KEGG   Homo sapiens (human): 3816
Entry
3816              CDS       T01001                                 
Symbol
KLK1, KLKR, Klk6, hK1
Name
(RefSeq) kallikrein 1
  KO
K01325  tissue kallikrein [EC:3.4.21.35]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04614  Renin-angiotensin system
hsa04961  Endocrine and other factor-regulated calcium reabsorption
Drug target
Gabexate (DG01400): D01672<JP> D08004
Rinvecalinase alfa: D12830
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09152 Endocrine system
   04614 Renin-angiotensin system
    3816 (KLK1)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    3816 (KLK1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    3816 (KLK1)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    3816 (KLK1)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.35  tissue kallikrein
     3816 (KLK1)
Peptidases and inhibitors [BR:hsa01002]
 Serine peptidases
  Family S1: chymotrypsin family
   3816 (KLK1)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   3816 (KLK1)
SSDB
Motif
Pfam: Trypsin Trypsin_2 DUF1986
Other DBs
NCBI-GeneID: 3816
NCBI-ProteinID: NP_002248
OMIM: 147910
HGNC: 6357
Ensembl: ENSG00000167748
UniProt: P06870 A0A1R3UCD2
Structure
Position
19:complement(50819146..50823787)
AA seq 262 aa
MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWV
LTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHD
LMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKIL
PNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNK
PSVAVRVLSYVKWIEDTIAENS
NT seq 789 nt   +upstreamnt  +downstreamnt
atgtggttcctggttctgtgcctcgccctgtccctgggggggactggtgctgcgcccccg
attcagtcccggattgtgggaggctgggagtgtgagcagcattcccagccctggcaggcg
gctctgtaccatttcagcactttccagtgtgggggcatcctggtgcaccgccagtgggtg
ctcacagctgctcattgcatcagcgacaattaccagctctggctgggtcgccacaacttg
tttgacgacgaaaacacagcccagtttgttcatgtcagtgagagcttcccacaccctggc
ttcaacatgagcctcctggagaaccacacccgccaagcagacgaggactacagccacgac
ctcatgctgctccgcctgacagagcctgctgataccatcacagatgctgtgaaggtcgtg
gagttgcccaccgaggaacccgaagtggggagcacctgtttggcttccggctggggcagc
atcgaaccagagaatttctcatttccagatgatctccagtgtgtggacctcaaaatcctg
cctaatgatgagtgcaaaaaagcccacgtccagaaggtgacagacttcatgctgtgtgtc
ggacacctggaaggtggcaaagacacctgtgtgggtgattcagggggcccgctgatgtgt
gatggtgtgctccaaggtgtcacatcatggggctacgtcccttgtggcacccccaataag
ccttctgtcgccgtcagagtgctgtcttatgtgaagtggatcgaggacaccatagcggag
aactcctga

  All links  
Disease (2)   
   OMIM (2)   
Gene (17)   
   RefGene (11)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (27)   
   RefSeq(nuc) (1)   
   GenBank (13)   
   EMBL (13)   
3D Structure (2)   
   PDB (2)   
Protein domain (3)   
   Pfam (3)   
All databases (55)   

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