| Entry |
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| Symbol |
CXCR2, CD182, CDw128b, CMKAR2, IL8R2, IL8RA, IL8RB, WHIMS2
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| Name |
(RefSeq) C-X-C motif chemokine receptor 2
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| KO |
| K05050 | C-X-C chemokine receptor type 2 |
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| Organism |
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| Pathway |
| hsa04060 | Cytokine-cytokine receptor interaction |
| hsa04061 | Viral protein interaction with cytokine and cytokine receptor |
| hsa04072 | Phospholipase D signaling pathway |
| hsa05120 | Epithelial cell signaling in Helicobacter pylori infection |
| hsa05163 | Human cytomegalovirus infection |
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| Network |
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV) nt06167 Human cytomegalovirus (HCMV) nt06224 CXCR signaling (cancer) nt06533 Chemokine signaling |
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| Element |
| N00152 | CXCR-GNB/G-ERK signaling pathway |
| N00153 | CCR/CXCR-GNB/G-PI3K-RAC signaling pathway |
| N00154 | CXCR-GNB/G-PI3K-AKT signaling pathway |
| N00427 | HCMV vCXCL to CXCR-GNB/G-PI3K-AKT signaling pathway |
| N01746 | CCR/CXCR-GNB/G-PI3K signaling pathway |
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| Disease |
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| Drug target |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
09132 Signal transduction
04072 Phospholipase D signaling pathway
3579 (CXCR2)
09133 Signaling molecules and interaction
04060 Cytokine-cytokine receptor interaction
3579 (CXCR2)
04061 Viral protein interaction with cytokine and cytokine receptor
3579 (CXCR2)
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
3579 (CXCR2)
09150 Organismal Systems
09151 Immune system
04062 Chemokine signaling pathway
3579 (CXCR2)
09160 Human Diseases
09172 Infectious disease: viral
05163 Human cytomegalovirus infection
3579 (CXCR2)
09171 Infectious disease: bacterial
05120 Epithelial cell signaling in Helicobacter pylori infection
3579 (CXCR2)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04030 G protein-coupled receptors [BR:hsa04030]
3579 (CXCR2)
04050 Cytokine receptors [BR:hsa04050]
3579 (CXCR2)
04090 CD molecules [BR:hsa04090]
3579 (CXCR2)
G protein-coupled receptors [BR:hsa04030]
Rhodopsin family
Chemokine
CXC Chemokine
3579 (CXCR2)
Cytokine receptors [BR:hsa04050]
Chemokine receptors
CXC Chemokine
3579 (CXCR2)
CD molecules [BR:hsa04090]
Proteins
3579 (CXCR2)
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| SSDB |
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| Motif |
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| Other DBs |
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| Structure |
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| Position |
2:218125294..218137251
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| AA seq |
360 aa
MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFL
LSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCK
VVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPV
LLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFK
AHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATE
ILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL |
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| NT seq |
1083 nt +upstreamnt +downstreamnt
atggaagattttaacatggagagtgacagctttgaagatttctggaaaggtgaagatctt
agtaattacagttacagctctaccctgcccccttttctactagatgccgccccatgtgaa
ccagaatccctggaaatcaacaagtattttgtggtcattatctatgccctggtattcctg
ctgagcctgctgggaaactccctcgtgatgctggtcatcttatacagcagggtcggccgc
tccgtcactgatgtctacctgctgaacctagccttggccgacctactctttgccctgacc
ttgcccatctgggccgcctccaaggtgaatggctggatttttggcacattcctgtgcaag
gtggtctcactcctgaaggaagtcaacttctatagtggcatcctgctactggcctgcatc
agtgtggaccgttacctggccattgtccatgccacacgcacactgacccagaagcgctac
ttggtcaaattcatatgtctcagcatctggggtctgtccttgctcctggccctgcctgtc
ttacttttccgaaggaccgtctactcatccaatgttagcccagcctgctatgaggacatg
ggcaacaatacagcaaactggcggatgctgttacggatcctgccccagtcctttggcttc
atcgtgccactgctgatcatgctgttctgctacggattcaccctgcgtacgctgtttaag
gcccacatggggcagaagcaccgggccatgcgggtcatctttgctgtcgtcctcatcttc
ctgctctgctggctgccctacaacctggtcctgctggcagacaccctcatgaggacccag
gtgatccaggagacctgtgagcgccgcaatcacatcgaccgggctctggatgccaccgag
attctgggcatccttcacagctgcctcaaccccctcatctacgccttcattggccagaag
tttcgccatggactcctcaagattctagctatacatggcttgatcagcaaggactccctg
cccaaagacagcaggccttcctttgttggctcttcttcagggcacacttccactactctc
taa |
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