KEGG   Homo sapiens (human): 4048
Entry
4048              CDS       T01001                                 

Gene name
LTA4H
Definition
(RefSeq) leukotriene A4 hydrolase
  KO
K01254  leukotriene-A4 hydrolase [EC:3.3.2.6]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00590  Arachidonic acid metabolism
hsa01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    4048 (LTA4H)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    4048 (LTA4H)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.3  Acting on ether bonds
   3.3.2  Ether hydrolases
    3.3.2.6  leukotriene-A4 hydrolase
     4048 (LTA4H)
Peptidases and inhibitors [BR:hsa01002]
 Metallo peptidases
  Family M1
   4048 (LTA4H)
SSDB
Motif
Pfam: Peptidase_M1 Leuk-A4-hydro_C Peptidase_M1_N E1_DerP2_DerF2
Other DBs
NCBI-GeneID: 4048
NCBI-ProteinID: NP_000886
OMIM: 151570
HGNC: 6710
Ensembl: ENSG00000111144
Vega: OTTHUMG00000170355
Pharos: P09960(Tchem)
UniProt: P09960 A0A140VK27
Structure
PDB: 

Position
12q23.1
AA seq 611 aa
MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDL
TIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLT
PEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETP
DPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETES
MLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISH
SWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGET
HPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSI
TTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAK
EDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWL
RLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVT
AMLVGKDLKVD
NT seq 1836 nt   +upstreamnt  +downstreamnt
atgcccgagatagtggatacctgttcgttggcctctccggcttccgtctgccggaccaag
cacctgcacctgcgctgcagcgtcgactttactcgccggacgctgaccgggactgctgct
ctcacggtccagtctcaggaggacaatctgcgcagcctggttttggatacaaaggacctt
acaatagaaaaagtagtgatcaatggacaagaagtcaaatatgctcttggagaaagacaa
agttacaagggatcgccaatggaaatctctcttcctatcgctttgagcaaaaatcaagaa
attgttatagaaatttcttttgagacctctccaaaatcttctgctctccagtggctcact
cctgaacagacttctgggaaggaacacccatatctctttagtcagtgccaggccatccac
tgcagagcaatccttccttgtcaggacactccttctgtgaaattaacctatactgcagag
gtgtctgtccctaaagaactggtggcacttatgagtgctattcgtgatggagaaacacct
gacccagaagacccaagcaggaaaatatacaaattcatccaaaaagttccaataccctgc
tacctgattgctttagttgttggagctttagaaagcaggcaaattggcccaagaactttg
gtgtggtctgagaaagagcaggtggaaaagtctgcttatgagttttctgagactgaatct
atgcttaaaatagcagaagatctgggaggaccgtatgtatggggacagtatgacctattg
gtcctgccaccatccttcccttatggtggcatggagaatccttgccttacttttgtaact
cctactctactggcaggcgacaagtcactctccaatgtcattgcacatgaaatatctcat
agctggacagggaatctagtgaccaacaaaacttgggatcacttttggttaaatgaggga
catactgtgtacttggaacgccacatttgcggacgattgtttggtgaaaagttcagacat
tttaatgctctgggaggatggggagaactacagaattcggtaaagacatttggggagaca
catcctttcaccaaacttgtggttgatctgacagatatagaccctgatgtagcttattct
tcagttccctatgagaagggctttgctttacttttttaccttgaacaactgcttggagga
ccagagattttcctaggattcttaaaagcttatgttgagaagttttcctataagagcata
actactgatgactggaaggatttcctgtattcctattttaaagataaggttgatgttctc
aatcaagttgattggaatgcctggctctactctcctggactgcctcccataaagcccaat
tatgatatgactctgacaaatgcttgtattgccttaagtcaaagatggattactgccaaa
gaagatgatttaaattcattcaatgccacagacctgaaggatctctcttctcatcaattg
aatgagtttttagcacagacgctccagagggcacctcttccattggggcacataaagcga
atgcaagaggtgtacaacttcaatgccattaacaattctgaaatacgattcagatggctg
cggctctgcattcaatccaagtgggaggacgcaattcctttggcgctaaagatggcaact
gaacaaggaagaatgaagtttacccggcccttattcaaggatcttgctgcctttgacaaa
tcccatgatcaagctgtccgaacctaccaagagcacaaagcaagcatgcatcccgtgact
gcaatgctggtggggaaagacttaaaagtggattaa

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (1)   
   OMIM (1)   
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (30)   
   KEGG ORTHOLOGY (1)   
   RefGene (10)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (12)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (8)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (44)   
   RefSeq(nuc) (8)   
   GenBank (18)   
   EMBL (18)   
Protein domain (4)   
   Pfam (4)   
All databases (98)   

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