KEGG   Homo sapiens (human): 3945
Entry
3945              CDS       T01001                                 

Gene name
LDHB, HEL-S-281, LDH-B, LDH-H, LDHBD, TRG-5
Definition
(RefSeq) lactate dehydrogenase B
  KO
K00016  L-lactate dehydrogenase [EC:1.1.1.27]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00010  Glycolysis / Gluconeogenesis
hsa00270  Cysteine and methionine metabolism
hsa00620  Pyruvate metabolism
hsa00640  Propanoate metabolism
hsa01100  Metabolic pathways
hsa04066  HIF-1 signaling pathway
hsa04922  Glucagon signaling pathway
hsa05230  Central carbon metabolism in cancer
Network
nt06017  Glycogen metabolism
  Element
N00731  Glycolysis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    3945 (LDHB)
   00620 Pyruvate metabolism
    3945 (LDHB)
   00640 Propanoate metabolism
    3945 (LDHB)
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    3945 (LDHB)
 09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    3945 (LDHB)
 09150 Organismal Systems
  09152 Endocrine system
   04922 Glucagon signaling pathway
    3945 (LDHB)
 09160 Human Diseases
  09161 Cancer: overview
   05230 Central carbon metabolism in cancer
    3945 (LDHB)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    3945 (LDHB)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.27  L-lactate dehydrogenase
     3945 (LDHB)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of epithelial cells
   3945 (LDHB)
  Exosomal proteins of breast milk
   3945 (LDHB)
SSDB
Motif
Pfam: Ldh_1_N Ldh_1_C Glyco_hydro_4
Other DBs
NCBI-GeneID: 3945
NCBI-ProteinID: NP_001167568
OMIM: 150100
HGNC: 6541
Ensembl: ENSG00000111716
Vega: OTTHUMG00000133760
Pharos: P07195(Tchem)
UniProt: P07195 Q5U077
Structure
PDB: 
1I0Z 1T2F

Position
12p12.1
AA seq 334 aa
MATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMACAISILGKSLADELALVDVLEDKLK
GEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKF
IIPQIVKYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLG
IHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVESAY
EVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKGMYGIENEVFLSLPCILNARG
LTSVINQKLKDDEVAQLKKSADTLWDIQKDLKDL
NT seq 1005 nt   +upstreamnt  +downstreamnt
atggcaactcttaaggaaaaactcattgcaccagttgcggaagaagaggcaacagttcca
aacaataagatcactgtagtgggtgttggacaagttggtatggcgtgtgctatcagcatt
ctgggaaagtctctggctgatgaacttgctcttgtggatgttttggaagataagcttaaa
ggagaaatgatggatctgcagcatgggagcttatttcttcagacacctaaaattgtggca
gataaagattattctgtgactgccaattctaagattgtagtggtaactgcaggagtccgt
cagcaagaaggggagagtcggctcaatctggtgcagagaaatgttaatgtcttcaaattc
attattcctcagatcgtcaagtacagtcctgattgcatcataattgtggtttccaaccca
gtggacattcttacgtatgttacctggaaactaagtggattacccaaacaccgcgtgatt
ggaagtggatgtaatctggattctgctagatttcgctaccttatggctgaaaaacttggc
attcatcccagcagctgccatggatggattttgggggaacatggcgactcaagtgtggct
gtgtggagtggtgtgaatgtggcaggtgtttctctccaggaattgaatccagaaatggga
actgacaatgatagtgaaaattggaaggaagtgcataagatggtggttgaaagtgcctat
gaagtcatcaagctaaaaggatataccaactgggctattggattaagtgtggctgatctt
attgaatccatgttgaaaaatctatccaggattcatcccgtgtcaacaatggtaaagggg
atgtatggcattgagaatgaagtcttcctgagccttccatgtatcctcaatgcccgggga
ttaaccagcgttatcaaccagaagctaaaggatgatgaggttgctcagctcaagaaaagt
gcagataccctgtgggacatccagaaggacctaaaagacctgtga

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