KEGG   Homo sapiens (human): 3717
Entry
3717              CDS       T01001                                 
Symbol
JAK2, JTK10
Name
(RefSeq) Janus kinase 2
  KO
K04447  Janus kinase 2 [EC:2.7.10.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa04062  Chemokine signaling pathway
hsa04081  Hormone signaling
hsa04148  Efferocytosis
hsa04151  PI3K-Akt signaling pathway
hsa04217  Necroptosis
hsa04550  Signaling pathways regulating pluripotency of stem cells
hsa04630  JAK-STAT signaling pathway
hsa04658  Th1 and Th2 cell differentiation
hsa04659  Th17 cell differentiation
hsa04725  Cholinergic synapse
hsa04917  Prolactin signaling pathway
hsa04920  Adipocytokine signaling pathway
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa04935  Growth hormone synthesis, secretion and action
hsa05140  Leishmaniasis
hsa05145  Toxoplasmosis
hsa05152  Tuberculosis
hsa05161  Hepatitis B
hsa05164  Influenza A
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05168  Herpes simplex virus 1 infection
hsa05200  Pathways in cancer
hsa05207  Chemical carcinogenesis - receptor activation
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05417  Lipid and atherosclerosis
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06162  Hepatitis B virus (HBV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06219  JAK-STAT signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06266  Non-small cell lung cancer
nt06276  Chronic myeloid leukemia
nt06324  GHRH-GH-IGF signaling
nt06325  Hormone/cytokine signaling
nt06518  JAK-STAT signaling
nt06527  Necroptosis
nt06535  Efferocytosis
  Element
N00053  Cytokine-Jak-STAT signaling pathway
N00181  KSHV vIL-6 to Jak-STAT signaling pathway
N00907  GH-Jak-STAT signaling pathway
N00920  PRL-JAK-STAT signaling pathway
N01340  ACH-CHRN-JAK-STAT signaling pathway
N01341  NNK/NNN to Jak-STAT signaling pathway
N01342  Nicotine to Jak-STAT signaling pathway
N01555  Hormone-like-cytokine to Jak-STAT signaling pathway
N01556  IL6 family to Jak-STAT signaling pathway
N01557  IL12/23 to Jak-STAT signaling pathway
N01559  Type II interferon to Jak-STAT signaling pathway
N01662  IFN-RIPK1/3 signaling pathway
N01751  Macrophage EPO signaling
N01800  LEP-LEPR signaling pathway
N01804  IL3 family to Jak-STAT signaling pathway
Disease
H00003  Acute myeloid leukemia
H00012  Polycythemia vera
H00236  Congenital polycythemia
H01433  Budd-Chiari syndrome
H01605  Myelofibrosis
H01612  Essential thrombocythemia
H02410  Myelodysplastic/myeloproliferative neoplasms
H02411  Chronic myelomonocytic leukemia
H02412  Atypical chronic myeloid leukemia
Drug target
Baricitinib: D10308<JP/US>
Delgocitinib: D11046<JP>
Deuruxolitinib (DG03114): D11866 D11867
Fedratinib (DG02968): D10630 D11296<US>
Filgotinib (DG01991): D11106<JP>
Frevecitinib: D12993
Gandotinib: D10365
Gusacitinib (DG03080): D11676 D11677
Momelotinib (DG01366): D10315 D10358 D10889<JP/US> D10889<JP/US>
Nezulcitinib: D12118
Pacritinib: D11768<US>
Peficitinib (DG01853): D10653 D10721<JP>
Ruxolitinib (DG00719): D09959 D09960<JP/US>
Tinengotinib: D12545
Tofacitinib (DG00742): D09783<JP/US> D09970
Tuspetinib: D12476
Zotiraciclib (DG03058): D11599 D11600
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    3717 (JAK2)
   04151 PI3K-Akt signaling pathway
    3717 (JAK2)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    3717 (JAK2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    3717 (JAK2)
  09143 Cell growth and death
   04217 Necroptosis
    3717 (JAK2)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    3717 (JAK2)
 09150 Organismal Systems
  09151 Immune system
   04658 Th1 and Th2 cell differentiation
    3717 (JAK2)
   04659 Th17 cell differentiation
    3717 (JAK2)
   04062 Chemokine signaling pathway
    3717 (JAK2)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    3717 (JAK2)
   04917 Prolactin signaling pathway
    3717 (JAK2)
   04935 Growth hormone synthesis, secretion and action
    3717 (JAK2)
  09156 Nervous system
   04725 Cholinergic synapse
    3717 (JAK2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    3717 (JAK2)
   05207 Chemical carcinogenesis - receptor activation
    3717 (JAK2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    3717 (JAK2)
  09172 Infectious disease: viral
   05161 Hepatitis B
    3717 (JAK2)
   05164 Influenza A
    3717 (JAK2)
   05168 Herpes simplex virus 1 infection
    3717 (JAK2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    3717 (JAK2)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    3717 (JAK2)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    3717 (JAK2)
   05140 Leishmaniasis
    3717 (JAK2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    3717 (JAK2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    3717 (JAK2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    3717 (JAK2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    3717 (JAK2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     3717 (JAK2)
Protein kinases [BR:hsa01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   3717 (JAK2)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase FERM_F2 FERM_F1 SH2_1 Jak1_Phl SH2 FERM_C_FAK1 ABC1 Kinase-like FERM_M
Other DBs
NCBI-GeneID: 3717
NCBI-ProteinID: NP_001309123
OMIM: 147796
HGNC: 6192
Ensembl: ENSG00000096968
UniProt: O60674
Structure
Position
9:4984390..5129948
AA seq 1132 aa
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSG
EYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYF
PRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQF
SQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSR
GKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQT
GLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNC
YQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKI
RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM
MSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWA
MHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAEL
ANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRD
PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE
ILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQI
CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW
YAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIE
LLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
NT seq 3399 nt   +upstreamnt  +downstreamnt
atgggaatggcctgccttacgatgacagaaatggagggaacatccacctcttctatatat
cagaatggtgatatttctggaaatgccaattctatgaagcaaatagatccagttcttcag
gtgtatctttaccattcccttgggaaatctgaggcagattatctgacctttccatctggg
gagtatgttgcagaagaaatctgtattgctgcttctaaagcttgtggtatcacacctgtg
tatcataatatgtttgctttaatgagtgaaacagaaaggatctggtatccacccaaccat
gtcttccatatagatgagtcaaccaggcataatgtactctacagaataagattttacttt
cctcgttggtattgcagtggcagcaacagagcctatcggcatggaatatctcgaggtgct
gaagctcctcttcttgatgactttgtcatgtcttacctctttgctcagtggcggcatgat
tttgtgcacggatggataaaagtacctgtgactcatgaaacacaggaagaatgtcttggg
atggcagtgttagatatgatgagaatagccaaagaaaacgatcaaaccccactggccatc
tataactctatcagctacaagacattcttaccaaaatgtattcgagcaaagatccaagac
tatcatattttgacaaggaagcgaataaggtacagatttcgcagatttattcagcaattc
agccaatgcaaagccactgccagaaacttgaaacttaagtatcttataaatctggaaact
ctgcagtctgccttctacacagagaaatttgaagtaaaagaacctggaagtggtccttca
ggtgaggagatttttgcaaccattataataactggaaacggtggaattcagtggtcaaga
gggaaacataaagaaagtgagacactgacagaacaggatttacagttatattgcgatttt
cctaatattattgatgtcagtattaagcaagcaaaccaagagggttcaaatgaaagccga
gttgtaactatccataagcaagatggtaaaaatctggaaattgaacttagctcattaagg
gaagctttgtctttcgtgtcattaattgatggatattatagattaactgcagatgcacat
cattacctctgtaaagaagtagcacctccagccgtgcttgaaaatatacaaagcaactgt
catggcccaatttcgatggattttgccattagtaaactgaagaaagcaggtaatcagact
ggactgtatgtacttcgatgcagtcctaaggactttaataaatattttttgacttttgct
gtcgagcgagaaaatgtcattgaatataaacactgtttgattacaaaaaatgagaatgaa
gagtacaacctcagtgggacaaagaagaacttcagcagtcttaaagatcttttgaattgt
taccagatggaaactgttcgctcagacaatataattttccagtttactaaatgctgtccc
ccaaagccaaaagataaatcaaaccttctagtcttcagaacgaatggtgtttctgatgta
ccaacctcaccaacattacagaggcctactcatatgaaccaaatggtgtttcacaaaatc
agaaatgaagatttgatatttaatgaaagccttggccaaggcacttttacaaagattttt
aaaggcgtacgaagagaagtaggagactacggtcaactgcatgaaacagaagttctttta
aaagttctggataaagcacacagaaactattcagagtctttctttgaagcagcaagtatg
atgagcaagctttctcacaagcatttggttttaaattatggagtatgtgtctgtggagac
gagaatattctggttcaggagtttgtaaaatttggatcactagatacatatctgaaaaag
aataaaaattgtataaatatattatggaaacttgaagttgctaaacagttggcatgggcc
atgcattttctagaagaaaacacccttattcatgggaatgtatgtgccaaaaatattctg
cttatcagagaagaagacaggaagacaggaaatcctcctttcatcaaacttagtgatcct
ggcattagtattacagttttgccaaaggacattcttcaggagagaataccatgggtacca
cctgaatgcattgaaaatcctaaaaatttaaatttggcaacagacaaatggagttttggt
accactttgtgggaaatctgcagtggaggagataaacctctaagtgctctggattctcaa
agaaagctacaattttatgaagataggcatcagcttcctgcaccaaagtgggcagaatta
gcaaaccttataaataattgtatggattatgaaccagatttcaggccttctttcagagcc
atcatacgagatcttaacagtttgtttactccagattatgaactattaacagaaaatgac
atgttaccaaatatgaggataggtgccctggggttttctggtgcctttgaagaccgggat
cctacacagtttgaagagagacatttgaaatttctacagcaacttggcaagggtaatttt
gggagtgtggagatgtgccggtatgaccctctacaggacaacactggggaggtggtcgct
gtaaaaaagcttcagcatagtactgaagagcacctaagagactttgaaagggaaattgaa
atcctgaaatccctacagcatgacaacattgtaaagtacaagggagtgtgctacagtgct
ggtcggcgtaatctaaaattaattatggaatatttaccatatggaagtttacgagactat
cttcaaaaacataaagaacggatagatcacataaaacttctgcagtacacatctcagata
tgcaagggtatggagtatcttggtacaaaaaggtatatccacagggatctggcaacgaga
aatatattggtggagaacgagaacagagttaaaattggagattttgggttaaccaaagtc
ttgccacaagacaaagaatactataaagtaaaagaacctggtgaaagtcccatattctgg
tatgctccagaatcactgacagagagcaagttttctgtggcctcagatgtttggagcttt
ggagtggttctgtatgaacttttcacatacattgagaagagtaaaagtccaccagcggaa
tttatgcgtatgattggcaatgacaaacaaggacagatgatcgtgttccatttgatagaa
cttttgaagaataatggaagattaccaagaccagatggatgcccagatgagatctatatg
atcatgacagaatgctggaacaataatgtaaatcaacgcccctcctttagggatctagct
cttcgagtggatcaaataagggataacatggctggatga

  All links  
Disease (7)   
   OMIM (7)   
Gene (19)   
   RefGene (12)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (9)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (7)   
DNA sequence (49)   
   RefSeq(nuc) (9)   
   GenBank (20)   
   EMBL (20)   
3D Structure (162)   
   PDB (162)   
Protein domain (11)   
   Pfam (11)   
All databases (257)   

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