KEGG   Homo sapiens (human): 3320
Entry
3320              CDS       T01001                                 

Gene name
HSP90AA1, EL52, HEL-S-65p, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp103, Hsp89, Hsp90, LAP-2, LAP2
Definition
(RefSeq) heat shock protein 90 alpha family class A member 1
  KO
K04079  molecular chaperone HtpG
Organism
hsa  Homo sapiens (human)
Pathway
hsa04141  Protein processing in endoplasmic reticulum
hsa04151  PI3K-Akt signaling pathway
hsa04217  Necroptosis
hsa04612  Antigen processing and presentation
hsa04621  NOD-like receptor signaling pathway
hsa04657  IL-17 signaling pathway
hsa04659  Th17 cell differentiation
hsa04914  Progesterone-mediated oocyte maturation
hsa04915  Estrogen signaling pathway
hsa05132  Salmonella infection
hsa05200  Pathways in cancer
hsa05207  Chemical carcinogenesis - receptor activation
hsa05215  Prostate cancer
hsa05417  Lipid and atherosclerosis
hsa05418  Fluid shear stress and atherosclerosis
Drug target
Alvespimycin hydrochloride: D06554
Ganetespib: D10126
Luminespib (DG01842): D10646 D10647
Onalespib (DG03099): D10719 D11766
Pimitespib: D11920
Retaspimycin (DG01880): D09375 D09376
Tanespimycin: D06650
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    3320 (HSP90AA1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    3320 (HSP90AA1)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    3320 (HSP90AA1)
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    3320 (HSP90AA1)
   04612 Antigen processing and presentation
    3320 (HSP90AA1)
   04659 Th17 cell differentiation
    3320 (HSP90AA1)
   04657 IL-17 signaling pathway
    3320 (HSP90AA1)
  09152 Endocrine system
   04915 Estrogen signaling pathway
    3320 (HSP90AA1)
   04914 Progesterone-mediated oocyte maturation
    3320 (HSP90AA1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    3320 (HSP90AA1)
   05207 Chemical carcinogenesis - receptor activation
    3320 (HSP90AA1)
  09162 Cancer: specific types
   05215 Prostate cancer
    3320 (HSP90AA1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    3320 (HSP90AA1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    3320 (HSP90AA1)
   05418 Fluid shear stress and atherosclerosis
    3320 (HSP90AA1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    3320 (HSP90AA1)
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts [BR:hsa03110]
    3320 (HSP90AA1)
   04131 Membrane trafficking [BR:hsa04131]
    3320 (HSP90AA1)
   03051 Proteasome [BR:hsa03051]
    3320 (HSP90AA1)
   03029 Mitochondrial biogenesis [BR:hsa03029]
    3320 (HSP90AA1)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    3320 (HSP90AA1)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-5
    PP5-interacting proteins
     3320 (HSP90AA1)
Chaperones and folding catalysts [BR:hsa03110]
 Heat shock proteins
  HSP90
   3320 (HSP90AA1)
Membrane trafficking [BR:hsa04131]
 Autophagy
  Chaperone mediated autophagy (CMA)
   Chaperones
    3320 (HSP90AA1)
Proteasome [BR:hsa03051]
 Eukaryotic proteasome
  Assembling factors
   Other assembling factors
    3320 (HSP90AA1)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial quality control factors
  Mitophagy factors
   Parkin-independent mechanism factors
    3320 (HSP90AA1)
Exosome [BR:hsa04147]
 Exosomal proteins
  Proteins found in most exosomes
   3320 (HSP90AA1)
SSDB
Motif
Pfam: HSP90 HATPase_c HATPase_c_3 Zip LOH1CR12
Other DBs
NCBI-GeneID: 3320
NCBI-ProteinID: NP_005339
OMIM: 140571
HGNC: 5253
Ensembl: ENSG00000080824
Vega: OTTHUMG00000171752
Pharos: P07900(Tchem)
UniProt: P07900 K9JA46
Structure
PDB: 
5J80 3T0H 5J2X 3T10 5XRD 3WHA 2YK9 5LRL 6GR5 3B28 5J64 3VHA 2YI7 3VHC 6GQS 2YKE 6OLX 5LR1 5LO5 2YKJ 3O0I 6GPO 6N8X 6CYH 6GR4 6CYG 5XR9 5XRE 4LWE 3T2S 3T1K 3B27 1BYQ 6GPP 3VHD 5LNZ 6GPF 4U93 2YEF 3EKO 6GPH 3RKZ 3QTF 3R91 3R92 5J2V 3HHU 6GPW 6B99 6ELN 5XQD 5XR5 4LWG 4AWQ 4EGH 4EEH 2YI0 3BMY 3BM9 4YKR 2YJW 5OCI 3OWD 5J6M 6B9A 5XRB 5NYH 4NH8 4L94 4HY6 1YER 2XJX 6EL5 2YKI 2YKC 2QFO 4EGK 6GP4 5XQE 5J27 4YKU 4XIP 4XIR 4LWH 4LWI 4L8Z 4B7P 4AWO 4FCR 3B24 3RLP 3RLR 3R4M 3R4P 1YC1 6GQU 4JQL 2YE5 2YEA 2YK2 2XDU 3D0B 6GP8 5J8U 5J6L 4LWF 4L91 3B25 3INX 1OSF 5J20 4YKY 5VYY 4O05 4EGI 3QDD 2CCS 6ELO 5J9X 5CF0 4YKX 4W7T 4R3M 4CWN 3WQ9 3TUH 2YI6 3OW6 2QG2 1YC4 5ODX 4O04 4AWP 2YJX 4XIQ 4L93 6ELP 5LS1 4YKT 4YKW 4YKZ 2QG0 5LR7 4XIT 4O07 5J86 6GR3 5LNY 6CEO 6EYB 5M4E 5LQ9 5J8M 5J6N 4CWT 4BQG 3RLQ 2YE2 2XJJ 3MNR 2XAB 3HYY 3HZ5 2WI3 3FT5 2UWD 2BZ5 2BT0 1YET 4YKQ 4O0B 2YKB 4CWP 2YE3 2XK2 3K97 3INW 3HEK 2JJC 4O09 2XDS 2XDK 2XDL 1UY8 6HHR 6GPT 6EY9 5OD7 5M4H 5LRZ 5FND 4CWQ 4CWR 4CWF 4NH7 4L90 4BQJ 4FCP 4EFU 3R4N 3FT8 3EKR 2VCI 2H55 1UY9 1UYC 1UYE 1UYF 1UYG 5GGZ 6GQR 6GR1 3OWB 2BSM 6F1N 2WI2 6EYA 5T21 5FNF 3B26 2YEC 2YED 2YEH 3K99 2WI5 2FWY 2FWZ 4EFT 1YC3 4FCQ 6EY8 5J82 2WI6 3T0Z 6EI5 5FNC 2YE7 2YE9 2YEI 2YEJ 2XHR 1UYD 1UYH 1UYI 1UYK 1YES 6GPY 6GQ6 2XJG 2XHT 5LO0 4CWS 2YE4 2YE8 2YEE 3HYZ 3HZ1 2WI1 2CCT 4CWO 6GPR 5LO6 2YEB 3K98 2WI4 2XDX 6FCJ 5ZR3 2YI5 2YEG 2WI7 2VCJ 2YE6 3R4O 5LO1 2CCU 2XHX 3Q6M 3Q6N 2QF6 2K5B 2BYH 2BYI 1UY6 1UY7 1UYL

Position
14q32.31
AA seq 732 aa
MPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIR
YESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFME
ALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGEPM
GRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEKED
KEEEKEKEEKESEDKPEIEDVGSDEEEEKKDGDKKKKKKIKEKYIDQEELNKTKPIWTRN
PDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENRKKKNN
IKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKC
LELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDY
CTRMKENQKHIYYITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKT
LVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIV
TSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVK
DLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPTADDTSAAVTEEMPPLE
GDDDTSRMEEVD
NT seq 2199 nt   +upstreamnt  +downstreamnt
atgcctgaggaaacccagacccaagaccaaccgatggaggaggaggaggttgagacgttc
gcctttcaggcagaaattgcccagttgatgtcattgatcatcaatactttctactcgaac
aaagagatctttctgagagagctcatttcaaattcatcagatgcattggacaaaatccgg
tatgaaagcttgacagatcccagtaaattagactctgggaaagagctgcatattaacctt
ataccgaacaaacaagatcgaactctcactattgtggatactggaattggaatgaccaag
gctgacttgatcaataaccttggtactatcgccaagtctgggaccaaagcgttcatggaa
gctttgcaggctggtgcagatatctctatgattggccagttcggtgttggtttttattct
gcttatttggttgctgagaaagtaactgtgatcaccaaacataacgatgatgagcagtac
gcttgggagtcctcagcagggggatcattcacagtgaggacagacacaggtgaacctatg
ggtcgtggaacaaaagttatcctacacctgaaagaagaccaaactgagtacttggaggaa
cgaagaataaaggagattgtgaagaaacattctcagtttattggatatcccattactctt
tttgtggagaaggaacgtgataaagaagtaagcgatgatgaggctgaagaaaaggaagac
aaagaagaagaaaaagaaaaagaagagaaagagtcggaagacaaacctgaaattgaagat
gttggttctgatgaggaagaagaaaagaaggatggtgacaagaagaagaagaagaagatt
aaggaaaagtacatcgatcaagaagagctcaacaaaacaaagcccatctggaccagaaat
cccgacgatattactaatgaggagtacggagaattctataagagcttgaccaatgactgg
gaagatcacttggcagtgaagcatttttcagttgaaggacagttggaattcagagccctt
ctatttgtcccacgacgtgctccttttgatctgtttgaaaacagaaagaaaaagaacaac
atcaaattgtatgtacgcagagttttcatcatggataactgtgaggagctaatccctgaa
tatctgaacttcattagaggggtggtagactcggaggatctccctctaaacatatcccgt
gagatgttgcaacaaagcaaaattttgaaagttatcaggaagaatttggtcaaaaaatgc
ttagaactctttactgaactggcggaagataaagagaactacaagaaattctatgagcag
ttctctaaaaacataaagcttggaatacacgaagactctcaaaatcggaagaagctttca
gagctgttaaggtactacacatctgcctctggtgatgagatggtttctctcaaggactac
tgcaccagaatgaaggagaaccagaaacatatctattatatcacaggtgagaccaaggac
caggtagctaactcagcctttgtggaacgtcttcggaaacatggcttagaagtgatctat
atgattgagcccattgatgagtactgtgtccaacagctgaaggaatttgaggggaagact
ttagtgtcagtcaccaaagaaggcctggaacttccagaggatgaagaagagaaaaagaag
caggaagagaaaaaaacaaagtttgagaacctctgcaaaatcatgaaagacatattggag
aaaaaagttgaaaaggtggttgtgtcaaaccgattggtgacatctccatgctgtattgtc
acaagcacatatggctggacagcaaacatggagagaatcatgaaagctcaagccctaaga
gacaactcaacaatgggttacatggcagcaaagaaacacctggagataaaccctgaccat
tccattattgagaccttaaggcaaaaggcagaggctgataagaacgacaagtctgtgaag
gatctggtcatcttgctttatgaaactgcgctcctgtcttctggcttcagtctggaagat
ccccagacacatgctaacaggatctacaggatgatcaaacttggtctgggtattgatgaa
gatgaccctactgctgatgataccagtgctgctgtaactgaagaaatgccaccccttgaa
ggagatgacgacacatcacgcatggaagaagtagactaa

  All links  
Ontology (7)   
   KEGG BRITE (7)   
Pathway (15)   
   KEGG PATHWAY (15)   
Disease (1)   
   OMIM (1)   
Drug (10)   
   KEGG DRUG (10)   
Genome (1)   
   KEGG GENOME (1)   
Gene (89)   
   KEGG ORTHOLOGY (1)   
   RefGene (43)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (38)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (6)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (53)   
   RefSeq(nuc) (3)   
   GenBank (25)   
   EMBL (25)   
Protein domain (5)   
   Pfam (5)   
All databases (187)   

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