KEGG   Homo sapiens (human): 4012
Entry
4012              CDS       T01001                                 

Symbol
LNPEP, CAP, IRAP, P-LAP, PLAP
Name
(RefSeq) leucyl and cystinyl aminopeptidase
  KO
K01257  cystinyl aminopeptidase [EC:3.4.11.3]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04614  Renin-angiotensin system
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09152 Endocrine system
   04614 Renin-angiotensin system
    4012 (LNPEP)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    4012 (LNPEP)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.11  Aminopeptidases
    3.4.11.3  cystinyl aminopeptidase
     4012 (LNPEP)
Peptidases and inhibitors [BR:hsa01002]
 Metallo peptidases
  Family M1
   4012 (LNPEP)
SSDB
Motif
Pfam: Peptidase_M1 ERAP1_C Peptidase_M1_N pP_pnuc_1 Dynactin Phytase-like
Other DBs
NCBI-GeneID: 4012
NCBI-ProteinID: NP_005566
OMIM: 151300
HGNC: 6656
Ensembl: ENSG00000113441
Vega: OTTHUMG00000128719
Pharos: Q9UIQ6(Tchem)
UniProt: Q9UIQ6
Structure
PDB: 
5MJ6 4PJ6 4P8Q 4Z7I 5C97

Position
5q15
AA seq 1025 aa
MEPFTNDRLQLPRNMIENSMFEEEPDVVDLAKEPCLHPLEPDEVEYEPRGSRLLVRGLGE
HEMEEDEEDYESSAKLLGMSFMNRSSGLRNSATGYRQSPDGACSVPSARTMVVCAFVIVV
AVSVIMVIYLLPRCTFTKEGCHKKNQSIGLIQPFATNGKLFPWAQIRLPTAVVPLRYELS
LHPNLTSMTFRGSVTISVQALQVTWNIILHSTGHNISRVTFMSAVSSQEKQAEILEYAYH
GQIAIVAPEALLAGHNYTLKIEYSANISSSYYGFYGFSYTDESNEKKYFAATQFEPLAAR
SAFPCFDEPAFKATFIIKIIRDEQYTALSNMPKKSSVVLDDGLVQDEFSESVKMSTYLVA
FIVGEMKNLSQDVNGTLVSIYAVPEKIGQVHYALETTVKLLEFFQNYFEIQYPLKKLDLV
AIPDFEAGAMENWGLLTFREETLLYDSNTSSMADRKLVTKIIAHELAHQWFGNLVTMKWW
NDLWLNEGFATFMEYFSLEKIFKELSSYEDFLDARFKTMKKDSLNSSHPISSSVQSSEQI
EEMFDSLSYFKGSSLLLMLKTYLSEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVTNQT
LDVKRMMKTWTLQKGFPLVTVQKKGKELFIQQERFFLNMKPEIQPSDTSYLWHIPLSYVT
EGRNYSKYQSVSLLDKKSGVINLTEEVLWVKVNINMNGYYIVHYADDDWEALIHQLKINP
YVLSDKDRANLINNIFELAGLGKVPLKRAFDLINYLGNENHTAPITEALFQTDLIYNLLE
KLGYMDLASRLVTRVFKLLQNQIQQQTWTDEGTPSMRELRSALLEFACTHNLGNCSTTAM
KLFDDWMASNGTQSLPTDVMTTVFKVGAKTDKGWSFLLGKYISIGSEAEKNKILEALASS
EDVRKLYWLMKSSLNGDNFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGS
YTIQNIVAGSTYLFSTKTHLSEVQAFFENQSEATFRLRCVQEALEVIQLNIQWMEKNLKS
LTWWL
NT seq 3078 nt   +upstreamnt  +downstreamnt
atggagcccttcaccaatgatcggcttcagctccccaggaatatgattgaaaacagcatg
tttgaggaagaaccagatgtggtggatttagccaaagagccttgtttacatcctctagag
cctgatgaggtggaatatgagccccggggttcccgactgctggtgcggggtcttggtgag
catgagatggaggaggatgaagaggattatgagtcatcagcaaagctgctgggcatgtcc
ttcatgaatagaagctcaggccttcggaacagtgcaactggttacaggcagagcccagat
ggggcttgttcagtaccctctgcaaggaccatggtggtctgtgcttttgtcatcgtggtt
gctgtttctgtaatcatggtgatttacttactgcccagatgtacctttaccaaagaaggc
tgccataaaaaaaaccagtcaattggactaattcagccatttgcaacaaatgggaaattg
tttccatgggcacagatcaggcttcccactgccgttgtgccactacgctatgaactcagc
ctacacccgaacctaacctcgatgacattcaggggttctgtgacaatttcagttcaggct
cttcaggtcacatggaatatcattcttcatagcacaggtcataatatttcaagagtgacc
tttatgtcagcagtttcaagccaagaaaaacaagctgagatcctggaatatgcatatcat
ggacagatcgccattgttgcccccgaagcccttctagcagggcacaattatacgttgaag
atagagtactcggcaaatatatctagttcttattatgggttttatggcttctcctacaca
gatgaaagtaatgagaaaaagtactttgcagcaactcagtttgaacccctggcagcaaga
tctgcttttccttgttttgatgaaccagcatttaaagccacttttatcatcaagatcata
agggatgagcaatacaccgctttatcaaatatgcctaagaagtcatcagtcgttctagat
gatggacttgttcaggatgagttttctgagagtgtgaagatgagcacttacttggttgct
ttcattgtgggagagatgaagaacctgagtcaggacgtaaatggaaccctggtttctata
tatgctgtaccagaaaagattggtcaagttcattatgccttggaaacaactgtgaagctt
cttgagttttttcaaaactactttgaaattcagtacccacttaagaaattggatttggtg
gctattcctgactttgaagcaggagcaatggaaaattggggtttgctcaccttccgagag
gagacacttctgtatgacagtaacacttcttcaatggcggatagaaagctggtgactaaa
atcattgctcatgagctggcccaccagtggtttggcaatctggtaacaatgaagtggtgg
aatgacctatggctaaatgaaggttttgccactttcatggagtatttctctttggaaaaa
atattcaaagagctttctagttatgaagatttcttagatgctcgatttaaaaccatgaag
aaagattccttaaattcatctcatccaatatcatcatctgttcagtcttcagaacaaatt
gaagaaatgtttgattctctttcctattttaagggatcttctctcttgttgatgttgaaa
acttaccttagtgaagatgtgtttcaacatgctgttgtcctttacctgcataatcacagc
tatgcatctattcaaagtgatgatctgtgggatagttttaatgaggtcacaaaccaaaca
ctagatgtaaagagaatgatgaaaacctggaccctgcagaaaggatttcctttagtgact
gttcaaaagaaaggaaaggaactttttatacaacaagagagattctttttaaatatgaag
cctgaaattcagccttcagatacaagctacctgtggcatattccactatcctatgtcact
gaaggaagaaattattcaaaatatcaatcggtatcattactggataagaaatcaggtgtc
atcaatcttacagaagaagtgctgtgggtcaaagtgaatataaacatgaatggttattat
attgtacactatgcagatgatgattgggaagcactaatccatcagttgaaaataaatcct
tatgttctgagtgacaaagaccgagccaaccttatcaacaacatctttgaacttgcaggc
ctaggcaaggtacctctcaagagggcctttgatttgattaattatcttggaaatgagaac
catactgcacccatcaccgaagccctgtttcagacagacctcatctataacctccttgaa
aaactgggatacatggatctggcctcaagactggtgactagggtatttaaattacttcaa
aaccaaattcaacaacaaacttggactgatgagggcactccatctatgcgagagcttcgg
tcagccctgctagagtttgcttgcacccacaacctggggaactgctctactactgccatg
aaactgtttgatgactggatggcatccaatggaactcaaagcctacctactgatgtcatg
acaactgtgttcaaagttggagcaaaaactgacaaaggctggtcattccttttgggcaaa
tacatttctataggctctgaagcagagaagaacaaaatactagaagcacttgccagctca
gaggatgtgcggaagctttactggttaatgaaaagtagcctgaatggagataacttccga
acacagaagctgtcttttatcattagaacagtgggtcgacattttcctggacacttactg
gcatgggattttgtcaaagagaactggaataagcttgtacagaagttccctctggggtcc
tataccatacaaaatattgttgctggatcaacttacctgttttcaacaaagacacattta
tctgaggttcaggcattctttgaaaatcagtcagaggcaaccttccggcttcgttgtgtc
caggaggctttggaagtcattcagttgaatatccagtggatggagaagaacctcaaaagt
ctcacatggtggctgtag

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (17)   
   KEGG ORTHOLOGY (1)   
   RefGene (9)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (25)   
   RefSeq(nuc) (3)   
   GenBank (11)   
   EMBL (11)   
Protein domain (6)   
   Pfam (6)   
All databases (60)   

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