KEGG   Homo sapiens (human): 3985
Entry
3985              CDS       T01001                                 

Gene name
LIMK2
Definition
(RefSeq) LIM domain kinase 2
  KO
K05744  LIM domain kinase 2 [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04360  Axon guidance
hsa04666  Fc gamma R-mediated phagocytosis
hsa04810  Regulation of actin cytoskeleton
hsa05170  Human immunodeficiency virus 1 infection
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    3985 (LIMK2)
 09150 Organismal Systems
  09151 Immune system
   04666 Fc gamma R-mediated phagocytosis
    3985 (LIMK2)
  09158 Development and regeneration
   04360 Axon guidance
    3985 (LIMK2)
 09160 Human Diseases
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    3985 (LIMK2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    3985 (LIMK2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     3985 (LIMK2)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: TKL group
  LISK family [OT]
   3985 (LIMK2)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase LIM PDZ Kdo PDZ_6 PDZ_2 APH
Other DBs
NCBI-GeneID: 3985
NCBI-ProteinID: NP_005560
OMIM: 601988
HGNC: 6614
Ensembl: ENSG00000182541
Vega: OTTHUMG00000151251
Pharos: P53671(Tchem)
UniProt: P53671 A0A024R1H6
Structure
PDB: 
5NXD 4TPT 1X6A

Position
22q12.2
AA seq 638 aa
MSALAGEDVWRCPGCGDHIAPSQIWYRTVNETWHGSCFRCSECQDSLTNWYYEKDGKLYC
PKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLY
CGKCHNEVVLAPMFERLSTESVQEQLPYSVTLISMPATTEGRRGFSVSVESACSNYATTV
QVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQLLIEHDPV
SQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLRRRSLRRSNSISKSPGPSSPK
EPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMK
ELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSM
DPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEER
KRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEII
GQVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESRPAFSKLEDS
FEALSLYLGELGIPLPAELEELDHTVSMQYGLTRDSPP
NT seq 1917 nt   +upstreamnt  +downstreamnt
atgtccgcgctggcgggtgaagatgtctggaggtgtccaggctgtggggaccacattgct
ccaagccagatatggtacaggactgtcaacgaaacctggcacggctcttgcttccggtgt
tcagaatgccaggattccctcaccaactggtactatgagaaggatgggaagctctactgc
cccaaggactactgggggaagtttggggagttctgtcatgggtgctccctgctgatgaca
gggccttttatggtggctggggagttcaagtaccacccagagtgctttgcctgtatgagc
tgcaaggtgatcattgaggatggggatgcatatgcactggtgcagcatgccaccctctac
tgtgggaagtgccacaatgaggtggtgctggcacccatgtttgagagactctccacagag
tctgttcaggagcagctgccctactctgtcacgctcatctccatgccggccaccactgaa
ggcaggcggggcttctccgtgtccgtggagagtgcctgctccaactacgccaccactgtg
caagtgaaagaggtcaaccggatgcacatcagtcccaacaatcgaaacgccatccaccct
ggggaccgcatcctggagatcaatgggacccccgtccgcacacttcgagtggaggaggtg
gaggatgcaattagccagacgagccagacacttcagctgttgattgaacatgaccccgtc
tcccaacgcctggaccagctgcggctggaggcccggctcgctcctcacatgcagaatgcc
ggacacccccacgccctcagcaccctggacaccaaggagaatctggaggggacactgagg
agacgttccctaaggcgcagtaacagtatctccaagtcccctggccccagctccccaaag
gagcccctgctgttcagccgtgacatcagccgctcagaatcccttcgttgttccagcagc
tattcacagcagatcttccggccctgtgacctaatccatggggaggtcctggggaagggc
ttctttgggcaggctatcaaggtgacacacaaagccacgggcaaagtgatggtcatgaaa
gagttaattcgatgtgatgaggagacccagaaaacttttctgactgaggtgaaagtgatg
cgcagcctggaccaccccaatgtgctcaagttcattggtgtgctgtacaaggataagaag
ctgaacctcctgacagagtacattgaggggggcacactgaaggactttctgcgcagtatg
gatccgttcccctggcagcagaaggtcaggtttgccaaaggaatcgcctccggaatggcc
tatttgcactctatgtgcatcatccaccgggatctgaactcgcacaactgcctcatcaag
ttggacaagactgtggtggtggcagactttgggctgtcacggctcatagtggaagagagg
aaaagggcccccatggagaaggccaccaccaagaaacgcaccttgcgcaagaacgaccgc
aagaagcgctacacggtggtgggaaacccctactggatggcccctgagatgctgaacgga
aagagctatgatgagacggtggatatcttctcctttgggatcgttctctgtgagatcatt
gggcaggtgtatgcagatcctgactgccttccccgaacactggactttggcctcaacgtg
aagcttttctgggagaagtttgttcccacagattgtcccccggccttcttcccgctggcc
gccatctgctgcagactggagcctgagagcagaccagcattctcgaaattggaggactcc
tttgaggccctctccctgtacctgggggagctgggcatcccgctgcctgcagagctggag
gagttggaccacactgtgagcatgcagtacggcctgacccgggactcacctccctag

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (4)   
   KEGG PATHWAY (4)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (18)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (6)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (35)   
   RefSeq(nuc) (3)   
   GenBank (16)   
   EMBL (16)   
Protein domain (8)   
   Pfam (8)   
All databases (77)   

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