KEGG   Homo sapiens (human): 4049
Entry
4049              CDS       T01001                                 
Symbol
LTA, LT, TNFB, TNFSF1, TNLG1E
Name
(RefSeq) lymphotoxin alpha
  KO
K05468  lymphotoxin alpha (TNF superfamily, member 1)
Organism
hsa  Homo sapiens (human)
Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04061  Viral protein interaction with cytokine and cytokine receptor
hsa04064  NF-kappa B signaling pathway
hsa04668  TNF signaling pathway
hsa04940  Type I diabetes mellitus
hsa05166  Human T-cell leukemia virus 1 infection
hsa05168  Herpes simplex virus 1 infection
Disease
H00344  Leprosy
H01730  Myocardial infarction
Drug target
Etanercept: D00742<JP/US>
Lenercept: D04690
Pateclizumab: D10187
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    4049 (LTA)
   04668 TNF signaling pathway
    4049 (LTA)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    4049 (LTA)
   04061 Viral protein interaction with cytokine and cytokine receptor
    4049 (LTA)
 09160 Human Diseases
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    4049 (LTA)
   05168 Herpes simplex virus 1 infection
    4049 (LTA)
  09167 Endocrine and metabolic disease
   04940 Type I diabetes mellitus
    4049 (LTA)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    4049 (LTA)
Cytokines and neuropeptides [BR:hsa04052]
 Cytokines
  Tumor necrosis fators
   4049 (LTA)
SSDB
Motif
Pfam: TNF
Other DBs
NCBI-GeneID: 4049
NCBI-ProteinID: NP_000586
OMIM: 153440
HGNC: 6709
Ensembl: ENSG00000226979
UniProt: P01374 Q5STV3
Structure
Position
6:31560610..31574324
AA seq 205 aa
MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHST
LKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSGKAY
SPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQ
LSTHTDGIPHLVLSPSTVFFGAFAL
NT seq 618 nt   +upstreamnt  +downstreamnt
atgacaccacctgaacgtctcttcctcccaagggtgtgtggcaccaccctacacctcctc
cttctggggctgctgctggttctgctgcctggggcccaggggctccctggtgttggcctc
acaccttcagctgcccagactgcccgtcagcaccccaagatgcatcttgcccacagcacc
ctcaaacctgctgctcacctcattggagaccccagcaagcagaactcactgctctggaga
gcaaacacggaccgtgccttcctccaggatggtttctccttgagcaacaattctctcctg
gtccccaccagtggcatctacttcgtctactcccaggtggtcttctctgggaaagcctac
tctcccaaggccacctcctccccactctacctggcccatgaggtccagctcttctcctcc
cagtaccccttccatgtgcctctcctcagctcccagaagatggtgtatccagggctgcag
gaaccctggctgcactcgatgtaccacggggctgcgttccagctcacccagggagaccag
ctatccacccacacagatggcatcccccacctagtcctcagccctagtactgtcttcttt
ggagccttcgctctgtag

  All links  
Disease (4)   
   OMIM (4)   
Gene (15)   
   RefGene (5)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (5)   
   OC (1)   
Protein sequence (20)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (17)   
DNA sequence (53)   
   RefSeq(nuc) (17)   
   GenBank (18)   
   EMBL (18)   
3D Structure (3)   
   PDB (3)   
Protein domain (1)   
   Pfam (1)   
All databases (96)   

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