| Entry |
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| Symbol |
IDH1, HEL-216, HEL-S-26, IDCD, IDH, IDP, IDPC, PICD
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| Name |
(RefSeq) isocitrate dehydrogenase (NADP(+)) 1
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| KO |
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| Organism |
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| Pathway |
| hsa01210 | 2-Oxocarboxylic acid metabolism |
| hsa05230 | Central carbon metabolism in cancer |
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| Module |
| hsa_M00010 | Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate |
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| Network |
nt06026 Glutathione biosynthesis nt06031 Citrate cycle and pyruvate metabolism |
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| Element |
| N01604 | Citrate cycle, first carbon oxidation |
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| Disease |
| H01892 | Peripheral T cell lymphoma |
| H02410 | Myelodysplastic/myeloproliferative neoplasms |
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| Drug target |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09100 Metabolism
09101 Carbohydrate metabolism
00020 Citrate cycle (TCA cycle)
3417 (IDH1)
09106 Metabolism of other amino acids
00480 Glutathione metabolism
3417 (IDH1)
09140 Cellular Processes
09141 Transport and catabolism
04146 Peroxisome
3417 (IDH1)
09160 Human Diseases
09161 Cancer: overview
05230 Central carbon metabolism in cancer
3417 (IDH1)
Enzymes [BR:hsa01000]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.42 isocitrate dehydrogenase (NADP+)
3417 (IDH1)
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| SSDB |
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| Motif |
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| Other DBs |
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| Structure |
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| Position |
2:complement(208236227..208255071)
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| AA seq |
414 aa
MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA
AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL
VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM
GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE
AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG
KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE
EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL |
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| NT seq |
1245 nt +upstreamnt +downstreamnt
atgtccaaaaaaatcagtggcggttctgtggtagagatgcaaggagatgaaatgacacga
atcatttgggaattgattaaagagaaactcatttttccctacgtggaattggatctacat
agctatgatttaggcatagagaatcgtgatgccaccaacgaccaagtcaccaaggatgct
gcagaagctataaagaagcataatgttggcgtcaaatgtgccactatcactcctgatgag
aagagggttgaggagttcaagttgaaacaaatgtggaaatcaccaaatggcaccatacga
aatattctgggtggcacggtcttcagagaagccattatctgcaaaaatatcccccggctt
gtgagtggatgggtaaaacctatcatcataggtcgtcatgcttatggggatcaatacaga
gcaactgattttgttgttcctgggcctggaaaagtagagataacctacacaccaagtgac
ggaacccaaaaggtgacatacctggtacataactttgaagaaggtggtggtgttgccatg
gggatgtataatcaagataagtcaattgaagattttgcacacagttccttccaaatggct
ctgtctaagggttggcctttgtatctgagcaccaaaaacactattctgaagaaatatgat
gggcgttttaaagacatctttcaggagatatatgacaagcagtacaagtcccagtttgaa
gctcaaaagatctggtatgagcataggctcatcgacgacatggtggcccaagctatgaaa
tcagagggaggcttcatctgggcctgtaaaaactatgatggtgacgtgcagtcggactct
gtggcccaagggtatggctctctcggcatgatgaccagcgtgctggtttgtccagatggc
aagacagtagaagcagaggctgcccacgggactgtaacccgtcactaccgcatgtaccag
aaaggacaggagacgtccaccaatcccattgcttccatttttgcctggaccagagggtta
gcccacagagcaaagcttgataacaataaagagcttgccttctttgcaaatgctttggaa
gaagtctctattgagacaattgaggctggcttcatgaccaaggacttggctgcttgcatt
aaaggtttacccaatgtgcaacgttctgactacttgaatacatttgagttcatggataaa
cttggagaaaacttgaagatcaaactagctcaggccaaactttaa |
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