KEGG   Homo sapiens (human): 3984
Entry
3984              CDS       T01001                                 
Symbol
LIMK1, LIMK, LIMK-1
Name
(RefSeq) LIM domain kinase 1
  KO
K05743  LIM domain kinase 1 [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04360  Axon guidance
hsa04666  Fc gamma R-mediated phagocytosis
hsa04810  Regulation of actin cytoskeleton
hsa05135  Yersinia infection
hsa05170  Human immunodeficiency virus 1 infection
Network
nt06124  Chemokine signaling (viruses)
nt06150  Cytokine-cytokine receptor interaction (viruses)
nt06161  Human immunodeficiency virus type 1 (HIV-1)
  Element
N00433  CXCR4-GNB/G-RAC signaling pathway
N00434  HIV gp120 to CXCR4-GNB/G-RAC signaling pathway
Disease
H01439  Williams-Beuren syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    3984 (LIMK1)
 09150 Organismal Systems
  09151 Immune system
   04666 Fc gamma R-mediated phagocytosis
    3984 (LIMK1)
  09158 Development and regeneration
   04360 Axon guidance
    3984 (LIMK1)
 09160 Human Diseases
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    3984 (LIMK1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    3984 (LIMK1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    3984 (LIMK1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     3984 (LIMK1)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: TKL group
  LISK family [OT]
   3984 (LIMK1)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase LIM PDZ Kdo PDZ_6 APH ABC1 Haspin_kinase RIO1 PDZ_2 Pkinase_fungal PknG_TPR
Other DBs
NCBI-GeneID: 3984
NCBI-ProteinID: NP_002305
OMIM: 601329
HGNC: 6613
Ensembl: ENSG00000106683
Pharos: P53667(Tchem)
UniProt: P53667
Structure
Position
7:74083804..74122525
AA seq 647 aa
MRLTLLCCTWREERMGEEGSELPVCASCGQRIYDGQYLQALNADWHADCFRCCDCSASLS
HQYYEKDGQLFCKKDYWARYGESCHGCSEQITKGLVMVAGELKYHPECFICLTCGTFIGD
GDTYTLVEHSKLYCGHCYYQTVVTPVIEQILPDSPGSHLPHTVTLVSIPASSHGKRGLSV
SIDPPHGPPGCGTEHSHTVRVQGVDPGCMSPDVKNSIHVGDRILEINGTPIRNVPLDEID
LLIQETSRLLQLTLEHDPHDTLGHGLGPETSPLSSPAYTPSGEAGSSARQKPVLRSCSID
RSPGAGSLGSPASQRKDLGRSESLRVVCRPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRE
TGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGT
LRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFG
LARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLC
EIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKL
EHWLETLRMHLAGHLPLGPQLEQLDRGFWETYRRGESGLPAHPEVPD
NT seq 1944 nt   +upstreamnt  +downstreamnt
atgaggttgacgctactttgttgcacctggagggaagaacgtatgggagaggaaggaagc
gagttgcccgtgtgtgcaagctgcggccagaggatctatgatggccagtacctccaggcc
ctgaacgcggactggcacgcagactgcttcaggtgttgtgactgcagtgcctccctgtcg
caccagtactatgagaaggatgggcagctcttctgcaagaaggactactgggcccgctat
ggcgagtcctgccatgggtgctctgagcaaatcaccaagggactggttatggtggctggg
gagctgaagtaccaccccgagtgtttcatctgcctcacgtgtgggacctttatcggtgac
ggggacacctacacgctggtggagcactccaagctgtactgcgggcactgctactaccag
actgtggtgacccccgtcatcgagcagatcctgcctgactcccctggctcccacctgccc
cacaccgtcaccctggtgtccatcccagcctcatctcatggcaagcgtggactttcagtc
tccattgaccccccgcacggcccaccgggctgtggcaccgagcactcacacaccgtccgc
gtccagggagtggatccgggctgcatgagcccagatgtgaagaattccatccacgtcgga
gaccggatcttggaaatcaatggcacgcccatccgaaatgtgcccctggacgagattgac
ctgctgattcaggaaaccagccgcctgctccagctgaccctcgagcatgaccctcacgat
acactgggccacgggctggggcctgagaccagccccctgagctctccggcttatactccc
agcggggaggcgggcagctctgcccggcagaaacctgtcttgaggagctgcagcatcgac
aggtctccgggcgctggctcactgggctccccggcctcccagcgcaaggacctgggtcgc
tctgagtccctccgcgtagtctgccggccacaccgcatcttccggccgtcggacctcatc
cacggggaggtgctgggcaagggctgcttcggccaggctatcaaggtgacacaccgtgag
acaggtgaggtgatggtgatgaaggagctgatccggttcgacgaggagacccagaggacg
ttcctcaaggaggtgaaggtcatgcgatgcctggaacaccccaacgtgctcaagttcatc
ggggtgctctacaaggacaagaggctcaacttcatcactgagtacatcaagggcggcacg
ctccggggcatcatcaagagcatggacagccagtacccatggagccagagagtgagcttt
gccaaggacatcgcatcagggatggcctacctccactccatgaacatcatccaccgagac
ctcaactcccacaactgcctggtccgcgagaacaagaatgtggtggtggctgacttcggg
ctggcgcgtctcatggtggacgagaagactcagcctgagggcctgcggagcctcaagaag
ccagaccgcaagaagcgctacaccgtggtgggcaacccctactggatggcacctgagatg
atcaacggccgcagctatgatgagaaggtggatgtgttctcctttgggatcgtcctgtgc
gagatcatcgggcgggtgaacgcagaccctgactacctgccccgcaccatggactttggc
ctcaacgtgcgaggattcctggaccgctactgccccccaaactgccccccgagcttcttc
cccatcaccgtgcgctgttgcgatctggaccccgagaagaggccatcctttgtgaagctg
gaacactggctggagaccctccgcatgcacctggccggccacctgccactgggcccacag
ctggagcagctggacagaggtttctgggagacctaccggcgcggcgagagcggactgcct
gcccaccctgaggtccccgactga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (5)   
   KEGG PATHWAY (5)   
Network (2)   
   KEGG NETWORK (2)   
Disease (2)   
   KEGG DISEASE (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (15)   
   KEGG ORTHOLOGY (1)   
   RefGene (7)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
   PHAROS (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (21)   
   RefSeq(nuc) (3)   
   GenBank (9)   
   EMBL (9)   
3D Structure (9)   
   PDB (9)   
Protein domain (13)   
   Pfam (13)   
All databases (76)   

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KEGG   Homo sapiens (human): 3985
Entry
3985              CDS       T01001                                 
Symbol
LIMK2
Name
(RefSeq) LIM domain kinase 2
  KO
K05744  LIM domain kinase 2 [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04360  Axon guidance
hsa04666  Fc gamma R-mediated phagocytosis
hsa04810  Regulation of actin cytoskeleton
hsa05170  Human immunodeficiency virus 1 infection
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    3985 (LIMK2)
 09150 Organismal Systems
  09151 Immune system
   04666 Fc gamma R-mediated phagocytosis
    3985 (LIMK2)
  09158 Development and regeneration
   04360 Axon guidance
    3985 (LIMK2)
 09160 Human Diseases
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    3985 (LIMK2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    3985 (LIMK2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     3985 (LIMK2)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: TKL group
  LISK family [OT]
   3985 (LIMK2)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase LIM PDZ Kdo PDZ_6 PDZ_2 ABC1 Peptidase_M50 APH DUF6510 Zn_ribbon_SprT
Other DBs
NCBI-GeneID: 3985
NCBI-ProteinID: NP_005560
OMIM: 601988
HGNC: 6614
Ensembl: ENSG00000182541
Pharos: P53671(Tchem)
UniProt: P53671 A0A024R1H6
Structure
Position
22:31212298..31280080
AA seq 638 aa
MSALAGEDVWRCPGCGDHIAPSQIWYRTVNETWHGSCFRCSECQDSLTNWYYEKDGKLYC
PKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLY
CGKCHNEVVLAPMFERLSTESVQEQLPYSVTLISMPATTEGRRGFSVSVESACSNYATTV
QVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQLLIEHDPV
SQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLRRRSLRRSNSISKSPGPSSPK
EPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMK
ELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSM
DPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEER
KRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEII
GQVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESRPAFSKLEDS
FEALSLYLGELGIPLPAELEELDHTVSMQYGLTRDSPP
NT seq 1917 nt   +upstreamnt  +downstreamnt
atgtccgcgctggcgggtgaagatgtctggaggtgtccaggctgtggggaccacattgct
ccaagccagatatggtacaggactgtcaacgaaacctggcacggctcttgcttccggtgt
tcagaatgccaggattccctcaccaactggtactatgagaaggatgggaagctctactgc
cccaaggactactgggggaagtttggggagttctgtcatgggtgctccctgctgatgaca
gggccttttatggtggctggggagttcaagtaccacccagagtgctttgcctgtatgagc
tgcaaggtgatcattgaggatggggatgcatatgcactggtgcagcatgccaccctctac
tgtgggaagtgccacaatgaggtggtgctggcacccatgtttgagagactctccacagag
tctgttcaggagcagctgccctactctgtcacgctcatctccatgccggccaccactgaa
ggcaggcggggcttctccgtgtccgtggagagtgcctgctccaactacgccaccactgtg
caagtgaaagaggtcaaccggatgcacatcagtcccaacaatcgaaacgccatccaccct
ggggaccgcatcctggagatcaatgggacccccgtccgcacacttcgagtggaggaggtg
gaggatgcaattagccagacgagccagacacttcagctgttgattgaacatgaccccgtc
tcccaacgcctggaccagctgcggctggaggcccggctcgctcctcacatgcagaatgcc
ggacacccccacgccctcagcaccctggacaccaaggagaatctggaggggacactgagg
agacgttccctaaggcgcagtaacagtatctccaagtcccctggccccagctccccaaag
gagcccctgctgttcagccgtgacatcagccgctcagaatcccttcgttgttccagcagc
tattcacagcagatcttccggccctgtgacctaatccatggggaggtcctggggaagggc
ttctttgggcaggctatcaaggtgacacacaaagccacgggcaaagtgatggtcatgaaa
gagttaattcgatgtgatgaggagacccagaaaacttttctgactgaggtgaaagtgatg
cgcagcctggaccaccccaatgtgctcaagttcattggtgtgctgtacaaggataagaag
ctgaacctcctgacagagtacattgaggggggcacactgaaggactttctgcgcagtatg
gatccgttcccctggcagcagaaggtcaggtttgccaaaggaatcgcctccggaatggcc
tatttgcactctatgtgcatcatccaccgggatctgaactcgcacaactgcctcatcaag
ttggacaagactgtggtggtggcagactttgggctgtcacggctcatagtggaagagagg
aaaagggcccccatggagaaggccaccaccaagaaacgcaccttgcgcaagaacgaccgc
aagaagcgctacacggtggtgggaaacccctactggatggcccctgagatgctgaacgga
aagagctatgatgagacggtggatatcttctcctttgggatcgttctctgtgagatcatt
gggcaggtgtatgcagatcctgactgccttccccgaacactggactttggcctcaacgtg
aagcttttctgggagaagtttgttcccacagattgtcccccggccttcttcccgctggcc
gccatctgctgcagactggagcctgagagcagaccagcattctcgaaattggaggactcc
tttgaggccctctccctgtacctgggggagctgggcatcccgctgcctgcagagctggag
gagttggaccacactgtgagcatgcagtacggcctgacccgggactcacctccctag

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (4)   
   KEGG PATHWAY (4)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (17)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
   PHAROS (1)   
Protein sequence (6)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (35)   
   RefSeq(nuc) (3)   
   GenBank (16)   
   EMBL (16)   
3D Structure (4)   
   PDB (4)   
Protein domain (12)   
   Pfam (12)   
All databases (84)   

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