chemical carcinogenesis - receptor activation
    3320 (HSP90AA1)
  09162 Cancer: specific types
   05215 Prostate cancer
    3320 (HSP90AA1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    3320 (HSP90AA1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    3320 (HSP90AA1)
   05418 Fluid shear stress and atherosclerosis
    3320 (HSP90AA1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    3320 (HSP90AA1)
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts [BR:hsa03110]
    3320 (HSP90AA1)
   04131 Membrane trafficking [BR:hsa04131]
    3320 (HSP90AA1)
   03051 Proteasome [BR:hsa03051]
    3320 (HSP90AA1)
   03029 Mitochondrial biogenesis [BR:hsa03029]
    3320 (HSP90AA1)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    3320 (HSP90AA1)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-5
    PP5-interacting proteins
     3320 (HSP90AA1)
Chaperones and folding catalysts [BR:hsa03110]
 Heat shock proteins
  HSP90
   3320 (HSP90AA1)
Membrane trafficking [BR:hsa04131]
 Autophagy
  Chaperone mediated autophagy (CMA)
   Chaperones
    3320 (HSP90AA1)
Proteasome [BR:hsa03051]
 Eukaryotic proteasome
  Assembling factors
   Other assembling factors
    3320 (HSP90AA1)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial quality control factors
  Mitophagy factors
   Parkin-independent mechanism factors
    3320 (HSP90AA1)
Exosome [BR:hsa04147]
 Exosomal proteins
  Proteins found in most exosomes
   3320 (HSP90AA1)
SSDB
Motif
Pfam: HSP90 HATPase_c_3 HATPase_c LOH1CR12
Other DBs
NCBI-GeneID: 3320
NCBI-ProteinID: NP_005339
OMIM: 140571
HGNC: 5253
Ensembl: ENSG00000080824
UniProt: P07900 K9JA46
Structure
Position
14:complement(102080742..102139749)
AA seq 732 aa
MPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIR
YESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFME
ALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGEPM
GRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEKED
KEEEKEKEEKESEDKPEIEDVGSDEEEEKKDGDKKKKKKIKEKYIDQEELNKTKPIWTRN
PDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENRKKKNN
IKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKC
LELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDY
CTRMKENQKHIYYITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKT
LVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIV
TSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVK
DLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPTADDTSAAVTEEMPPLE
GDDDTSRMEEVD
NT seq 2199 nt   +upstreamnt  +downstreamnt
atgcctgaggaaacccagacccaagaccaaccgatggaggaggaggaggttgagacgttc
gcctttcaggcagaaattgcccagttgatgtcattgatcatcaatactttctactcgaac
aaagagatctttctgagagagctcatttcaaattcatcagatgcattggacaaaatccgg
tatgaaagcttgacagatcccagtaaattagactctgggaaagagctgcatattaacctt
ataccgaacaaacaagatcgaactctcactattgtggatactggaattggaatgaccaag
gctgacttgatcaataaccttggtactatcgccaagtctgggaccaaagcgttcatggaa
gctttgcaggctggtgcagatatctctatgattggccagttcggtgttggtttttattct
gcttatttggttgctgagaaagtaactgtgatcaccaaacataacgatgatgagcagtac
gcttgggagtcctcagcagggggatcattcacagtgaggacagacacaggtgaacctatg
ggtcgtggaacaaaagttatcctacacctgaaagaagaccaaactgagtacttggaggaa
cgaagaataaaggagattgtgaagaaacattctcagtttattggatatcccattactctt
tttgtggagaaggaacgtgataaagaagtaagcgatgatgaggctgaagaaaaggaagac
aaagaagaagaaaaagaaaaagaagagaaagagtcggaagacaaacctgaaattgaagat
gttggttctgatgaggaagaagaaaagaaggatggtgacaagaagaagaagaagaagatt
aaggaaaagtacatcgatcaagaagagctcaacaaaacaaagcccatctggaccagaaat
cccgacgatattactaatgaggagtacggagaattctataagagcttgaccaatgactgg
gaagatcacttggcagtgaagcatttttcagttgaaggacagttggaattcagagccctt
ctatttgtcccacgacgtgctccttttgatctgtttgaaaacagaaagaaaaagaacaac
atcaaattgtatgtacgcagagttttcatcatggataactgtgaggagctaatccctgaa
tatctgaacttcattagaggggtggtagactcggaggatctccctctaaacatatcccgt
gagatgttgcaacaaagcaaaattttgaaagttatcaggaagaatttggtcaaaaaatgc
ttagaactctttactgaactggcggaagataaagagaactacaagaaattctatgagcag
ttctctaaaaacataaagcttggaatacacgaagactctcaaaatcggaagaagctttca
gagctgttaaggtactacacatctgcctctggtgatgagatggtttctctcaaggactac
tgcaccagaatgaaggagaaccagaaacatatctattatatcacaggtgagaccaaggac
caggtagctaactcagcctttgtggaacgtcttcggaaacatggcttagaagtgatctat
atgattgagcccattgatgagtactgtgtccaacagctgaaggaatttgaggggaagact
ttagtgtcagtcaccaaagaaggcctggaacttccagaggatgaagaagagaaaaagaag
caggaagagaaaaaaacaaagtttgagaacctctgcaaaatcatgaaagacatattggag
aaaaaagttgaaaaggtggttgtgtcaaaccgattggtgacatctccatgctgtattgtc
acaagcacatatggctggacagcaaacatggagagaatcatgaaagctcaagccctaaga
gacaactcaacaatgggttacatggcagcaaagaaacacctggagataaaccctgaccat
tccattattgagaccttaaggcaaaaggcagaggctgataagaacgacaagtctgtgaag
gatctggtcatcttgctttatgaaactgcgctcctgtcttctggcttcagtctggaagat
ccccagacacatgctaacaggatctacaggatgatcaaacttggtctgggtattgatgaa
gatgaccctactgctgatgataccagtgctgctgtaactgaagaaatgccaccccttgaa
ggagatgacgacacatcacgcatggaagaagtagactaa

  All links  
Disease (1)   
   OMIM (1)   
Gene (86)   
   RefGene (43)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (38)   
   OC (1)   
Protein sequence (7)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (54)   
   RefSeq(nuc) (4)   
   GenBank (25)   
   EMBL (25)   
3D Structure (344)   
   PDB (344)   
Protein domain (4)   
   Pfam (4)   
All databases (496)   

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