KEGG   Homo sapiens (human): 3818
Entry
3818              CDS       T01001                                 
Symbol
KLKB1, KLK3, PKK, PKKD, PPK
Name
(RefSeq) kallikrein B1
  KO
K01324  plasma kallikrein [EC:3.4.21.34]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04610  Complement and coagulation cascades
Network
nt06514  Coagulation cascade
  Element
N01516  Kallikrein-kinin system, prekallikrein activation
Disease
H01078  Fletcher factor deficiency
Drug target
Berotralstat (DG03079): D11673 D11674<JP/US>
Conestat alfa: D10845<US>
Ecallantide: D03931<US>
Feniralstat (DG03263): D12573 D12574
Gabexate (DG01400): D01672<JP> D08004
Lanadelumab: D11094<JP/US>
Navenibart: D12770
Sebetralstat: D12396
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    3818 (KLKB1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    3818 (KLKB1)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.34  plasma kallikrein
     3818 (KLKB1)
Peptidases and inhibitors [BR:hsa01002]
 Serine peptidases
  Family S1: chymotrypsin family
   3818 (KLKB1)
SSDB
Motif
Pfam: Trypsin PAN_1 PAN_4 DUF1986 Trypsin_2 PAN_2
Other DBs
NCBI-GeneID: 3818
NCBI-ProteinID: NP_000883
OMIM: 229000
HGNC: 6371
Ensembl: ENSG00000164344
CPD: C01715
UniProt: P03952 A8K9A9
Structure
Position
4:186210853..186258471
AA seq 638 aa
MILFKQATYFISLFATVSCGCLTQLYENAFFRGGDVASMYTPNAQYCQMRCTFHPRCLLF
SFLPASSINDMEKRFGCFLKDSVTGTLPKVHRTGAVSGHSLKQCGHQISACHRDIYKGVD
MRGVNFNVSKVSSVEECQKRCTSNIRCQFFSYATQTFHKAEYRNNCLLKYSPGGTPTAIK
VLSNVESGFSLKPCALSEIGCHMNIFQHLAFSDVDVARVLTPDAFVCRTICTYHPNCLFF
TFYTNVWKIESQRNVCLLKTSESGTPSSSTPQENTISGYSLLTCKRTLPEPCHSKIYPGV
DFGGEELNVTFVKGVNVCQETCTKMIRCQFFTYSLLPEDCKEEKCKCFLRLSMDGSPTRI
AYGTQGSSGYSLRLCNTGDNSVCTTKTSTRIVGGTNSSWGEWPWQVSLQVKLTAQRHLCG
GSLIGHQWVLTAAHCFDGLPLQDVWRIYSGILNLSDITKDTPFSQIKEIIIHQNYKVSEG
NHDIALIKLQAPLNYTEFQKPICLPSKGDTSTIYTNCWVTGWGFSKEKGEIQNILQKVNI
PLVTNEECQKRYQDYKITQRMVCAGYKEGGKDACKGDSGGPLVCKHNGMWRLVGITSWGE
GCARREQPGVYTKVAEYMDWILEKTQSSDGKAQMQSPA
NT seq 1917 nt   +upstreamnt  +downstreamnt
atgattttattcaagcaagcaacttatttcatttccttgtttgctacagtttcctgtgga
tgtctgactcaactctatgaaaacgccttcttcagaggtggggatgtagcttccatgtac
accccaaatgcccaatactgccagatgaggtgcacattccacccaaggtgtttgctattc
agttttcttccagcaagttcaatcaatgacatggagaaaaggtttggttgcttcttgaaa
gatagtgttacaggaaccctgccaaaagtacatcgaacaggtgcagtttctggacattcc
ttgaagcaatgtggtcatcaaataagtgcttgccatcgagacatttataaaggagttgat
atgagaggagtcaattttaatgtgtctaaggttagcagtgttgaagaatgccaaaaaagg
tgcaccagtaacattcgctgccagtttttttcatatgccacgcaaacatttcacaaggca
gagtaccggaacaattgcctattaaagtacagtcccggaggaacacctaccgctataaag
gtgctgagtaacgtggaatctggattctcactgaagccctgtgccctttcagaaattggt
tgccacatgaacatcttccagcatcttgcgttctcagatgtggatgttgccagggttctc
actccagatgcttttgtgtgtcggaccatctgcacctatcaccccaactgcctcttcttt
acattctatacaaatgtatggaaaatcgagtcacaaagaaatgtttgtcttcttaaaaca
tctgaaagtggcacaccaagttcctctactcctcaagaaaacaccatatctggatatagc
cttttaacctgcaaaagaactttacctgaaccctgccattctaaaatttacccgggagtt
gactttggaggagaagaattgaatgtgacttttgttaaaggagtgaatgtttgccaagag
acttgcacaaagatgattcgctgtcagtttttcacttattctttactcccagaagactgt
aaggaagagaagtgtaagtgtttcttaagattatctatggatggttctccaactaggatt
gcgtatgggacacaagggagctctggttactctttgagattgtgtaacactggggacaac
tctgtctgcacaacaaaaacaagcacacgcattgttggaggaacaaactcttcttgggga
gagtggccctggcaggtgagcctgcaggtgaagctgacagctcagaggcacctgtgtgga
gggtcactcataggacaccagtgggtcctcactgctgcccactgctttgatgggcttccc
ctgcaggatgtttggcgcatctatagtggcattttaaatctgtcagacattacaaaagat
acacctttctcacaaataaaagagattattattcaccaaaactataaagtctcagaaggg
aatcatgatatcgccttgataaaactccaggctcctttgaattacactgaattccaaaaa
ccaatatgcctaccttccaaaggtgacacaagcacaatttataccaactgttgggtaacc
ggatggggcttctcgaaggagaaaggtgaaatccaaaatattctacaaaaggtaaatatt
cctttggtaacaaatgaagaatgccagaaaagatatcaagattataaaataacccaacgg
atggtctgtgctggctataaagaagggggaaaagatgcttgtaagggagattcaggtggt
cccttagtttgcaaacacaatggaatgtggcgtttggtgggcatcaccagctggggtgaa
ggctgtgcccgcagggagcaacctggtgtctacaccaaagtcgctgagtacatggactgg
attttagagaaaacacagagcagtgatggaaaagctcagatgcagtcaccagcatga

  All links  
Disease (2)   
   OMIM (2)   
Gene (46)   
   RefGene (40)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (18)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (15)   
DNA sequence (35)   
   RefSeq(nuc) (15)   
   GenBank (10)   
   EMBL (10)   
3D Structure (16)   
   PDB (16)   
Protein domain (6)   
   Pfam (6)   
All databases (123)   

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