KEGG   Homo sapiens (human): 4012
Entry
4012              CDS       T01001                                 
Symbol
LNPEP, CAP, IRAP, P-LAP, PLAP
Name
(RefSeq) leucyl and cystinyl aminopeptidase
  KO
K01257  cystinyl aminopeptidase [EC:3.4.11.3]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04614  Renin-angiotensin system
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09152 Endocrine system
   04614 Renin-angiotensin system
    4012 (LNPEP)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    4012 (LNPEP)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.11  Aminopeptidases
    3.4.11.3  cystinyl aminopeptidase
     4012 (LNPEP)
Peptidases and inhibitors [BR:hsa01002]
 Metallo peptidases
  Family M1
   4012 (LNPEP)
SSDB
Motif
Pfam: Peptidase_M1 ERAP1_C Peptidase_M1_N pP_pnuc_1 Dynactin
Other DBs
NCBI-GeneID: 4012
NCBI-ProteinID: NP_005566
OMIM: 151300
HGNC: 6656
Ensembl: ENSG00000113441
UniProt: Q9UIQ6
Structure
Position
5:96936080..97037513
AA seq 1025 aa
MEPFTNDRLQLPRNMIENSMFEEEPDVVDLAKEPCLHPLEPDEVEYEPRGSRLLVRGLGE
HEMEEDEEDYESSAKLLGMSFMNRSSGLRNSATGYRQSPDGACSVPSARTMVVCAFVIVV
AVSVIMVIYLLPRCTFTKEGCHKKNQSIGLIQPFATNGKLFPWAQIRLPTAVVPLRYELS
LHPNLTSMTFRGSVTISVQALQVTWNIILHSTGHNISRVTFMSAVSSQEKQAEILEYAYH
GQIAIVAPEALLAGHNYTLKIEYSANISSSYYGFYGFSYTDESNEKKYFAATQFEPLAAR
SAFPCFDEPAFKATFIIKIIRDEQYTALSNMPKKSSVVLDDGLVQDEFSESVKMSTYLVA
FIVGEMKNLSQDVNGTLVSIYAVPEKIGQVHYALETTVKLLEFFQNYFEIQYPLKKLDLV
AIPDFEAGAMENWGLLTFREETLLYDSNTSSMADRKLVTKIIAHELAHQWFGNLVTMKWW
NDLWLNEGFATFMEYFSLEKIFKELSSYEDFLDARFKTMKKDSLNSSHPISSSVQSSEQI
EEMFDSLSYFKGSSLLLMLKTYLSEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVTNQT
LDVKRMMKTWTLQKGFPLVTVQKKGKELFIQQERFFLNMKPEIQPSDTSYLWHIPLSYVT
EGRNYSKYQSVSLLDKKSGVINLTEEVLWVKVNINMNGYYIVHYADDDWEALIHQLKINP
YVLSDKDRANLINNIFELAGLGKVPLKRAFDLINYLGNENHTAPITEALFQTDLIYNLLE
KLGYMDLASRLVTRVFKLLQNQIQQQTWTDEGTPSMRELRSALLEFACTHNLGNCSTTAM
KLFDDWMASNGTQSLPTDVMTTVFKVGAKTDKGWSFLLGKYISIGSEAEKNKILEALASS
EDVRKLYWLMKSSLNGDNFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGS
YTIQNIVAGSTYLFSTKTHLSEVQAFFENQSEATFRLRCVQEALEVIQLNIQWMEKNLKS
LTWWL
NT seq 3078 nt   +upstreamnt  +downstreamnt
atggagcccttcaccaatgatcggcttcagctccccaggaatatgattgaaaacagcatg
tttgaggaagaaccagatgtggtggatttagccaaagagccttgtttacatcctctagag
cctgatgaggtggaatatgagccccggggttcccgactgctggtgcggggtcttggtgag
catgagatggaggaggatgaagaggattatgagtcatcagcaaagctgctgggcatgtcc
ttcatgaatagaagctcaggccttcggaacagtgcaactggttacaggcagagcccagat
ggggcttgttcagtaccctctgcaaggaccatggtggtctgtgcttttgtcatcgtggtt
gctgtttctgtaatcatggtgatttacttactgcccagatgtacctttaccaaagaaggc
tgccataaaaaaaaccagtcaattggactaattcagccatttgcaacaaatgggaaattg
tttccatgggcacagatcaggcttcccactgccgttgtgccactacgctatgaactcagc
ctacacccgaacctaacctcgatgacattcaggggttctgtgacaatttcagttcaggct
cttcaggtcacatggaatatcattcttcatagcacaggtcataatatttcaagagtgacc
tttatgtcagcagtttcaagccaagaaaaacaagctgagatcctggaatatgcatatcat
ggacagatcgccattgttgcccccgaagcccttctagcagggcacaattatacgttgaag
atagagtactcggcaaatatatctagttcttattatgggttttatggcttctcctacaca
gatgaaagtaatgagaaaaagtactttgcagcaactcagtttgaacccctggcagcaaga
tctgcttttccttgttttgatgaaccagcatttaaagccacttttatcatcaagatcata
agggatgagcaatacaccgctttatcaaatatgcctaagaagtcatcagtcgttctagat
gatggacttgttcaggatgagttttctgagagtgtgaagatgagcacttacttggttgct
ttcattgtgggagagatgaagaacctgagtcaggacgtaaatggaaccctggtttctata
tatgctgtaccagaaaagattggtcaagttcattatgccttggaaacaactgtgaagctt
cttgagttttttcaaaactactttgaaattcagtacccacttaagaaattggatttggtg
gctattcctgactttgaagcaggagcaatggaaaattggggtttgctcaccttccgagag
gagacacttctgtatgacagtaacacttcttcaatggcggatagaaagctggtgactaaa
atcattgctcatgagctggcccaccagtggtttggcaatctggtaacaatgaagtggtgg
aatgacctatggctaaatgaaggttttgccactttcatggagtatttctctttggaaaaa
atattcaaagagctttctagttatgaagatttcttagatgctcgatttaaaaccatgaag
aaagattccttaaattcatctcatccaatatcatcatctgttcagtcttcagaacaaatt
gaagaaatgtttgattctctttcctattttaagggatcttctctcttgttgatgttgaaa
acttaccttagtgaagatgtgtttcaacatgctgttgtcctttacctgcataatcacagc
tatgcatctattcaaagtgatgatctgtgggatagttttaatgaggtcacaaaccaaaca
ctagatgtaaagagaatgatgaaaacctggaccctgcagaaaggatttcctttagtgact
gttcaaaagaaaggaaaggaactttttatacaacaagagagattctttttaaatatgaag
cctgaaattcagccttcagatacaagctacctgtggcatattccactatcctatgtcact
gaaggaagaaattattcaaaatatcaatcggtatcattactggataagaaatcaggtgtc
atcaatcttacagaagaagtgctgtgggtcaaagtgaatataaacatgaatggttattat
attgtacactatgcagatgatgattgggaagcactaatccatcagttgaaaataaatcct
tatgttctgagtgacaaagaccgagccaaccttatcaacaacatctttgaacttgcaggc
ctaggcaaggtacctctcaagagggcctttgatttgattaattatcttggaaatgagaac
catactgcacccatcaccgaagccctgtttcagacagacctcatctataacctccttgaa
aaactgggatacatggatctggcctcaagactggtgactagggtatttaaattacttcaa
aaccaaattcaacaacaaacttggactgatgagggcactccatctatgcgagagcttcgg
tcagccctgctagagtttgcttgcacccacaacctggggaactgctctactactgccatg
aaactgtttgatgactggatggcatccaatggaactcaaagcctacctactgatgtcatg
acaactgtgttcaaagttggagcaaaaactgacaaaggctggtcattccttttgggcaaa
tacatttctataggctctgaagcagagaagaacaaaatactagaagcacttgccagctca
gaggatgtgcggaagctttactggttaatgaaaagtagcctgaatggagataacttccga
acacagaagctgtcttttatcattagaacagtgggtcgacattttcctggacacttactg
gcatgggattttgtcaaagagaactggaataagcttgtacagaagttccctctggggtcc
tataccatacaaaatattgttgctggatcaacttacctgttttcaacaaagacacattta
tctgaggttcaggcattctttgaaaatcagtcagaggcaaccttccggcttcgttgtgtc
caggaggctttggaagtcattcagttgaatatccagtggatggagaagaacctcaaaagt
ctcacatggtggctgtag

  All links  
Disease (1)   
   OMIM (1)   
Gene (14)   
   RefGene (9)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (6)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (28)   
   RefSeq(nuc) (4)   
   GenBank (12)   
   EMBL (12)   
3D Structure (10)   
   PDB (10)   
Protein domain (5)   
   Pfam (5)   
All databases (64)   

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