KEGG T01001: 3767

Homo sapiens (human): 3767

Entry

3767              CDS       T01001

Symbol

KCNJ11, BIR, HHF2, IKATP, KIR6.2, MODY13, PHHI, PNDM2, TNDM3

Name

(RefSeq) potassium inwardly rectifying channel subfamily J member 11

K05004

potassium inwardly-rectifying channel subfamily J member 11

Organism

hsa Homo sapiens (human)

Pathway

hsa04911

Insulin secretion

hsa04929

GnRH secretion

hsa04930

Type II diabetes mellitus

Disease

H00409

Type 2 diabetes mellitus

H00410

Maturity onset diabetes of the young (MODY)

H00512

Permanent neonatal diabetes mellitus

H00513

Transient neonatal diabetes mellitus

H01267

Familial hyperinsulinemic hypoglycemia

Drug target

Amiodarone (DG00204):

D00636<JP/US> D02910

Bepridil (DG00333):

D00631<JP> D07520

Chlorpropamide:

D00271

Diazoxide:

D00294<JP/US>

Diazoxide (DG03325):

D12987<US>

Dronedarone (DG00207):

D03914<US>

Glibenclamide:

D00336<JP/US>

Glymidine:

D01356

Levcromakalim:

D02385 D02385

Linogliride (DG02893):

D04739 D04740

Minoxidil:

D00418<US>

Mitiglinide:

D01854<JP>

Naminidil:

D05114 D05114

Nateglinide:

D01111<JP/US>

Nicorandil:

D01810<JP> D01810<JP>

Pinacidil:

D05482 D05482

Repaglinide:

D00594<JP/US>

Tolazamide:

D00379

Tolbutamide (DG00115):

D00380 D06177

Brite

KEGG Orthology (KO) [BR:hsa00001]
09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    3767 (KCNJ11)
   04929 GnRH secretion
    3767 (KCNJ11)
09160 Human Diseases
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    3767 (KCNJ11)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    3767 (KCNJ11)
Ion channels [BR:hsa04040]
Voltage-gated cation channels
  Potassium channel, inwardly-rectifying (Kir)
   3767 (KCNJ11)

SSDB

Motif

Pfam:

IRK_C IRK Ion_trans Ion_trans_2

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

Position

11:complement(17385248..17389346)

AA seq 390 aa
MLSRKGIIPEEYVLTRLAEDPAKPRYRARQRRARFVSKKGNCNVAHKNIREQGRFLQDVF
TTLVDLKWPHTLLIFTMSFLCSWLLFAMAWWLIAFAHGDLAPSEGTAEPCVTSIHSFSSA
FLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMKTAQAHRRAET
LIFSKHAVIALRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVDIPM
ENGVGGNSIFLVAPLIIYHVIDANSPLYDLAPSDLHHHQDLEIIVILEGVVETTGITTQA
RTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTVKVPTPLCTARQLDEDHSLLEALT
LASARGPLRKRSVPMAKAKPKFSISPDSLS

NT seq 1173 nt +upstreamnt +downstreamnt
atgctgtcccgcaagggcatcatccccgaggaatacgtgctgacacgcctggcagaggac
cctgccaagcccaggtaccgtgcccgccagcggagggcccgctttgtgtccaagaaaggc
aactgcaacgtggcccacaagaacatccgggagcagggccgcttcctgcaggacgtgttc
accacgctggtggacctcaagtggccacacacattgctcatcttcaccatgtccttcctg
tgcagctggctgctcttcgccatggcctggtggctcatcgccttcgcccacggtgacctg
gcccccagcgagggcactgctgagccctgtgtcaccagcatccactccttctcgtctgcc
ttccttttctccattgaggtccaagtgactattggctttggggggcgcatggtgactgag
gagtgcccactggccatcctgatcctcatcgtgcagaacatcgtggggctcatgatcaac
gccatcatgcttggctgcatcttcatgaagactgcccaagcccaccgcagggctgagacc
ctcatcttcagcaagcatgcggtgatcgccctgcgccacggccgcctctgcttcatgcta
cgtgtgggtgacctccgcaagagcatgatcatcagcgccaccatccacatgcaggtggta
cgcaagaccaccagccccgagggcgaggtggtgcccctccaccaggtggacatccccatg
gagaacggcgtgggtggcaacagcatcttcctggtggccccgctgatcatctaccatgtc
attgatgccaacagcccactctacgacctggcacccagcgacctgcaccaccaccaggac
ctcgagatcatcgtcatcctggaaggcgtggtggaaaccacgggcatcaccacccaggcc
cgcacctcctacctggccgatgagatcctgtggggccagcgctttgtgcccattgtagct
gaggaggacggacgttactctgtggactactccaagtttggcaacaccgtcaaagtgccc
acaccactctgcacggcccgccagcttgatgaggaccacagcctactggaagctctgacc
ctcgcctcagcccgcgggcccctgcgcaagcgcagcgtgcccatggccaaggccaagccc
aagttcagcatctctccagattccctgtcctga

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