KEGG   Homo sapiens (human): 348654
Entry
348654            CDS       T01001                                 
Symbol
GEN1, Gen
Name
(RefSeq) GEN1 Holliday junction 5' flap endonuclease
  KO
K15338  holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
Organism
hsa  Homo sapiens (human)
Network
nt06506  Double-strand break repair
  Element
N01448  Double Holliday junction resolution
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins [BR:hsa03400]
    348654 (GEN1)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  DSBR (double strand breaks repair)
   HR (homologous recombination)
    Other HR factors
     348654 (GEN1)
SSDB
Motif
Pfam: XPG_I Chromo_2 XPG_N SpoU_methylas_C
Other DBs
NCBI-GeneID: 348654
NCBI-ProteinID: NP_001123481
OMIM: 612449
HGNC: 26881
Ensembl: ENSG00000178295
UniProt: Q17RS7
Structure
Position
2:17753278..17788946
AA seq 908 aa
MGVNDLWQILEPVKQHIPLRNLGGKTIAVDLSLWVCEAQTVKKMMGSVMKPHLRNLFFRI
SYLTQMDVKLVFVMEGEPPKLKADVISKRNQSRYGSSGKSWSQKTGRSHFKSVLRECLHM
LECLGIPWVQAAGEAEAMCAYLNAGGHVDGCLTNDGDTFLYGAQTVYRNFTMNTKDPHVD
CYTMSSIKSKLGLDRDALVGLAILLGCDYLPKGVPGVGKEQALKLIQILKGQSLLQRFNR
WNETSCNSSPQLLVTKKLAHCSVCSHPGSPKDHERNGCRLCKSDKYCEPHDYEYCCPCEW
HRTEHDRQLSEVENNIKKKACCCEGFPFHEVIQEFLLNKDKLVKVIRYQRPDLLLFQRFT
LEKMEWPNHYACEKLLVLLTHYDMIERKLGSRNSNQLQPIRIVKTRIRNGVHCFEIEWEK
PEHYAMEDKQHGEFALLTIEEESLFEAAYPEIVAVYQKQKLEIKGKKQKRIKPKENNLPE
PDEVMSFQSHMTLKPTCEIFHKQNSKLNSGISPDPTLPQESISASLNSLLLPKNTPCLNA
QEQFMSSLRPLAIQQIKAVSKSLISESSQPNTSSHNISVIADLHLSTIDWEGTSFSNSPA
IQRNTFSHDLKSEVESELSAIPDGFENIPEQLSCESERYTANIKKVLDEDSDGISPEEHL
LSGITDLCLQDLPLKERIFTKLSYPQDNLQPDVNLKTLSILSVKESCIANSGSDCTSHLS
KDLPGIPLQNESRDSKILKGDQLLQEDYKVNTSVPYSVSNTVVKTCNVRPPNTALDHSRK
VDMQTTRKILMKKSVCLDRHSSDEQSAPVFGKAKYTTQRMKHSSQKHNSSHFKESGHNKL
SSPKIHIKETEQCVRSYETAENEESCFPDSTKSSLSSLQCHKKENNSGTCLDSPLPLRQR
LKLRFQST
NT seq 2727 nt   +upstreamnt  +downstreamnt
atgggagtgaatgacttgtggcaaattttggagcctgttaagcaacacatccccttgcgt
aatcttggtgggaaaaccattgcagttgatctgagtctctgggtgtgtgaggcacagaca
gtcaaaaaaatgatgggcagcgtcatgaagccccacctcaggaacttattttttcgtatc
tcatatttaacacaaatggatgtaaaactggtatttgttatggaaggggaaccaccaaag
ctgaaagctgatgtcataagcaagaggaatcagtctcggtatgggtcttctggaaaatcg
tggtctcagaaaacagggagatcacattttaaatcagtcttaagagagtgcctccatatg
ctcgaatgcttaggaatcccctgggttcaggctgctggggaagctgaagccatgtgtgct
tatctcaatgctggtggtcatgtcgatggctgcctcaccaatgatggagatactttcctt
tatggggcccagactgtttacaggaatttcactatgaatacaaaggacccacatgttgac
tgttacacaatgtcatctatcaagagtaaactaggtttggatagagatgctctggttgga
ttagcaatacttcttggctgtgattatctcccaaagggagtccctggagttggaaaagag
caagcattaaaacttatacagattttgaaagggcaaagtttacttcagaggtttaatcgg
tggaatgaaacatcttgtaactctagtccacaactgctagtcactaaaaaactggctcat
tgttccgtatgttcccatccaggttcacctaaggatcatgaacgtaatggatgcagatta
tgtaaaagtgataaatattgtgagccacatgactatgaatactgctgtccttgtgagtgg
caccgtacagaacatgataggcaactcagtgaagtagagaacaatattaagaagaaagct
tgctgttgtgagggattcccattccatgaggttattcaagaattccttttaaacaaggat
aaattggtgaaggttatcaggtaccaaagacctgatttgttattgtttcagagatttact
cttgaaaaaatggagtggcccaatcactatgcatgtgagaaattgctggtacttttgacc
cattatgacatgatagaaagaaagcttggtagcagaaactctaatcaactacagccaatt
cgaattgttaagactcgaatcagaaatggagttcattgttttgaaatagaatgggaaaag
cctgaacattatgctatggaagataaacaacatggagaatttgctttattaacaattgag
gaagaatcattgtttgaagcagcatatcctgagatcgttgctgtttaccaaaaacaaaag
ttagaaattaaagggaagaaacaaaaacgtattaagcctaaagaaaacaatttgccagaa
ccagatgaagtaatgagctttcagtcacacatgactttaaaacccacatgtgaaatcttt
cataagcagaattccaagttaaattcggggatttcccctgatcctacattaccacaggaa
tctatttctgcctcattgaatagcttgcttttacctaaaaatactccatgtttgaatgca
caagaacagttcatgtcttctctaagacctttggctatacagcaaattaaagctgtcagt
aagtctctaatttcagaatctagtcaacccaatacctcatctcataatatatccgtgatt
gctgatctacacttgagcactattgactgggaaggtacttcttttagtaattctccagct
attcaaaggaatactttttctcatgatttaaaatcagaagttgaatcagagctatcagcc
atccctgatggctttgaaaatatcccagaacaactgtcctgtgaatcagaaaggtacact
gcaaacataaagaaagtgttggatgaggattctgatgggattagtcctgaagagcatcta
ctttctggcattactgatttatgtcttcaggatttgcctttaaaggaacgaatatttaca
aaattatcatatcctcaggataatctacaaccagatgtcaacctgaaaactttgtccata
cttagtgtaaaagaatcttgtattgctaacagtggttctgattgtacatcacatctttca
aaggatcttccaggaattcccttgcaaaatgaatccagagactctaaaattctaaaagga
gaccagctgcttcaagaagactataaagtcaatacttctgtcccttattctgtcagtaac
acagtggtaaagacctgcaatgttagaccaccaaatactgctttagatcatagtagaaaa
gttgatatgcaaaccactcggaaaattttaatgaagaagagtgtttgccttgacagacat
tcctctgatgaacaaagtgccccagtgtttgggaaagctaagtacacaactcaaagaatg
aagcacagttctcaaaagcataattcatcccatttcaaagaaagtggccataacaagttg
agtagccctaagatacatattaaagaaactgaacagtgtgtcagatcttatgaaacagct
gaaaatgaagaaagctgtttcccagattcaacaaaaagttctctgagttctctacaatgt
cataagaaagaaaacaactctggtacttgtttggatagccctcttcctttacgccagaga
ttaaaactaagattccaaagcacttga

  All links  
Disease (1)   
   OMIM (1)   
Gene (21)   
   RefGene (16)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (26)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (24)   
DNA sequence (50)   
   RefSeq(nuc) (24)   
   GenBank (13)   
   EMBL (13)   
3D Structure (1)   
   PDB (1)   
Protein domain (4)   
   Pfam (4)   
All databases (103)   

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