KEGG   Homo sapiens (human): 3758
Entry
3758              CDS       T01001                                 

Gene name
KCNJ1, KIR1.1, ROMK, ROMK1
Definition
(RefSeq) potassium inwardly rectifying channel subfamily J member 1
  KO
K04995  potassium inwardly-rectifying channel subfamily J member 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04960  Aldosterone-regulated sodium reabsorption
hsa04971  Gastric acid secretion
Disease
H00239  Bartter syndrome
Drug target
Betanidine: D01603
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09154 Digestive system
   04971 Gastric acid secretion
    3758 (KCNJ1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    3758 (KCNJ1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    3758 (KCNJ1)
Ion channels [BR:hsa04040]
 Voltage-gated cation channels
  Potassium channel, inwardly-rectifying (Kir)
   3758 (KCNJ1)
SSDB
Motif
Pfam: IRK_C IRK
Other DBs
NCBI-GeneID: 3758
NCBI-ProteinID: NP_000211
OMIM: 600359
HGNC: 6255
Ensembl: ENSG00000151704
Vega: OTTHUMG00000048247
Pharos: P48048(Tchem)
UniProt: P48048 A8K432
Position
11q24.3
AA seq 391 aa
MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQS
RFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTP
CVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILA
KISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGE
TIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGT
VESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLY
NEKDVRARMKRGYDNPNFILSEVNETDDTKM
NT seq 1176 nt   +upstreamnt  +downstreamnt
atgaatgcttccagtcggaatgtgtttgacacgttgatcagggtgttgacagaaagtatg
ttcaaacatcttcggaaatgggtcgtcactcgcttttttgggcattctcggcaaagagca
aggctagtctccaaagatggaaggtgcaacatagaatttggcaatgtggaggcacagtca
aggtttatattctttgtggacatctggacaacggtacttgacctcaagtggagatacaaa
atgaccattttcatcacagccttcttggggagttggtttttctttggtctcctgtggtat
gcagtagcgtacattcacaaagacctcccggaattccatccttctgccaatcacactccc
tgtgtggagaatattaatggcttgacctcagcttttctgttttctctggagactcaagtg
accattggatatggattcaggtgtgtgacagaacagtgtgccactgccatttttctgctt
atctttcagtctatacttggagttataatcaattctttcatgtgtggggccatcttagcc
aagatctccaggcccaaaaaacgtgccaagaccattacgttcagcaagaacgcagtgatc
agcaaacggggagggaagctttgcctcctaatccgagtggctaatctcaggaagagcctt
cttattggcagtcacatttatggaaagcttctgaagaccacagtcactcctgaaggagag
accattattttggaccagatcaatatcaactttgtagttgacgctgggaatgaaaattta
ttcttcatctccccattgacaatttaccatgtcattgatcacaacagccctttcttccac
atggcagcggagacccttctccagcaggactttgaattagtggtgtttttagatggcaca
gtggagtccaccagtgctacctgccaagtccggacatcctatgtcccagaggaggtgctt
tggggctaccgttttgctcccatagtatccaagacaaaggaagggaaataccgagtggat
ttccataactttagcaagacagtggaagtggagacccctcactgtgccatgtgcctttat
aatgagaaagatgttagagccaggatgaagagaggctatgacaaccccaacttcatcttg
tcagaagtcaatgaaacagatgacaccaaaatgtaa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Drug (1)   
   KEGG DRUG (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (11)   
   KEGG ORTHOLOGY (1)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (8)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (47)   
   RefSeq(nuc) (5)   
   GenBank (21)   
   EMBL (21)   
Protein domain (2)   
   Pfam (2)   
All databases (77)   

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