KEGG   Homo sapiens (human): 3816Help
Entry
3816              CDS       T01001                                 

Gene name
KLK1, KLKR, Klk6, hK1
Definition
(RefSeq) kallikrein 1
  KO
K01325  tissue kallikrein [EC:3.4.21.35]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04614  Renin-angiotensin system
hsa04961  Endocrine and other factor-regulated calcium reabsorption
Drug target
Gabexate (DG01400): D01672 D08004
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Organismal Systems
  Endocrine system
   04614 Renin-angiotensin system
    3816 (KLK1)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    3816 (KLK1)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.35  tissue kallikrein
     3816 (KLK1)
Peptidases [BR:hsa01002]
 Serine Peptidases
  Family S1: chymotrypsin family
   3816 (KLK1)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   3816 (KLK1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Trypsin Trypsin_2 DUF1986
Motif
Other DBs
NCBI-GeneID: 3816
NCBI-ProteinID: NP_002248
OMIM: 147910
HGNC: 6357
Ensembl: ENSG00000167748
Vega: OTTHUMG00000182876
Pharos: P06870(Tchem)
UniProt: P06870 A0A1R3UCD2
Structure
PDB: 

Position
19q13.33
AA seq 262 aa AA seqDB search
MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWV
LTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHD
LMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKIL
PNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNK
PSVAVRVLSYVKWIEDTIAENS
NT seq 789 nt NT seq  +upstreamnt  +downstreamnt
atgtggttcctggttctgtgcctcgccctgtccctgggggggactggtgctgcgcccccg
attcagtcccggattgtgggaggctgggagtgtgagcagcattcccagccctggcaggcg
gctctgtaccatttcagcactttccagtgtgggggcatcctggtgcaccgccagtgggtg
ctcacagctgctcattgcatcagcgacaattaccagctctggctgggtcgccacaacttg
tttgacgacgaaaacacagcccagtttgttcatgtcagtgagagcttcccacaccctggc
ttcaacatgagcctcctggagaaccacacccgccaagcagacgaggactacagccacgac
ctcatgctgctccgcctgacagagcctgctgataccatcacagatgctgtgaaggtcgtg
gagttgcccaccgaggaacccgaagtggggagcacctgtttggcttccggctggggcagc
atcgaaccagagaatttctcatttccagatgatctccagtgtgtggacctcaaaatcctg
cctaatgatgagtgcaaaaaagcccacgtccagaaggtgacagacttcatgctgtgtgtc
ggacacctggaaggtggcaaagacacctgtgtgggtgattcagggggcccgctgatgtgt
gatggtgtgctccaaggtgtcacatcatggggctacgtcccttgtggcacccccaataag
ccttctgtcgccgtcagagtgctgtcttatgtgaagtggatcgaggacaccatagcggag
aactcctga

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (2)   
   OMIM (2)   
Drug (2)   
   KEGG DRUG (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (21)   
   KEGG ORTHOLOGY (1)   
   RefGene (11)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   UniGene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (5)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (28)   
   RefSeq(nuc) (2)   
   GenBank (13)   
   EMBL (13)   
Protein domain (3)   
   Pfam (3)   
All databases (69)   

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