KEGG   Homo sapiens (human): 3552
Entry
3552              CDS       T01001                                 
Symbol
IL1A, IL-1_alpha, IL-1A, IL1, IL1-ALPHA, IL1F1
Name
(RefSeq) interleukin 1 alpha
  KO
K04383  interleukin 1 alpha
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04217  Necroptosis
hsa04218  Cellular senescence
hsa04380  Osteoclast differentiation
hsa04640  Hematopoietic cell lineage
hsa04932  Non-alcoholic fatty liver disease
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa04940  Type I diabetes mellitus
hsa05010  Alzheimer disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05133  Pertussis
hsa05140  Leishmaniasis
hsa05152  Tuberculosis
hsa05162  Measles
hsa05164  Influenza A
hsa05321  Inflammatory bowel disease
hsa05323  Rheumatoid arthritis
hsa05332  Graft-versus-host disease
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06211  Other MAPK signaling (cancer)
nt06526  MAPK signaling
  Element
N00186  IL1-IL1R-p38 signaling pathway
N00188  IL1-IL1R-JNK signaling pathway
Disease
H00084  Graft-versus-host disease
Drug target
Bermekimab: D11253
Lunlekitug: D12851
Lutikizumab: D12370
Pirfenidone: D01583<JP/US>
Rilonacept: D06635<US>
Vilamakitug: D12350
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    3552 (IL1A)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    3552 (IL1A)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    3552 (IL1A)
   04218 Cellular senescence
    3552 (IL1A)
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    3552 (IL1A)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    3552 (IL1A)
 09160 Human Diseases
  09172 Infectious disease: viral
   05164 Influenza A
    3552 (IL1A)
   05162 Measles
    3552 (IL1A)
  09171 Infectious disease: bacterial
   05133 Pertussis
    3552 (IL1A)
   05152 Tuberculosis
    3552 (IL1A)
  09174 Infectious disease: parasitic
   05140 Leishmaniasis
    3552 (IL1A)
  09163 Immune disease
   05323 Rheumatoid arthritis
    3552 (IL1A)
   05321 Inflammatory bowel disease
    3552 (IL1A)
   05332 Graft-versus-host disease
    3552 (IL1A)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    3552 (IL1A)
   05020 Prion disease
    3552 (IL1A)
   05022 Pathways of neurodegeneration - multiple diseases
    3552 (IL1A)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    3552 (IL1A)
  09167 Endocrine and metabolic disease
   04940 Type I diabetes mellitus
    3552 (IL1A)
   04932 Non-alcoholic fatty liver disease
    3552 (IL1A)
   04933 AGE-RAGE signaling pathway in diabetic complications
    3552 (IL1A)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    3552 (IL1A)
Cytokines and neuropeptides [BR:hsa04052]
 Cytokines
  Interleukins
   3552 (IL1A)
SSDB
Motif
Pfam: IL1_propep IL1 DUF6108
Other DBs
NCBI-GeneID: 3552
NCBI-ProteinID: NP_000566
OMIM: 147760
HGNC: 5991
Ensembl: ENSG00000115008
UniProt: P01583
Structure
Position
2:complement(112773925..112784493)
AA seq 271 aa
MAKVPDMFEDLKNCYSENEEDSSSIDHLSLNQKSFYHVSYGPLHEGCMDQSVSLSISETS
KTSKLTFKESMVVVATNGKVLKKRRLSLSQSITDDDLEAIANDSEEEIIKPRSAPFSFLS
NVKYNFMRIIKYEFILNDALNQSIIRANDQYLTAAALHNLDEAVKFDMGAYKSSKDDAKI
TVILRISKTQLYVTAQDEDQPVLLKEMPEIPKTITGSETNLLFFWETHGTKNYFTSVAHP
NLFIATKQDYWVCLAGGPPSITDFQILENQA
NT seq 816 nt   +upstreamnt  +downstreamnt
atggccaaagttccagacatgtttgaagacctgaagaactgttacagtgaaaatgaagaa
gacagttcctccattgatcatctgtctctgaatcagaaatccttctatcatgtaagctat
ggcccactccatgaaggctgcatggatcaatctgtgtctctgagtatctctgaaacctct
aaaacatccaagcttaccttcaaggagagcatggtggtagtagcaaccaacgggaaggtt
ctgaagaagagacggttgagtttaagccaatccatcactgatgatgacctggaggccatc
gccaatgactcagaggaagaaatcatcaagcctaggtcagcaccttttagcttcctgagc
aatgtgaaatacaactttatgaggatcatcaaatacgaattcatcctgaatgacgccctc
aatcaaagtataattcgagccaatgatcagtacctcacggctgctgcattacataatctg
gatgaagcagtgaaatttgacatgggtgcttataagtcatcaaaggatgatgctaaaatt
accgtgattctaagaatctcaaaaactcaattgtatgtgactgcccaagatgaagaccaa
ccagtgctgctgaaggagatgcctgagatacccaaaaccatcacaggtagtgagaccaac
ctcctcttcttctgggaaactcacggcactaagaactatttcacatcagttgcccatcca
aacttgtttattgccacaaagcaagactactgggtgtgcttggcaggggggccaccctct
atcactgactttcagatactggaaaaccaggcgtag

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (21)   
   KEGG PATHWAY (21)   
Network (5)   
   KEGG NETWORK (5)   
Disease (2)   
   KEGG DISEASE (1)   
   OMIM (1)   
Drug (6)   
   KEGG DRUG (6)   
Genome (1)   
   KEGG GENOME (1)   
Gene (10)   
   KEGG ORTHOLOGY (1)   
   RefGene (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (24)   
   RefSeq(nuc) (2)   
   GenBank (11)   
   EMBL (11)   
3D Structure (4)   
   PDB (4)   
Protein domain (3)   
   Pfam (3)   
All databases (82)   

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