KEGG   Homo sapiens (human): 3931
Entry
3931              CDS       T01001                                 
Symbol
LCAT
Name
(RefSeq) lecithin-cholesterol acyltransferase
  KO
K00650  lecithin-cholesterol acyltransferase [EC:2.3.1.43]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00564  Glycerophospholipid metabolism
hsa04979  Cholesterol metabolism
Disease
H00158  Lecithin:cholesterol acyltransferase deficiency
H02505  Atherosclerosis
Drug target
Elastase ES: D04268<JP>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00564 Glycerophospholipid metabolism
    3931 (LCAT)
 09150 Organismal Systems
  09154 Digestive system
   04979 Cholesterol metabolism
    3931 (LCAT)
Enzymes [BR:hsa01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.43  phosphatidylcholine---sterol O-acyltransferase
     3931 (LCAT)
SSDB
Motif
Pfam: LCAT Abhydrolase_6 Hydrolase_4 Abhydrolase_1 TM225 Ser_hydrolase LD_cluster2
Other DBs
NCBI-GeneID: 3931
NCBI-ProteinID: NP_000220
OMIM: 606967
HGNC: 6522
Ensembl: ENSG00000213398
UniProt: P04180 A0A140VK24
Structure
Position
16:complement(67939750..67944120)
AA seq 440 aa
MGPPGSPWQWVTLLLGLLLPPAAPFWLLNVLFPPHTTPKAELSNHTRPVILVPGCLGNQL
EAKLDKPDVVNWMCYRKTEDFFTIWLDLNMFLPLGVDCWIDNTRVVYNRSSGLVSNAPGV
QIRVPGFGKTYSVEYLDSSKLAGYLHTLVQNLVNNGYVRDETVRAAPYDWRLEPGQQEEY
YRKLAGLVEEMHAAYGKPVFLIGHSLGCLHLLYFLLRQPQAWKDRFIDGFISLGAPWGGS
IKPMLVLASGDNQGIPIMSSIKLKEEQRITTTSPWMFPSRMAWPEDHVFISTPSFNYTGR
DFQRFFADLHFEEGWYMWLQSRDLLAGLPAPGVEVYCLYGVGLPTPRTYIYDHGFPYTDP
VGVLYEDGDDTVATRSTELCGLWQGRQPQPVHLLPLHGIQHLNMVFSNLTLEHINAILLG
AYRQGPPASPTASPEPPPPE
NT seq 1323 nt   +upstreamnt  +downstreamnt
atggggccgcccggctccccatggcagtgggtgacgctgctgctggggctgctgctccct
cctgccgcccccttctggctcctcaatgtgctcttccccccgcacaccacgcccaaggct
gagctcagtaaccacacacggcccgtcatcctcgtgcccggctgcctggggaatcagcta
gaagccaagctggacaaaccagatgtggtgaactggatgtgctaccgcaagacagaggac
ttcttcaccatctggctggatctcaacatgttcctaccccttggggtagactgctggatc
gataacaccagggttgtctacaaccggagctctgggctcgtgtccaacgcccctggtgtc
cagatccgcgtccctggctttggcaagacctactctgtggagtacctggacagcagcaag
ctggcagggtacctgcacacactggtgcagaacctggtcaacaatggctacgtgcgggac
gagactgtgcgcgccgccccctatgactggcggctggagcccggccagcaggaggagtac
taccgcaagctcgcagggctggtggaggagatgcacgctgcctatgggaagcctgtcttc
ctcattggccacagcctcggctgtctacacttgctctatttcctgctgcgccagccccag
gcctggaaggaccgctttattgatggcttcatctctcttggggctccctggggtggctcc
atcaagcccatgctggtcttggcctcaggtgacaaccagggcatccccatcatgtccagc
atcaagctgaaagaggagcagcgcataaccaccacctccccctggatgtttccctctcgc
atggcgtggcctgaggaccacgtgttcatttccacacccagcttcaactacacaggccgt
gacttccaacgcttctttgcagacctgcactttgaggaaggctggtacatgtggctgcag
tcacgtgacctcctggcaggactcccagcacctggtgtggaagtatactgtctttacggc
gtgggcctgcccacgccccgcacctacatctacgaccacggcttcccctacacggaccct
gtgggtgtgctctatgaggatggtgatgacacggtggcgacccgcagcaccgagctctgt
ggcctgtggcagggccgccagccacagcctgtgcacctgctgcccctgcacgggatacag
catctcaacatggtcttcagcaacctgaccctggagcacatcaatgccatcctgctgggt
gcctaccgccagggtccccctgcatccccgactgccagcccagagcccccgcctcctgaa
taa

  All links  
Disease (3)   
   OMIM (3)   
Gene (15)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (6)   
   OC (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (13)   
   RefSeq(nuc) (1)   
   GenBank (6)   
   EMBL (6)   
3D Structure (7)   
   PDB (7)   
Protein domain (7)   
   Pfam (7)   
All databases (49)   

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