KEGG   Homo sapiens (human): 3757
Entry
3757              CDS       T01001                                 

Gene name
KCNH2, ERG-1, ERG1, H-ERG, HERG, HERG1, Kv11.1, LQT2, SQT1
Definition
(RefSeq) potassium voltage-gated channel subfamily H member 2
  KO
K04905  potassium voltage-gated channel Eag-related subfamily H member 2
Organism
hsa  Homo sapiens (human)
Disease
H00720  Long QT syndrome
H00725  Short QT syndrome
Drug target
Ambasilide: D09758
Amiodarone (DG00204): D00636<JP/US> D02910
Azimilide dihydrochloride: D03037
Bepridil (DG00333): D00631<JP> D07520
Clofilium phosphate: D03547
Cocaine (DG00808): D00110 D02182<JP/US>
Dexsotalol hydrochloride: D03732
Dofetilide: D00647<US>
Dronedarone (DG00207): D02537 D03914<US>
Ibutilide (DG00205): D00648<US> D08060
Nifekalant hydrochloride: D01856<JP>
Sematilide hydrochloride: D04955
Sotalol (DG00307): D01026<JP/US> D08525
Terfenadine: D00521
Terikalant: D09757
Trecetilide (DG02906): D06206 D09759
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    3757 (KCNH2)
Ion channels [BR:hsa04040]
 Voltage-gated cation channels
  Potassium channel, voltage-gated (Kv)
   3757 (KCNH2)
SSDB
Motif
Pfam: Ion_trans PAS_9 Ion_trans_2 cNMP_binding PAS PAS_3 PAS_4 PAS_8
Other DBs
NCBI-GeneID: 3757
NCBI-ProteinID: NP_000229
OMIM: 152427
HGNC: 6251
Ensembl: ENSG00000055118
Vega: OTTHUMG00000158341
Pharos: Q12809(Tclin)
UniProt: Q12809 Q15BH2 A0A090N8Q0
Structure
PDB: 

Position
7q36.1
AA seq 1159 aa
MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVM
QRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDG
AVIMFILNFEVVMEKDMVGSPAHDTNHRGPPTSWLAPGRAKTFRLKLPALLALTARESSV
RSGGAGGAGAPGAVVVDVDLTPAAPSSESLALDEVTAMDNHVAGLGPAEERRALVGPGSP
PRSAPGQLPSPRAHSLNPDASGSSCSLARTRSRESCASVRRASSADDIEAMRAGVLPPPP
RHASTGAMHPLRSGLLNSTSDSDLVRYRTISKIPQITLNFVDLKGDPFLASPTSDREIIA
PKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIY
TAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANE
EVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLD
RYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSS
GLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVS
AIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGF
PECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALY
FISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLE
VLDMYPEFSDHFWSSLEITFNLRDTNMIPGSPGSTELEGGFSRQRKRKLSFRRRTDKDTE
QPGEVSALGPGRAGAGPSSRGRPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSS
PRPPGEPPGGEPLMEDCEKSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPTP
SLLNIPLSSPGRRPRGDVESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSA
VTTPGPGPTSTSPLLPVSPLPTLTLDSLSQVSQFMACEELPPGAPELPQEGPTRRLSLPG
QLGALTSQPLHRHGSDPGS
NT seq 3480 nt   +upstreamnt  +downstreamnt
atgccggtgcggaggggccacgtcgcgccgcagaacaccttcctggacaccatcatccgc
aagtttgagggccagagccgtaagttcatcatcgccaacgctcgggtggagaactgcgcc
gtcatctactgcaacgacggcttctgcgagctgtgcggctactcgcgggccgaggtgatg
cagcgaccctgcacctgcgacttcctgcacgggccgcgcacgcagcgccgcgctgccgcg
cagatcgcgcaggcactgctgggcgccgaggagcgcaaagtggaaatcgccttctaccgg
aaagatgggagctgcttcctatgtctggtggatgtggtgcccgtgaagaacgaggatggg
gctgtcatcatgttcatcctcaatttcgaggtggtgatggagaaggacatggtggggtcc
ccggctcatgacaccaaccaccggggcccccccaccagctggctggccccaggccgcgcc
aagaccttccgcctgaagctgcccgcgctgctggcgctgacggcccgggagtcgtcggtg
cggtcgggcggcgcgggcggcgcgggcgccccgggggccgtggtggtggacgtggacctg
acgcccgcggcacccagcagcgagtcgctggccctggacgaagtgacagccatggacaac
cacgtggcagggctcgggcccgcggaggagcggcgtgcgctggtgggtcccggctctccg
ccccgcagcgcgcccggccagctcccatcgccccgggcgcacagcctcaaccccgacgcc
tcgggctccagctgcagcctggcccggacgcgctcccgagaaagctgcgccagcgtgcgc
cgcgcctcgtcggccgacgacatcgaggccatgcgcgccggggtgctgcccccgccaccg
cgccacgccagcaccggggccatgcacccactgcgcagcggcttgctcaactccacctcg
gactccgacctcgtgcgctaccgcaccattagcaagattccccaaatcaccctcaacttt
gtggacctcaagggcgaccccttcttggcttcgcccaccagtgaccgtgagatcatagca
cctaagataaaggagcgaacccacaatgtcactgagaaggtcacccaggtcctgtccctg
ggcgccgacgtgctgcctgagtacaagctgcaggcaccgcgcatccaccgctggaccatc
ctgcattacagccccttcaaggccgtgtgggactggctcatcctgctgctggtcatctac
acggctgtcttcacaccctactcggctgccttcctgctgaaggagacggaagaaggcccg
cctgctaccgagtgtggctacgcctgccagccgctggctgtggtggacctcatcgtggac
atcatgttcattgtggacatcctcatcaacttccgcaccacctacgtcaatgccaacgag
gaggtggtcagccaccccggccgcatcgccgtccactacttcaagggctggttcctcatc
gacatggtggccgccatccccttcgacctgctcatcttcggctctggctctgaggagctg
atcgggctgctgaagactgcgcggctgctgcggctggtgcgcgtggcgcggaagctggat
cgctactcagagtacggcgcggccgtgctgttcttgctcatgtgcacctttgcgctcatc
gcgcactggctagcctgcatctggtacgccatcggcaacatggagcagccacacatggac
tcacgcatcggctggctgcacaacctgggcgaccagataggcaaaccctacaacagcagc
ggcctgggcggcccctccatcaaggacaagtatgtgacggcgctctacttcaccttcagc
agcctcaccagtgtgggcttcggcaacgtctctcccaacaccaactcagagaagatcttc
tccatctgcgtcatgctcattggctccctcatgtatgctagcatcttcggcaacgtgtcg
gccatcatccagcggctgtactcgggcacagcccgctaccacacacagatgctgcgggtg
cgggagttcatccgcttccaccagatccccaatcccctgcgccagcgcctcgaggagtac
ttccagcacgcctggtcctacaccaacggcatcgacatgaacgcggtgctgaagggcttc
cctgagtgcctgcaggctgacatctgcctgcacctgaaccgctcactgctgcagcactgc
aaacccttccgaggggccaccaagggctgccttcgggccctggccatgaagttcaagacc
acacatgcaccgccaggggacacactggtgcatgctggggacctgctcaccgccctgtac
ttcatctcccggggctccatcgagatcctgcggggcgacgtcgtcgtggccatcctgggg
aagaatgacatctttggggagcctctgaacctgtatgcaaggcctggcaagtcgaacggg
gatgtgcgggccctcacctactgtgacctacacaagatccatcgggacgacctgctggag
gtgctggacatgtaccctgagttctccgaccacttctggtccagcctggagatcaccttc
aacctgcgagataccaacatgatcccgggctcccccggcagtacggagttagagggtggc
ttcagtcggcaacgcaagcgcaagttgtccttccgcaggcgcacggacaaggacacggag
cagccaggggaggtgtcggccttggggccgggccgggcgggggcagggccgagtagccgg
ggccggccgggggggccgtggggggagagcccgtccagtggcccctccagccctgagagc
agtgaggatgagggcccaggccgcagctccagccccctccgcctggtgcccttctccagc
cccaggccccccggagagccgccgggtggggagcccctgatggaggactgcgagaagagc
agcgacacttgcaaccccctgtcaggcgccttctcaggagtgtccaacattttcagcttc
tggggggacagtcggggccgccagtaccaggagctccctcgatgccccgcccccaccccc
agcctcctcaacatccccctctccagcccgggtcggcggccccggggcgacgtggagagc
aggctggatgccctccagcgccagctcaacaggctggagacccggctgagtgcagacatg
gccactgtcctgcagctgctacagaggcagatgacgctggtcccgcccgcctacagtgct
gtgaccaccccggggcctggccccacttccacatccccgctgttgcccgtcagccccctc
cccaccctcaccttggactcgctttctcaggtttcccagttcatggcgtgtgaggagctg
cccccgggggccccagagcttccccaagaaggccccacacgacgcctctccctaccgggc
cagctgggggccctcacctcccagcccctgcacagacacggctcggacccgggcagttag

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Disease (5)   
   KEGG DISEASE (2)   
   OMIM (3)   
Drug (23)   
   KEGG DRUG (23)   
Genome (1)   
   KEGG GENOME (1)   
Gene (27)   
   KEGG ORTHOLOGY (1)   
   RefGene (15)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (12)   
   UniProt (3)   
   SWISS-PROT (1)   
   RefSeq(pep) (8)   
DNA sequence (48)   
   RefSeq(nuc) (8)   
   GenBank (20)   
   EMBL (20)   
Protein domain (8)   
   Pfam (8)   
All databases (126)   

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