Entry |
|
Symbol |
JUN, AP-1, AP1, c-Jun, cJUN, p39
|
Name |
(RefSeq) Jun proto-oncogene, AP-1 transcription factor subunit
|
KO |
K04448 | transcription factor AP-1 |
|
Organism |
|
Pathway |
hsa04620 | Toll-like receptor signaling pathway |
hsa04621 | NOD-like receptor signaling pathway |
hsa04625 | C-type lectin receptor signaling pathway |
hsa04658 | Th1 and Th2 cell differentiation |
hsa04660 | T cell receptor signaling pathway |
hsa04662 | B cell receptor signaling pathway |
hsa04932 | Non-alcoholic fatty liver disease |
hsa04933 | AGE-RAGE signaling pathway in diabetic complications |
hsa05120 | Epithelial cell signaling in Helicobacter pylori infection |
hsa05130 | Pathogenic Escherichia coli infection |
hsa05166 | Human T-cell leukemia virus 1 infection |
hsa05167 | Kaposi sarcoma-associated herpesvirus infection |
hsa05170 | Human immunodeficiency virus 1 infection |
hsa05207 | Chemical carcinogenesis - receptor activation |
hsa05208 | Chemical carcinogenesis - reactive oxygen species |
hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer |
hsa05418 | Fluid shear stress and atherosclerosis |
|
Network |
nt06110 MAPK signaling (viruses and bacteria) nt06121 TLR signaling (viruses and bacteria) nt06123 TNF signaling (viruses and bacteria) nt06124 Chemokine signaling (viruses) nt06150 Cytokine-cytokine receptor interaction (viruses) nt06160 Human T-cell leukemia virus 1 (HTLV-1) nt06161 Human immunodeficiency virus type 1 (HIV-1) nt06162 Hepatitis B virus (HBV) nt06164 Kaposi sarcoma-associated herpesvirus (KSHV) nt06210 ERK signaling nt06211 Other MAPK signaling nt06214 PI3K signaling nt06223 TNF signaling nt06224 CXCR signaling nt06263 Hepatocellular carcinoma nt06416 TNF signaling nt06461 Huntington disease |
Element |
N00157 | KSHV vGPCR to GNB/G-ERK signaling pathway |
N00188 | IL1-IL1R-JNK signaling pathway |
N00189 | KSHV K15 to JNK signaling pathway |
N00438 | TLR2/4-MAPK signaling pathway |
N00446 | TNF-JNK signaling pathway |
N00447 | HIV Vpr/Tat to TNF-JNK signaling pathway |
N00503 | HTLV-1 Tax to TNF-JNK signaling pathway |
N00543 | HBV HBx to JNK signaling pathway |
N00545 | HBV HBx to ERK signaling pathway |
N00547 | HBV LHBs to PKC-ERK signaling pathway |
N01344 | NNK/NNN to RAS-ERK signaling pathway |
N01350 | NNK/NNN to PI3K signaling pathway |
N01353 | E2 to RAS-ERK signaling pathway |
N01407 | Metals to JNK signaling pathway |
N01408 | Metals to RAS-ERK signaling pathway |
|
Brite |
KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
3725 (JUN)
04012 ErbB signaling pathway
3725 (JUN)
04310 Wnt signaling pathway
3725 (JUN)
04668 TNF signaling pathway
3725 (JUN)
04024 cAMP signaling pathway
3725 (JUN)
09140 Cellular Processes
09141 Transport and catabolism
04137 Mitophagy - animal
3725 (JUN)
09143 Cell growth and death
04210 Apoptosis
3725 (JUN)
09144 Cellular community - eukaryotes
04510 Focal adhesion
3725 (JUN)
04530 Tight junction
3725 (JUN)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
3725 (JUN)
04621 NOD-like receptor signaling pathway
3725 (JUN)
04625 C-type lectin receptor signaling pathway
3725 (JUN)
04660 T cell receptor signaling pathway
3725 (JUN)
04658 Th1 and Th2 cell differentiation
3725 (JUN)
04659 Th17 cell differentiation
3725 (JUN)
04657 IL-17 signaling pathway
3725 (JUN)
04662 B cell receptor signaling pathway
3725 (JUN)
09152 Endocrine system
04912 GnRH signaling pathway
3725 (JUN)
04915 Estrogen signaling pathway
3725 (JUN)
04921 Oxytocin signaling pathway
3725 (JUN)
04926 Relaxin signaling pathway
3725 (JUN)
09156 Nervous system
04722 Neurotrophin signaling pathway
3725 (JUN)
09158 Development and regeneration
04380 Osteoclast differentiation
3725 (JUN)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
3725 (JUN)
05207 Chemical carcinogenesis - receptor activation
3725 (JUN)
05208 Chemical carcinogenesis - reactive oxygen species
3725 (JUN)
05203 Viral carcinogenesis
3725 (JUN)
05231 Choline metabolism in cancer
3725 (JUN)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
3725 (JUN)
09162 Cancer: specific types
05210 Colorectal cancer
3725 (JUN)
05211 Renal cell carcinoma
3725 (JUN)
05224 Breast cancer
3725 (JUN)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
3725 (JUN)
05170 Human immunodeficiency virus 1 infection
3725 (JUN)
05161 Hepatitis B
3725 (JUN)
05171 Coronavirus disease - COVID-19
3725 (JUN)
05162 Measles
3725 (JUN)
05167 Kaposi sarcoma-associated herpesvirus infection
3725 (JUN)
05169 Epstein-Barr virus infection
3725 (JUN)
09171 Infectious disease: bacterial
05120 Epithelial cell signaling in Helicobacter pylori infection
3725 (JUN)
05130 Pathogenic Escherichia coli infection
3725 (JUN)
05132 Salmonella infection
3725 (JUN)
05131 Shigellosis
3725 (JUN)
05135 Yersinia infection
3725 (JUN)
05133 Pertussis
3725 (JUN)
09174 Infectious disease: parasitic
05140 Leishmaniasis
3725 (JUN)
05142 Chagas disease
3725 (JUN)
09163 Immune disease
05323 Rheumatoid arthritis
3725 (JUN)
05321 Inflammatory bowel disease
3725 (JUN)
09165 Substance dependence
05030 Cocaine addiction
3725 (JUN)
05031 Amphetamine addiction
3725 (JUN)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
3725 (JUN)
05418 Fluid shear stress and atherosclerosis
3725 (JUN)
09167 Endocrine and metabolic disease
04932 Non-alcoholic fatty liver disease
3725 (JUN)
04933 AGE-RAGE signaling pathway in diabetic complications
3725 (JUN)
09176 Drug resistance: antineoplastic
01522 Endocrine resistance
3725 (JUN)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03000 Transcription factors [BR:hsa03000]
3725 (JUN)
Transcription factors [BR:hsa03000]
Eukaryotic type
Basic leucine zipper (bZIP)
AP-1(-like) components, Jun
3725 (JUN)
|
SSDB |
|
Motif |
|
Other DBs |
|
Structure |
|
Position |
1:complement(58780791..58784047)
|
AA seq |
331 aa
MTAKMETTFYDDALNASFLPSESGPYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDL
LTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAE
LHSQNTLPSVTSAAQPVNGAGMVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGA
LSSGGGAPSYGAAGLAFPAQPQQQQQPPHHLPQQMPVQHPRLQALKEEPQTVPEMPGETP
PLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANM
LREQVAQLKQKVMNHVNSGCQLMLTQQLQTF |
NT seq |
996 nt +upstreamnt +downstreamnt
atgactgcaaagatggaaacgaccttctatgacgatgccctcaacgcctcgttcctcccg
tccgagagcggaccttatggctacagtaaccccaagatcctgaaacagagcatgaccctg
aacctggccgacccagtggggagcctgaagccgcacctccgcgccaagaactcggacctc
ctcacctcgcccgacgtggggctgctcaagctggcgtcgcccgagctggagcgcctgata
atccagtccagcaacgggcacatcaccaccacgccgacccccacccagttcctgtgcccc
aagaacgtgacagatgagcaggagggcttcgccgagggcttcgtgcgcgccctggccgaa
ctgcacagccagaacacgctgcccagcgtcacgtcggcggcgcagccggtcaacggggca
ggcatggtggctcccgcggtagcctcggtggcagggggcagcggcagcggcggcttcagc
gccagcctgcacagcgagccgccggtctacgcaaacctcagcaacttcaacccaggcgcg
ctgagcagcggcggcggggcgccctcctacggcgcggccggcctggcctttcccgcgcaa
ccccagcagcagcagcagccgccgcaccacctgccccagcagatgcccgtgcagcacccg
cggctgcaggccctgaaggaggagcctcagacagtgcccgagatgcccggcgagacaccg
cccctgtcccccatcgacatggagtcccaggagcggatcaaggcggagaggaagcgcatg
aggaaccgcatcgctgcctccaagtgccgaaaaaggaagctggagagaatcgcccggctg
gaggaaaaagtgaaaaccttgaaagctcagaactcggagctggcgtccacggccaacatg
ctcagggaacaggtggcacagcttaaacagaaagtcatgaaccacgttaacagtgggtgc
caactcatgctaacgcagcagttgcaaacattttga |