KEGG   Homo sapiens (human): 4047
Entry
4047              CDS       T01001                                 
Symbol
LSS, APMR4, CTRCT44, HYPT14, OSC
Name
(RefSeq) lanosterol synthase
  KO
K01852  lanosterol synthase [EC:5.4.99.7]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00100  Steroid biosynthesis
hsa01100  Metabolic pathways
Module
hsa_M00101  Cholesterol biosynthesis, FPP => cholesterol
Network
nt06034  Cholesterol biosynthesis
  Element
N01624  Cholesterol biosynthesis
Disease
H00786  Hypotrichosis
H01202  Cataract
H02303  Alopecia-mental retardation syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00100 Steroid biosynthesis
    4047 (LSS)
Enzymes [BR:hsa01000]
 5. Isomerases
  5.4  Intramolecular transferases
   5.4.99  Transferring other groups
    5.4.99.7  lanosterol synthase
     4047 (LSS)
SSDB
Motif
Pfam: SQHop_cyclase_C SQHop_cyclase_N Prenyltrans
Other DBs
NCBI-GeneID: 4047
NCBI-ProteinID: NP_001001438
OMIM: 600909
HGNC: 6708
Ensembl: ENSG00000160285
UniProt: P48449 B2R694
Structure
Position
21:complement(46188446..46228774)
AA seq 732 aa
MTEGTCLRRRGGPYKTEPATDLGRWRLNCERGRQTWTYLQDERAGREQTGLEAYALGLDT
KNYFKDLPKAHTAFEGALNGMTFYVGLQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLP
AGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVSLRILGVGPDDPDLVRARNIL
HKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQVYLPM
SYCYAVRLSAAEDPLVQSLRQELYVEDFASIDWLAQRNNVAPDELYTPHSWLLRVVYALL
NLYEHHHSAHLRQRAVQKLYEHIVADDRFTKSISIGPISKTINMLVRWYVDGPASTAFQE
HVSRIPDYLWMGLDGMKMQGTNGSQIWDTAFAIQALLEAGGHHRPEFSSCLQKAHEFLRL
SQVPDNPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLLQEKCPHVTEHIPR
ERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQA
LKYFHKRFPEHRAAEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMG
QTYRDGTACAEVSRACDFLLSRQMADGGWGEDFESCEERRYLQSAQSQIHNTCWAMMGLM
AVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSCAISYTSYRNIFPIWALGRFS
QLYPERALAGHP
NT seq 2199 nt   +upstreamnt  +downstreamnt
atgacggagggcacgtgtctgcggcgccgagggggcccctacaagaccgagcccgccacc
gacctcggccgctggcgactcaactgcgagaggggccggcagacgtggacctacctgcag
gacgagcgcgccggccgcgagcagaccggcctggaagcctacgccctggggctggacacc
aagaattactttaaggacttgcccaaagcccacaccgcctttgagggggctctgaacggg
atgacattttacgtggggctgcaggctgaggatgggcactggacgggtgattatggtggc
ccacttttcctcctgccaggcctcctgatcacttgccacgtggcacgcatccctctgcca
gccggatacagagaagagattgtgcggtacctgcggtcagtgcagctccctgacggtggc
tggggcctgcacattgaggataagtccaccgtgtttgggactgcgctcaactatgtgtct
ctcagaattctgggtgttgggcctgacgatcctgacctggtacgagcccggaacattctt
cacaagaaaggtggtgctgtggccatcccctcctgggggaagttctggctggctgtcctg
aatgtttacagctgggaaggcctcaataccctgttcccagagatgtggctgtttcctgac
tgggcaccggcacacccctccacactctggtgccactgccggcaggtgtacctgcccatg
agctactgctacgccgttcggctgagtgccgcggaagacccgctggtccagagcctccgc
caggagctctatgtggaggacttcgccagcattgactggctggcgcagaggaacaacgtg
gcccccgacgagctgtacacgccgcacagctggctgctccgcgtggtatatgcgctcctc
aacctgtatgagcaccaccacagtgcccacctgcggcagcgggccgtgcagaagctgtat
gaacacattgtggccgacgaccgattcaccaagagcatcagcatcggcccgatctcgaaa
accatcaacatgcttgtgcgctggtatgtggacgggcccgcctccactgccttccaggag
catgtctccagaatcccggactatctctggatgggccttgacggcatgaaaatgcagggc
accaacggctcacagatctgggacaccgcattcgccatccaggctctgcttgaggcgggc
gggcaccacaggcccgagttttcgtcctgcctgcagaaggctcatgagttcctgaggctc
tcacaggtcccagataaccctcccgactaccagaagtactaccgccagatgcgcaagggt
ggcttctccttcagtacgctggactgcggctggatcgtttctgactgcacggctgaggcc
ttgaaggctgtgctgctcctgcaggagaagtgtccccatgtcaccgagcacatccccaga
gaacggctctgcgatgctgtggctgtgctgctgaacatgagaaatccagatggagggttc
gccacctatgagaccaagcgtggggggcacttgctggagctgctgaacccctcggaggtc
ttcggggacatcatgattgactacacctatgtggagtgcacctcagccgtgatgcaggcg
cttaagtatttccacaagcgtttcccggagcacagggcagcggagatccgggagaccctc
acgcagggcttagagttctgtcggcggcagcagagggccgatggctcctgggaaggctcc
tggggagtttgcttcacctacggcacctggtttggcctggaggccttcgcctgtatgggg
cagacctaccgagatgggactgcctgtgcagaggtctcccgggcctgtgacttcctgctg
tcccggcagatggcagacggaggctggggggaggactttgagtcctgcgaggagcggcgt
tatttgcagagtgcccagtcccagatccataacacatgctgggccatgatggggctgatg
gccgttcggcatcctgacatcgaggcccaggagagaggagtccggtgtctacttgagaaa
cagctccccaatggcgactggccgcaggaaaacattgctggggtcttcaacaagtcctgt
gccatctcctacacgagctacaggaacatcttccccatctgggccctcggccgcttctcc
cagctgtaccctgagagagcccttgctggccacccctga

  All links  
Disease (4)   
   OMIM (4)   
Gene (23)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (10)   
   OC (1)   
Protein sequence (7)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (40)   
   RefSeq(nuc) (4)   
   GenBank (18)   
   EMBL (18)   
3D Structure (2)   
   PDB (2)   
Protein domain (3)   
   Pfam (3)   
All databases (79)   

Download RDF
DBGET integrated database retrieval system