KEGG T01001: 3459

Homo sapiens (human): 3459

Entry

3459              CDS       T01001

Symbol

IFNGR1, CD119, IFNGR, IMD27A, IMD27B

Name

(RefSeq) interferon gamma receptor 1

K05132

interferon gamma receptor 1

Organism

hsa Homo sapiens (human)

Pathway

hsa04060

Cytokine-cytokine receptor interaction

hsa04066

HIF-1 signaling pathway

hsa04217

Necroptosis

hsa04380

Osteoclast differentiation

hsa04630

JAK-STAT signaling pathway

hsa04650

Natural killer cell mediated cytotoxicity

hsa04658

Th1 and Th2 cell differentiation

hsa04659

Th17 cell differentiation

hsa05140

Leishmaniasis

hsa05142

Chagas disease

hsa05145

Toxoplasmosis

hsa05152

Tuberculosis

hsa05164

Influenza A

hsa05167

Kaposi sarcoma-associated herpesvirus infection

hsa05168

Herpes simplex virus 1 infection

hsa05200

Pathways in cancer

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

hsa05321

Inflammatory bowel disease

Network

nt06129  MHC presentation (viruses)
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06162  Hepatitis B virus (HBV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06219  JAK-STAT signaling
nt06229  MHC presentation
nt06263  Hepatocellular carcinoma
nt06266  Non-small cell lung cancer
nt06276  Chronic myeloid leukemia
nt06518  JAK-STAT signaling

Element

N00053

Cytokine-Jak-STAT signaling pathway

N00185

KSHV MIR2 to cell surface molecule-endocytosis

N01559

Type II interferon to Jak-STAT signaling pathway

Disease

H00089

IFN-gamma/IL-12 axis

H00342

Tuberculosis

H00412

Hepatitis B

Drug target

Interferon gamma (DG00737):

D00747<US> D03357<JP> D08805

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    3459 (IFNGR1)
   04066 HIF-1 signaling pathway
    3459 (IFNGR1)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    3459 (IFNGR1)
09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    3459 (IFNGR1)
09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    3459 (IFNGR1)
   04658 Th1 and Th2 cell differentiation
    3459 (IFNGR1)
   04659 Th17 cell differentiation
    3459 (IFNGR1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    3459 (IFNGR1)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    3459 (IFNGR1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    3459 (IFNGR1)
  09172 Infectious disease: viral
   05164 Influenza A
    3459 (IFNGR1)
   05168 Herpes simplex virus 1 infection
    3459 (IFNGR1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    3459 (IFNGR1)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    3459 (IFNGR1)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    3459 (IFNGR1)
   05140 Leishmaniasis
    3459 (IFNGR1)
   05142 Chagas disease
    3459 (IFNGR1)
  09163 Immune disease
   05321 Inflammatory bowel disease
    3459 (IFNGR1)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04050 Cytokine receptors [BR:hsa04050]
    3459 (IFNGR1)
   04090 CD molecules [BR:hsa04090]
    3459 (IFNGR1)
Cytokine receptors [BR:hsa04050]
Interleukin receptor families
  IFN receptor family
   3459 (IFNGR1)
CD molecules [BR:hsa04090]
Proteins
  3459 (IFNGR1)

SSDB

Motif

Pfam:

IFNGR1 Tissue_fac Interfer-bind

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Pharos:

P15260(Tbio)

UniProt:

P15260 A0A0S2Z3Y2

Structure

Position

6:complement(137197484..137219385)

AA seq 489 aa
MALLFLLPLVMQGVSRAEMGTADLGPSSVPTPTNVTIESYNMNPIVYWEYQIMPQVPVFT
VEVKNYGVKNSEWIDACINISHHYCNISDHVGDPSNSLWVRVKARVGQKESAYAKSEEFA
VCRDGKIGPPKLDIRKEEKQIMIDIFHPSVFVNGDEQEVDYDPETTCYIRVYNVYVRMNG
SEIQYKILTQKEDDCDEIQCQLAIPVSSLNSQYCVSAEGVLHVWGVTTEKSKEVCITIFN
SSIKGSLWIPVVAALLLFLVLSLVFICFYIKKINPLKEKSIILPKSLISVVRSATLETKP
ESKYVSLITSYQPFSLEKEVVCEEPLSPATVPGMHTEDNPGKVEHTEELSSITEVVTTEE
NIPDVVPGSHLTPIERESSSPLSSNQSEPGSIALNSYHSRNCSESDHSRNGFDTDSSCLE
SHSSLSDSEFPPNNKGEIKTEGQELITVIKAPTSFGYDKPHVLVDLLVDDSGKESLIGYR
PTEDSKEFS

NT seq 1470 nt +upstreamnt +downstreamnt
atggctctcctctttctcctaccccttgtcatgcagggtgtgagcagggctgagatgggc
accgcggatctggggccgtcctcagtgcctacaccaactaatgttacaattgaatcctat
aacatgaaccctatcgtatattgggagtaccagatcatgccacaggtccctgtttttacc
gtagaggtaaagaactatggtgttaagaattcagaatggattgatgcctgcatcaatatt
tctcatcattattgtaatatttctgatcatgttggtgatccatcaaattctctttgggtc
agagttaaagccagggttggacaaaaagaatctgcctatgcaaagtcagaagaatttgct
gtatgccgagatggaaaaattggaccacctaaactggatatcagaaaggaggagaagcaa
atcatgattgacatatttcacccttcagtttttgtaaatggagacgagcaggaagtcgat
tatgatcccgaaactacctgttacattagggtgtacaatgtgtatgtgagaatgaacgga
agtgagatccagtataaaatactcacgcagaaggaagatgattgtgacgagattcagtgc
cagttagcgattccagtatcctcactgaattctcagtactgtgtttcagcagaaggagtc
ttacatgtgtggggtgttacaactgaaaagtcaaaagaagtttgtattaccattttcaat
agcagtataaaaggttctctttggattccagttgttgctgctttactactctttctagtg
cttagcctggtattcatctgtttttatattaagaaaattaatccattgaaggaaaaaagc
ataatattacccaagtccttgatctctgtggtaagaagtgctactttagagacaaaacct
gaatcaaaatatgtatcactcatcacgtcataccagccattttccttagaaaaggaggtg
gtctgtgaagagccgttgtctccagcaacagttccaggcatgcataccgaagacaatcca
ggaaaagtggaacatacagaagaactttctagtataacagaagtggtgactactgaagaa
aatattcctgacgtggtcccgggcagccatctgactccaatagagagagagagttcttca
cctttaagtagtaaccagtctgaacctggcagcatcgctttaaactcgtatcactccaga
aattgttctgagagtgatcactccagaaatggttttgatactgattccagctgtctggaa
tcacatagctccttatctgactcagaatttcccccaaataataaaggtgaaataaaaaca
gaaggacaagagctcataaccgtaataaaagcccccacctcctttggttatgataaacca
catgtgctagtggatctacttgtggatgatagcggtaaagagtccttgattggttataga
ccaacagaagattccaaagaattttcatga

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