KEGG   Homo sapiens (human): 411
Entry
411               CDS       T01001                                 
Symbol
ARSB, ASB, G4S, MPS6
Name
(RefSeq) arylsulfatase B
  KO
K01135  arylsulfatase B [EC:3.1.6.12]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00531  Glycosaminoglycan degradation
hsa01100  Metabolic pathways
hsa04142  Lysosome
Module
hsa_M00076  Dermatan sulfate degradation
hsa_M00077  Chondroitin sulfate degradation
Network
nt06012  Glycosaminoglycan degradation
  Element
N00610  Dermatan sulfate degradation
Disease
H00131  Mucopolysaccharidosis type VI
H00421  Mucopolysaccharidosis
Drug target
Galsulfase: D06565<JP/US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00531 Glycosaminoglycan degradation
    411 (ARSB)
 09140 Cellular Processes
  09141 Transport and catabolism
   04142 Lysosome
    411 (ARSB)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.6  Sulfuric-ester hydrolases
    3.1.6.12  N-acetylgalactosamine-4-sulfatase
     411 (ARSB)
SSDB
Motif
Pfam: Sulfatase Phosphodiest Sulfatase_C
Other DBs
NCBI-GeneID: 411
NCBI-ProteinID: NP_000037
OMIM: 611542
HGNC: 714
Ensembl: ENSG00000113273
UniProt: P15848
Structure
Position
5:complement(78777209..78985958)
AA seq 533 aa
MGPRGAASLPRGPGPRRLLLPVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDV
GFHGSRIRTPHLDALAAGGVLLDNYYTQPLCTPSRSQLLTGRYQIRTGLQHQIIWPCQPS
CVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHER
CTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQS
VHEPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTD
NGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKL
ARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPNFVDSSPCPRNSMAPAKDDSSLP
EYSAFNTSVHAAIRHGNWKLLTGYPGCGYWFPPPSQYNVSEIPSSDPPTKTLWLFDIDRD
PEERHDLSREYPHIVTKLLSRLQFYHKHSVPVYFPAQDPRCDPKATGVWGPWM
NT seq 1602 nt   +upstreamnt  +downstreamnt
atgggtccgcgcggcgcggcgagcttgccccgaggccccggacctcggcggctgctcctc
cccgtcgtcctcccgctgctgctgctgctgttgttggcgccgccgggctcgggcgccggg
gccagccggccgccccacctggtcttcttgctggcagacgacctaggctggaacgacgtc
ggcttccacggctcccgcatccgcacgccgcacctggacgcgctggcggccggcggggtg
ctcctggacaactactacacgcagccgctgtgcacgccgtcgcggagccagctgctcact
ggccgctaccagatccgtacaggtttacagcaccaaataatctggccctgtcagcccagc
tgtgttcctctggatgaaaaactcctgccccagctcctaaaagaagcaggttatactacc
catatggtcggaaaatggcacctgggaatgtaccggaaagaatgccttccaacccgccga
ggatttgatacctactttggatatctcctgggtagtgaagattattattcccatgaacgc
tgtacattaattgacgctctgaatgtcacacgatgtgctcttgattttcgagatggcgaa
gaagttgcaacaggatataaaaatatgtattcaacaaacatattcaccaaaagggctata
gccctcataactaaccatccaccagagaagcctctgtttctctaccttgctctccagtct
gtgcatgagccccttcaggtccctgaggaatacttgaagccatatgactttatccaagac
aagaacaggcatcactatgcaggaatggtgtcccttatggatgaagcagtaggaaatgtc
actgcagctttaaaaagcagtgggctctggaacaacacggtgttcatcttttctacagat
aacggagggcagactttggcagggggtaataactggccccttcgaggaagaaaatggagc
ctgtgggaaggaggcgtccgaggggtgggctttgtggcaagccccttgctgaagcagaag
ggcgtgaagaaccgggagctcatccacatctctgactggctgccaacactcgtgaagctg
gccaggggacacaccaatggcacaaagcctctggatggcttcgacgtgtggaaaaccatc
agtgaaggaagcccatcccccagaattgagctgctgcataatattgacccgaacttcgtg
gactcttcaccgtgtcccaggaacagcatggctccagcaaaggatgactcttctcttcca
gaatattcagcctttaacacatctgtccatgctgcaattagacatggaaattggaaactc
ctcacgggctacccaggctgtggttactggttccctccaccgtctcaatacaatgtttct
gagataccctcatcagacccaccaaccaagaccctctggctctttgatattgatcgggac
cctgaagaaagacatgacctgtccagagaatatcctcacatcgtcacaaagctcctgtcc
cgcctacagttctaccataaacactcagtccccgtgtacttccctgcacaggacccccgc
tgtgatcccaaggccactggggtgtggggcccttggatgtag

  All links  
Disease (2)   
   OMIM (2)   
Gene (29)   
   RefGene (14)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (10)   
   OC (1)   
Protein sequence (18)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (16)   
DNA sequence (68)   
   RefSeq(nuc) (20)   
   GenBank (24)   
   EMBL (24)   
3D Structure (1)   
   PDB (1)   
Protein domain (3)   
   Pfam (3)   
All databases (121)   

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