KEGG   Homo sapiens (human): 3992
Entry
3992              CDS       T01001                                 
Symbol
FADS1, D5D, FADS6, FADSD5, LLCDL1, TU12
Name
(RefSeq) fatty acid desaturase 1
  KO
K10224  acyl-CoA (8-3)-desaturase (Delta-5 desaturase) [EC:1.14.19.44]
Organism
hsa  Homo sapiens (human)
Pathway
hsa01040  Biosynthesis of unsaturated fatty acids
hsa01100  Metabolic pathways
hsa01212  Fatty acid metabolism
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   01040 Biosynthesis of unsaturated fatty acids
    3992 (FADS1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01004 Lipid biosynthesis proteins [BR:hsa01004]
    3992 (FADS1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.19  With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
    1.14.19.44  acyl-CoA (8-3)-desaturase
     3992 (FADS1)
Lipid biosynthesis proteins [BR:hsa01004]
 Desaturase
  Front-end
   3992 (FADS1)
SSDB
Motif
Pfam: FA_desaturase Cyt-b5 Defensin_propep
Other DBs
NCBI-GeneID: 3992
NCBI-ProteinID: NP_037534
OMIM: 606148
HGNC: 3574
Ensembl: ENSG00000149485
UniProt: O60427 A0A0A0MR51
Position
11:complement(61799627..61817003)
AA seq 501 aa
MGTRAARPAGLPCGAENPARRRLALGARQQIHSWSPRTPSTRLTAPAGPARGVARPAMAP
DPVAAETAAQGPTPRYFTWDEVAQRSGCEERWLVIDRKVYNISEFTRRHPGGSRVISHYA
GQDATDPFVAFHINKGLVKKYMNSLLIGELSPEQPSFEPTKNKELTDEFRELRATVERMG
LMKANHVFFLLYLLHILLLDGAAWLTLWVFGTSFLPFLLCAVLLSAVQAQAGWLQHDFGH
LSVFSTSKWNHLLHHFVIGHLKGAPASWWNHMHFQHHAKPNCFRKDPDINMHPFFFALGK
ILSVELGKQKKKYMPYNHQHKYFFLIGPPALLPLYFQWYIFYFVIQRKKWVDLAWMITFY
VRFFLTYVPLLGLKAFLGLFFIVRFLESNWFVWVTQMNHIPMHIDHDRNMDWVSTQLQAT
CNVHKSAFNDWFSGHLNFQIEHHLFPTMPRHNYHKVAPLVQSLCAKHGIEYQSKPLLSAF
ADIIHSLKESGQLWLDAYLHQ
NT seq 1506 nt   +upstreamnt  +downstreamnt
atgggaacgcgcgctgcgaggcccgccggtctgccctgcggtgctgaaaacccggcgcgc
aggcggctggctctgggcgcgcgccagcaaatccactcctggagcccgcggaccccgagc
acgcgcctgacagcccctgctggcccggcgcgcggcgtcgccaggccagctatggccccc
gacccggtggccgccgagaccgcggctcagggacctaccccgcgctacttcacctgggac
gaggtggcccagcgctcagggtgcgaggagcggtggctagtgatcgaccgtaaggtgtac
aacatcagcgagttcacccgccggcatccagggggctcccgggtcatcagccactacgcc
gggcaggatgccacggatccctttgtggccttccacatcaacaagggccttgtgaagaag
tatatgaactctctcctgattggagaactgtctccagagcagcccagctttgagcccacc
aagaataaagagctgacagatgagttccgggagctgcgggccacagtggagcggatgggg
ctcatgaaggccaaccatgtcttcttcctgctgtacctgctgcacatcttgctgctggat
ggtgcagcctggctcaccctttgggtctttgggacgtcctttttgcccttcctcctctgt
gcggtgctgctcagtgcagttcaggcccaggctggctggctgcagcatgactttgggcac
ctgtcggtcttcagcacctcaaagtggaaccatctgctacatcattttgtgattggccac
ctgaagggggcccccgccagttggtggaaccacatgcacttccagcaccatgccaagccc
aactgcttccgcaaagacccagacatcaacatgcatcccttcttctttgccttggggaag
atcctctctgtggagcttgggaaacagaagaaaaaatatatgccgtacaaccaccagcac
aaatacttcttcctaattgggcccccagccttgctgcctctctacttccagtggtatatt
ttctattttgttatccagcgaaagaagtgggtggacttggcctggatgattaccttctac
gtccgcttcttcctcacttatgtgccactattggggctgaaagccttcctgggccttttc
ttcatagtcaggttcctggaaagcaactggtttgtgtgggtgacacagatgaaccatatt
cccatgcacattgatcatgaccggaacatggactgggtttccacccagctccaggccaca
tgcaatgtccacaagtctgccttcaatgactggttcagtggacacctcaacttccagatt
gagcaccatctttttcccacgatgcctcgacacaattaccacaaagtggctcccctggtg
cagtccttgtgtgccaagcatggcatagagtaccagtccaagcccctgctgtcagccttc
gccgacatcatccactcactaaaggagtcagggcagctctggctagatgcctatcttcac
caataa

  All links  
Disease (1)   
   OMIM (1)   
Gene (18)   
   RefGene (11)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (8)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (45)   
   RefSeq(nuc) (5)   
   GenBank (20)   
   EMBL (20)   
Protein domain (3)   
   Pfam (3)   
All databases (75)   

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