KEGG   Homo sapiens (human): 347688Help
Entry
347688            CDS       T01001                                 

Gene name
TUBB8, OOMD, OOMD2, bA631M21.2
Definition
(RefSeq) tubulin beta 8 class VIII
  KO
K07375  tubulin beta
Organism
hsa  Homo sapiens (human)
Pathway
hsa04145  Phagosome
hsa04540  Gap junction
hsa05130  Pathogenic Escherichia coli infection
Disease
H01897  Oocyte maturation defect
Drug target
Batabulin (DG01412): D03059 D06560
Brentuximab vedotin: D09587
Cabazitaxel (DG00695): D09755 D10452
Cevipabulin (DG01413): D06576 D08889
Colchicine: D00570
Denintuzumab mafodotin: D11232
Docetaxel (DG00694): D02165 D07866
Eribulin: D08914
Estramustine (DG00724): D02398 D04066 D06397
Glembatumumab vedotin: D09912
Indibulin: D10013
Ixabepilone: D04645
Lexibulin: D10073
Lifastuzumab vedotin: D11238
Lisavanbulin: D11494
Maytansine: D04864
Mivobulin isethionate: D05062
Paclitaxel: D00491
Paclitaxel poliglumex: D05333
Podophyllotoxin: D05529
Soblidotin: D01919
Taltobulin: D06001
Tasidotin hydrochloride: D06009
Trastuzumab emtansine: D09980
Verubulin (DG01411): D10029 D10030
Vinblastine (DG00689): D01068 D08675
Vincristine (DG00690): D02197 D08679
Vindesine (DG00691): D01769 D06304
Vinepidine sulfate: D06305
Vinflunine: D09032
Vinglycinate sulfate: D06306
Vinleurosine sulfate: D06307
Vinorelbine (DG00692): D01935 D08680
Vinrosidine sulfate: D06308
Vinzolidine sulfate: D06309
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    347688 (TUBB8)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    347688 (TUBB8)
 09160 Human Diseases
  09171 Infectious diseases: Bacterial
   05130 Pathogenic Escherichia coli infection
    347688 (TUBB8)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    347688 (TUBB8)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    347688 (TUBB8)
   04147 Exosome [BR:hsa04147]
    347688 (TUBB8)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic Type
  Centrosome formation and ciliogenesis proteins
   Microtubules and associated factors
    Other tubulins
     347688 (TUBB8)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulins
    347688 (TUBB8)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   347688 (TUBB8)
  Exosomal proteins of colorectal cancer cells
   347688 (TUBB8)
  Exosomal proteins of bladder cancer cells
   347688 (TUBB8)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Tubulin Tubulin_C Misat_Tub_SegII Tubulin_3 Tubulin_2
Motif
Other DBs
NCBI-GeneID: 347688
NCBI-ProteinID: NP_817124
OMIM: 616768
HGNC: 20773
Ensembl: ENSG00000261456
Vega: OTTHUMG00000174803
Pharos: Q3ZCM7(Tclin)
UniProt: Q3ZCM7
Position
10p15.3
AA seq 444 aa AA seqDB search
MREIVLTQIGQCGNQIGAKFWEVISDEHAIDSAGTYHGDSHLQLERINVYYNEASGGRYV
PRAVLVDLEPGTMDSVRSGPFGQVFRPDNFIFGQCGAGNNWAKGHYTEGAELMESVMDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLLSKIREEYPDRIINTFSILPSPKVSDTVV
EPYNATLSVHQLIENADETFCIDNEALYDICSKTLKLPTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVAELTQQMFDAKNMM
AACDPRHGRYLTAAAIFRGRMPMREVDEQMFNIQDKNSSYFADWLPNNVKTAVCDIPPRG
LKMSATFIGNNTAIQELFKRVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEEEDEEYAEEEVA
NT seq 1335 nt NT seq  +upstreamnt  +downstreamnt
atgagggagatcgtgctcacgcagatcgggcagtgcgggaatcagatcggcgccaagttc
tgggaggtgatctctgatgaacatgccatcgactccgctggcacctaccacggggacagc
cacctgcagctggagcgcatcaacgtgtactacaacgaggccagcggtggcaggtacgtg
ccccgcgctgtgctcgtggatctggagccgggcaccatggactctgtgcgctcggggccc
ttcgggcaggtcttcaggccagacaacttcatcttcggtcagtgtggggccggaaacaac
tgggccaagggacactacaccgaaggcgcggagctgatggagtcagtgatggacgttgtc
agaaaggaggctgagagctgtgactgcctgcagggtttccagctgacccactccctgggt
ggggggactgggtctgggatgggtacccttctgctcagtaagatccgggaggagtaccca
gacaggatcataaacacattcagcatcctgccctcgcccaaggtgtcggacaccgtggtg
gagccctacaacgccaccctctcagtccaccagctcatagaaaacgcagatgagaccttt
tgcatagataacgaagctctgtatgacatatgttccaagaccctaaaactgcccacaccc
acctatggtgacctgaaccacctggtgtctgctaccatgagtggggtcaccacgtgcctg
cgcttcccgggccagctgaatgctgacctgcggaagctggccgtgaacatggtcccgttt
ccccggctgcatttcttcatgcccggctttgccccactgaccagccggggcagccagcag
taccgggccttgactgtggctgagcttacccagcagatgtttgatgctaagaacatgatg
gctgcctgtgacccccgtcacggccgctacctaacggcggctgccattttcaggggtcgc
atgcccatgagggaggtggatgaacaaatgttcaacattcaagataagaacagcagttac
tttgctgactggctccccaacaacgtaaaaacagccgtctgtgacatcccaccccggggg
ctaaaaatgtcagccaccttcattgggaataatacggccatccaggaactcttcaagcgt
gtctcagagcagtttacagcaatgttcaggcgcaaggccttcctccactggtacacgggc
gagggcatggatgagatggaattcaccgaggccgagagcaacatgaacgacctggtgtct
gaatatcagcaatatcaggatgccacggccgaggaggaggaggatgaggagtatgccgag
gaggaggtggcctag

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (3)   
   KEGG PATHWAY (3)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Drug (46)   
   KEGG DRUG (46)   
Genome (1)   
   KEGG GENOME (1)   
Gene (128)   
   KEGG ORTHOLOGY (1)   
   RefGene (119)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   UniGene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (7)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (10)   
   RefSeq(nuc) (6)   
   GenBank (2)   
   EMBL (2)   
Protein domain (5)   
   Pfam (5)   
All databases (207)   

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