KEGG T01001: 3350

Homo sapiens (human): 3350

Entry

3350              CDS       T01001

Symbol

HTR1A, 5-HT-1A, 5-HT1A, 5HT1a, ADRB2RL1, ADRBRL1, G-21, PFMCD

Name

(RefSeq) 5-hydroxytryptamine receptor 1A

K04153

5-hydroxytryptamine receptor 1

Organism

hsa Homo sapiens (human)

Pathway

hsa04024

cAMP signaling pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04082

Neuroactive ligand signaling

hsa04726

Serotonergic synapse

hsa04742

Taste transduction

Network

nt06544 Neuroactive ligand signaling

Element

N01901

Serotonin-HTR1/5-GNAI/O signaling pathway

Disease

H02773

Menstrual cycle-dependent periodic fever

Drug target

Adatanserin hydrochloride:

D02767

Aripiprazole (DG00906):

D01164<JP/US> D10355 D10364<US> D10516<JP/US>

Asenapine (DG03100):

D02995<JP/US>

Bifeprunox (DG01304):

D06566 D06567

Binospirone mesylate:

D03121

Brexpiprazole:

D10309<JP/US>

Buspirone (DG00913):

D00702<US> D07593

Cariprazine (DG01305):

D09876<US> D09997

Cinitapride (DG01520):

D07700 D07701

Cyproheptadine (DG01109):

D02234<JP/US> D07765

Eptapirone:

D02576

Ergot alkaloids:

D07906

Ergotamine (DG00834):

D00679<US>

Flesinoxan:

D02568

Flibanserin:

D02577<US>

Gepirone:

D04314<US>

Indorenate hydrochloride:

D04533

Ipsapirone hydrochloride:

D04611

Lecozotan hydrochloride:

D04683

Methysergide (DG00835):

D00681 D02357

Naluzotan (DG01279):

D09358 D09359

Pardoprunox (DG01324):

D09366 D09397

Pipotiazine (DG00884):

D02680 D08385

Pizotifen (DG00842):

D05523 D08397

Sarizotan hydrochloride:

D05804

Sunepitron hydrochloride:

D02569

Tandospirone (DG01306):

D01992<JP> D08561

Tiospirone hydrochloride:

D02688

Ulotaront (DG03247):

D12474 D12475

Vilazodone (DG00964):

D09698 D09699<US>

Vortioxetine (DG00965):

D10184 D10185<JP/US> D12544

Xaliproden (DG01008):

D01537 D06327

Zalospirone hydrochloride:

D06354

Zotepine:

D01321<JP>

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    3350 (HTR1A)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    3350 (HTR1A)
   04082 Neuroactive ligand signaling
    3350 (HTR1A)
09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    3350 (HTR1A)
  09157 Sensory system
   04742 Taste transduction
    3350 (HTR1A)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    3350 (HTR1A)
G protein-coupled receptors [BR:hsa04030]
Rhodopsin family
  Biogenic amine
   Serotonin
    3350 (HTR1A)

SSDB

Motif

Pfam:

7tm_1 7TM_GPCR_Srsx 7tm_4 7TM_GPCR_Srx

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

Position

5:complement(63957874..63962445)

AA seq 422 aa
MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADT
RHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGN
SKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RQ

NT seq 1269 nt +upstreamnt +downstreamnt
atggatgtgctcagccctggtcagggcaacaacaccacatcaccaccggctccctttgag
accggcggcaacactactggtatctccgacgtgaccgtcagctaccaagtgatcacctct
ctgctgctgggcacgctcatcttctgcgcggtgctgggcaatgcgtgcgtggtggctgcc
atcgccttggagcgctccctgcagaacgtggccaattatcttattggctctttggcggtc
accgacctcatggtgtcggtgttggtgctgcccatggccgcgctgtatcaggtgctcaac
aagtggacactgggccaggtaacctgcgacctgttcatcgccctcgacgtgctgtgctgc
acctcatccatcttgcacctgtgcgccatcgcgctggacaggtactgggccatcacggac
cccatcgactacgtgaacaagaggacgccccggcgcgccgctgcgctcatctcgctcact
tggcttattggcttcctcatctctatcccgcccatgctgggctggcgcaccccggaagac
cgctcggaccccgacgcatgcaccattagcaaggatcatggctacactatctattccacc
tttggagctttctacatcccgctgctgctcatgctggttctctatgggcgcatattccga
gctgcgcgcttccgcatccgcaagacggtcaaaaaggtggagaagaccggagcggacacc
cgccatggagcatctcccgccccgcagcccaagaagagtgtgaatggagagtcggggagc
aggaactggaggctgggcgtggagagcaaggctgggggtgctctgtgcgccaatggcgcg
gtgaggcaaggtgacgatggcgccgccctggaggtgatcgaggtgcaccgagtgggcaac
tccaaagagcacttgcctctgcccagcgaggctggtcctaccccttgtgcccccgcctct
ttcgagaggaaaaatgagcgcaacgccgaggcgaagcgcaagatggccctggcccgagag
aggaagacagtgaagacgctgggcatcatcatgggcaccttcatcctctgctggctgccc
ttcttcatcgtggctcttgttctgcccttctgcgagagcagctgccacatgcccaccctg
ttgggcgccataatcaattggctgggctactccaactctctgcttaaccccgtcatttac
gcatacttcaacaaggactttcaaaacgcgtttaagaagatcattaagtgtaagttctgc
cgccagtga

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