KEGG   Homo sapiens (human): 3459
Entry
3459              CDS       T01001                                 
Symbol
IFNGR1, CD119, IFNGR, IMD27A, IMD27B
Name
(RefSeq) interferon gamma receptor 1
  KO
K05132  interferon gamma receptor 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04066  HIF-1 signaling pathway
hsa04217  Necroptosis
hsa04380  Osteoclast differentiation
hsa04630  JAK-STAT signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity
hsa04658  Th1 and Th2 cell differentiation
hsa04659  Th17 cell differentiation
hsa05140  Leishmaniasis
hsa05142  Chagas disease
hsa05145  Toxoplasmosis
hsa05152  Tuberculosis
hsa05164  Influenza A
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05168  Herpes simplex virus 1 infection
hsa05200  Pathways in cancer
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05321  Inflammatory bowel disease
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06162  Hepatitis B virus (HBV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06219  JAK-STAT signaling (cancer)
nt06229  MHC presentation (cancer)
nt06263  Hepatocellular carcinoma
nt06266  Non-small cell lung cancer
nt06276  Chronic myeloid leukemia
nt06518  JAK-STAT signaling
nt06527  Necroptosis
  Element
N00053  Cytokine-Jak-STAT signaling pathway
N00185  KSHV MIR2 to cell surface molecule-endocytosis
N01559  Type II interferon to Jak-STAT signaling pathway
N01662  IFN-RIPK1/3 signaling pathway
Disease
H00089  IFN-gamma/IL-12 axis
H00342  Tuberculosis
H00412  Hepatitis B
Drug target
Interferon gamma (DG00737): D00747<US> D03357<JP> D08805
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    3459 (IFNGR1)
   04066 HIF-1 signaling pathway
    3459 (IFNGR1)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    3459 (IFNGR1)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    3459 (IFNGR1)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    3459 (IFNGR1)
   04658 Th1 and Th2 cell differentiation
    3459 (IFNGR1)
   04659 Th17 cell differentiation
    3459 (IFNGR1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    3459 (IFNGR1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    3459 (IFNGR1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    3459 (IFNGR1)
  09172 Infectious disease: viral
   05164 Influenza A
    3459 (IFNGR1)
   05168 Herpes simplex virus 1 infection
    3459 (IFNGR1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    3459 (IFNGR1)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    3459 (IFNGR1)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    3459 (IFNGR1)
   05140 Leishmaniasis
    3459 (IFNGR1)
   05142 Chagas disease
    3459 (IFNGR1)
  09163 Immune disease
   05321 Inflammatory bowel disease
    3459 (IFNGR1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04050 Cytokine receptors [BR:hsa04050]
    3459 (IFNGR1)
   04090 CD molecules [BR:hsa04090]
    3459 (IFNGR1)
Cytokine receptors [BR:hsa04050]
 Interleukin receptor families
  IFN receptor family
   3459 (IFNGR1)
CD molecules [BR:hsa04090]
 Proteins
  3459 (IFNGR1)
SSDB
Motif
Pfam: IFNGR1_D2 IFNGR1_transm Tissue_fac Interfer-bind CR4_N
Other DBs
NCBI-GeneID: 3459
NCBI-ProteinID: NP_000407
OMIM: 107470
HGNC: 5439
Ensembl: ENSG00000027697
UniProt: P15260 A0A0S2Z3Y2
Structure
Position
6:complement(137197484..137219385)
AA seq 489 aa
MALLFLLPLVMQGVSRAEMGTADLGPSSVPTPTNVTIESYNMNPIVYWEYQIMPQVPVFT
VEVKNYGVKNSEWIDACINISHHYCNISDHVGDPSNSLWVRVKARVGQKESAYAKSEEFA
VCRDGKIGPPKLDIRKEEKQIMIDIFHPSVFVNGDEQEVDYDPETTCYIRVYNVYVRMNG
SEIQYKILTQKEDDCDEIQCQLAIPVSSLNSQYCVSAEGVLHVWGVTTEKSKEVCITIFN
SSIKGSLWIPVVAALLLFLVLSLVFICFYIKKINPLKEKSIILPKSLISVVRSATLETKP
ESKYVSLITSYQPFSLEKEVVCEEPLSPATVPGMHTEDNPGKVEHTEELSSITEVVTTEE
NIPDVVPGSHLTPIERESSSPLSSNQSEPGSIALNSYHSRNCSESDHSRNGFDTDSSCLE
SHSSLSDSEFPPNNKGEIKTEGQELITVIKAPTSFGYDKPHVLVDLLVDDSGKESLIGYR
PTEDSKEFS
NT seq 1470 nt   +upstreamnt  +downstreamnt
atggctctcctctttctcctaccccttgtcatgcagggtgtgagcagggctgagatgggc
accgcggatctggggccgtcctcagtgcctacaccaactaatgttacaattgaatcctat
aacatgaaccctatcgtatattgggagtaccagatcatgccacaggtccctgtttttacc
gtagaggtaaagaactatggtgttaagaattcagaatggattgatgcctgcatcaatatt
tctcatcattattgtaatatttctgatcatgttggtgatccatcaaattctctttgggtc
agagttaaagccagggttggacaaaaagaatctgcctatgcaaagtcagaagaatttgct
gtatgccgagatggaaaaattggaccacctaaactggatatcagaaaggaggagaagcaa
atcatgattgacatatttcacccttcagtttttgtaaatggagacgagcaggaagtcgat
tatgatcccgaaactacctgttacattagggtgtacaatgtgtatgtgagaatgaacgga
agtgagatccagtataaaatactcacgcagaaggaagatgattgtgacgagattcagtgc
cagttagcgattccagtatcctcactgaattctcagtactgtgtttcagcagaaggagtc
ttacatgtgtggggtgttacaactgaaaagtcaaaagaagtttgtattaccattttcaat
agcagtataaaaggttctctttggattccagttgttgctgctttactactctttctagtg
cttagcctggtattcatctgtttttatattaagaaaattaatccattgaaggaaaaaagc
ataatattacccaagtccttgatctctgtggtaagaagtgctactttagagacaaaacct
gaatcaaaatatgtatcactcatcacgtcataccagccattttccttagaaaaggaggtg
gtctgtgaagagccgttgtctccagcaacagttccaggcatgcataccgaagacaatcca
ggaaaagtggaacatacagaagaactttctagtataacagaagtggtgactactgaagaa
aatattcctgacgtggtcccgggcagccatctgactccaatagagagagagagttcttca
cctttaagtagtaaccagtctgaacctggcagcatcgctttaaactcgtatcactccaga
aattgttctgagagtgatcactccagaaatggttttgatactgattccagctgtctggaa
tcacatagctccttatctgactcagaatttcccccaaataataaaggtgaaataaaaaca
gaaggacaagagctcataaccgtaataaaagcccccacctcctttggttatgataaacca
catgtgctagtggatctacttgtggatgatagcggtaaagagtccttgattggttataga
ccaacagaagattccaaagaattttcatga

  All links  
Disease (6)   
   OMIM (6)   
Gene (26)   
   RefGene (10)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (11)   
   OC (1)   
Protein sequence (14)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (11)   
DNA sequence (41)   
   RefSeq(nuc) (11)   
   GenBank (15)   
   EMBL (15)   
3D Structure (5)   
   PDB (5)   
Protein domain (5)   
   Pfam (5)   
All databases (97)   

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