KEGG T01001: 347688

Homo sapiens (human): 347688

Entry

347688 CDS T01001

Gene name

TUBB8, OOMD, OOMD2, bA631M21.2

Definition

(RefSeq) tubulin beta 8 class VIII

K07375

tubulin beta

Organism

hsa Homo sapiens (human)

Pathway

hsa04145

Phagosome

hsa04540

Gap junction

hsa05010

Alzheimer disease

hsa05012

Parkinson disease

hsa05014

Amyotrophic lateral sclerosis

hsa05016

Huntington disease

hsa05020

Prion disease

hsa05022

Pathways of neurodegeneration - multiple diseases

hsa05130

Pathogenic Escherichia coli infection

hsa05132

Salmonella infection

Network

nt06419  Microtubule-based transport
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease

Element

N00976

Retrograde axonal transport

N00977

Mutation-caused aberrant Htt to retrograde axonal transport

N00978

Anterograde axonal transport

N00979

Mutation-caused aberrant Htt to anterograde axonal transport

N01018

Mutation-caused aberrant Abeta to anterograde axonal transport

N01055

Mutation-caused aberrant SNCA to anterograde axonal transport

N01158

Mutation-caused aberrant DCTN1 to retrograde axonal transport

Disease

H01897

Oocyte maturation defect

Drug target

Avanbulin:

D11681

Batabulin (DG01412):

D03059 D06560

Brentuximab vedotin:

D09587<JP/US>

Cabazitaxel (DG00695):

D09755 D10452<JP/US>

Cevipabulin (DG01413):

D06576 D08889

Colchicine:

D00570<JP/US>

Denintuzumab mafodotin:

D11232

Docetaxel (DG00694):

D02165<JP/US> D07866<JP/US>

Enfortumab vedotin:

D11525<US>

Eribulin:

D08914<JP/US>

Estramustine (DG00724):

D02398 D04066 D06397<JP/US>

Glembatumumab vedotin:

D09912

Indibulin:

D10013

Ixabepilone:

D04645<US>

Lexibulin:

D10073

Lifastuzumab vedotin:

D11238

Lisavanbulin:

D11494

Maytansine:

D04864

Mivobulin isethionate:

D05062

Paclitaxel:

D00491<JP/US>

Paclitaxel poliglumex:

D05333

Podophyllotoxin:

D05529<US>

Soblidotin:

D01919

Taltobulin:

D06001

Tasidotin hydrochloride:

D06009

Trastuzumab emtansine:

D09980<JP/US>

Verubulin (DG01411):

D10029 D10030

Vinblastine (DG00689):

D01068<JP/US> D08675

Vincristine (DG00690):

D02197<JP/US> D08679

Vindesine (DG00691):

D01769<JP> D06304

Vinepidine sulfate:

D06305

Vinflunine:

D09032

Vinglycinate sulfate:

D06306

Vinleurosine sulfate:

D06307

Vinorelbine (DG00692):

D01935<JP/US> D08680

Vinrosidine sulfate:

D06308

Vinzolidine sulfate:

D06309

Brite

KEGG Orthology (KO) [BR:hsa00001]
09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    347688 (TUBB8)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    347688 (TUBB8)
09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    347688 (TUBB8)
   05012 Parkinson disease
    347688 (TUBB8)
   05014 Amyotrophic lateral sclerosis
    347688 (TUBB8)
   05016 Huntington disease
    347688 (TUBB8)
   05020 Prion disease
    347688 (TUBB8)
   05022 Pathways of neurodegeneration - multiple diseases
    347688 (TUBB8)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    347688 (TUBB8)
   05132 Salmonella infection
    347688 (TUBB8)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    347688 (TUBB8)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    347688 (TUBB8)
   04147 Exosome [BR:hsa04147]
    347688 (TUBB8)
Chromosome and associated proteins [BR:hsa03036]
Eukaryotic type
  Centrosome formation and ciliogenesis proteins
   Microtubules and associated factors
    Other tubulins
     347688 (TUBB8)
Cytoskeleton proteins [BR:hsa04812]
Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulins
    347688 (TUBB8)
Exosome [BR:hsa04147]
Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   347688 (TUBB8)
  Exosomal proteins of colorectal cancer cells
   347688 (TUBB8)
  Exosomal proteins of bladder cancer cells
   347688 (TUBB8)

SSDB

Motif

Pfam:

Tubulin Tubulin_C Misat_Tub_SegII Tubulin_3 Tubulin_2

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

Q3ZCM7(Tclin)

UniProt:

Q3ZCM7

Position

10p15.3

AA seq 444 aa
MREIVLTQIGQCGNQIGAKFWEVISDEHAIDSAGTYHGDSHLQLERINVYYNEASGGRYV
PRAVLVDLEPGTMDSVRSGPFGQVFRPDNFIFGQCGAGNNWAKGHYTEGAELMESVMDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLLSKIREEYPDRIINTFSILPSPKVSDTVV
EPYNATLSVHQLIENADETFCIDNEALYDICSKTLKLPTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVAELTQQMFDAKNMM
AACDPRHGRYLTAAAIFRGRMPMREVDEQMFNIQDKNSSYFADWLPNNVKTAVCDIPPRG
LKMSATFIGNNTAIQELFKRVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEEEDEEYAEEEVA

NT seq 1335 nt +upstreamnt +downstreamnt
atgagggagatcgtgctcacgcagatcgggcagtgcgggaatcagatcggcgccaagttc
tgggaggtgatctctgatgaacatgccatcgactccgctggcacctaccacggggacagc
cacctgcagctggagcgcatcaacgtgtactacaacgaggccagcggtggcaggtacgtg
ccccgcgctgtgctcgtggatctggagccgggcaccatggactctgtgcgctcggggccc
ttcgggcaggtcttcaggccagacaacttcatcttcggtcagtgtggggccggaaacaac
tgggccaagggacactacaccgaaggcgcggagctgatggagtcagtgatggacgttgtc
agaaaggaggctgagagctgtgactgcctgcagggtttccagctgacccactccctgggt
ggggggactgggtctgggatgggtacccttctgctcagtaagatccgggaggagtaccca
gacaggatcataaacacattcagcatcctgccctcgcccaaggtgtcggacaccgtggtg
gagccctacaacgccaccctctcagtccaccagctcatagaaaacgcagatgagaccttt
tgcatagataacgaagctctgtatgacatatgttccaagaccctaaaactgcccacaccc
acctatggtgacctgaaccacctggtgtctgctaccatgagtggggtcaccacgtgcctg
cgcttcccgggccagctgaatgctgacctgcggaagctggccgtgaacatggtcccgttt
ccccggctgcatttcttcatgcccggctttgccccactgaccagccggggcagccagcag
taccgggccttgactgtggctgagcttacccagcagatgtttgatgctaagaacatgatg
gctgcctgtgacccccgtcacggccgctacctaacggcggctgccattttcaggggtcgc
atgcccatgagggaggtggatgaacaaatgttcaacattcaagataagaacagcagttac
tttgctgactggctccccaacaacgtaaaaacagccgtctgtgacatcccaccccggggg
ctaaaaatgtcagccaccttcattgggaataatacggccatccaggaactcttcaagcgt
gtctcagagcagtttacagcaatgttcaggcgcaaggccttcctccactggtacacgggc
gagggcatggatgagatggaattcaccgaggccgagagcaacatgaacgacctggtgtct
gaatatcagcaatatcaggatgccacggccgaggaggaggaggatgaggagtatgccgag
gaggaggtggcctag

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