KEGG   Homo sapiens (human): 3553
Entry
3553              CDS       T01001                                 

Gene name
IL1B, IL-1, IL1-BETA, IL1F2, IL1beta
Definition
(RefSeq) interleukin 1 beta
  KO
K04519  interleukin 1 beta
Organism
hsa  Homo sapiens (human)
Pathway
hsa01523  Antifolate resistance
hsa04010  MAPK signaling pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04064  NF-kappa B signaling pathway
hsa04217  Necroptosis
hsa04380  Osteoclast differentiation
hsa04620  Toll-like receptor signaling pathway
hsa04621  NOD-like receptor signaling pathway
hsa04623  Cytosolic DNA-sensing pathway
hsa04625  C-type lectin receptor signaling pathway
hsa04640  Hematopoietic cell lineage
hsa04657  IL-17 signaling pathway
hsa04659  Th17 cell differentiation
hsa04668  TNF signaling pathway
hsa04750  Inflammatory mediator regulation of TRP channels
hsa04932  Non-alcoholic fatty liver disease
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa04940  Type I diabetes mellitus
hsa05010  Alzheimer disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05130  Pathogenic Escherichia coli infection
hsa05131  Shigellosis
hsa05132  Salmonella infection
hsa05133  Pertussis
hsa05134  Legionellosis
hsa05135  Yersinia infection
hsa05140  Leishmaniasis
hsa05142  Chagas disease
hsa05143  African trypanosomiasis
hsa05144  Malaria
hsa05146  Amoebiasis
hsa05152  Tuberculosis
hsa05162  Measles
hsa05163  Human cytomegalovirus infection
hsa05164  Influenza A
hsa05168  Herpes simplex virus 1 infection
hsa05171  Coronavirus disease - COVID-19
hsa05321  Inflammatory bowel disease
hsa05323  Rheumatoid arthritis
hsa05332  Graft-versus-host disease
hsa05417  Lipid and atherosclerosis
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06110  MAPK signaling (viruses and bacteria)
nt06139  NLR signaling (viruses and bacteria)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06170  Influenza A virus (IAV)
nt06171  Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
nt06211  Other MAPK signaling
  Element
N00186  IL1-IL1R-p38 signaling pathway
N00188  IL1-IL1R-JNK signaling pathway
N00742  NLRP3 Inflammasome signaling pathway
N00867  NLRC4 Inflammasome signaling pathway
N00868  Pyrin Inflammasome signaling pathway
N00934  Non-canonical inflammasome signaling pathway
N00948  Shigella IpaH7.8 to NLRP3 Inflammasome signaling pathway
N00949  Shigella IpaB to NLRC4 Inflammasome signaling pathway
N01126  Salmonella SipB to Inflammasome signaling pathway
N01127  Salmonella SopE to Inflammasome signaling pathway
N01307  SARS-CoV-2 S to AngII-AT1R-NOX2 signaling pathway
Disease
H01492  Systemic sclerosis
Drug target
Canakinumab: D09315<JP/US>
Gevokizumab: D09911
Pirfenidone: D01583<JP/US>
Rilonacept: D06635<US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    3553 (IL1B)
   04064 NF-kappa B signaling pathway
    3553 (IL1B)
   04668 TNF signaling pathway
    3553 (IL1B)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    3553 (IL1B)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    3553 (IL1B)
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    3553 (IL1B)
   04620 Toll-like receptor signaling pathway
    3553 (IL1B)
   04621 NOD-like receptor signaling pathway
    3553 (IL1B)
   04623 Cytosolic DNA-sensing pathway
    3553 (IL1B)
   04625 C-type lectin receptor signaling pathway
    3553 (IL1B)
   04659 Th17 cell differentiation
    3553 (IL1B)
   04657 IL-17 signaling pathway
    3553 (IL1B)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    3553 (IL1B)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    3553 (IL1B)
 09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    3553 (IL1B)
   05164 Influenza A
    3553 (IL1B)
   05162 Measles
    3553 (IL1B)
   05168 Herpes simplex virus 1 infection
    3553 (IL1B)
   05163 Human cytomegalovirus infection
    3553 (IL1B)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    3553 (IL1B)
   05132 Salmonella infection
    3553 (IL1B)
   05131 Shigellosis
    3553 (IL1B)
   05135 Yersinia infection
    3553 (IL1B)
   05133 Pertussis
    3553 (IL1B)
   05134 Legionellosis
    3553 (IL1B)
   05152 Tuberculosis
    3553 (IL1B)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    3553 (IL1B)
   05144 Malaria
    3553 (IL1B)
   05140 Leishmaniasis
    3553 (IL1B)
   05142 Chagas disease
    3553 (IL1B)
   05143 African trypanosomiasis
    3553 (IL1B)
  09163 Immune disease
   05323 Rheumatoid arthritis
    3553 (IL1B)
   05321 Inflammatory bowel disease
    3553 (IL1B)
   05332 Graft-versus-host disease
    3553 (IL1B)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    3553 (IL1B)
   05020 Prion disease
    3553 (IL1B)
   05022 Pathways of neurodegeneration - multiple diseases
    3553 (IL1B)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    3553 (IL1B)
   05418 Fluid shear stress and atherosclerosis
    3553 (IL1B)
  09167 Endocrine and metabolic disease
   04940 Type I diabetes mellitus
    3553 (IL1B)
   04932 Non-alcoholic fatty liver disease
    3553 (IL1B)
   04933 AGE-RAGE signaling pathway in diabetic complications
    3553 (IL1B)
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    3553 (IL1B)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors [BR:hsa04052]
    3553 (IL1B)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    3553 (IL1B)
Cytokines and growth factors [BR:hsa04052]
 Cytokines
  Interleukins
   3553 (IL1B)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate / Heparin
  Cytokines
   3553 (IL1B)
Motif
Pfam: IL1 IL1_propep
Other DBs
NCBI-GeneID: 3553
NCBI-ProteinID: NP_000567
OMIM: 147720
HGNC: 5992
Ensembl: ENSG00000125538
Vega: OTTHUMG00000131344
Pharos: P01584(Tclin)
UniProt: P01584
Structure
PDB: 

Position
2q14.1
AA seq 269 aa
MAEVPELASEMMAYYSGNEDDLFFEADGPKQMKCSFQDLDLCPLDGGIQLRISDHHYSKG
FRQAASVVVAMDKLRKMLVPCPQTFQENDLSTFFPFIFEEEPIFFDTWDNEAYVHDAPVR
SLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKE
KNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYIST
SQAENMPVFLGGTKGGQDITDFTMQFVSS
NT seq 810 nt   +upstreamnt  +downstreamnt
atggcagaagtacctgagctcgccagtgaaatgatggcttattacagtggcaatgaggat
gacttgttctttgaagctgatggccctaaacagatgaagtgctccttccaggacctggac
ctctgccctctggatggcggcatccagctacgaatctccgaccaccactacagcaagggc
ttcaggcaggccgcgtcagttgttgtggccatggacaagctgaggaagatgctggttccc
tgcccacagaccttccaggagaatgacctgagcaccttctttcccttcatctttgaagaa
gaacctatcttcttcgacacatgggataacgaggcttatgtgcacgatgcacctgtacga
tcactgaactgcacgctccgggactcacagcaaaaaagcttggtgatgtctggtccatat
gaactgaaagctctccacctccagggacaggatatggagcaacaagtggtgttctccatg
tcctttgtacaaggagaagaaagtaatgacaaaatacctgtggccttgggcctcaaggaa
aagaatctgtacctgtcctgcgtgttgaaagatgataagcccactctacagctggagagt
gtagatcccaaaaattacccaaagaagaagatggaaaagcgatttgtcttcaacaagata
gaaatcaataacaagctggaatttgagtctgcccagttccccaactggtacatcagcacc
tctcaagcagaaaacatgcccgtcttcctgggagggaccaaaggcggccaggatataact
gacttcaccatgcaatttgtgtcttcctaa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (43)   
   KEGG PATHWAY (43)   
Network (11)   
   KEGG NETWORK (11)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Drug (4)   
   KEGG DRUG (4)   
Genome (1)   
   KEGG GENOME (1)   
Gene (61)   
   KEGG ORTHOLOGY (1)   
   RefGene (11)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (17)   
   OC (1)   
   PHAROS (1)   
   PROTHERM (25)   
   VEGA (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (24)   
   RefSeq(nuc) (2)   
   GenBank (11)   
   EMBL (11)   
Protein domain (2)   
   Pfam (2)   
All databases (156)   

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