KEGG   Homo sapiens (human): 3376
Entry
3376              CDS       T01001                                 

Gene name
IARS1, GRIDHH, IARS, ILERS, ILRS, IRS, PRO0785
Definition
(RefSeq) isoleucyl-tRNA synthetase 1
  KO
K01870  isoleucyl-tRNA synthetase [EC:6.1.1.5]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00970  Aminoacyl-tRNA biosynthesis
Disease
H02437  Growth retardation, impaired intellectual development, hypotonia, and hepatopathy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09122 Translation
   00970 Aminoacyl-tRNA biosynthesis
    3376 (IARS1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01007 Amino acid related enzymes [BR:hsa01007]
    3376 (IARS1)
  09182 Protein families: genetic information processing
   03016 Transfer RNA biogenesis [BR:hsa03016]
    3376 (IARS1)
Enzymes [BR:hsa01000]
 6. Ligases
  6.1  Forming carbon-oxygen bonds
   6.1.1  Ligases forming aminoacyl-tRNA and related compounds
    6.1.1.5  isoleucine---tRNA ligase
     3376 (IARS1)
Amino acid related enzymes [BR:hsa01007]
 Aminoacyl-tRNA synthetase
  Class I (U)
   3376 (IARS1)
Transfer RNA biogenesis [BR:hsa03016]
 Eukaryotic type
  Aminoacyl-tRNA synthetases (AARSs)
   Multi-aminoacyl-tRNA synthetase complex (MSC)
    3376 (IARS1)
 Prokaryotic type
   Other AARSs
    3376 (IARS1)
SSDB
Motif
Pfam: tRNA-synt_1 Anticodon_1 tRNA-synt_1g tRNA-synt_1e
Other DBs
NCBI-GeneID: 3376
NCBI-ProteinID: NP_002152
OMIM: 600709
HGNC: 5330
Ensembl: ENSG00000196305
Vega: OTTHUMG00000020219
Pharos: P41252(Tchem)
UniProt: P41252 Q7L4K8 Q6P0M4
Position
9q22.31
AA seq 1262 aa
MLQQVPENINFPAEEEKILEFWTEFNCFQECLKQSKHKPKFTFYDGPPFATGLPHYGHIL
AGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVEYEIDKTLGIRGPEDVAKMGITEYNNQC
RAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKVMP
FSTACNTPLSNFESHQNYKDVQDPSVFVTFPLEEDETVSLVAWTTTPWTLPSNLAVCVNP
EMQYVKIKDVARGRLLILMEARLSALYKLESDYEILERFPGAYLKGKKYRPLFDYFLKCK
ENGAFTVLVDNYVKEEEGTGVVHQAPYFGAEDYRVCMDFNIIRKDSLPVCPVDASGCFTT
EVTDFAGQYVKDADKSIIRTLKEQGRLLVATTFTHSYPFCWRSDTPLIYKAVPSWFVRVE
NMVDQLLRNNDLCYWVPELVREKRFGNWLKDARDWTISRNRYWGTPIPLWVSDDFEEVVC
IGSVAELEELSGAKISDLHRESVDHLTIPSRCGKGSLHRISEVFDCWFESGSMPYAQVHY
PFENKREFEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQK
MSKRKKNYPDPVSIIQKYGADALRLYLINSPVVRAENLRFKEEGVRDVLKDVLLPWYNAY
RFLIQNVLRLQKEEEIEFLYNENTVRESPNITDRWILSFMQSLIGFFETEMAAYRLYTVV
PRLVKFVDILTNWYVRMNRRRLKGENGMEDCVMALETLFSVLLSLCRLMAPYTPFLTELM
YQNLKVLIDPVSVQDKDTLSIHYLMLPRVREELIDKKTESAVSQMQSVIELGRVIRDRKT
IPIKYPLKEIVVIHQDPEALKDIKSLEKYIIEELNVRKVTLSTDKNKYGIRLRAEPDHMV
LGKRLKGAFKAVMTSIKQLSSEELEQFQKTGTIVVEGHELHDEDIRLMYTFDQATGGTAQ
FEAHSDAQALVLLDVTPDQSMVDEGMAREVINRIQKLRKKCNLVPTDEITVYYKAKSEGT
YLNSVIESHTEFIFTTIKAPLKPYPVSPSDKVLIQEKTQLKGSELEITLTRGSSLPGPAC
AYVNLNICANGSEQGGVLLLENPKGDNRLDLLKLKSVVTSIFGVKNTELAVFHDETEIQN
QTDLLSLSGKTLCVTAGSAPSLINSSSTLLCQYINLQLLNAKPQECLMGTVGTLLLENPL
GQNGLTHQGLLYEAAKVFGLRSRKLKLFLNETQTQEITEDIPVKTLNMKTVYVSVLPTTA
DF
NT seq 3789 nt   +upstreamnt  +downstreamnt
atgcttcaacaagttccagaaaacataaattttcctgctgaagaagagaaaatcttggag
ttttggactgaatttaattgttttcaggaatgcttaaagcaatcaaaacataaaccaaaa
tttaccttctatgatggtcctccttttgcaactggactgcctcactatggacatatactt
gcgggtacaattaaagatatagttacaagatatgctcaccagagtgggtttcatgttgac
agaagatttggatgggattgccatggcttacctgtggaatatgaaattgataagacactg
ggaatcagaggaccagaggatgtggccaaaatggggattacagagtataacaatcagtgc
cgagcaattgtgatgagatattctgctgagtggaagtctactgttagcagacttggccga
tggattgactttgacaatgactataaaactctgtatccacaattcatggaatcagtctgg
tgggtcttcaaacaactctatgataaaggccttgtttatagaggtgtgaaagtcatgccc
ttctctacggcatgtaacactccactttccaacttcgagtcacaccagaattataaggat
gttcaagatccttcagtatttgtaactttccctttggaagaagatgaaactgtatcttta
gttgcttggacaaccactccctggactctacctagtaaccttgctgtgtgtgttaatcca
gaaatgcaatatgtgaaaattaaagatgttgccagaggacgattactcattttaatggaa
gccagattgtcagccctctataaattggagagtgactatgagatccttgaaagatttcct
ggtgcctatcttaaaggcaagaagtacaggcccctgtttgactatttcctgaagtgtaaa
gagaatggcgctttcactgtgcttgttgacaactatgtgaaggaagaagaaggcacaggg
gttgtccaccaagctccttacttcggtgctgaggactatcgggtctgtatggactttaac
attattcggaaagactcactccctgtttgccctgtggatgcttcaggctgcttcacaacg
gaggtgacagatttcgcaggacagtatgtgaaggatgctgacaaaagtatcatcaggact
ttgaaggaacaaggccgacttctggttgccaccaccttcactcacagctaccctttttgc
tggagatcagacactcctctaatttacaaagcagtgcccagctggtttgtgcgagtggag
aacatggtggaccagctcctaaggaacaatgacctgtgctactgggtcccagagttggta
cgagaaaaacgatttggaaattggctgaaagatgcacgtgactggacaatttccagaaac
agatactggggcacccccatcccactgtgggtcagcgatgactttgaggaggtggtatgc
attgggtcagtggcggaacttgaagaactgtcaggagcaaagatctcagatctccacaga
gagagtgttgaccacctgaccattccttcacgctgtgggaagggatccttgcaccgcatc
tctgaagtgtttgactgttggtttgagagtggcagcatgccctatgctcaggttcattac
ccgtttgaaaacaagagggagtttgaggatgcttttcctgcagatttcattgccgagggc
atcgaccaaaccagaggatggttttataccctgctggtgctggccacggccctctttgga
caaccgcctttcaagaacgtaattgtgaatgggcttgtcctggcaagtgatggccaaaaa
atgagcaaacggaaaaagaattatccagatccagtttccatcatccagaagtatggtgct
gatgccctcagattatatctgattaactcccctgtggtgagagcagaaaacctccgcttt
aaagaagagggtgtgcgggacgtccttaaggatgtactgctcccatggtacaatgcctat
cgcttcttaatccagaacgttctgaggctccagaaggaggaagaaatagaatttctctac
aatgagaacacggttagagaaagccccaacattacagaccggtggatcctgtccttcatg
cagtctctcattggcttctttgagactgaaatggcagcttataggctttatactgtggtg
cctcgcctggtcaagtttgtagatattctgaccaattggtatgttagaatgaaccgcaga
agattaaagggtgaaaatgggatggaggattgtgtcatggccctagaaaccttgtttagt
gttctgctttctctttgcagacttatggctccctacacaccttttctcactgaattgatg
taccagaatctaaaggtgctgattgaccctgtttctgttcaggacaaggacacactcagc
attcactacctcatgctgccccgtgttcgagaagaattgattgacaagaaaacagagagt
gcagtatctcagatgcagtctgtgattgaacttggaagagtgatcagagaccgaaaaact
attcccataaagtatcctttgaaagaaattgtggttatccatcaagatccagaagctctt
aaagatatcaagtctttggagaagtatatcattgaggaactcaatgttcgaaaagttaca
ctgtctacagataaaaacaagtatggcattcggctaagggcagaaccagatcacatggtc
ctggggaagcgtctgaagggagcctttaaggcagtgatgacgtccatcaagcagttgagc
agtgaggagctggagcagttccagaagactgggaccattgttgtggaaggccatgaattg
cacgatgaagacatccgcctcatgtacacctttgatcaggccacaggtgggactgcgcaa
tttgaagcacactcagatgctcaggctttggtcctcttagatgtcactcctgaccagtca
atggtagatgaaggaatggctcgggaagtcatcaatcgcatacagaaacttcgcaaaaag
tgcaatctggttccaactgatgaaatcacagtgtactataaagcaaagtctgaaggaaca
tatctgaatagtgttattgaaagccacacagagttcatatttaccaccataaaggctccc
ttgaaaccatatccagtttctccatcggataaagtccttattcaagaaaaaacacagttg
aagggatctgaactggaaattacactcaccagaggatcttcccttcctggtcctgcttgt
gcatatgtcaatcttaacatttgtgcaaatggcagtgaacaaggtggagtattgctcctg
gaaaatccaaaaggtgacaataggttggaccttttaaagctgaagagtgttgtcactagc
atttttggtgtgaaaaatacagagctggctgtcttccatgatgaaacagaaatacaaaac
caaactgacttactgagtcttagtggaaaaacactttgtgtgactgcaggatcggctccc
tctctgatcaacagttctagtactcttctttgtcagtatatcaacctacagctcctgaat
gcaaagccacaagagtgtttaatggggacagtgggcactctcctgcttgaaaacccactt
gggcagaatggactcacccaccaaggtcttctgtatgaagcagccaaggtgtttggcctt
cggagcaggaagctaaagctgtttctgaatgagacccaaacgcaggaaattacagaagac
atccccgtgaagactttgaatatgaagactgtgtatgtttctgtgttaccaacaacagca
gacttctag

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (23)   
   KEGG ORTHOLOGY (1)   
   RefGene (9)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (6)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (25)   
   UniProt (3)   
   SWISS-PROT (1)   
   RefSeq(pep) (21)   
DNA sequence (62)   
   RefSeq(nuc) (22)   
   GenBank (20)   
   EMBL (20)   
Protein domain (4)   
   Pfam (4)   
All databases (131)   

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