KEGG   Homo sapiens (human): 3455Help
Entry
3455              CDS       T01001                                 

Gene name
IFNAR2, IFN-R, IFN-alpha-REC, IFNABR, IFNARB, IMD45
Definition
(RefSeq) interferon alpha and beta receptor subunit 2
  KO
K05131  interferon receptor 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04151  PI3K-Akt signaling pathway
hsa04217  Necroptosis
hsa04380  Osteoclast differentiation
hsa04620  Toll-like receptor signaling pathway
hsa04621  NOD-like receptor signaling pathway
hsa04630  Jak-STAT signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity
hsa05160  Hepatitis C
hsa05162  Measles
hsa05164  Influenza A
hsa05165  Human papillomavirus infection
hsa05167  Kaposi's sarcoma-associated herpesvirus infection
hsa05168  Herpes simplex infection
hsa05200  Pathways in cancer
Network
N00053  Cytokine-Jak-STAT signaling pathway
N00150  Type I IFN signaling pathway
Drug target
Albinterferon alfa-2b: D08844
Interferon alfa natural: D03305
Interferon alfa-2a: D00745
Interferon alfa-2b: D02745
Interferon alfa-n1: D04552
Interferon alfacon-1: D02744
Interferon alpha (DG01750): D04553
Interferon beta natural: D03304
Interferon beta-1a: D04554
Interferon beta-1b: D00746
Peginterferon alfa-2a: D02747
Peginterferon alfa-2b: D02748
Peginterferon beta-1a: D10483
Ropeginterferon alfa-2b: D11027
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04630 Jak-STAT signaling pathway
    3455 (IFNAR2)
   04151 PI3K-Akt signaling pathway
    3455 (IFNAR2)
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    3455 (IFNAR2)
 Cellular Processes
  Cell growth and death
   04217 Necroptosis
    3455 (IFNAR2)
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    3455 (IFNAR2)
   04621 NOD-like receptor signaling pathway
    3455 (IFNAR2)
   04650 Natural killer cell mediated cytotoxicity
    3455 (IFNAR2)
  Development
   04380 Osteoclast differentiation
    3455 (IFNAR2)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    3455 (IFNAR2)
  Infectious diseases
   05162 Measles
    3455 (IFNAR2)
   05164 Influenza A
    3455 (IFNAR2)
   05160 Hepatitis C
    3455 (IFNAR2)
   05168 Herpes simplex infection
    3455 (IFNAR2)
   05167 Kaposi's sarcoma-associated herpesvirus infection
    3455 (IFNAR2)
   05165 Human papillomavirus infection
    3455 (IFNAR2)
Cytokine receptors [BR:hsa04050]
 Interleukin receptor families
  IFN receptor family
   3455 (IFNAR2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Tissue_fac Interfer-bind
Motif
Other DBs
NCBI-GeneID: 3455
NCBI-ProteinID: NP_001276054
OMIM: 602376
HGNC: 5433
Ensembl: ENSG00000159110 ENSG00000249624
Vega: OTTHUMG00000065127
Pharos: P48551(Tclin)
UniProt: P48551
Structure
PDB: 

Position
21q22.11
AA seq 515 aa AA seqDB search
MLLSQNAFIFRSLNLVLMVYISLVFGISYDSPDYTDESCTFKISLRNFRSILSWELKNHS
IVPTHYTLLYTIMSKPEDLKVVKNCANTTRSFCDLTDEWRSTHEAYVTVLEGFSGNTTLF
SCSHNFWLAIDMSFEPPEFEIVGFTNHINVMVKFPSIVEEELQFDLSLVIEEQSEGIVKK
HKPEIKGNMSGNFTYIIDKLIPNTNYCVSVYLEHSDEQAVIKSPLKCTLLPPGQESESAE
SAKIGGIITVFLIALVLTSTIVTLKWIGYICLRNSLPKVLNFHNFLAWPFPNLPPLEAMD
MVEVIYINRKKKVWDYNYDDESDSDTEAAPRTSGGGYTMHGLTVRPLGQASATSTESQLI
DPESEEEPDLPEVDVELPTMPKDSPQQLELLSGPCERRKSPLQDPFPEEDYSSTEGSGGR
ITFNVDLNSVFLRVLDDEDSDDLEAPLMLSSHLEEMVDPEDPDNVQSNHLLASGEGTQPT
FPSPSSEGLWSEDAPSDQSDTSESDVDLGDGYIMR
NT seq 1548 nt NT seq  +upstreamnt  +downstreamnt
atgcttttgagccagaatgccttcatcttcagatcacttaatttggttctcatggtgtat
atcagcctcgtgtttggtatttcatatgattcgcctgattacacagatgaatcttgcact
ttcaagatatcattgcgaaatttccggtccatcttatcatgggaattaaaaaaccactcc
attgtaccaactcactatacattgctgtatacaatcatgagtaaaccagaagatttgaag
gtggttaagaactgtgcaaataccacaagatcattttgtgacctcacagatgagtggaga
agcacacacgaggcctatgtcaccgtcctagaaggattcagcgggaacacaacgttgttc
agttgctcacacaatttctggctggccatagacatgtcttttgaaccaccagagtttgag
attgttggttttaccaaccacattaatgtgatggtgaaatttccatctattgttgaggaa
gaattacagtttgatttatctctcgtcattgaagaacagtcagagggaattgttaagaag
cataaacccgaaataaaaggaaacatgagtggaaatttcacctatatcattgacaagtta
attccaaacacgaactactgtgtatctgtttatttagagcacagtgatgagcaagcagta
ataaagtctcccttaaaatgcaccctccttccacctggccaggaatcagaatcagcagaa
tctgccaaaataggaggaataattactgtgtttttgatagcattggtcttgacaagcacc
atagtgacactgaaatggattggttatatatgcttaagaaatagcctccccaaagtcttg
aattttcataactttttagcctggccatttcctaacctgccaccgttggaagccatggat
atggtggaggtcatttacatcaacagaaagaagaaagtgtgggattataattatgatgat
gaaagtgatagcgatactgaggcagcgcccaggacaagtggcggtggctataccatgcat
ggactgactgtcaggcctctgggtcaggcctctgccacctctacagaatcccagttgata
gacccggagtccgaggaggagcctgacctgcctgaggttgatgtggagctccccacgatg
ccaaaggacagccctcagcagttggaactcttgagtgggccctgtgagaggagaaagagt
ccactccaggacccttttcccgaagaggactacagctccacggaggggtctgggggcaga
attaccttcaatgtggacttaaactctgtgtttttgagagttcttgatgacgaggacagt
gacgacttagaagcccctctgatgctatcgtctcatctggaagagatggttgacccagag
gatcctgataatgtgcaatcaaaccatttgctggccagcggggaagggacacagccaacc
tttcccagcccctcttcagagggcctgtggtccgaagatgctccatctgatcaaagtgac
acttctgagtcagatgttgaccttggggatggttatataatgagatga

DBGET integrated database retrieval system