Entry |
|
Symbol |
TUBB8, OOMD, OOMD2, OZEMA2, bA631M21.2
|
Name |
(RefSeq) tubulin beta 8 class VIII
|
KO |
|
Organism |
|
Pathway |
hsa05022 | Pathways of neurodegeneration - multiple diseases |
hsa05130 | Pathogenic Escherichia coli infection |
|
Network |
|
Element |
N00976 | Retrograde axonal transport |
N00977 | Mutation-caused aberrant Htt to retrograde axonal transport |
N00978 | Anterograde axonal transport |
N00979 | Mutation-caused aberrant Htt to anterograde axonal transport |
N01018 | Mutation-caused aberrant Abeta to anterograde axonal transport |
N01055 | Mutation-caused aberrant SNCA to anterograde axonal transport |
N01158 | Mutation-caused aberrant DCTN1 to retrograde axonal transport |
N01285 | Microtubule-RHOA signaling pathway |
N01286 | Escherichia EspG to Microtubule-RHOA signaling pathway |
N01295 | Rab7-regulated microtubule minus-end directed transport |
N01297 | Arl8-regulated microtubule plus-end directed transport |
N01298 | Salmonella SifA to microtubule plus-end directed transport |
N01299 | Salmonella PipB2 to microtubule plus-end directed transport |
N01403 | Zn to anterograde axonal transport |
N01414 | Iron to anterograde axonal transport |
N01535 | Kinetochore microtubule attachment |
N01547 | Kinetochore fiber organization |
N01549 | Branching microtubule nucleation |
N01553 | Promotion of microtubule growth |
N01561 | Microtubule depolymerization |
N01562 | Microtubule depolymerization at the minus ends |
N01832 | NTN1-MAP1B axon guidance signaling |
N01833 | DRAXIN-MAP1B axon guidance signaling |
N01834 | SEMA3A-MAP1B axon guidance signaling |
N01835 | SEMA3-CRMP2/MAPT axon guidance signaling |
N01836 | Microtubule plus end regulation network |
N01837 | Regulation of neurite extension, NAV1-TRIO |
N01838 | Regulation of synaptic plasticity, p140Cap |
N01839 | Severing of microtubule, SPAST/KATN |
N01840 | Severing of microtubule, KIF2A |
N01841 | Anterograde axonal transport, Kinesin-2 |
N01842 | Anterograde axonal/dendrite transport, Kinesin-3 |
N01843 | Anterograde dendrite transport, Kinesin-4 |
N01844 | Anterograde dendrite transport, Kinesin-6 |
N01845 | Anterograde axonal/dendrite transport, Kinesin-12 |
N01846 | Retrograde axonal/dendrite transport, Dynein |
N01857 | SEMA3A-DCX axon guidance signaling |
N01858 | EFNB1-MAPT axon guidance signaling |
N01859 | Anterograde axonal/dendrite transport, Kinesin-1 |
|
Disease |
H01897 | Oocyte/zygote/embryo maturation arrest |
|
Drug target |
Belantamab mafodotin: | D11595<JP> |
Brentuximab vedotin: | D09587<JP/US> |
Denintuzumab mafodotin: | D11232 |
Enfortumab vedotin: | D11525<JP/US> |
Farletuzumab ecteribulin: | D12183 |
Lorvotuzumab mertansine: | D09927 |
Mirvetuximab soravtansine: | D10954<US> |
Tasidotin hydrochloride: | D06009 |
Tisotumab vedotin: | D11814<JP/US> |
Trastuzumab emtansine: | D09980<JP/US> |
Tusamitamab ravtansine: | D12310 |
|
Brite |
KEGG Orthology (KO) [BR:hsa00001]
09140 Cellular Processes
09141 Transport and catabolism
04145 Phagosome
347688 (TUBB8)
09144 Cellular community - eukaryotes
04540 Gap junction
347688 (TUBB8)
09142 Cell motility
04814 Motor proteins
347688 (TUBB8)
09160 Human Diseases
09171 Infectious disease: bacterial
05130 Pathogenic Escherichia coli infection
347688 (TUBB8)
05132 Salmonella infection
347688 (TUBB8)
09164 Neurodegenerative disease
05010 Alzheimer disease
347688 (TUBB8)
05012 Parkinson disease
347688 (TUBB8)
05014 Amyotrophic lateral sclerosis
347688 (TUBB8)
05016 Huntington disease
347688 (TUBB8)
05020 Prion disease
347688 (TUBB8)
05022 Pathways of neurodegeneration - multiple diseases
347688 (TUBB8)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:hsa03036]
347688 (TUBB8)
09183 Protein families: signaling and cellular processes
04812 Cytoskeleton proteins [BR:hsa04812]
347688 (TUBB8)
04147 Exosome [BR:hsa04147]
347688 (TUBB8)
Chromosome and associated proteins [BR:hsa03036]
Eukaryotic type
Centrosome formation proteins
Microtubules and associated factors
Other tubulins
347688 (TUBB8)
Cytoskeleton proteins [BR:hsa04812]
Eukaryotic cytoskeleton proteins
Microtubules
Tubulins
347688 (TUBB8)
Exosome [BR:hsa04147]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
347688 (TUBB8)
Exosomal proteins of colorectal cancer cells
347688 (TUBB8)
Exosomal proteins of bladder cancer cells
347688 (TUBB8)
|
SSDB |
|
Motif |
|
Other DBs |
|
Position |
10:complement(46455..76621)
|
AA seq |
444 aa
MREIVLTQIGQCGNQIGAKFWEVISDEHAIDSAGTYHGDSHLQLERINVYYNEASGGRYV
PRAVLVDLEPGTMDSVRSGPFGQVFRPDNFIFGQCGAGNNWAKGHYTEGAELMESVMDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLLSKIREEYPDRIINTFSILPSPKVSDTVV
EPYNATLSVHQLIENADETFCIDNEALYDICSKTLKLPTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVAELTQQMFDAKNMM
AACDPRHGRYLTAAAIFRGRMPMREVDEQMFNIQDKNSSYFADWLPNNVKTAVCDIPPRG
LKMSATFIGNNTAIQELFKRVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEEEDEEYAEEEVA |
NT seq |
1335 nt +upstreamnt +downstreamnt
atgagggagatcgtgctcacgcagatcgggcagtgcgggaatcagatcggcgccaagttc
tgggaggtgatctctgatgaacatgccatcgactccgctggcacctaccacggggacagc
cacctgcagctggagcgcatcaacgtgtactacaacgaggccagcggtggcaggtacgtg
ccccgcgctgtgctcgtggatctggagccgggcaccatggactctgtgcgctcggggccc
ttcgggcaggtcttcaggccagacaacttcatcttcggtcagtgtggggccggaaacaac
tgggccaagggacactacaccgaaggcgcggagctgatggagtcagtgatggacgttgtc
agaaaggaggctgagagctgtgactgcctgcagggtttccagctgacccactccctgggt
ggggggactgggtctgggatgggtacccttctgctcagtaagatccgggaggagtaccca
gacaggatcataaacacattcagcatcctgccctcgcccaaggtgtcggacaccgtggtg
gagccctacaacgccaccctctcagtccaccagctcatagaaaacgcagatgagaccttt
tgcatagataacgaagctctgtatgacatatgttccaagaccctaaaactgcccacaccc
acctatggtgacctgaaccacctggtgtctgctaccatgagtggggtcaccacgtgcctg
cgcttcccgggccagctgaatgctgacctgcggaagctggccgtgaacatggtcccgttt
ccccggctgcatttcttcatgcccggctttgccccactgaccagccggggcagccagcag
taccgggccttgactgtggctgagcttacccagcagatgtttgatgctaagaacatgatg
gctgcctgtgacccccgtcacggccgctacctaacggcggctgccattttcaggggtcgc
atgcccatgagggaggtggatgaacaaatgttcaacattcaagataagaacagcagttac
tttgctgactggctccccaacaacgtaaaaacagccgtctgtgacatcccaccccggggg
ctaaaaatgtcagccaccttcattgggaataatacggccatccaggaactcttcaagcgt
gtctcagagcagtttacagcaatgttcaggcgcaaggccttcctccactggtacacgggc
gagggcatggatgagatggaattcaccgaggccgagagcaacatgaacgacctggtgtct
gaatatcagcaatatcaggatgccacggccgaggaggaggaggatgaggagtatgccgag
gaggaggtggcctag |