KEGG   Homo sapiens (human): 369Help
Entry
369               CDS       T01001                                 

Gene name
ARAF, A-RAF, ARAF1, PKS2, RAFA1
Definition
(RefSeq) A-Raf proto-oncogene, serine/threonine kinase
  KO
K08845  A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa01522  Endocrine resistance
hsa04010  MAPK signaling pathway
hsa04012  ErbB signaling pathway
hsa04068  FoxO signaling pathway
hsa04270  Vascular smooth muscle contraction
hsa04650  Natural killer cell mediated cytotoxicity
hsa04720  Long-term potentiation
hsa04726  Serotonergic synapse
hsa04730  Long-term depression
hsa04810  Regulation of actin cytoskeleton
hsa04910  Insulin signaling pathway
hsa04914  Progesterone-mediated oocyte maturation
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa05034  Alcoholism
hsa05160  Hepatitis C
hsa05200  Pathways in cancer
hsa05205  Proteoglycans in cancer
hsa05210  Colorectal cancer
hsa05211  Renal cell carcinoma
hsa05212  Pancreatic cancer
hsa05213  Endometrial cancer
hsa05214  Glioma
hsa05215  Prostate cancer
hsa05218  Melanoma
hsa05219  Bladder cancer
hsa05220  Chronic myeloid leukemia
hsa05221  Acute myeloid leukemia
hsa05223  Non-small cell lung cancer
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
Module
hsa_M00687  MAPK (ERK1/2) signaling
Network
N00001  EGF-EGFR-RAS-ERK signaling pathway
N00002  BCR-ABL fusion kinase to RAS-ERK signaling pathway
N00003  Mutation-activated KIT to RAS-ERK signaling pathway
N00004  Duplication-activated FLT3 to RAS-ERK signaling pathway
N00005  Mutation-activated MET to RAS-ERK signaling pathway
N00006  Amplified EGFR to RAS-ERK signaling pathway
N00007  EML4-ALK fusion kinase to RAS-ERK signaling pathway
N00008  RET-PTC fusion kinase to RAS-ERK signaling pathway
N00009  TRK fusion kinase to RAS-ERK signaling pathway
N00011  Mutation-activated FGFR3 to RAS-ERK signaling pathway
N00012  Mutation-activated KRAS/NRAS to ERK signaling pathway
N00014  Mutation-activated EGFR to RAS-ERK signaling pathway
N00015  PDGF-PDGFR-RAS-ERK signaling pathway
N00016  PDGF-overexpression to RAS-ERK signaling pathway
N00018  Amplified PDGFR to RAS-ERK signaling pathway
N00019  FGF-FGFR-RAS-ERK signaling pathway
N00020  Amplified FGFR to RAS-ERK signaling pathway
N00021  EGF-ERBB2-RAS-ERK signaling pathway
N00022  ERBB2-overexpression to RAS-ERK signaling pathway
N00023  EGF-EGFR-PLCG-ERK signaling pathway
N00024  Mutation-activated EGFR to PLCG-ERK signaling pathway
N00025  EML4-ALK fusion kinase to PLCG-ERK signaling pathway
N00041  EGFR-overexpression to RAS-ERK signaling pathway
N00077  HRAS-overexpression to RAS-ERK signaling pathway
N00078  Mutation-activated HRAS to RAS-ERK signaling pathway
N00160  KSHV K1 to RAS-ERK signaling pathway
N00215  KITLG-KIT-RAS-ERK signaling pathway
N00216  HGF-MET-RAS-ERK signaling pathway
N00217  FLT3LG-FLT3-RAS-ERK signaling pathway
N00229  TGFA-EGFR-RAS-ERK signaling pathway
N00230  TGFA-overexpression to RAS-ERK signaling pathway
N00233  IGF2-IGF1R-RAS-ERK signaling pathway
N00235  IGF2-overexpression to RAS-ERK signaling pathway
N00237  IGF1R-overexpression to RAS-ERK signaling pathway
N00246  HGF-overexpression to RAS-ERK signaling pathway
N00248  MET-overexpression to RAS-ERK signaling pathway
N00252  Amplified ERBB2 to RAS-ERK signaling pathway
N00259  Amplified MET to RAS-ERK signaling pathway
N00276  EGF-overexpression to RAS-ERK signaling pathway
N00277  EREG-EGFR-RAS-ERK signaling pathway
N00278  EREG-overexpression to RAS-ERK signaling pathway
N00279  AREG-EGFR-RAS-ERK signaling pathway
N00280  AREG-overexpression to RAS-ERK signaling pathway
N00367  HPV E5 to EGFR-RAS-ERK signaling pathway
N00369  HPV E5 to PDGFR-RAS-ERK signaling pathway
N00386  HCMV gB to PDGFR-RAS-ERK signaling pathway
N00392  HCMV gB to EGFR-RAS-ERK signaling pathway
 » show all
Disease
H00523  Noonan syndrome and related disorders
H01738  Noonan syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    369 (ARAF)
   04012 ErbB signaling pathway
    369 (ARAF)
   04068 FoxO signaling pathway
    369 (ARAF)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    369 (ARAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    369 (ARAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    369 (ARAF)
   04914 Progesterone-mediated oocyte maturation
    369 (ARAF)
   04928 Parathyroid hormone synthesis, secretion and action
    369 (ARAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    369 (ARAF)
  09156 Nervous system
   04726 Serotonergic synapse
    369 (ARAF)
   04720 Long-term potentiation
    369 (ARAF)
   04730 Long-term depression
    369 (ARAF)
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    369 (ARAF)
   05205 Proteoglycans in cancer
    369 (ARAF)
   05210 Colorectal cancer
    369 (ARAF)
   05212 Pancreatic cancer
    369 (ARAF)
   05225 Hepatocellular carcinoma
    369 (ARAF)
   05226 Gastric cancer
    369 (ARAF)
   05214 Glioma
    369 (ARAF)
   05221 Acute myeloid leukemia
    369 (ARAF)
   05220 Chronic myeloid leukemia
    369 (ARAF)
   05218 Melanoma
    369 (ARAF)
   05211 Renal cell carcinoma
    369 (ARAF)
   05219 Bladder cancer
    369 (ARAF)
   05215 Prostate cancer
    369 (ARAF)
   05213 Endometrial cancer
    369 (ARAF)
   05224 Breast cancer
    369 (ARAF)
   05223 Non-small cell lung cancer
    369 (ARAF)
  09164 Substance dependence
   05034 Alcoholism
    369 (ARAF)
  09167 Infectious diseases
   05160 Hepatitis C
    369 (ARAF)
  09168 Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    369 (ARAF)
   01522 Endocrine resistance
    369 (ARAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    369 (ARAF)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     369 (ARAF)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   369 (ARAF)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Pkinase_Tyr Pkinase RBD C1_1 Kinase-like zf-RING-like APH TUG-UBL1 Kdo
Motif
Other DBs
NCBI-GeneID: 369
NCBI-ProteinID: NP_001645
OMIM: 311010
HGNC: 646
Ensembl: ENSG00000078061
Vega: OTTHUMG00000021446
Pharos: P10398(Tbio)
UniProt: P10398 A0A024R178
Structure
PDB: 

Position
Xp11.3
AA seq 606 aa AA seqDB search
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSVQDLSGGSRQHEAPSNRPLNELL
TPQGPSPRTQHCDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSNLIQLTGQSFS
TDAAGSRGGSDGTPRGSPSPASVSSGRKSPHSKSPAEQRERKSLADDKKKVKNLGYRDSG
YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRK
TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL
HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM
QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPK
AMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLS
AARLVP
NT seq 1821 nt NT seq  +upstreamnt  +downstreamnt
atggagccaccacggggcccccctgccaatggggccgagccatcccgggcagtgggcacc
gtcaaagtatacctgcccaacaagcaacgcacggtggtgactgtccgggatggcatgagt
gtctacgactctctagacaaggccctgaaggtgcggggtctaaatcaggactgctgtgtg
gtctaccgactcatcaagggacgaaagacggtcactgcctgggacacagccattgctccc
ctggatggcgaggagctcattgtcgaggtccttgaagatgtcccgctgaccatgcacaat
tttgtacggaagaccttcttcagcctggcgttctgtgacttctgccttaagtttctgttc
catggcttccgttgccaaacctgtggctacaagttccaccagcattgttcctccaaggtc
cccacagtctgtgttgacatgagtaccaaccgccaacagttctaccacagtgtccaggat
ttgtccggaggctccagacagcatgaggctccctcgaaccgccccctgaatgagttgcta
accccccagggtcccagcccccgcacccagcactgtgacccggagcacttccccttccct
gccccagccaatgcccccctacagcgcatccgctccacgtccactcccaacgtccatatg
gtcagcaccacggcccccatggactccaacctcatccagctcactggccagagtttcagc
actgatgctgccggtagtagaggaggtagtgatggaaccccccgggggagccccagccca
gccagcgtgtcctcggggaggaagtccccacattccaagtcaccagcagagcagcgcgag
cggaagtccttggccgatgacaagaagaaagtgaagaacctggggtaccgggactcaggc
tattactgggaggtaccacccagtgaggtgcagctgctgaagaggatcgggacgggctcg
tttggcaccgtgtttcgagggcggtggcatggcgatgtggccgtgaaggtgctcaaggtg
tcccagcccacagctgagcaggcccaggctttcaagaatgagatgcaggtgctcaggaag
acgcgacatgtcaacatcttgctgtttatgggcttcatgacccggccgggatttgccatc
atcacacagtggtgtgagggctccagcctctaccatcacctgcatgtggccgacacacgc
ttcgacatggtccagctcatcgacgtggcccggcagactgcccagggcatggactacctc
catgccaagaacatcatccaccgagatctcaagtctaacaacatcttcctacatgagggg
ctcacggtgaagatcggtgactttggcttggccacagtgaagactcgatggagcggggcc
cagcccttggagcagccctcaggatctgtgctgtggatggcagctgaggtgatccgtatg
caggacccgaacccctacagcttccagtcagacgtctatgcctacggggttgtgctctac
gagcttatgactggctcactgccttacagccacattggctgccgtgaccagattatcttt
atggtgggccgtggctatctgtccccggacctcagcaaaatctccagcaactgccccaag
gccatgcggcgcctgctgtctgactgcctcaagttccagcgggaggagcggcccctcttc
ccccagatcctggccacaattgagctgctgcaacggtcactccccaagattgagcggagt
gcctcggaaccctccttgcaccgcacccaggccgatgagttgcctgcctgcctactcagc
gcagcccgccttgtgccttag

KEGG   Homo sapiens (human): 5894Help
Entry
5894              CDS       T01001                                 

Gene name
RAF1, CMD1NN, CRAF, NS5, Raf-1, c-Raf
Definition
(RefSeq) Raf-1 proto-oncogene, serine/threonine kinase
  KO
K04366  RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa01522  Endocrine resistance
hsa04010  MAPK signaling pathway
hsa04012  ErbB signaling pathway
hsa04014  Ras signaling pathway
hsa04015  Rap1 signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04062  Chemokine signaling pathway
hsa04068  FoxO signaling pathway
hsa04071  Sphingolipid signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04140  Autophagy - animal
hsa04150  mTOR signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04210  Apoptosis
hsa04218  Cellular senescence
hsa04270  Vascular smooth muscle contraction
hsa04360  Axon guidance
hsa04370  VEGF signaling pathway
hsa04371  Apelin signaling pathway
hsa04510  Focal adhesion
hsa04540  Gap junction
hsa04550  Signaling pathways regulating pluripotency of stem cells
hsa04625  C-type lectin receptor signaling pathway
hsa04630  Jak-STAT signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity
hsa04660  T cell receptor signaling pathway
hsa04662  B cell receptor signaling pathway
hsa04664  Fc epsilon RI signaling pathway
hsa04666  Fc gamma R-mediated phagocytosis
hsa04720  Long-term potentiation
hsa04722  Neurotrophin signaling pathway
hsa04726  Serotonergic synapse
hsa04730  Long-term depression
hsa04810  Regulation of actin cytoskeleton
hsa04910  Insulin signaling pathway
hsa04912  GnRH signaling pathway
hsa04914  Progesterone-mediated oocyte maturation
hsa04915  Estrogen signaling pathway
hsa04916  Melanogenesis
hsa04917  Prolactin signaling pathway
hsa04919  Thyroid hormone signaling pathway
hsa04921  Oxytocin signaling pathway
hsa04926  Relaxin signaling pathway
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa05034  Alcoholism
hsa05152  Tuberculosis
hsa05160  Hepatitis C
hsa05161  Hepatitis B
hsa05163  Human cytomegalovirus infection
hsa05164  Influenza A
hsa05165  Human papillomavirus infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05200  Pathways in cancer
hsa05205  Proteoglycans in cancer
hsa05206  MicroRNAs in cancer
hsa05210  Colorectal cancer
hsa05211  Renal cell carcinoma
hsa05212  Pancreatic cancer
hsa05213  Endometrial cancer
hsa05214  Glioma
hsa05215  Prostate cancer
hsa05218  Melanoma
hsa05219  Bladder cancer
hsa05220  Chronic myeloid leukemia
hsa05221  Acute myeloid leukemia
hsa05223  Non-small cell lung cancer
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
hsa05230  Central carbon metabolism in cancer
hsa05231  Choline metabolism in cancer
Module
hsa_M00687  MAPK (ERK1/2) signaling
Network
N00001  EGF-EGFR-RAS-ERK signaling pathway
N00002  BCR-ABL fusion kinase to RAS-ERK signaling pathway
N00003  Mutation-activated KIT to RAS-ERK signaling pathway
N00004  Duplication-activated FLT3 to RAS-ERK signaling pathway
N00005  Mutation-activated MET to RAS-ERK signaling pathway
N00006  Amplified EGFR to RAS-ERK signaling pathway
N00007  EML4-ALK fusion kinase to RAS-ERK signaling pathway
N00008  RET-PTC fusion kinase to RAS-ERK signaling pathway
N00009  TRK fusion kinase to RAS-ERK signaling pathway
N00011  Mutation-activated FGFR3 to RAS-ERK signaling pathway
N00012  Mutation-activated KRAS/NRAS to ERK signaling pathway
N00014  Mutation-activated EGFR to RAS-ERK signaling pathway
N00015  PDGF-PDGFR-RAS-ERK signaling pathway
N00016  PDGF-overexpression to RAS-ERK signaling pathway
N00018  Amplified PDGFR to RAS-ERK signaling pathway
N00019  FGF-FGFR-RAS-ERK signaling pathway
N00020  Amplified FGFR to RAS-ERK signaling pathway
N00021  EGF-ERBB2-RAS-ERK signaling pathway
N00022  ERBB2-overexpression to RAS-ERK signaling pathway
N00023  EGF-EGFR-PLCG-ERK signaling pathway
N00024  Mutation-activated EGFR to PLCG-ERK signaling pathway
N00025  EML4-ALK fusion kinase to PLCG-ERK signaling pathway
N00041  EGFR-overexpression to RAS-ERK signaling pathway
N00077  HRAS-overexpression to RAS-ERK signaling pathway
N00078  Mutation-activated HRAS to RAS-ERK signaling pathway
N00152  CXCR-GNB/G-ERK signaling pathway
N00157  KSHV vGPCR to GNB/G-ERK signaling pathway
N00160  KSHV K1 to RAS-ERK signaling pathway
N00215  KITLG-KIT-RAS-ERK signaling pathway
N00216  HGF-MET-RAS-ERK signaling pathway
N00217  FLT3LG-FLT3-RAS-ERK signaling pathway
N00229  TGFA-EGFR-RAS-ERK signaling pathway
N00230  TGFA-overexpression to RAS-ERK signaling pathway
N00233  IGF2-IGF1R-RAS-ERK signaling pathway
N00235  IGF2-overexpression to RAS-ERK signaling pathway
N00237  IGF1R-overexpression to RAS-ERK signaling pathway
N00246  HGF-overexpression to RAS-ERK signaling pathway
N00248  MET-overexpression to RAS-ERK signaling pathway
N00252  Amplified ERBB2 to RAS-ERK signaling pathway
N00259  Amplified MET to RAS-ERK signaling pathway
N00276  EGF-overexpression to RAS-ERK signaling pathway
N00277  EREG-EGFR-RAS-ERK signaling pathway
N00278  EREG-overexpression to RAS-ERK signaling pathway
N00279  AREG-EGFR-RAS-ERK signaling pathway
N00280  AREG-overexpression to RAS-ERK signaling pathway
N00367  HPV E5 to EGFR-RAS-ERK signaling pathway
N00369  HPV E5 to PDGFR-RAS-ERK signaling pathway
N00386  HCMV gB to PDGFR-RAS-ERK signaling pathway
N00392  HCMV gB to EGFR-RAS-ERK signaling pathway
 » show all
Disease
H01984  Leopard syndrome
Drug target
Regorafenib (DG00720): D10137 D10138
Sorafenib (DG00713): D06272 D08524
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    5894 (RAF1)
   04015 Rap1 signaling pathway
    5894 (RAF1)
   04010 MAPK signaling pathway
    5894 (RAF1)
   04012 ErbB signaling pathway
    5894 (RAF1)
   04370 VEGF signaling pathway
    5894 (RAF1)
   04371 Apelin signaling pathway
    5894 (RAF1)
   04630 Jak-STAT signaling pathway
    5894 (RAF1)
   04068 FoxO signaling pathway
    5894 (RAF1)
   04072 Phospholipase D signaling pathway
    5894 (RAF1)
   04071 Sphingolipid signaling pathway
    5894 (RAF1)
   04024 cAMP signaling pathway
    5894 (RAF1)
   04022 cGMP - PKG signaling pathway
    5894 (RAF1)
   04151 PI3K-Akt signaling pathway
    5894 (RAF1)
   04150 mTOR signaling pathway
    5894 (RAF1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    5894 (RAF1)
  09143 Cell growth and death
   04210 Apoptosis
    5894 (RAF1)
   04218 Cellular senescence
    5894 (RAF1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    5894 (RAF1)
   04540 Gap junction
    5894 (RAF1)
   04550 Signaling pathways regulating pluripotency of stem cells
    5894 (RAF1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    5894 (RAF1)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    5894 (RAF1)
   04650 Natural killer cell mediated cytotoxicity
    5894 (RAF1)
   04660 T cell receptor signaling pathway
    5894 (RAF1)
   04662 B cell receptor signaling pathway
    5894 (RAF1)
   04664 Fc epsilon RI signaling pathway
    5894 (RAF1)
   04666 Fc gamma R-mediated phagocytosis
    5894 (RAF1)
   04062 Chemokine signaling pathway
    5894 (RAF1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    5894 (RAF1)
   04912 GnRH signaling pathway
    5894 (RAF1)
   04915 Estrogen signaling pathway
    5894 (RAF1)
   04914 Progesterone-mediated oocyte maturation
    5894 (RAF1)
   04917 Prolactin signaling pathway
    5894 (RAF1)
   04921 Oxytocin signaling pathway
    5894 (RAF1)
   04926 Relaxin signaling pathway
    5894 (RAF1)
   04919 Thyroid hormone signaling pathway
    5894 (RAF1)
   04928 Parathyroid hormone synthesis, secretion and action
    5894 (RAF1)
   04916 Melanogenesis
    5894 (RAF1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    5894 (RAF1)
  09156 Nervous system
   04726 Serotonergic synapse
    5894 (RAF1)
   04720 Long-term potentiation
    5894 (RAF1)
   04730 Long-term depression
    5894 (RAF1)
   04722 Neurotrophin signaling pathway
    5894 (RAF1)
  09158 Development
   04360 Axon guidance
    5894 (RAF1)
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    5894 (RAF1)
   05230 Central carbon metabolism in cancer
    5894 (RAF1)
   05231 Choline metabolism in cancer
    5894 (RAF1)
   05206 MicroRNAs in cancer
    5894 (RAF1)
   05205 Proteoglycans in cancer
    5894 (RAF1)
   05210 Colorectal cancer
    5894 (RAF1)
   05212 Pancreatic cancer
    5894 (RAF1)
   05225 Hepatocellular carcinoma
    5894 (RAF1)
   05226 Gastric cancer
    5894 (RAF1)
   05214 Glioma
    5894 (RAF1)
   05221 Acute myeloid leukemia
    5894 (RAF1)
   05220 Chronic myeloid leukemia
    5894 (RAF1)
   05218 Melanoma
    5894 (RAF1)
   05211 Renal cell carcinoma
    5894 (RAF1)
   05219 Bladder cancer
    5894 (RAF1)
   05215 Prostate cancer
    5894 (RAF1)
   05213 Endometrial cancer
    5894 (RAF1)
   05224 Breast cancer
    5894 (RAF1)
   05223 Non-small cell lung cancer
    5894 (RAF1)
  09164 Substance dependence
   05034 Alcoholism
    5894 (RAF1)
  09167 Infectious diseases
   05152 Tuberculosis
    5894 (RAF1)
   05164 Influenza A
    5894 (RAF1)
   05161 Hepatitis B
    5894 (RAF1)
   05160 Hepatitis C
    5894 (RAF1)
   05163 Human cytomegalovirus infection
    5894 (RAF1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    5894 (RAF1)
   05165 Human papillomavirus infection
    5894 (RAF1)
  09168 Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    5894 (RAF1)
   01522 Endocrine resistance
    5894 (RAF1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    5894 (RAF1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     5894 (RAF1)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   5894 (RAF1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Pkinase_Tyr Pkinase RBD C1_1 Kinase-like zf-RING-like C1_2
Motif
Other DBs
NCBI-GeneID: 5894
NCBI-ProteinID: NP_002871
OMIM: 164760
HGNC: 9829
Ensembl: ENSG00000132155
Vega: OTTHUMG00000129789
Pharos: P04049(Tclin)
UniProt: P04049 L7RRS6
Structure
PDB: 

Position
3p25.2
AA seq 648 aa AA seqDB search
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
NT seq 1947 nt NT seq  +upstreamnt  +downstreamnt
atggagcacatacagggagcttggaagacgatcagcaatggttttggattcaaagatgcc
gtgtttgatggctccagctgcatctctcctacaatagttcagcagtttggctatcagcgc
cgggcatcagatgatggcaaactcacagatccttctaagacaagcaacactatccgtgtt
ttcttgccgaacaagcaaagaacagtggtcaatgtgcgaaatggaatgagcttgcatgac
tgccttatgaaagcactcaaggtgaggggcctgcaaccagagtgctgtgcagtgttcaga
cttctccacgaacacaaaggtaaaaaagcacgcttagattggaatactgatgctgcgtct
ttgattggagaagaacttcaagtagatttcctggatcatgttcccctcacaacacacaac
tttgctcggaagacgttcctgaagcttgccttctgtgacatctgtcagaaattcctgctc
aatggatttcgatgtcagacttgtggctacaaatttcatgagcactgtagcaccaaagta
cctactatgtgtgtggactggagtaacatcagacaactcttattgtttccaaattccact
attggtgatagtggagtcccagcactaccttctttgactatgcgtcgtatgcgagagtct
gtttccaggatgcctgttagttctcagcacagatattctacacctcacgccttcaccttt
aacacctccagtccctcatctgaaggttccctctcccagaggcagaggtcgacatccaca
cctaatgtccacatggtcagcaccaccctgcctgtggacagcaggatgattgaggatgca
attcgaagtcacagcgaatcagcctcaccttcagccctgtccagtagccccaacaatctg
agcccaacaggctggtcacagccgaaaacccccgtgccagcacaaagagagcgggcacca
gtatctgggacccaggagaaaaacaaaattaggcctcgtggacagagagattcaagctat
tattgggaaatagaagccagtgaagtgatgctgtccactcggattgggtcaggctctttt
ggaactgtttataagggtaaatggcacggagatgttgcagtaaagatcctaaaggttgtc
gacccaaccccagagcaattccaggccttcaggaatgaggtggctgttctgcgcaaaaca
cggcatgtgaacattctgcttttcatggggtacatgacaaaggacaacctggcaattgtg
acccagtggtgcgagggcagcagcctctacaaacacctgcatgtccaggagaccaagttt
cagatgttccagctaattgacattgcccggcagacggctcagggaatggactatttgcat
gcaaagaacatcatccatagagacatgaaatccaacaatatatttctccatgaaggctta
acagtgaaaattggagattttggtttggcaacagtaaagtcacgctggagtggttctcag
caggttgaacaacctactggctctgtcctctggatggccccagaggtgatccgaatgcag
gataacaacccattcagtttccagtcggatgtctactcctatggcatcgtattgtatgaa
ctgatgacgggggagcttccttattctcacatcaacaaccgagatcagatcatcttcatg
gtgggccgaggatatgcctccccagatcttagtaagctatataagaactgccccaaagca
atgaagaggctggtagctgactgtgtgaagaaagtaaaggaagagaggcctctttttccc
cagatcctgtcttccattgagctgctccaacactctctaccgaagatcaaccggagcgct
tccgagccatccttgcatcgggcagcccacactgaggatatcaatgcttgcacgctgacc
acgtccccgaggctgcctgtcttctag

KEGG   Homo sapiens (human): 673Help
Entry
673               CDS       T01001                                 

Gene name
BRAF, B-RAF1, B-raf, BRAF1, NS7, RAFB1
Definition
(RefSeq) B-Raf proto-oncogene, serine/threonine kinase
  KO
K04365  B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa01522  Endocrine resistance
hsa04010  MAPK signaling pathway
hsa04012  ErbB signaling pathway
hsa04015  Rap1 signaling pathway
hsa04024  cAMP signaling pathway
hsa04062  Chemokine signaling pathway
hsa04068  FoxO signaling pathway
hsa04150  mTOR signaling pathway
hsa04270  Vascular smooth muscle contraction
hsa04510  Focal adhesion
hsa04650  Natural killer cell mediated cytotoxicity
hsa04720  Long-term potentiation
hsa04722  Neurotrophin signaling pathway
hsa04726  Serotonergic synapse
hsa04730  Long-term depression
hsa04810  Regulation of actin cytoskeleton
hsa04910  Insulin signaling pathway
hsa04914  Progesterone-mediated oocyte maturation
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa04934  Cushing syndrome
hsa05034  Alcoholism
hsa05160  Hepatitis C
hsa05200  Pathways in cancer
hsa05205  Proteoglycans in cancer
hsa05210  Colorectal cancer
hsa05211  Renal cell carcinoma
hsa05212  Pancreatic cancer
hsa05213  Endometrial cancer
hsa05214  Glioma
hsa05215  Prostate cancer
hsa05216  Thyroid cancer
hsa05218  Melanoma
hsa05219  Bladder cancer
hsa05220  Chronic myeloid leukemia
hsa05221  Acute myeloid leukemia
hsa05223  Non-small cell lung cancer
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
Module
hsa_M00687  MAPK (ERK1/2) signaling
Network
N00001  EGF-EGFR-RAS-ERK signaling pathway
N00002  BCR-ABL fusion kinase to RAS-ERK signaling pathway
N00003  Mutation-activated KIT to RAS-ERK signaling pathway
N00004  Duplication-activated FLT3 to RAS-ERK signaling pathway
N00005  Mutation-activated MET to RAS-ERK signaling pathway
N00006  Amplified EGFR to RAS-ERK signaling pathway
N00007  EML4-ALK fusion kinase to RAS-ERK signaling pathway
N00008  RET-PTC fusion kinase to RAS-ERK signaling pathway
N00009  TRK fusion kinase to RAS-ERK signaling pathway
N00011  Mutation-activated FGFR3 to RAS-ERK signaling pathway
N00012  Mutation-activated KRAS/NRAS to ERK signaling pathway
N00013  Mutation-activated BRAF to ERK signaling pathway
N00014  Mutation-activated EGFR to RAS-ERK signaling pathway
N00015  PDGF-PDGFR-RAS-ERK signaling pathway
N00016  PDGF-overexpression to RAS-ERK signaling pathway
N00018  Amplified PDGFR to RAS-ERK signaling pathway
N00019  FGF-FGFR-RAS-ERK signaling pathway
N00020  Amplified FGFR to RAS-ERK signaling pathway
N00021  EGF-ERBB2-RAS-ERK signaling pathway
N00022  ERBB2-overexpression to RAS-ERK signaling pathway
N00023  EGF-EGFR-PLCG-ERK signaling pathway
N00024  Mutation-activated EGFR to PLCG-ERK signaling pathway
N00025  EML4-ALK fusion kinase to PLCG-ERK signaling pathway
N00041  EGFR-overexpression to RAS-ERK signaling pathway
N00077  HRAS-overexpression to RAS-ERK signaling pathway
N00078  Mutation-activated HRAS to RAS-ERK signaling pathway
N00160  KSHV K1 to RAS-ERK signaling pathway
N00215  KITLG-KIT-RAS-ERK signaling pathway
N00216  HGF-MET-RAS-ERK signaling pathway
N00217  FLT3LG-FLT3-RAS-ERK signaling pathway
N00229  TGFA-EGFR-RAS-ERK signaling pathway
N00230  TGFA-overexpression to RAS-ERK signaling pathway
N00233  IGF2-IGF1R-RAS-ERK signaling pathway
N00235  IGF2-overexpression to RAS-ERK signaling pathway
N00237  IGF1R-overexpression to RAS-ERK signaling pathway
N00246  HGF-overexpression to RAS-ERK signaling pathway
N00248  MET-overexpression to RAS-ERK signaling pathway
N00252  Amplified ERBB2 to RAS-ERK signaling pathway
N00259  Amplified MET to RAS-ERK signaling pathway
N00276  EGF-overexpression to RAS-ERK signaling pathway
N00277  EREG-EGFR-RAS-ERK signaling pathway
N00278  EREG-overexpression to RAS-ERK signaling pathway
N00279  AREG-EGFR-RAS-ERK signaling pathway
N00280  AREG-overexpression to RAS-ERK signaling pathway
N00367  HPV E5 to EGFR-RAS-ERK signaling pathway
N00369  HPV E5 to PDGFR-RAS-ERK signaling pathway
N00386  HCMV gB to PDGFR-RAS-ERK signaling pathway
N00392  HCMV gB to EGFR-RAS-ERK signaling pathway
N10007  Kinase inhibitor to BRAF mutation
 » show all
Disease
H00032  Thyroid cancer
H00038  Melanoma
H00523  Noonan syndrome and related disorders
H01512  Langerhans cell histiocytosis
H01738  Noonan syndrome
H01984  Leopard syndrome
Drug target
Dabrafenib (DG00721): D10064 D10104
Encorafenib: D11053
Regorafenib (DG00720): D10137 D10138
Sorafenib (DG00713): D06272 D08524
Vemurafenib: D09996
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    673 (BRAF)
   04010 MAPK signaling pathway
    673 (BRAF)
   04012 ErbB signaling pathway
    673 (BRAF)
   04068 FoxO signaling pathway
    673 (BRAF)
   04024 cAMP signaling pathway
    673 (BRAF)
   04150 mTOR signaling pathway
    673 (BRAF)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    673 (BRAF)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    673 (BRAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    673 (BRAF)
   04062 Chemokine signaling pathway
    673 (BRAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    673 (BRAF)
   04914 Progesterone-mediated oocyte maturation
    673 (BRAF)
   04928 Parathyroid hormone synthesis, secretion and action
    673 (BRAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    673 (BRAF)
  09156 Nervous system
   04726 Serotonergic synapse
    673 (BRAF)
   04720 Long-term potentiation
    673 (BRAF)
   04730 Long-term depression
    673 (BRAF)
   04722 Neurotrophin signaling pathway
    673 (BRAF)
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    673 (BRAF)
   05205 Proteoglycans in cancer
    673 (BRAF)
   05210 Colorectal cancer
    673 (BRAF)
   05212 Pancreatic cancer
    673 (BRAF)
   05225 Hepatocellular carcinoma
    673 (BRAF)
   05226 Gastric cancer
    673 (BRAF)
   05214 Glioma
    673 (BRAF)
   05216 Thyroid cancer
    673 (BRAF)
   05221 Acute myeloid leukemia
    673 (BRAF)
   05220 Chronic myeloid leukemia
    673 (BRAF)
   05218 Melanoma
    673 (BRAF)
   05211 Renal cell carcinoma
    673 (BRAF)
   05219 Bladder cancer
    673 (BRAF)
   05215 Prostate cancer
    673 (BRAF)
   05213 Endometrial cancer
    673 (BRAF)
   05224 Breast cancer
    673 (BRAF)
   05223 Non-small cell lung cancer
    673 (BRAF)
  09164 Substance dependence
   05034 Alcoholism
    673 (BRAF)
  09166 Endocrine and metabolic diseases
   04934 Cushing syndrome
    673 (BRAF)
  09167 Infectious diseases
   05160 Hepatitis C
    673 (BRAF)
  09168 Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    673 (BRAF)
   01522 Endocrine resistance
    673 (BRAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    673 (BRAF)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     673 (BRAF)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   673 (BRAF)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Pkinase_Tyr Pkinase RBD C1_1 Kinase-like zf-RING-like C1_2 APH Kdo
Motif
Other DBs
NCBI-GeneID: 673
NCBI-ProteinID: NP_004324
OMIM: 164757
HGNC: 1097
Ensembl: ENSG00000157764
Vega: OTTHUMG00000157457
Pharos: P15056(Tclin)
UniProt: P15056
Structure
PDB: 

Position
7q34
AA seq 766 aa AA seqDB search
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEH
IEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTV
TSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRK
TFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPI
PQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQR
DRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSP
GPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDV
AVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHH
LHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATV
KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNIN
NRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS
LPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
NT seq 2301 nt NT seq  +upstreamnt  +downstreamnt
atggcggcgctgagcggtggcggtggtggcggcgcggagccgggccaggctctgttcaac
ggggacatggagcccgaggccggcgccggcgccggcgccgcggcctcttcggctgcggac
cctgccattccggaggaggtgtggaatatcaaacaaatgattaagttgacacaggaacat
atagaggccctattggacaaatttggtggggagcataatccaccatcaatatatctggag
gcctatgaagaatacaccagcaagctagatgcactccaacaaagagaacaacagttattg
gaatctctggggaacggaactgatttttctgtttctagctctgcatcaatggataccgtt
acatcttcttcctcttctagcctttcagtgctaccttcatctctttcagtttttcaaaat
cccacagatgtggcacggagcaaccccaagtcaccacaaaaacctatcgttagagtcttc
ctgcccaacaaacagaggacagtggtacctgcaaggtgtggagttacagtccgagacagt
ctaaagaaagcactgatgatgagaggtctaatcccagagtgctgtgctgtttacagaatt
caggatggagagaagaaaccaattggttgggacactgatatttcctggcttactggagaa
gaattgcatgtggaagtgttggagaatgttccacttacaacacacaactttgtacgaaaa
acgtttttcaccttagcattttgtgacttttgtcgaaagctgcttttccagggtttccgc
tgtcaaacatgtggttataaatttcaccagcgttgtagtacagaagttccactgatgtgt
gttaattatgaccaacttgatttgctgtttgtctccaagttctttgaacaccacccaata
ccacaggaagaggcgtccttagcagagactgccctaacatctggatcatccccttccgca
cccgcctcggactctattgggccccaaattctcaccagtccgtctccttcaaaatccatt
ccaattccacagcccttccgaccagcagatgaagatcatcgaaatcaatttgggcaacga
gaccgatcctcatcagctcccaatgtgcatataaacacaatagaacctgtcaatattgat
gacttgattagagaccaaggatttcgtggtgatggaggatcaaccacaggtttgtctgct
accccccctgcctcattacctggctcactaactaacgtgaaagccttacagaaatctcca
ggacctcagcgagaaaggaagtcatcttcatcctcagaagacaggaatcgaatgaaaaca
cttggtagacgggactcgagtgatgattgggagattcctgatgggcagattacagtggga
caaagaattggatctggatcatttggaacagtctacaagggaaagtggcatggtgatgtg
gcagtgaaaatgttgaatgtgacagcacctacacctcagcagttacaagccttcaaaaat
gaagtaggagtactcaggaaaacacgacatgtgaatatcctactcttcatgggctattcc
acaaagccacaactggctattgttacccagtggtgtgagggctccagcttgtatcaccat
ctccatatcattgagaccaaatttgagatgatcaaacttatagatattgcacgacagact
gcacagggcatggattacttacacgccaagtcaatcatccacagagacctcaagagtaat
aatatatttcttcatgaagacctcacagtaaaaataggtgattttggtctagctacagtg
aaatctcgatggagtgggtcccatcagtttgaacagttgtctggatccattttgtggatg
gcaccagaagtcatcagaatgcaagataaaaatccatacagctttcagtcagatgtatat
gcatttggaattgttctgtatgaattgatgactggacagttaccttattcaaacatcaac
aacagggaccagataatttttatggtgggacgaggatacctgtctccagatctcagtaag
gtacggagtaactgtccaaaagccatgaagagattaatggcagagtgcctcaaaaagaaa
agagatgagagaccactctttccccaaattctcgcctctattgagctgctggcccgctca
ttgccaaaaattcaccgcagtgcatcagaaccctccttgaatcgggctggtttccaaaca
gaggattttagtctatatgcttgtgcttctccaaaaacacccatccaggcagggggatat
ggtgcgtttcctgtccactga

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