KEGG   Homo sapiens (human): 383
Entry
383               CDS       T01001                                 
Symbol
ARG1
Name
(RefSeq) arginase 1
  KO
K01476  arginase [EC:3.5.3.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00220  Arginine biosynthesis
hsa00330  Arginine and proline metabolism
hsa01100  Metabolic pathways
hsa01230  Biosynthesis of amino acids
hsa04148  Efferocytosis
hsa05146  Amoebiasis
Module
hsa_M00029  Urea cycle
hsa_M00134  Polyamine biosynthesis, arginine => ornithine => putrescine
Network
nt06010  Urea cycle
nt06535  Efferocytosis
  Element
N00593  Urea cycle
N01779  Continual efferocytosis enhanced by the AC-derived arginine and ornithine
Disease
H00186  Hyperargininemia
H01398  Primary hyperammonemia (Urea cycle disorders)
Drug target
Numidargistat: D11792
Pegzilarginase: D11695
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00220 Arginine biosynthesis
    383 (ARG1)
   00330 Arginine and proline metabolism
    383 (ARG1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    383 (ARG1)
 09160 Human Diseases
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    383 (ARG1)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.3  In linear amidines
    3.5.3.1  arginase
     383 (ARG1)
SSDB
Motif
Pfam: Arginase
Other DBs
NCBI-GeneID: 383
NCBI-ProteinID: NP_000036
OMIM: 608313
HGNC: 663
Ensembl: ENSG00000118520
UniProt: P05089
Structure
Position
6:131573226..131584329
AA seq 322 aa
MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPN
DSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGV
IWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLR
DVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSF
TPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAIT
LACFGLAREGNHKPIDYLNPPK
NT seq 969 nt   +upstreamnt  +downstreamnt
atgagcgccaagtccagaaccatagggattattggagctcctttctcaaagggacagcca
cgaggaggggtggaagaaggccctacagtattgagaaaggctggtctgcttgagaaactt
aaagaacaagagtgtgatgtgaaggattatggggacctgccctttgctgacatccctaat
gacagtccctttcaaattgtgaagaatccaaggtctgtgggaaaagcaagcgagcagctg
gctggcaaggtggcagaagtcaagaagaacggaagaatcagcctggtgctgggcggagac
cacagtttggcaattggaagcatctctggccatgccagggtccaccctgatcttggagtc
atctgggtggatgctcacactgatatcaacactccactgacaaccacaagtggaaacttg
catggacaacctgtatctttcctcctgaaggaactaaaaggaaagattcccgatgtgcca
ggattctcctgggtgactccctgtatatctgccaaggatattgtgtatattggcttgaga
gacgtggaccctggggaacactacattttgaaaactctaggcattaaatacttttcaatg
actgaagtggacagactaggaattggcaaggtgatggaagaaacactcagctatctacta
ggaagaaagaaaaggccaattcatctaagttttgatgttgacggactggacccatctttc
acaccagctactggcacaccagtcgtgggaggtctgacatacagagaaggtctctacatc
acagaagaaatctacaaaacagggctactctcaggattagatataatggaagtgaaccca
tccctggggaagacaccagaagaagtaactcgaacagtgaacacagcagttgcaataacc
ttggcttgtttcggacttgctcgggagggtaatcacaagcctattgactaccttaaccca
cctaagtaa

  All links  
Disease (2)   
   OMIM (2)   
Gene (18)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (10)   
   OC (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (22)   
   RefSeq(nuc) (4)   
   GenBank (9)   
   EMBL (9)   
3D Structure (60)   
   PDB (60)   
Protein domain (1)   
   Pfam (1)   
All databases (108)   

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