KEGG   Homo sapiens (human): 3856
Entry
3856              CDS       T01001                                 
Symbol
KRT8, CARD2, CK-8, CK8, CYK8, K2C8, K8, KO
Name
(RefSeq) keratin 8
  KO
K07605  type II keratin, basic
Organism
hsa  Homo sapiens (human)
Pathway
hsa04382  Cornified envelope formation
Disease
H02225  Familial cirrhosis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09158 Development and regeneration
   04382 Cornified envelope formation
    3856 (KRT8)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    3856 (KRT8)
   04147 Exosome [BR:hsa04147]
    3856 (KRT8)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Intermediate filaments
   Intermediate filaments
    Types I and II: Acidic and basic keratins
     3856 (KRT8)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of epithelial cells
   3856 (KRT8)
  Exosomal proteins of other body fluids (saliva and urine)
   3856 (KRT8)
  Exosomal proteins of colorectal cancer cells
   3856 (KRT8)
  Exosomal proteins of bladder cancer cells
   3856 (KRT8)
SSDB
Motif
Pfam: Filament Keratin_2_head CENP-F_leu_zip TPR_MLP1_2 CALCOCO1 DUF7491 ADIP ABC_tran_CTD DivIC Tropomyosin
Other DBs
NCBI-GeneID: 3856
NCBI-ProteinID: NP_001243222
OMIM: 148060
HGNC: 6446
Ensembl: ENSG00000170421
UniProt: P05787
Structure
Position
12:complement(52897191..52949860)
AA seq 483 aa
MSIRVTQKSYKVSTSGPRAFSSRSYTSGPGSRISSSSFSRVGSSNFRGGLGGGYGGASGM
GGITAVTVNQSLLSPLVLEVDPNIQAVRTQEKEQIKTLNNKFASFIDKVRFLEQQNKMLE
TKWSLLQQQKTARSNMDNMFESYINNLRRQLETLGQEKLKLEAELGNMQGLVEDFKNKYE
DEINKRTEMENEFVLIKKDVDEAYMNKVELESRLEGLTDEINFLRQLYEEEIRELQSQIS
DTSVVLSMDNSRSLDMDSIIAEVKAQYEDIANRSRAEAESMYQIKYEELQSLAGKHGDDL
RRTKTEISEMNRNISRLQAEIEGLKGQRASLEAAIADAEQRGELAIKDANAKLSELEAAL
QRAKQDMARQLREYQELMNVKLALDIEIATYRKLLEGEESRLESGMQNMSIHTKTTSGYA
GGLSSAYGGLTSPGLSYSLGSSFGSGAGSSSFSRTSSSRAVVVKKIETRDGKLVSESSDV
LPK
NT seq 1452 nt   +upstreamnt  +downstreamnt
atgtccatcagggtgacccagaagtcctacaaggtgtccacctctggcccccgggccttc
agcagccgctcctacacgagtgggcccggttcccgcatcagctcctcgagcttctcccga
gtgggcagcagcaactttcgcggtggcctgggcggcggctatggtggggccagcggcatg
ggaggcatcaccgcagttacggtcaaccagagcctgctgagcccccttgtcctggaggtg
gaccccaacatccaggccgtgcgcacccaggagaaggagcagatcaagaccctcaacaac
aagtttgcctccttcatagacaaggtacggttcctggagcagcagaacaagatgctggag
accaagtggagcctcctgcagcagcagaagacggctcgaagcaacatggacaacatgttc
gagagctacatcaacaaccttaggcggcagctggagactctgggccaggagaagctgaag
ctggaggcggagcttggcaacatgcaggggctggtggaggacttcaagaacaagtatgag
gatgagatcaataagcgtacagagatggagaacgaatttgtcctcatcaagaaggatgtg
gatgaagcttacatgaacaaggtagagctggagtctcgcctggaagggctgaccgacgag
atcaacttcctcaggcagctatatgaagaggagatccgggagctgcagtcccagatctcg
gacacatctgtggtgctgtccatggacaacagccgctccctggacatggacagcatcatt
gctgaggtcaaggcacagtacgaggatattgccaaccgcagccgggctgaggctgagagc
atgtaccagatcaagtatgaggagctgcagagcctggctgggaagcacggggatgacctg
cggcgcacaaagactgagatctctgagatgaaccggaacatcagccggctccaggctgag
attgagggcctcaaaggccagagggcttccctggaggccgccattgcagatgccgagcag
cgtggagagctggccattaaggatgccaacgccaagttgtccgagctggaggccgccctg
cagcgggccaagcaggacatggcgcggcagctgcgtgagtaccaggagctgatgaacgtc
aagctggccctggacatcgagatcgccacctacaggaagctgctggagggcgaggagagc
cggctggagtctgggatgcagaacatgagtattcatacgaagaccaccagcggctatgca
ggtggtctgagctcggcctatgggggcctcacaagccccggcctcagctacagcctgggc
tccagctttggctctggcgcgggctccagctccttcagccgcaccagctcctccagggcc
gtggttgtgaagaagatcgagacacgtgatgggaagctggtgtctgagtcctctgacgtc
ctgcccaagtga

  All links  
Disease (1)   
   OMIM (1)   
Gene (51)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (43)   
   OC (1)   
Protein sequence (6)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (55)   
   RefSeq(nuc) (5)   
   GenBank (25)   
   EMBL (25)   
3D Structure (3)   
   PDB (3)   
Protein domain (10)   
   Pfam (10)   
All databases (126)   

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